JP2010513853A - 電極システム及び分子特性付けに使用される電極システム - Google Patents
電極システム及び分子特性付けに使用される電極システム Download PDFInfo
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Abstract
2個の電極(16a、16b)を提供して電極間にトンネル隙間を規定する工程と、該電極間に電位差を与える工程と、該トンネル隙間に分子を通過させる工程と、測定期間の間に亘って該電極間のトンネル電流を計測する工程と、を有し、該測定期間のうち少なくとも一部の期間においては該分子の少なくとも一部が該隙間内に位置している分子特性付け方法。
【選択図】 図1
Description
20 隙間
12、58、 細孔
16a、16b,54a、54b、74a、74b,84a、84b,94a、94b、94c、94d、104a、104b、104c 電極
78、98、108 開口
78a、88 スリット
85 導電性材料
Claims (36)
- 2個の電極を提供して電極間にトンネル隙間を規定する工程と、
該電極間に電位差を与える工程と、
該トンネル隙間に分子を通過させる工程と、
測定期間の間に亘って該電極間のトンネル電流を計測する工程と、を有し、該測定期間のうち少なくとも一部の期間においては該分子の少なくとも一部が該隙間内に位置していることを特徴とする分子特性付け方法。 - 該分子はポリマーであることを特徴とする請求項1に記載の方法。
- 該ポリマーの複数の部分が分子に沿って位置している配列順に連続的に該隙間を通過するように、該ポリマーを案内する工程を更に備える請求項2に記載の方法。
- 時間の関数であるトンネル電流を記録する工程を更に備える請求項1乃至3のいずれか一記載の方法。
- 2個の電極を提供して該電極間に隙間を規定する工程と、
該電極間に電位差を与える工程と、
該ポリマーの複数の部分が分子に沿って位置している配列順に連続的に該電極間を通過するように、該分子を該隙間に通過させる工程と、
該分子が該電極間を通過するときの電極間の電流を測定する工程と、を備えたことを特徴とする分子特性付け方法。 - 測定される電流は、実質的に該分子を横切る方向に通過する電流であることを特徴とする請求項6記載の方法。
- 該分子は、溶液中にある状態で該隙間を通過することを特徴とする請求項1乃至6のいずれか一記載の方法。
- .
該分子の複数の位置で該電流を測定してそれぞれの分子の部分が特徴づけられることを特徴とする請求項5乃至7のいずれか一に記載の方法。 - それぞれが一対の電極を備える複数のガイド手段を提供し、分子がガイド手段を通過してそれぞれの一対の電極間の電流が同時に計測されることを特徴とする請求項7又は8に記載の方法。
- 該溶液に駆動電位を印加して該隙間を通過する分子を駆動する工程を更に備え、該駆動電位は分子が移動する速度を変化させるように変更されることを特徴とする請求項7乃至9のいずれか一に記載の方法。
- 駆動電位をパルス状として分子を徐々に移動させることを特徴とする請求項10に記載の方法。
- 該分子が該電極間を通過するときに、該分子の一部が該電極間に存在している時間を計測して該分子の長さを計測する工程を更に備えたことを特徴とする請求項1乃至11のいずれか一に記載の方法。
- 一対の電極とガイド手段とを有し、該一対の電極はその間にトンネル隙間を規定し、トンネル隙間を横切るようにトンネル電流が流れ、該ガイド手段は該電極間に分子を案内することを特徴とする分子特性付け装置。
- 該案内手段はダクトを規定し、該ダクト内を溶液内の分子が通過することを特徴とする請求項13記載の装置。
- 該案内手段は、細孔が貫通形成された物体によって構成されることを特徴とする請求項13又は14に記載の装置。
- 該電極は該物体の表面に支持されていることを特徴とする請求項15に記載の装置。
- 該電極は該細孔の互いに反対側に位置していることを特徴とする請求項16に記載の装置。
- 該電極は該細孔の同一の端面側に位置していることを特徴とする請求項16又は17に記載の装置。
- 該物体は、該物体を貫通する複数の細孔を有し、それぞれの細孔は一対の電極が設けられていることを特徴とする請求項15乃至18のいずれか一に記載の装置。
- 一対の電極間の電流を計測するための制御手段が更に設けられていることを特徴とする請求項12乃至18のいずれか一に記載の装置。
- 該制御手段は、一対の電極間の電流に関する電流データを記録し、該電流データを分析して該分子を特徴付けることを特徴とする請求項20に記載の装置。
- 少なくとも一方の電極は、その一部の表面がSERS活性材料によって形成されていることを特徴とする請求項13乃至21のいずれか一に記載の装置。
- 隙間が形成され該隙間の開口の近傍に電極が設けられた材料層を提供する工程と、該電極に導電性材料を付着させる工程とを備えたことを特徴とする電極システムを製造する方法。
- 該開口は一方向に長さを、それに直交する方向に幅を有し、長さは幅よりも長いことを特徴とする請求項23に記載の方法。
- 該電極は該隙間の一端部に位置していることを特徴とする請求項24に記載の方法。
- 該隙間の他端側にも別の電極が設けられていることを特徴とする請求項2に記載の方法。
- 導電性材料を付着させる前の状態で、該電極の幅は開口の幅よりも広いことを特徴とする請求項25又は26に記載の方法。
- 該材料層は2個のリザーバの間に配置され、該電極に付着する少なくとも1種の導電性物質を提供可能な反応物質の濃度が2個のリザーバ間で異なっていることを特徴とする請求項23乃至27のいずれか一に記載の方法。
- 該電極は該隙間の一方の開口側に設けられ、該反応物質の濃度が高い側のリザーバは、該隙間の他方の開口側にあることを特徴とする請求項28に記載の方法。
- 該導電材料は、電極が隙間内で成長するように該電極に付着することを特徴とする請求項23乃至29のいずれか一に記載の方法。
- 該電極は、該隙間に関して該電極に向かう方向よりもむしろ該隙間の下方に向かって成長することを特徴とする請求項23乃至30のいずれか一に記載の方法。
- 該導電性材料は、SERS活性材料であることを特徴とする請求項23乃至31のいずれか一に記載の方法。
- 隙間が貫通する材料層と、該材料層に設けられた電極とを備え、該電極は該材料層の表面であって該隙間の近傍に設けられまた該材料層の表面から隙間内に延びていることを特徴とする電極システム。
- 該表面は実質的に平坦面であり、該隙間は側面と、該平坦面と該側面との間の縁部とを有し、該電極は該縁部上をまた該側面上を覆うように延びていることを特徴とする請求項33に記載の電極システム。
- 該隙間開口端の長さはその幅よりも長く、一方の電極は該開口の一端に設けられ、他方の電極は開口端の他端に設けられることを特徴とする請求項33又は34に記載の電極システム。
- 該隙間は、複数のスロットが結合した構成であり、個々のスロットの一端は互いにつながり合った開放端となり、個々のスロットの他端は閉鎖端となり、それぞれの電極はそれぞれのスロットのそれぞれの閉鎖端に設けられていることを特徴とする請求項32又は33に記載の電極システム。
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GBGB0625070.8A GB0625070D0 (en) | 2006-12-15 | 2006-12-15 | Characterization of molecules |
PCT/GB2007/004796 WO2008071982A2 (en) | 2006-12-15 | 2007-12-13 | Electrode systems and their use in the characterization of molecules |
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EP2092072A2 (en) | 2009-08-26 |
CN101605910A (zh) | 2009-12-16 |
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WO2008071982A2 (en) | 2008-06-19 |
US20100188109A1 (en) | 2010-07-29 |
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KR20090112636A (ko) | 2009-10-28 |
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