JP2005509846A - 薄層を用いた生体分子の電子的検出 - Google Patents
薄層を用いた生体分子の電子的検出 Download PDFInfo
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- JP2005509846A JP2005509846A JP2003544210A JP2003544210A JP2005509846A JP 2005509846 A JP2005509846 A JP 2005509846A JP 2003544210 A JP2003544210 A JP 2003544210A JP 2003544210 A JP2003544210 A JP 2003544210A JP 2005509846 A JP2005509846 A JP 2005509846A
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| US37893802P | 2002-05-10 | 2002-05-10 | |
| PCT/US2002/018319 WO2003042396A2 (en) | 2001-06-11 | 2002-06-10 | Electronic detection of biological molecules using thin layers |
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Cited By (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004184414A (ja) * | 2002-12-03 | 2004-07-02 | Hewlett-Packard Development Co Lp | 自立ナノワイヤセンサ及び流体内の分析物を検出するための方法 |
| JP2006234799A (ja) * | 2005-01-10 | 2006-09-07 | Korea Advanced Inst Of Sci Technol | ナノギャップを形成する方法、分子素子とバイオセンサーのためのナノ電界効果トランジスタを作製する方法、及びその方法により作製された分子素子とバイオセンサー |
| JP2009524046A (ja) * | 2006-01-20 | 2009-06-25 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | バイオセンサセル及びバイオセンサアレイ |
| JP2010513853A (ja) * | 2006-12-15 | 2010-04-30 | インペリアル イノベーションズ リミテッド | 電極システム及び分子特性付けに使用される電極システム |
| JP2013525808A (ja) * | 2010-05-06 | 2013-06-20 | ソウル・ナショナル・ユニバーシティ・アール・アンド・ディ・ファウンデイション | 容量素子センサー及びその製造方法 |
| KR101418389B1 (ko) | 2013-03-29 | 2014-07-11 | 한국과학기술원 | 멀티 나노센서 및 그 제조 방법 |
| KR20170096707A (ko) * | 2016-02-17 | 2017-08-25 | 한국과학기술원 | 광전기화학적 전지(PEC cell)를 이용한 보조인자 재생방법 |
| JP2018522236A (ja) * | 2015-06-25 | 2018-08-09 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 生体分子センサーおよび方法 |
| JP2019503485A (ja) * | 2016-01-14 | 2019-02-07 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 分子センサーおよび関連方法 |
| JP2019510207A (ja) * | 2016-01-28 | 2019-04-11 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 超パラレルｄｎａ配列決定装置 |
| JP2019523411A (ja) * | 2016-07-26 | 2019-08-22 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 分子感知デバイスのための多電極構造およびそれの作成方法 |
| JP2019530853A (ja) * | 2016-08-01 | 2019-10-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 分子認識のためのマイクロ流体アレイ内のトンネル接合 |
| KR20190121247A (ko) * | 2018-04-17 | 2019-10-25 | 한국화학연구원 | 멀티웰 전극 기반 바이오센서 |
| KR20200004809A (ko) * | 2017-05-09 | 2020-01-14 | 로스웰 바이오테크놀로지스 인코포레이티드 | 분자 센서들을 위한 결합 프로브 회로들 |
| JP2022526946A (ja) * | 2019-03-26 | 2022-05-27 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 調整可能なナノピラーおよびナノギャップ電極構造体およびそれらの方法 |
| JP2022544464A (ja) * | 2019-07-31 | 2022-10-19 | エーエックスバイオ インコーポレイテッド | 標的分子を評価するためのシステム及び方法 |
| JP2022544663A (ja) * | 2019-08-22 | 2022-10-20 | ユニバーサル シーケンシング テクノロジー コーポレイション | 生体分子の検知および検出のための方法 |
| JP2023531437A (ja) * | 2020-06-18 | 2023-07-24 | セント・ジュード・メディカル，カーディオロジー・ディヴィジョン，インコーポレイテッド | エレクトロポレーション治療を送達するためのデバイスおよび方法 |
| US12227801B2 (en) | 2018-05-22 | 2025-02-18 | Axbio Inc. | Methods, systems, and compositions for nucelic acid sequencing |
| US12252742B2 (en) | 2021-09-28 | 2025-03-18 | Axbio Inc. | Methods for processing a nucleic acid sample and compositions thereof |
Families Citing this family (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7899511B2 (en) | 2004-07-13 | 2011-03-01 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US9155496B2 (en) | 1997-03-04 | 2015-10-13 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| US6036924A (en) | 1997-12-04 | 2000-03-14 | Hewlett-Packard Company | Cassette of lancet cartridges for sampling blood |
| US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
| US8641644B2 (en) | 2000-11-21 | 2014-02-04 | Sanofi-Aventis Deutschland Gmbh | Blood testing apparatus having a rotatable cartridge with multiple lancing elements and testing means |
| US6723299B1 (en) | 2001-05-17 | 2004-04-20 | Zyvex Corporation | System and method for manipulating nanotubes |
| US20040023253A1 (en) * | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
| US7537571B2 (en) | 2001-06-12 | 2009-05-26 | Pelikan Technologies, Inc. | Integrated blood sampling analysis system with multi-use sampling module |
| US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US7981056B2 (en) | 2002-04-19 | 2011-07-19 | Pelikan Technologies, Inc. | Methods and apparatus for lancet actuation |
| CA2448905C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Blood sampling apparatus and method |
| US9795747B2 (en) | 2010-06-02 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Methods and apparatus for lancet actuation |
| EP1404233B1 (en) | 2001-06-12 | 2009-12-02 | Pelikan Technologies Inc. | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties |
| AU2002348683A1 (en) | 2001-06-12 | 2002-12-23 | Pelikan Technologies, Inc. | Method and apparatus for lancet launching device integrated onto a blood-sampling cartridge |
| US7344507B2 (en) | 2002-04-19 | 2008-03-18 | Pelikan Technologies, Inc. | Method and apparatus for lancet actuation |
| US9427532B2 (en) | 2001-06-12 | 2016-08-30 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| WO2002100461A2 (en) | 2001-06-12 | 2002-12-19 | Pelikan Technologies, Inc. | Method and apparatus for improving success rate of blood yield from a fingerstick |
| CA2448790C (en) | 2001-06-12 | 2010-09-07 | Pelikan Technologies, Inc. | Electric lancet actuator |
| US7041068B2 (en) | 2001-06-12 | 2006-05-09 | Pelikan Technologies, Inc. | Sampling module device and method |
| US9226699B2 (en) | 2002-04-19 | 2016-01-05 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling module with a continuous compression tissue interface surface |
| US7344894B2 (en) | 2001-10-16 | 2008-03-18 | Agilent Technologies, Inc. | Thermal regulation of fluidic samples within a diagnostic cartridge |
| US8364229B2 (en) | 2003-07-25 | 2013-01-29 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US7613491B2 (en) | 2002-05-22 | 2009-11-03 | Dexcom, Inc. | Silicone based membranes for use in implantable glucose sensors |
| US7491178B2 (en) | 2002-04-19 | 2009-02-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7563232B2 (en) | 2002-04-19 | 2009-07-21 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7892183B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US9795334B2 (en) | 2002-04-19 | 2017-10-24 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7244265B2 (en) | 2002-04-19 | 2007-07-17 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8784335B2 (en) | 2002-04-19 | 2014-07-22 | Sanofi-Aventis Deutschland Gmbh | Body fluid sampling device with a capacitive sensor |
| US7229458B2 (en) | 2002-04-19 | 2007-06-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US9314194B2 (en) | 2002-04-19 | 2016-04-19 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| US8702624B2 (en) | 2006-09-29 | 2014-04-22 | Sanofi-Aventis Deutschland Gmbh | Analyte measurement device with a single shot actuator |
| US7485128B2 (en) | 2002-04-19 | 2009-02-03 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7374544B2 (en) | 2002-04-19 | 2008-05-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7547287B2 (en) | 2002-04-19 | 2009-06-16 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7901362B2 (en) | 2002-04-19 | 2011-03-08 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7648468B2 (en) | 2002-04-19 | 2010-01-19 | Pelikon Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7291117B2 (en) | 2002-04-19 | 2007-11-06 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8221334B2 (en) | 2002-04-19 | 2012-07-17 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US8360992B2 (en) | 2002-04-19 | 2013-01-29 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7976476B2 (en) | 2002-04-19 | 2011-07-12 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US7232451B2 (en) | 2002-04-19 | 2007-06-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7892185B2 (en) | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
| US9248267B2 (en) | 2002-04-19 | 2016-02-02 | Sanofi-Aventis Deustchland Gmbh | Tissue penetration device |
| US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
| US7371247B2 (en) | 2002-04-19 | 2008-05-13 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
| US7410468B2 (en) | 2002-04-19 | 2008-08-12 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7524293B2 (en) | 2002-04-19 | 2009-04-28 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7297122B2 (en) | 2002-04-19 | 2007-11-20 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8267870B2 (en) | 2002-04-19 | 2012-09-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for body fluid sampling with hybrid actuation |
| US7674232B2 (en) | 2002-04-19 | 2010-03-09 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7909778B2 (en) | 2002-04-19 | 2011-03-22 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| WO2003088824A2 (en) | 2002-04-19 | 2003-10-30 | Pelikan Technologies, Inc. | Device and method for variable speed lancet |
| US7331931B2 (en) | 2002-04-19 | 2008-02-19 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US8579831B2 (en) | 2002-04-19 | 2013-11-12 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for penetrating tissue |
| US7717863B2 (en) | 2002-04-19 | 2010-05-18 | Pelikan Technologies, Inc. | Method and apparatus for penetrating tissue |
| US7141058B2 (en) | 2002-04-19 | 2006-11-28 | Pelikan Technologies, Inc. | Method and apparatus for a body fluid sampling device using illumination |
| US7582099B2 (en) | 2002-04-19 | 2009-09-01 | Pelikan Technologies, Inc | Method and apparatus for penetrating tissue |
| US6905667B1 (en) | 2002-05-02 | 2005-06-14 | Zyvex Corporation | Polymer and method for using the polymer for noncovalently functionalizing nanotubes |
| US20040034177A1 (en) | 2002-05-02 | 2004-02-19 | Jian Chen | Polymer and method for using the polymer for solubilizing nanotubes |
| US7015471B2 (en) * | 2002-09-25 | 2006-03-21 | North Carolina State University | Surface plasmon resonance systems and methods having a variable charge density layer |
| US8574895B2 (en) | 2002-12-30 | 2013-11-05 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus using optical techniques to measure analyte levels |
| WO2004106420A2 (en) | 2003-05-22 | 2004-12-09 | Zyvex Corporation | Nanocomposites and method for production |
| WO2004107975A2 (en) | 2003-05-30 | 2004-12-16 | Pelikan Technologies, Inc. | Method and apparatus for fluid injection |
| WO2004107964A2 (en) | 2003-06-06 | 2004-12-16 | Pelikan Technologies, Inc. | Blood harvesting device with electronic control |
| WO2006001797A1 (en) | 2004-06-14 | 2006-01-05 | Pelikan Technologies, Inc. | Low pain penetrating |
| EP1635700B1 (en) | 2003-06-13 | 2016-03-09 | Sanofi-Aventis Deutschland GmbH | Apparatus for a point of care device |
| US7460898B2 (en) | 2003-12-05 | 2008-12-02 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7651596B2 (en) | 2005-04-08 | 2010-01-26 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
| US7467003B2 (en) | 2003-12-05 | 2008-12-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| WO2007120442A2 (en) | 2003-07-25 | 2007-10-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US9763609B2 (en) | 2003-07-25 | 2017-09-19 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| US7424318B2 (en) | 2003-12-05 | 2008-09-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7366556B2 (en) | 2003-12-05 | 2008-04-29 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| KR101214179B1 (ko) | 2003-08-06 | 2013-01-10 | 더 프록터 앤드 갬블 컴퍼니 | 표적 물질 검출용 가교 부재 |
| US7547381B2 (en) * | 2003-09-26 | 2009-06-16 | Agency For Science, Technology And Research And National University Of Singapore | Sensor array integrated electrochemical chip, method of forming same, and electrode coating |
| US8282576B2 (en) | 2003-09-29 | 2012-10-09 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for an improved sample capture device |
| US7132298B2 (en) * | 2003-10-07 | 2006-11-07 | Hewlett-Packard Development Company, L.P. | Fabrication of nano-object array |
| WO2005037095A1 (en) | 2003-10-14 | 2005-04-28 | Pelikan Technologies, Inc. | Method and apparatus for a variable user interface |
| EP2239566B1 (en) | 2003-12-05 | 2014-04-23 | DexCom, Inc. | Calibration techniques for a continuous analyte sensor |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| DE10359173B4 (de) * | 2003-12-17 | 2006-11-09 | Robert Bosch Gmbh | Messvorrichtung mit mehreren auf einem Substrat angeordneten potentiometrischen Elektrodenpaaren |
| WO2005065414A2 (en) | 2003-12-31 | 2005-07-21 | Pelikan Technologies, Inc. | Method and apparatus for improving fluidic flow and sample capture |
| US7822454B1 (en) | 2005-01-03 | 2010-10-26 | Pelikan Technologies, Inc. | Fluid sampling device with improved analyte detecting member configuration |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US7655404B2 (en) | 2004-04-29 | 2010-02-02 | Agency For Science, Technology And Research | Method and device for detection of nucleic acids and/or polypeptides |
| WO2006011062A2 (en) | 2004-05-20 | 2006-02-02 | Albatros Technologies Gmbh & Co. Kg | Printable hydrogel for biosensors |
| US9775553B2 (en) | 2004-06-03 | 2017-10-03 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for a fluid sampling device |
| WO2005120365A1 (en) | 2004-06-03 | 2005-12-22 | Pelikan Technologies, Inc. | Method and apparatus for a fluid sampling device |
| US7296576B2 (en) | 2004-08-18 | 2007-11-20 | Zyvex Performance Materials, Llc | Polymers for enhanced solubility of nanomaterials, compositions and methods therefor |
| US8652831B2 (en) | 2004-12-30 | 2014-02-18 | Sanofi-Aventis Deutschland Gmbh | Method and apparatus for analyte measurement test time |
| US20060207880A1 (en) * | 2005-03-15 | 2006-09-21 | Joyce Timothy H | Microfluidic devices and methods of using microfluidic devices |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| US20070099306A1 (en) * | 2005-09-28 | 2007-05-03 | Kent State University | Liquid crystal sensor system |
| US7741142B2 (en) * | 2005-11-22 | 2010-06-22 | Hewlett-Packard Development Company, L.P. | Method of fabricating a biosensor |
| US9757061B2 (en) | 2006-01-17 | 2017-09-12 | Dexcom, Inc. | Low oxygen in vivo analyte sensor |
| JP4861739B2 (ja) * | 2006-04-11 | 2012-01-25 | キヤノン株式会社 | 磁気センサ、該センサの作製方法、並びに、該センサを用いた標的物質検出装置及びバイオセンサキット |
| US7831287B2 (en) | 2006-10-04 | 2010-11-09 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US20200037874A1 (en) | 2007-05-18 | 2020-02-06 | Dexcom, Inc. | Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise |
| CA2688184A1 (en) | 2007-06-08 | 2008-12-18 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| AT505495A1 (de) * | 2007-07-04 | 2009-01-15 | Arc Austrian Res Centers Gmbh | Verfahren zur identifizierung und quantifizierung von organischen und biochemischen substanzen |
| US20100285601A1 (en) * | 2007-09-28 | 2010-11-11 | Agency For Science, Technology And Research | Method of electrically detecting a nucleic acid molecule |
| EP4098177A1 (en) | 2007-10-09 | 2022-12-07 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
| US7827852B2 (en) * | 2007-12-20 | 2010-11-09 | General Electric Company | Gas sensor and method of making |
| WO2009126900A1 (en) | 2008-04-11 | 2009-10-15 | Pelikan Technologies, Inc. | Method and apparatus for analyte detecting device |
| US20090261346A1 (en) * | 2008-04-16 | 2009-10-22 | Ding-Yuan Chen | Integrating CMOS and Optical Devices on a Same Chip |
| US9375169B2 (en) | 2009-01-30 | 2016-06-28 | Sanofi-Aventis Deutschland Gmbh | Cam drive for managing disposable penetrating member actions with a single motor and motor and control system |
| WO2011108540A1 (ja) | 2010-03-03 | 2011-09-09 | 国立大学法人大阪大学 | ヌクレオチドを識別する方法および装置、ならびにポリヌクレオチドのヌクレオチド配列を決定する方法および装置 |
| US8965476B2 (en) | 2010-04-16 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
| CN106104274B (zh) | 2013-09-18 | 2018-05-22 | 量子生物有限公司 | 生物分子测序装置、系统和方法 |
| JP2015077652A (ja) | 2013-10-16 | 2015-04-23 | クオンタムバイオシステムズ株式会社 | ナノギャップ電極およびその製造方法 |
| US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
| WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
| WO2016160877A1 (en) * | 2015-03-31 | 2016-10-06 | Rapid Pathogen Screening, Inc. | Non-enzymatic nucleic acid detection using an oligonucleotide linker with a large cell gap |
| CN107810411B (zh) | 2015-06-30 | 2020-04-14 | 豪夫迈·罗氏有限公司 | 用于使用纳米制造的设备来测量分析物的设计和方法 |
| CN109071212A (zh) | 2016-01-28 | 2018-12-21 | 罗斯韦尔生物技术股份有限公司 | 使用大规模分子电子传感器阵列测量分析物的方法和装置 |
| JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ，インコーポレイテッド | 電子的、標識フリーのｄｎａおよびゲノムシークエンシング |
| US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
| CN115595360A (zh) | 2016-04-27 | 2023-01-13 | 因美纳剑桥有限公司（Gb） | 用于生物分子的测量和测序的系统和方法 |
| CN108130273B (zh) | 2016-12-01 | 2021-10-12 | 京东方科技集团股份有限公司 | 检测基板及其制作方法、检测核酸的方法 |
| CA3052062A1 (en) | 2017-01-10 | 2018-07-19 | Roswell Biotechnologies, Inc. | Methods and systems for dna data storage |
| EP3571286A4 (en) | 2017-01-19 | 2020-10-28 | Roswell Biotechnologies, Inc | SEMICONDUCTOR SEQUENCING DEVICES INCLUDING TWO-DIMENSIONAL LAYER MATERIALS |
| CN110546276A (zh) | 2017-04-25 | 2019-12-06 | 罗斯威尔生命技术公司 | 用于分子传感器的酶电路 |
| US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
| TWI745392B (zh) * | 2017-06-29 | 2021-11-11 | 瑞禾生物科技股份有限公司 | 生物感測元件及其製造方法以及生物分子檢測方法 |
| WO2019046589A1 (en) | 2017-08-30 | 2019-03-07 | Roswell Biotechnologies, Inc. | PROCESSIVE ENZYME MOLECULAR ELECTRONIC SENSORS FOR STORING DNA DATA |
| WO2019065904A1 (en) * | 2017-09-27 | 2019-04-04 | Quantum Biosystems Inc. | NANOELECTRODES DEVICES AND METHODS OF MANUFACTURING THE SAME |
| KR102717872B1 (ko) | 2017-10-10 | 2024-10-14 | 로스웰 엠이 아이엔씨. | 무증폭 dna 데이터 저장을 위한 방법, 장치 및 시스템 |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| CA3077720A1 (en) | 2017-10-24 | 2019-05-02 | Dexcom, Inc. | Pre-connected analyte sensors |
| US20210231599A1 (en) * | 2018-05-04 | 2021-07-29 | LeNano Diagnostics Inc. | Biosensor for the Detection of an Analyte |
| EP3803363A4 (en) * | 2018-06-06 | 2022-03-23 | Khalifa University of Science and Technology | GLUCOSE SENSING DEVICE |
| NL2021376B1 (en) * | 2018-06-29 | 2020-01-06 | Illumina Inc | Sensor and sensing system |
| US11621345B2 (en) * | 2018-08-14 | 2023-04-04 | Pawan Tyagi | Systems and methods of fabricating gate electrode on trenched bottom electrode based molecular spintronics device |
| US10833162B2 (en) * | 2018-08-14 | 2020-11-10 | Pawan Tyagi | Trenched bottom electrode and liftoff based molecular devices |
| JP7232433B2 (ja) * | 2018-10-19 | 2023-03-03 | エフ． ホフマン－ラ ロシュ アーゲー | 配列決定のための電場補助型接合部 |
| CN110297030B (zh) * | 2019-08-02 | 2021-11-16 | 盐城工学院 | 一种高选择性黄体酮光电化学生物传感器的构建方法 |
| US12146852B2 (en) | 2019-09-06 | 2024-11-19 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
| CN112744791B (zh) * | 2019-10-30 | 2023-01-06 | Tcl科技集团股份有限公司 | 金属氧化物纳米颗粒及其制备方法及其应用 |
| CN111272848B (zh) * | 2020-03-06 | 2022-04-26 | 安徽大学 | 一种检测miRNA159c的高灵敏光电化学生物传感器及其制备和检测方法 |
| CN115684305A (zh) * | 2021-07-28 | 2023-02-03 | 瑞禾生物科技股份有限公司 | 生物感测装置 |
| EP4124853A1 (en) * | 2021-07-29 | 2023-02-01 | NEAT Biotech, Inc. | Biosensor apparatus |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846708A (en) * | 1991-11-19 | 1998-12-08 | Massachusetts Institiute Of Technology | Optical and electrical methods and apparatus for molecule detection |
| US5965452A (en) * | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
| US6127127A (en) * | 1995-06-27 | 2000-10-03 | The University Of North Carolina At Chapel Hill | Monolayer and electrode for detecting a label-bearing target and method of use thereof |
| JPH10146183A (ja) * | 1996-09-19 | 1998-06-02 | Toshiba Corp | 電極、検出装置およびセンサ |
| FR2757948B1 (fr) * | 1996-12-30 | 1999-01-22 | Commissariat Energie Atomique | Microsystemes pour analyses biologiques, leur utilisation pour la detection d'analytes et leur procede de realisation |
| US6048692A (en) * | 1997-10-07 | 2000-04-11 | Motorola, Inc. | Sensors for electrically sensing binding events for supported molecular receptors |
| US6060023A (en) * | 1998-03-31 | 2000-05-09 | Motorola, Inc. | Molecular sensing apparatus |
| IL124322A (en) * | 1998-05-04 | 2002-05-23 | Technion Res & Dev Foundation | Detection of an entity in a sample |
| DE19860547C1 (de) * | 1998-12-23 | 2000-10-12 | Genetrix B V I O | Affinitätssensor für den Nachweis spezifischer molekularer Bindungsereignisse und dessen Verwendung |
| DE19960076C2 (de) * | 1999-12-13 | 2002-12-05 | November Ag Molekulare Medizin | Verfahren und Vorrichtung zum Nachweis und zur Quantifizierung von Biomolekülen |
| WO2001043870A2 (en) * | 1999-12-15 | 2001-06-21 | Motorola Inc. | Column and row addressable high density biochip array |
| US6824974B2 (en) * | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
-
2002
- 2002-06-10 WO PCT/US2002/018319 patent/WO2003042396A2/en not_active Ceased
- 2002-06-10 CA CA002450109A patent/CA2450109A1/en not_active Abandoned
- 2002-06-10 AU AU2002363627A patent/AU2002363627A1/en not_active Abandoned
- 2002-06-10 JP JP2003544210A patent/JP2005509846A/ja active Pending
- 2002-06-10 US US10/480,409 patent/US20040248282A1/en not_active Abandoned
- 2002-06-10 EP EP02799869A patent/EP1417352A4/en not_active Withdrawn
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2003042396A3 (en) | 2004-03-11 |
| WO2003042396A2 (en) | 2003-05-22 |
| EP1417352A2 (en) | 2004-05-12 |
| EP1417352A4 (en) | 2006-11-08 |
| CA2450109A1 (en) | 2003-05-22 |
| AU2002363627A1 (en) | 2003-05-26 |
| US20040248282A1 (en) | 2004-12-09 |
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