JP2019523411A - 分子感知デバイスのための多電極構造およびそれの作成方法 - Google Patents
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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Abstract
Description
本願は、2016年7月26日に出願され“Multi−Electrode Molecular Sensing Devices and Methods of Making the Same”と題された米国出願第15/220,307号に対する優先権を主張するものであり、該出願の開示の全体は、参照により本明細書中に援用される。
Claims (20)
- 分子センサデバイスで使用可能な構造を製造する方法であって、前記方法は、
基板平面に対する角度で基板から突出する突出部を伴って、前記基板平面を画定する前記基板を提供するステップと、
前記突出部の側面に沿った配向で第1の電極層を堆積させ、前記基板平面に対する前記角度で第1の電極シートを形成するステップと、
前記第1の電極層上に内側誘電体層を堆積させ、前記基板平面に対する前記角度で内側誘電体シートを形成するステップと、
前記内側誘電体層上に第2の電極層を堆積させ、前記基板平面に対する前記角度で第2の電極シートを形成するステップであって、前記第1の電極シートおよび前記第2の電極シートは、前記第1の電極シートと前記第2の電極シートとの間で前記内側誘電体シートによって離間される電極シートの対を形成する、ステップと、
前記第2の電極上に外側誘電体層を堆積させ、前記基板平面に対する角度で外側誘電体シートを形成するステップと、
前記第1の電極層、前記内側誘電体層、前記第2の電極層、および前記外側誘電体層の堆積を少なくとも1回繰り返し、前記電極シートの対の中の各電極シートの間の内側誘電体シートおよび各対の電極シートの間の外側誘電体シートを伴って、離間した電極シートの対を形成するステップと、
前記電極シートの対、前記内側誘電体シート、および前記外側誘電体シートを平坦化するステップと、
各内側誘電体シートの露出端部分を除去し、前記基板に向かって前記平坦化された縁から降下する溝を各内側誘電体シートに形成するステップと
を含む、方法。 - 各内側誘電体層は、第1の厚さで堆積され、各外側誘電体シートは、前記第1の厚さよりも少なくとも1桁大きい第2の厚さで堆積される、請求項1に記載の方法。
- 前記平坦化するステップに先立って、前記堆積された第1の電極層、内側誘電体層、第2の電極層、および外側誘電体層によって形成されるスタックに隣接して、機械的支持ブロック材料を取り付けるステップをさらに含む、請求項1に記載の方法。
- 前記内側誘電体シートおよび前記外側誘電体シートは、異なる誘電材料を備える、請求項1に記載の方法。
- 各内側誘電体シートに前記溝を形成するステップは、
前記内側誘電体シートの部分を除去するステップと、
前記電極シートの対の間の電気、静電容量、または光学測定に基づいて、前記内側誘電体シートのさらなる除去を停止するステップと
を含む、請求項1に記載の方法。 - 複数のリード導体を前記離間した電極シートの対に接続するステップをさらに含み、各リード導体は、個別の電極シートに接続され、前記リード導体が前記電極シートの縁から離れるように延在するにつれて、各リード導体は、幅が分散する、請求項1に記載の方法。
- 前記基板平面と平行に、かつ前記離間した電極シートの対の中の電極シートによって画定される電極平面と垂直に、ゲート電極を堆積させるステップをさらに含む、請求項1に記載の方法。
- 分子センサで使用可能なデバイススタックを製造する方法であって、前記方法は、
第1の外側誘電体層を提供するステップと、
前記第1の外側誘電体層上に第1の電極層を堆積させるステップと、
前記第1の電極層上に内側誘電体層を堆積させるステップと、
前記内側誘電体層上に第2の電極層を堆積させるステップと、
前記第2の電極層上に第2の外側誘電体層を堆積させるステップと、
前記スタックの中の前記層に対する角度で、少なくとも1回、前記スタックを通してスライスし、前記スタックの前記スライスされた部分から少なくとも2つのチップを形成するステップと、
前記第1の電極層および前記第2の電極層の前記スライスされた部分が、基板によって画定される基板平面に対する角度で複数対の電極シートを形成するように、かつ前記内側誘電体層の前記スライスされた部分が、各対の電極シートの中の各電極シートの間に各内側誘電体シートを伴って複数の内側誘電体シートを形成するように、前記チップを前記基板に取り付けるステップと、
を含む、方法。 - 前記デバイススタックを形成するステップはさらに、前記複数のチップのうちの各チップが、複数対の電極シートを含むように、前記第1の電極層、前記内側誘電体層、前記第2の電極層、および前記第2の外側誘電体層の前記堆積を少なくとも1回繰り返すステップを含む、請求項8に記載の方法。
- 前記内側誘電体層は、第1の厚さを有し、前記第2の外側誘電体層は、前記第1の厚さよりも少なくとも1桁大きい第2の厚さを有する、請求項8に記載の方法。
- 前記基板平面と平行に、かつ前記複数対の電極シートの中の電極シートによって画定される電極平面と垂直に、ゲート電極を堆積させるステップをさらに含む、請求項8に記載の方法。
- 分子センサデバイスで使用可能な構造であって、前記構造は、
基板平面を画定する基板と、
離間した電極シートの対であって、前記離間した電極シートの対は、前記基板平面に対する角度で、前記電極シートの縁上で前記基板に取り付けられる、離間した電極シートの対と、
各対の電極シートの中の前記電極シートの間に配置される、内側誘電体シートと、
離間した電極シートの対の間に配置される、外側誘電体シートと、
を備え、
前記基板の反対側の各電極シート、内側誘電体シート、および外側誘電体シートの縁は、同一平面上にある、構造。 - 各内側誘電体シートは、第1の厚さを有し、各外側誘電体シートは、前記第1の厚さよりも少なくとも1桁大きい第2の厚さを有する、請求項12に記載の構造。
- 前記内側誘電体シートおよび前記外側誘電体シートは、異なる誘電材料を備える、請求項12に記載の構造。
- 前記基板の反対側の各内側誘電体シートの露出端部分上に位置する溝をさらに備える、請求項12に記載の構造。
- 前記基板の反対側の前記離間した電極の対の前記縁の部分を被覆する、誘電体カバー層であって、前記離間した電極の対の一部が露出される間隙によって離間される、誘電体カバー層をさらに備える、請求項12に記載の構造。
- 誘電体カバー層の間の前記間隙は、幅が約2nm〜約40nmである、請求項16に記載の構造。
- 複数のリード導体であって、前記複数のリード導体のうちの各リード導体は、前記複数対の電極シートから延在する、複数のリード導体と、
複数の接点であって、前記複数の接点のうちの各接点は、前記複数のリード導体のうちのリード導体と電気通信する、複数の接点と、
をさらに備え、前記複数のリード導体のうちの各リード導体は、前記電極シートの縁から前記接点まで幅が分散する、
請求項12に記載の構造。 - 前記基板平面と平行であり、かつ離間対の中の電極シートによって画定される電極平面と垂直である、ゲート電極をさらに備える、請求項12に記載の構造。
- 前記構造は、前記分子センサ内の電子信号を測定することによって、DNA分子、抗体分子、ヌクレオチド、およびタンパク質分子のうちの少なくとも1つを検出するために使用される、分子センサの一部を備える、請求項12に記載の構造。
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US15/220,307 US9829456B1 (en) | 2016-07-26 | 2016-07-26 | Method of making a multi-electrode structure usable in molecular sensing devices |
US15/220,307 | 2016-07-26 | ||
PCT/US2017/044023 WO2018022799A1 (en) | 2016-07-26 | 2017-07-26 | Multi-electrode structures for molecular sensing devices and methods of making same |
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Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108027335B (zh) | 2015-06-25 | 2021-05-04 | 罗斯韦尔生物技术股份有限公司 | 生物分子传感器和方法 |
US11624725B2 (en) | 2016-01-28 | 2023-04-11 | Roswell Blotechnologies, Inc. | Methods and apparatus for measuring analytes using polymerase in large scale molecular electronics sensor arrays |
EP4137808A1 (en) | 2016-01-28 | 2023-02-22 | Roswell Biotechnologies, Inc. | Method of making a sequencing device |
JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 電子的、標識フリーのdnaおよびゲノムシークエンシング |
US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
CA3052062A1 (en) | 2017-01-10 | 2018-07-19 | Roswell Biotechnologies, Inc. | Methods and systems for dna data storage |
KR20230158636A (ko) | 2017-01-19 | 2023-11-20 | 로스웰 바이오테크놀로지스 인코포레이티드 | 2차원 레이어 재료를 포함하는 솔리드 스테이트 시퀀싱 디바이스들 |
KR20200002897A (ko) | 2017-04-25 | 2020-01-08 | 로스웰 바이오테크놀로지스 인코포레이티드 | 분자 센서들을 위한 효소 회로들 |
US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
KR102606670B1 (ko) | 2017-05-09 | 2023-11-24 | 로스웰 바이오테크놀로지스 인코포레이티드 | 분자 센서들을 위한 결합 프로브 회로들 |
KR20200039795A (ko) | 2017-08-30 | 2020-04-16 | 로스웰 바이오테크놀로지스 인코포레이티드 | Dna 데이터 저장을 위한 진행성 효소 분자 전자 센서들 |
WO2019075100A1 (en) | 2017-10-10 | 2019-04-18 | Roswell Biotechnologies, Inc. | METHODS, APPARATUS AND SYSTEMS FOR STORING DNA DATA WITHOUT AMPLIFICATION |
CN111316072B (zh) * | 2017-11-17 | 2021-12-07 | 美国西门子医学诊断股份有限公司 | 传感器组件和使用所述传感器组件的方法 |
US20240011086A1 (en) | 2018-11-15 | 2024-01-11 | Omniome, Inc. | Electronic detection of nucleic acid structure |
CN211311477U (zh) | 2018-12-04 | 2020-08-21 | 欧姆尼欧美公司 | 测序系统 |
US11499189B2 (en) | 2019-02-14 | 2022-11-15 | Pacific Biosciences Of California, Inc. | Mitigating adverse impacts of detection systems on nucleic acids and other biological analytes |
WO2021045900A1 (en) * | 2019-09-06 | 2021-03-11 | Roswell Biotechnologies, Inc. | Methods of fabricating nanoscale structures usable in molecular sensors and other devices |
EP4028407B1 (en) | 2019-09-10 | 2023-08-16 | Pacific Biosciences of California, Inc. | Reversible modification of nucleotides |
USD929133S1 (en) * | 2019-11-12 | 2021-08-31 | Shenzhen Golden Wish Personal Care Co., Ltd | Facial brush |
DE202019106694U1 (de) | 2019-12-02 | 2020-03-19 | Omniome, Inc. | System zur Sequenzierung von Nukleinsäuren in Fluidschaum |
US20230054204A1 (en) | 2020-02-04 | 2023-02-23 | Pacific Biosciences Of California, Inc. | Flow cells and methods for their manufacture and use |
WO2021252800A1 (en) | 2020-06-11 | 2021-12-16 | Nautilus Biotechnology, Inc. | Methods and systems for computational decoding of biological, chemical, and physical entities |
AU2021378290A1 (en) | 2020-11-11 | 2023-06-29 | Nautilus Subsidiary, Inc. | Affinity reagents having enhanced binding and detection characteristics |
US20220227890A1 (en) | 2021-01-21 | 2022-07-21 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
CA3209038A1 (en) | 2021-03-11 | 2022-09-15 | Tural AKSEL | Systems and methods for biomolecule retention |
WO2023039307A2 (en) * | 2021-05-28 | 2023-03-16 | University Of Florida Research Foundation, Inc. | Self-amplified resonators with embedded piezoresistive elements for high performance, ultra-low swap microwave and millimeter-wave applications |
WO2023038859A1 (en) | 2021-09-09 | 2023-03-16 | Nautilus Biotechnology, Inc. | Characterization and localization of protein modifications |
WO2022223061A1 (en) * | 2021-09-16 | 2022-10-27 | Vysoká Škola Báňská - Technická Univerzita Ostrava | Method for obtaining iron concentrate from metallurgical slags |
AU2022352593A1 (en) | 2021-09-22 | 2024-02-15 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
US20230314324A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | Integrated arrays for single-analyte processes |
WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6094335A (en) * | 1998-10-09 | 2000-07-25 | Advanced Micro Devices, Inc. | Vertical parallel plate capacitor |
JP2003037313A (ja) * | 1998-09-17 | 2003-02-07 | Internatl Business Mach Corp <Ibm> | Dnaを利用した自己組織化ナノデバイス構造およびその製造方法 |
JP2005509846A (ja) * | 2001-06-11 | 2005-04-14 | ジェノークス,インコーポレーテッド | 薄層を用いた生体分子の電子的検出 |
JP2005526371A (ja) * | 2001-07-13 | 2005-09-02 | ノース・キャロライナ・ステイト・ユニヴァーシティ | 絶縁層の厚さが電極間の間隔を形成する単一電子トランジスタ及び製造方法 |
US20140367749A1 (en) * | 2013-06-18 | 2014-12-18 | International Business Machines Corporation | Nanochannel process and structure for bio-detection |
Family Cites Families (237)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5082627A (en) * | 1987-05-01 | 1992-01-21 | Biotronic Systems Corporation | Three dimensional binding site array for interfering with an electrical field |
US5486449A (en) | 1989-02-07 | 1996-01-23 | Rohm Co., Ltd. | Photomask, photoresist and photolithography for a monolithic IC |
GB2244135B (en) * | 1990-05-04 | 1994-07-13 | Gen Electric Co Plc | Sensor devices |
US6051380A (en) * | 1993-11-01 | 2000-04-18 | Nanogen, Inc. | Methods and procedures for molecular biological analysis and diagnostics |
IL103674A0 (en) * | 1991-11-19 | 1993-04-04 | Houston Advanced Res Center | Method and apparatus for molecule detection |
US5414588A (en) | 1993-09-20 | 1995-05-09 | The Regents Of The University Of California | High performance capacitors using nano-structure multilayer materials fabrication |
US5366140A (en) | 1993-09-30 | 1994-11-22 | Minnesota Mining And Manufacturing Company | Patterned array of uniform metal microbeads |
US5871918A (en) * | 1996-06-20 | 1999-02-16 | The University Of North Carolina At Chapel Hill | Electrochemical detection of nucleic acid hybridization |
US5583359A (en) * | 1995-03-03 | 1996-12-10 | Northern Telecom Limited | Capacitor structure for an integrated circuit |
US6673533B1 (en) * | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
US5639507A (en) * | 1995-05-03 | 1997-06-17 | Avx Corporation | Method of making a planar multi-layer capacitor |
AU719454B2 (en) * | 1995-12-01 | 2000-05-11 | Innogenetics N.V. | Impedimetric detection system and method of production thereof |
US6033582A (en) | 1996-01-22 | 2000-03-07 | Etex Corporation | Surface modification of medical implants |
US5881184A (en) | 1996-05-22 | 1999-03-09 | Eastman Kodak Company | Active pixel sensor with single pixel reset |
US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
EP0855132B1 (en) * | 1996-08-14 | 2002-06-19 | Koninklijke Philips Electronics N.V. | Circuit arrangement |
US6202471B1 (en) | 1997-10-10 | 2001-03-20 | Nanomaterials Research Corporation | Low-cost multilaminate sensors |
US6110354A (en) | 1996-11-01 | 2000-08-29 | University Of Washington | Microband electrode arrays |
US5767687A (en) * | 1996-11-29 | 1998-06-16 | Geist; Jon | Surface-capacitor type condensable-vapor sensor |
US6706473B1 (en) | 1996-12-06 | 2004-03-16 | Nanogen, Inc. | Systems and devices for photoelectrophoretic transport and hybridization of oligonucleotides |
US7169272B2 (en) * | 1997-04-30 | 2007-01-30 | Board Of Trustees Of The University Of Arkansas | Microfabricated recessed disk microelectrodes: characterization in static and convective solutions |
US5982018A (en) | 1997-05-23 | 1999-11-09 | Micron Technology, Inc. | Thin film capacitor coupons for memory modules and multi-chip modules |
FR2764386B1 (fr) * | 1997-06-06 | 1999-07-16 | Commissariat Energie Atomique | Support d'electrodes comportant au moins une electrode recouverte par un depot et systeme de lecture de ce support |
JP2000033712A (ja) * | 1997-09-30 | 2000-02-02 | Seiko Epson Corp | マイクロセンサーデバイス作成方法及びそれを用いた液体機能評価方法 |
US6123819A (en) * | 1997-11-12 | 2000-09-26 | Protiveris, Inc. | Nanoelectrode arrays |
US6537747B1 (en) | 1998-02-03 | 2003-03-25 | Lucent Technologies Inc. | Data transmission using DNA oligomers |
US6060023A (en) | 1998-03-31 | 2000-05-09 | Motorola, Inc. | Molecular sensing apparatus |
CA2330207C (en) | 1998-06-10 | 2005-08-30 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
AU6412799A (en) | 1998-10-05 | 2000-04-26 | Mosaic Technologies | Reverse displacement assay for detection of nucleic acid sequences |
WO2000050232A1 (fr) | 1999-02-25 | 2000-08-31 | Seiko Epson Corporation | Element structure presentant d'excellentes proprietes hydrofuges et son procede de fabrication |
US6517669B2 (en) * | 1999-02-26 | 2003-02-11 | Micron Technology, Inc. | Apparatus and method of detecting endpoint of a dielectric etch |
WO2000060125A2 (en) | 1999-04-07 | 2000-10-12 | Dennis Michael Connolly | High resolution dna detection methods and devices |
DE19916921A1 (de) | 1999-04-14 | 2000-10-19 | Fraunhofer Ges Forschung | Elektrisches Sensorarray |
US7122152B2 (en) * | 1999-05-10 | 2006-10-17 | University Of Florida | Spatiotemporal and geometric optimization of sensor arrays for detecting analytes fluids |
KR20010099859A (ko) * | 1999-10-20 | 2001-11-09 | 시게오리 다케나카 | 유전자 검출용 칩, 검출 장치 및 검출 방법 |
DE19960076C2 (de) | 1999-12-13 | 2002-12-05 | November Ag Molekulare Medizin | Verfahren und Vorrichtung zum Nachweis und zur Quantifizierung von Biomolekülen |
US20020090649A1 (en) * | 1999-12-15 | 2002-07-11 | Tony Chan | High density column and row addressable electrode arrays |
DE10015818A1 (de) * | 2000-03-30 | 2001-10-18 | Infineon Technologies Ag | Biosensor und Verfahren zum Ermitteln makromolekularer Biopolymere mit einem Biosensor |
AU2001252973A1 (en) * | 2000-04-17 | 2001-10-30 | Purdue Research Foundation | Biosensor and related method |
CN100457887C (zh) | 2000-05-03 | 2009-02-04 | 高振智 | 具有集成生物传感器芯片的生物识别系统 |
FR2811316B1 (fr) | 2000-07-06 | 2003-01-10 | Saint Gobain | Substrat texture transparent et procedes pour l'obtenir |
US6670131B2 (en) * | 2000-11-30 | 2003-12-30 | Kabushiki Kaisha Toshiba | Nucleic acid detection method and apparatus, and vessel for detecting nucleic acid |
NL1016779C2 (nl) | 2000-12-02 | 2002-06-04 | Cornelis Johannes Maria V Rijn | Matrijs, werkwijze voor het vervaardigen van precisieproducten met behulp van een matrijs, alsmede precisieproducten, in het bijzonder microzeven en membraanfilters, vervaardigd met een dergelijke matrijs. |
DE10063739B4 (de) | 2000-12-21 | 2009-04-02 | Ferro Gmbh | Substrate mit selbstreinigender Oberfläche, Verfahren zu deren Herstellung und deren Verwendung |
US6958216B2 (en) * | 2001-01-10 | 2005-10-25 | The Trustees Of Boston College | DNA-bridged carbon nanotube arrays |
US6749731B2 (en) * | 2001-01-31 | 2004-06-15 | Kyocera Corporation | Gene detection chip and detection device |
CA2451882A1 (en) * | 2001-03-14 | 2002-09-19 | University Of Massachusetts | Nanofabrication |
DE10113550A1 (de) | 2001-03-20 | 2002-10-02 | Infineon Technologies Ag | Verfahren zum Erfassen von makromolekularen Biopolymeren mittels einer Elektrodenanordnung |
US20040023253A1 (en) | 2001-06-11 | 2004-02-05 | Sandeep Kunwar | Device structure for closely spaced electrodes |
US6824974B2 (en) | 2001-06-11 | 2004-11-30 | Genorx, Inc. | Electronic detection of biological molecules using thin layers |
CA2453489A1 (en) * | 2001-07-12 | 2003-01-23 | Merck & Co., Inc. | Electrical field stimulation of eukaryotic cells |
US20030040000A1 (en) | 2001-08-08 | 2003-02-27 | Connolly Dennis M. | Methods for attaching nucleic acid molecules to electrically conductive surfaces |
US6861224B2 (en) * | 2001-11-02 | 2005-03-01 | Fujitsu Limited | Protein detecting device |
US20040014106A1 (en) * | 2002-05-14 | 2004-01-22 | Nanosphere, Inc. | Electrical detection of DNA hybridization and specific binding events |
US20030224387A1 (en) * | 2002-05-22 | 2003-12-04 | Sandeep Kunwar | Association of molecules with electrodes of an array of electrodes |
TWI223903B (en) * | 2002-06-05 | 2004-11-11 | Reveo Inc | Layered electrochemical cell and manufacturing method therefor |
EP1376111A1 (en) * | 2002-06-24 | 2004-01-02 | Universite Catholique De Louvain | Method and device for high sensitivity detection of the presence of DNA and other probes |
DE10397002B4 (de) | 2002-07-02 | 2015-04-30 | Panasonic Healthcare Holdings Co., Ltd. | Biosensor, Biosensorchip und Biosensoreinrichtung |
US6755423B2 (en) | 2002-07-17 | 2004-06-29 | Li Jiun Chiu | Tool coupling device for changeable tool members |
US7470533B2 (en) | 2002-12-20 | 2008-12-30 | Acea Biosciences | Impedance based devices and methods for use in assays |
DE10242560A1 (de) | 2002-09-13 | 2004-03-25 | Creavis Gesellschaft Für Technologie Und Innovation Mbh | Herstellung von selbstreinigenden Oberflächen auf textilen Beschichtungen |
US20040063100A1 (en) | 2002-09-30 | 2004-04-01 | Wang Chung Lin | Nanoneedle chips and the production thereof |
DE10247679A1 (de) | 2002-10-12 | 2004-04-22 | Fujitsu Ltd., Kawasaki | Halbleitergrundstruktur für Molekularelektronik und Molekularelektronik-basierte Biosensorik |
US7183055B2 (en) * | 2002-11-01 | 2007-02-27 | Wisconsin Alumni Research Foundation | Direct radio-frequency detection of nucleotide hybridization at microelectrodes |
CA2516820A1 (en) | 2003-02-07 | 2004-11-18 | Wisconsin Alumni Research Foundation | Nanocylinder-modified surfaces |
US7172917B2 (en) * | 2003-04-17 | 2007-02-06 | Robert Bosch Gmbh | Method of making a nanogap for variable capacitive elements, and device having a nanogap |
AU2004256392B2 (en) | 2003-04-28 | 2009-10-01 | Oned Material Llc | Super-hydrophobic surfaces, methods of their construction and uses therefor |
WO2004096986A2 (en) | 2003-04-29 | 2004-11-11 | Integrated Nano-Technologies, Llc | Method for quantitative detection of nucleic acid molecules |
JP4059181B2 (ja) * | 2003-09-29 | 2008-03-12 | 株式会社村田製作所 | 多端子型積層セラミック電子部品の製造方法 |
JP2005109269A (ja) * | 2003-09-30 | 2005-04-21 | Hitachi Ltd | 半導体放射線検出器及び半導体放射線撮像装置 |
US7132298B2 (en) * | 2003-10-07 | 2006-11-07 | Hewlett-Packard Development Company, L.P. | Fabrication of nano-object array |
MXPA06005558A (es) | 2003-11-20 | 2006-12-15 | Biowarn Llc | Metodologia y aparato para la deteccion de sustancias biologicas. |
WO2005108612A2 (en) | 2003-11-28 | 2005-11-17 | Genorx, Inc. | Nanoscale biosensor device, system and technique |
AU2003294867B2 (en) | 2003-12-16 | 2010-03-11 | F. Hoffmann-La Roche Ag | Cartridge device for blood analysis |
DE10359173B4 (de) * | 2003-12-17 | 2006-11-09 | Robert Bosch Gmbh | Messvorrichtung mit mehreren auf einem Substrat angeordneten potentiometrischen Elektrodenpaaren |
US7451381B2 (en) | 2004-02-03 | 2008-11-11 | Phonex Broadband Corporation | Reliable method and system for efficiently transporting dynamic data across a network |
US20050247573A1 (en) * | 2004-03-23 | 2005-11-10 | Hideaki Nakamura | Biosensors |
US8354066B2 (en) * | 2004-03-24 | 2013-01-15 | Technion Research & Development Foundation Ltd. | Artificial receptors |
US20050221473A1 (en) * | 2004-03-30 | 2005-10-06 | Intel Corporation | Sensor array integrated circuits |
US20060019273A1 (en) | 2004-05-12 | 2006-01-26 | Connolly Dennis M | Detection card for analyzing a sample for a target nucleic acid molecule, and uses thereof |
US7385295B2 (en) * | 2004-06-24 | 2008-06-10 | California Institute Of Technology | Fabrication of nano-gap electrode arrays by the construction and selective chemical etching of nano-crosswire stacks |
US7265019B2 (en) * | 2004-06-30 | 2007-09-04 | International Business Machines Corporation | Elastomeric CMOS based micro electromechanical varactor |
US7150904B2 (en) | 2004-07-27 | 2006-12-19 | Ut-Battelle, Llc | Composite, ordered material having sharp surface features |
US7258731B2 (en) | 2004-07-27 | 2007-08-21 | Ut Battelle, Llc | Composite, nanostructured, super-hydrophobic material |
US7655275B2 (en) | 2004-08-02 | 2010-02-02 | Hewlett-Packard Delopment Company, L.P. | Methods of controlling flow |
US20060029808A1 (en) | 2004-08-06 | 2006-02-09 | Lei Zhai | Superhydrophobic coatings |
EP1630127B1 (en) * | 2004-08-31 | 2008-09-10 | STMicroelectronics S.r.l. | Method for realising a hosting structure of nanometric elements |
EP1630882B1 (en) | 2004-08-31 | 2012-05-02 | STMicroelectronics S.r.l. | Nanometric structure and corresponding manufacturing method |
DE102004042729B4 (de) * | 2004-09-03 | 2018-02-01 | Robert Bosch Gmbh | Bio-Chip mit einem Elektrodenarray auf einem Substrat |
US20070048748A1 (en) | 2004-09-24 | 2007-03-01 | Li-Cor, Inc. | Mutant polymerases for sequencing and genotyping |
US7507320B2 (en) | 2004-10-09 | 2009-03-24 | Academia Sinica | Single-atom tip and preparation method thereof |
TWI303714B (en) | 2004-10-14 | 2008-12-01 | Toshiba Kk | Nucleic acid detecting sensor, nucleic acid detecting chip, and nucleic acid detecting circuit |
US7785785B2 (en) | 2004-11-12 | 2010-08-31 | The Board Of Trustees Of The Leland Stanford Junior University | Charge perturbation detection system for DNA and other molecules |
US7541004B2 (en) * | 2004-11-12 | 2009-06-02 | Predict, Inc. | MEMS-based sensor for lubricant analysis |
DE102004060738B4 (de) | 2004-12-15 | 2008-07-03 | Forschungszentrum Jülich GmbH | Verfahren zum strukturierten Aufbringen von Molekülen auf eine Leiterbahn |
WO2006102292A2 (en) | 2005-03-21 | 2006-09-28 | The Trustees Of The University Of Pennsylvania | Nanogaps: methods and devices containing same |
EP1890598A1 (en) * | 2005-03-31 | 2008-02-27 | Gregersen Enterprises 2005 Aps | Apparatus and method for a global model of hollow internal organs including the determination of cross-sectional areas and volume in internal hollow organs and wall properties |
WO2006132694A2 (en) | 2005-04-01 | 2006-12-14 | Clemson University | Ultrahydrophobic substrates |
WO2006130535A2 (en) * | 2005-06-02 | 2006-12-07 | Michigan State University | Methods to increase dynamic range and improve quantitative analysis in rapid biosensors |
US7417418B1 (en) * | 2005-06-14 | 2008-08-26 | Ayliffe Harold E | Thin film sensor |
WO2007053242A2 (en) | 2005-09-19 | 2007-05-10 | Wayne State University | Transparent hydrophobic article having self-cleaning and liquid repellant features and method of fabricating same |
FR2893266B1 (fr) | 2005-11-14 | 2007-12-21 | Commissariat Energie Atomique | Produit superhydrophile ou superhydrophobe, procede pour sa realisation et utilisation de ce produit |
KR100757389B1 (ko) | 2005-12-06 | 2007-09-11 | 한국전자통신연구원 | 나노갭 전극을 갖는 센서 및 그 제조 방법 |
WO2007120312A2 (en) | 2005-12-15 | 2007-10-25 | The Trustees Of Columbia University In The City Of New York | Sensing devices from molecular electronic devices |
US8706219B2 (en) * | 2005-12-22 | 2014-04-22 | Board Of Regents, The University Of Texas System | Method and apparatus for monitoring an organ of a patient |
US7649198B2 (en) | 2005-12-28 | 2010-01-19 | Industrial Technology Research Institute | Nano-array and fabrication method thereof |
WO2007087377A2 (en) | 2006-01-25 | 2007-08-02 | Massachusetts Institute Of Technology | Photoelectrochemical synthesis of high density combinatorial polymer arrays |
WO2007102960A2 (en) | 2006-01-30 | 2007-09-13 | Ashland Licensing And Intellectual Property Llc | Hydrophobic self-cleaning coating compositions |
US20070184247A1 (en) | 2006-02-03 | 2007-08-09 | Simpson John T | Transparent, super-hydrophobic, disordered composite material |
WO2007107844A1 (en) | 2006-03-17 | 2007-09-27 | Element Six Limited | Microelectrode array |
US20090011222A1 (en) | 2006-03-27 | 2009-01-08 | Georgia Tech Research Corporation | Superhydrophobic surface and method for forming same |
US20070227300A1 (en) | 2006-03-31 | 2007-10-04 | Quantumsphere, Inc. | Compositions of nanometal particles containing a metal or alloy and platinum particles for use in fuel cells |
US20070231542A1 (en) | 2006-04-03 | 2007-10-04 | General Electric Company | Articles having low wettability and high light transmission |
GB2437328A (en) | 2006-04-10 | 2007-10-24 | Cambridge Display Tech Ltd | Electric devices and methods of manufacture |
GB0607205D0 (en) * | 2006-04-10 | 2006-05-17 | Diagnoswiss Sa | Miniaturised biosensor with optimized anperimetric detection |
JP2008026109A (ja) | 2006-07-20 | 2008-02-07 | Fujifilm Corp | 微細構造体及びその製造方法、センサデバイス及びラマン分光用デバイス |
US8394590B2 (en) | 2006-08-02 | 2013-03-12 | California Institute Of Technology | Capture agents and related methods and systems for detecting and/or sorting targets |
WO2008020813A1 (en) * | 2006-08-16 | 2008-02-21 | Agency For Science, Technology And Research | Method of electrically detecting a biological analyte molecule |
ITTO20060774A1 (it) | 2006-10-27 | 2008-04-28 | St Microelectronics Srl | Sensore microelettromeccanico avente molteplici valori di fondo scala e di sensibilita' |
JP4986138B2 (ja) | 2006-11-15 | 2012-07-25 | 独立行政法人産業技術総合研究所 | 反射防止構造を有する光学素子用成形型の製造方法 |
JP5622392B2 (ja) | 2006-12-14 | 2014-11-12 | ライフ テクノロジーズ コーポレーション | 大規模fetアレイを用いた分析物測定のための方法および装置 |
GB0625070D0 (en) | 2006-12-15 | 2007-01-24 | Imp Innovations Ltd | Characterization of molecules |
KR100854486B1 (ko) | 2007-04-05 | 2008-08-26 | 한국기계연구원 | 초발수 표면 제조 방법 |
AT505495A1 (de) | 2007-07-04 | 2009-01-15 | Arc Austrian Res Centers Gmbh | Verfahren zur identifizierung und quantifizierung von organischen und biochemischen substanzen |
US8278188B2 (en) | 2007-07-19 | 2012-10-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Manipulation, detection, and assay of small scale biological particles |
US20100285601A1 (en) * | 2007-09-28 | 2010-11-11 | Agency For Science, Technology And Research | Method of electrically detecting a nucleic acid molecule |
WO2009070796A1 (en) | 2007-11-29 | 2009-06-04 | President And Fellows Of Harvard College | Assembly and deposition of materials using a superhydrophobic surface structure |
WO2009082706A1 (en) | 2007-12-21 | 2009-07-02 | The Trustees Of Columbia University In The City Of New York | Active cmos sensor array for electrochemical biomolecular detection |
US8372585B2 (en) | 2007-12-31 | 2013-02-12 | Intel Corporation | Electronic sensing for nucleic acid sequencing |
WO2009131724A2 (en) | 2008-01-24 | 2009-10-29 | Massachusetts Institute Of Technology | Insulated nanogap devices and methods of use thereof |
US8183648B2 (en) | 2008-01-25 | 2012-05-22 | Ut-Battelle, Llc | Nanoscopic electrode molecular probes |
US20090297913A1 (en) * | 2008-03-25 | 2009-12-03 | The University Of Georgia Research Foundation, Inc. | Nanostructure-Enhanced stereo-electrodes for fuel cells and biosensors |
WO2009154710A2 (en) * | 2008-06-19 | 2009-12-23 | Plexigen, Inc. | Multi-dimensional fluid sensors and related detectors and methods |
US7970332B2 (en) | 2008-06-30 | 2011-06-28 | Xerox Corporation | Oil less fusing using nano/micro textured fusing surfaces |
WO2010044932A2 (en) | 2008-07-11 | 2010-04-22 | Cornell University | Nanofluidic channels with integrated charge sensors and methods based thereon |
US9108880B2 (en) | 2008-08-18 | 2015-08-18 | The Regents Of The University Of California | Nanostructured superhydrophobic, superoleophobic and/or superomniphobic coatings, methods for fabrication, and applications thereof |
US20100044212A1 (en) * | 2008-08-21 | 2010-02-25 | Snu R&Db Foundation | Vertically standing ionic polymer-metal composite |
EP2803988B1 (en) | 2008-09-02 | 2017-04-12 | The Governing Council Of The University Of Toronto | Nanostructured microelectrodes and biosensing devices incorporating the same |
US20100132771A1 (en) * | 2008-10-06 | 2010-06-03 | The Regents Of The University Of California | 3D Carbon Nanotubes Membrane as a Solar Energy Absorbing Layer |
CN101383256B (zh) * | 2008-10-23 | 2011-09-28 | 上海交通大学 | 大长径比侧壁电极及其制造方法 |
EP2350644B1 (en) | 2008-11-18 | 2015-01-07 | THE UNITED STATES OF AMERICA as represented by the Secretary, Department of Health and Human Services | A semiconductor for measuring biological interactions |
US20100206367A1 (en) | 2009-02-18 | 2010-08-19 | Korea Institute Of Industrial Technology | Method for fabricating silicon nano wire, solar cell including silicon nano wire and method for fabricating solar cell |
KR20120013322A (ko) | 2009-04-14 | 2012-02-14 | 나노잉크, 인크. | 전도성 라인, 나노입자, 잉크 및 패터닝 |
CN102301227A (zh) | 2009-04-27 | 2011-12-28 | 夏普株式会社 | 化学传感器 |
US20100285272A1 (en) | 2009-05-06 | 2010-11-11 | Shari Elizabeth Koval | Multi-length scale textured glass substrates for anti-fingerprinting |
US8911972B2 (en) | 2009-12-16 | 2014-12-16 | Pacific Biosciences Of California, Inc. | Sequencing methods using enzyme conformation |
KR20110104245A (ko) | 2010-03-16 | 2011-09-22 | 주식회사 나노플랫폼 | Fet 기반 바이오센서, 이의 제조방법, 및 이를 이용하는 표적 물질 검출방법 |
US8940663B2 (en) * | 2010-04-07 | 2015-01-27 | Board Of Regents, The University Of Texas System | Nano-scale biosensors |
US20110311853A1 (en) | 2010-06-17 | 2011-12-22 | Lsi Corporation | Electrochemical cell system and apparatus to provide energy to a portable electronic device |
US9353412B2 (en) | 2010-06-18 | 2016-05-31 | Illumina, Inc. | Conformational probes and methods for sequencing nucleic acids |
KR101136534B1 (ko) * | 2010-09-07 | 2012-04-17 | 한국기계연구원 | 프로브 카드 및 이의 제조 방법 |
US9231133B2 (en) | 2010-09-10 | 2016-01-05 | International Business Machines Corporation | Nanowires formed by employing solder nanodots |
WO2012037118A2 (en) | 2010-09-14 | 2012-03-22 | The General Hospital Corporation | Nanoporous metal multiple electrode array and method of making same |
NZ610129A (en) | 2010-10-04 | 2014-08-29 | Genapsys Inc | Systems and methods for automated reusable parallel biological reactions |
KR101885936B1 (ko) * | 2010-10-21 | 2018-09-10 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 무선 전력이 공급되는 전자 회로를 포함하는 미세 유체 |
WO2012071428A2 (en) | 2010-11-22 | 2012-05-31 | Solulink, Inc. | Methods and/or use of oligonucleotide conjugates for assays and detections |
WO2012087352A2 (en) | 2010-12-20 | 2012-06-28 | The Regents Of The University Of California | Superhydrophobic and superoleophobic nanosurfaces |
EP2659268A4 (en) | 2010-12-31 | 2017-01-18 | Cilag GmbH International | Systems and methods for high accuracy analyte measurement |
EP2661775A1 (en) | 2011-01-04 | 2013-11-13 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Semiconductor device |
TW201231948A (en) | 2011-01-26 | 2012-08-01 | zhi-yu Zhao | Method for forming frozen biological test strip for electron microscope and device thereof |
US8652768B1 (en) | 2011-01-31 | 2014-02-18 | Sandia Corporation | Nanopatterns by phase separation of patterned mixed polymer monolayers |
EP2492674A1 (en) | 2011-02-28 | 2012-08-29 | Lexogen GmbH | Biosensor array formed by junctions of functionalized electrodes |
EP2492673A1 (en) | 2011-02-28 | 2012-08-29 | Lexogen GmbH | Biosensor array formed by junctions of functionalized electrodes |
US20140045190A1 (en) | 2011-04-19 | 2014-02-13 | The Hong Kong University Of Science And Technology | Method and device for monitoring real-time polymerase chain reaction (pcr) utilizing electro-active hydrolysis probe (e-tag probe) |
KR101548771B1 (ko) | 2011-06-23 | 2015-09-01 | 삼성전기주식회사 | 칩 타입 적층 커패시터 |
US10175195B2 (en) | 2011-07-27 | 2019-01-08 | The Board Of Trustees Of The University Of Illinois | Nanopore sensors for biomolecular characterization |
US9240327B2 (en) | 2011-08-04 | 2016-01-19 | Nissan Chemical Industries, Ltd. | Resist underlayer film-forming composition for EUV lithography containing condensation polymer |
US8685858B2 (en) | 2011-08-30 | 2014-04-01 | International Business Machines Corporation | Formation of metal nanospheres and microspheres |
EP2758772B1 (en) * | 2011-09-19 | 2018-10-24 | University of Utah Research Foundation | Multimode platform for detection of compounds |
WO2013056241A2 (en) | 2011-10-14 | 2013-04-18 | Pacific Biosciences Of California, Inc. | Real-time redox sequencing |
US20130108956A1 (en) | 2011-11-01 | 2013-05-02 | Az Electronic Materials Usa Corp. | Nanocomposite positive photosensitive composition and use thereof |
CN103975240B (zh) | 2011-12-15 | 2016-09-07 | 英特尔公司 | 金刚石电极纳米间隙换能器 |
ES2953308T3 (es) | 2011-12-22 | 2023-11-10 | Harvard College | Composiciones y métodos para la detección de analitos |
US20130183492A1 (en) | 2012-01-17 | 2013-07-18 | Snu R&Db Foundation | Metal nanoparticles on substrate and method of forming the same |
US20130214875A1 (en) | 2012-02-16 | 2013-08-22 | Elwha Llc | Graphene sheet and nanomechanical resonator |
US20130239349A1 (en) * | 2012-03-14 | 2013-09-19 | Palo Alto Research Center Incorporated | Self-powered manual toothbrush with sensors |
UA125112C2 (uk) | 2012-04-09 | 2022-01-12 | Енвіролоджикс Інк. | Спосіб ампліфікації полінуклеотиду |
US9393590B2 (en) | 2012-04-16 | 2016-07-19 | Temple University—Of the Commonwealth System of Higher Education | Self-assembly of small structures |
WO2013165588A1 (en) * | 2012-05-01 | 2013-11-07 | Life Technologies Corporation | Methods for analysis of dna fragments |
US9551682B2 (en) | 2012-06-29 | 2017-01-24 | Intel Corporation | High throughput biochemical detection using single molecule fingerprinting arrays |
WO2014013260A1 (en) | 2012-07-19 | 2014-01-23 | Oxford Nanopore Technologies Limited | Modified helicases |
US8741688B2 (en) | 2012-07-24 | 2014-06-03 | Micron Technology, Inc. | Methods of forming a metal chalcogenide material |
CN104703700B (zh) | 2012-08-06 | 2018-01-12 | 康特姆斯集团有限公司 | 用于核酸测序的方法和试剂盒 |
TWI492384B (zh) | 2012-08-17 | 2015-07-11 | Univ Nat Chiao Tung | 蛋白質電晶體裝置 |
TWI514566B (zh) | 2012-09-19 | 2015-12-21 | Univ Nat Chiao Tung | 半導體生物奈米線裝置及其製作方法 |
EP2909601B1 (en) | 2012-10-16 | 2019-09-11 | Abbott Laboratories | Method of increasing the debye length on a sensor surface within a sample solution and corresponding computer readable strorage medium |
KR20150102962A (ko) | 2012-10-26 | 2015-09-09 | 리서치 트라이앵글 인스티튜트 | 중간 밴드 반도체들, 이종접합들, 및 용액 처리된 양자 점들을 이용한 광전자 소자들, 및 관련 방법들 |
US20150293025A1 (en) | 2012-12-18 | 2015-10-15 | Toray Industries Inc. | Metal dot substrate and method of manufacturing metal dot substrate |
CN102995620B (zh) * | 2012-12-27 | 2015-01-28 | 大连理工大学 | 一种真空/电渗/磁场/堆载联合预压加固软基的方法 |
CN103187119B (zh) * | 2013-02-06 | 2014-08-06 | 南昌欧菲光科技有限公司 | 导电膜及其制备方法以及包含该导电膜的触摸屏 |
US20140218637A1 (en) * | 2013-02-06 | 2014-08-07 | Nanchang O-Film Tech. Co., Ltd. | Conductive film, manufacturing method thereof, and touch screen including the conducting film |
US9040363B2 (en) | 2013-03-20 | 2015-05-26 | International Business Machines Corporation | FinFET with reduced capacitance |
FR3003751A1 (fr) * | 2013-03-27 | 2014-10-03 | Jacques Geloen | Dispositif de visualisation de saturation pour protection de l'incontinence urofecale. |
CN105378113B (zh) | 2013-05-06 | 2020-02-21 | 加利福尼亚太平洋生物科学股份有限公司 | 实时电子测序 |
TW201502276A (zh) | 2013-07-09 | 2015-01-16 | Univ Nat Chiao Tung | 單分子無標定核酸定序方法 |
DE102013012145A1 (de) | 2013-07-20 | 2015-01-22 | Borros Arneth | Protein-Transistor auf Anti-Silizium Antikörper Basis |
US20150049332A1 (en) | 2013-07-30 | 2015-02-19 | The Curators Of The University Of Missouri | Gold nanoisland arrays |
KR20160079780A (ko) | 2013-09-18 | 2016-07-06 | 퀀텀 바이오시스템즈 가부시키가이샤 | 생체분자를 서열화하는 디바이스들, 시스템들 및 방법들 |
WO2015102746A2 (en) | 2013-11-04 | 2015-07-09 | Massachusetts Institute Of Technology | Electronics including graphene-based hybrid structures |
BR112016011084B8 (pt) | 2013-11-17 | 2021-11-09 | Quantum Si Incorporated | Dispositivo integrado para analisar uma pluralidade de amostras em paralelo, métodos de análise desta pluralidade de amostras, para a fabricação de uma cavidade de amostra e estrutura ótica alinhada à referida cavidade, de sequenciamento de uma molécula de ácido nucleico e de formação de uma fonte de excitação de escala nano alinhada, e instrumento portátil |
CN105980581B (zh) | 2013-12-12 | 2021-03-26 | 阿尔查技术有限公司 | 电容传感器及使用方法 |
US9683967B2 (en) * | 2014-01-27 | 2017-06-20 | Cornell University | Integrated circuits based biosensors |
US9472396B2 (en) | 2014-04-15 | 2016-10-18 | University Of Central Florida Research Foundation, Inc. | Plasma treated semiconductor dichalcogenide materials and devices therefrom |
WO2015167019A1 (en) | 2014-04-28 | 2015-11-05 | Quantum Biosystems Inc. | Nanogap electrode devices and systems and methods for forming the same |
EP2947779A1 (en) | 2014-05-23 | 2015-11-25 | Thomson Licensing | Method and apparatus for storing information units in nucleic acid molecules and nucleic acid storage system |
CN113584139A (zh) | 2014-06-03 | 2021-11-02 | 亿明达股份有限公司 | 使用对纳米颗粒或纳米颗粒附近锚定的系链检测事件的组合物,系统和方法 |
EP3152308A4 (en) | 2014-06-06 | 2017-12-27 | Solstice Biologics, Ltd. | Polynucleotide constructs having bioreversible and non-bioreversible groups |
CA2955356C (en) | 2014-07-15 | 2024-01-02 | Illumina, Inc. | Biochemically activated electronic device |
GB2528682A (en) * | 2014-07-28 | 2016-02-03 | Isis Innovation | Plasmonic filter |
US9859513B2 (en) | 2014-11-25 | 2018-01-02 | University Of Kentucky Research Foundation | Integrated multi-terminal devices consisting of carbon nanotube, few-layer graphene nanogaps and few-layer graphene nanoribbons having crystallographically controlled interfaces |
CN107109466A (zh) | 2014-12-18 | 2017-08-29 | 加利福尼亚大学董事会 | 使用纳米管的核酸聚合酶构象变化的检测 |
US20160187282A1 (en) | 2014-12-26 | 2016-06-30 | Intel Corporation | Device for single molecule detection and fabrication methods thereof |
US9306164B1 (en) * | 2015-01-30 | 2016-04-05 | International Business Machines Corporation | Electrode pair fabrication using directed self assembly of diblock copolymers |
FR3035220A1 (fr) * | 2015-04-20 | 2016-10-21 | Commissariat Energie Atomique | " dispositif electronique de mesure d'au moins une caracteristique electrique d'un objet " |
JP2016210986A (ja) | 2015-05-07 | 2016-12-15 | 学校法人日本大学 | 希土類フリー蛍光体の製造方法および希土類フリー蛍光体 |
IL293410B2 (en) | 2015-06-03 | 2024-01-01 | Illumina Inc | Compositions, systems and methods for sequencing polynucleotides using tethers anchored to polymerases attached to nanopores |
CN108027335B (zh) | 2015-06-25 | 2021-05-04 | 罗斯韦尔生物技术股份有限公司 | 生物分子传感器和方法 |
WO2017024049A1 (en) | 2015-08-06 | 2017-02-09 | Pacific Biosciences Of California, Inc. | Single-molecule nanofet sequencing systems and methods |
EP4303314A3 (en) | 2015-09-10 | 2024-04-17 | F. Hoffmann-La Roche AG | Polypeptide tagged nucleotides and use thereof in nucleic acid sequencing by nanopore detection |
KR20180072717A (ko) | 2015-10-08 | 2018-06-29 | 퀀텀 바이오시스템즈 가부시키가이샤 | 핵산 시퀀싱을 위한 장치, 시스템 및 방법 |
CN113985017A (zh) | 2016-01-14 | 2022-01-28 | 罗斯韦尔生物技术股份有限公司 | 分子传感器及相关方法 |
US11624725B2 (en) | 2016-01-28 | 2023-04-11 | Roswell Blotechnologies, Inc. | Methods and apparatus for measuring analytes using polymerase in large scale molecular electronics sensor arrays |
EP4137808A1 (en) | 2016-01-28 | 2023-02-22 | Roswell Biotechnologies, Inc. | Method of making a sequencing device |
JP6854532B2 (ja) | 2016-02-09 | 2021-04-07 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 電子的、標識フリーのdnaおよびゲノムシークエンシング |
US10597767B2 (en) | 2016-02-22 | 2020-03-24 | Roswell Biotechnologies, Inc. | Nanoparticle fabrication |
SG11201807334SA (en) | 2016-02-29 | 2018-09-27 | Dodo Omnidata Inc | Methods, compositions, and devices for information storage |
US10883140B2 (en) | 2016-04-21 | 2021-01-05 | President And Fellows Of Harvard College | Method and system of nanopore-based information encoding |
US20170332918A1 (en) * | 2016-05-19 | 2017-11-23 | Dragon Medical Development Limited | Guidewire apparatus and method for multiple parameter analysis of coronary stenosis |
WO2018011632A1 (en) * | 2016-07-15 | 2018-01-18 | Dragon Medical Development Limited | Multi-spline, multi-electrode catheter and method of use for mapping of internal organs |
US9829456B1 (en) | 2016-07-26 | 2017-11-28 | Roswell Biotechnologies, Inc. | Method of making a multi-electrode structure usable in molecular sensing devices |
JP7022443B2 (ja) | 2016-08-01 | 2022-02-18 | ロズウェル バイオテクノロジーズ,インコーポレイテッド | 分子電子センサーのための修飾ヌクレオチド三リン酸 |
EP3545076A4 (en) | 2016-11-22 | 2020-07-29 | Roswell Biotechnologies, Inc | NUCLEIC ACID SEQUENCING DEVICE WITH GRAPHEN |
CA3052062A1 (en) | 2017-01-10 | 2018-07-19 | Roswell Biotechnologies, Inc. | Methods and systems for dna data storage |
KR20230158636A (ko) | 2017-01-19 | 2023-11-20 | 로스웰 바이오테크놀로지스 인코포레이티드 | 2차원 레이어 재료를 포함하는 솔리드 스테이트 시퀀싱 디바이스들 |
KR20200002897A (ko) | 2017-04-25 | 2020-01-08 | 로스웰 바이오테크놀로지스 인코포레이티드 | 분자 센서들을 위한 효소 회로들 |
US10508296B2 (en) | 2017-04-25 | 2019-12-17 | Roswell Biotechnologies, Inc. | Enzymatic circuits for molecular sensors |
KR102606670B1 (ko) | 2017-05-09 | 2023-11-24 | 로스웰 바이오테크놀로지스 인코포레이티드 | 분자 센서들을 위한 결합 프로브 회로들 |
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- 2019-12-31 US US16/731,749 patent/US20200385855A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003037313A (ja) * | 1998-09-17 | 2003-02-07 | Internatl Business Mach Corp <Ibm> | Dnaを利用した自己組織化ナノデバイス構造およびその製造方法 |
US6094335A (en) * | 1998-10-09 | 2000-07-25 | Advanced Micro Devices, Inc. | Vertical parallel plate capacitor |
JP2005509846A (ja) * | 2001-06-11 | 2005-04-14 | ジェノークス,インコーポレーテッド | 薄層を用いた生体分子の電子的検出 |
JP2005526371A (ja) * | 2001-07-13 | 2005-09-02 | ノース・キャロライナ・ステイト・ユニヴァーシティ | 絶縁層の厚さが電極間の間隔を形成する単一電子トランジスタ及び製造方法 |
US20140367749A1 (en) * | 2013-06-18 | 2014-12-18 | International Business Machines Corporation | Nanochannel process and structure for bio-detection |
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CN109791120A (zh) | 2019-05-21 |
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EP3491148A1 (en) | 2019-06-05 |
WO2018022799A1 (en) | 2018-02-01 |
US10378103B2 (en) | 2019-08-13 |
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