JP2005508380A5 - - Google Patents
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- Publication number
- JP2005508380A5 JP2005508380A5 JP2003542128A JP2003542128A JP2005508380A5 JP 2005508380 A5 JP2005508380 A5 JP 2005508380A5 JP 2003542128 A JP2003542128 A JP 2003542128A JP 2003542128 A JP2003542128 A JP 2003542128A JP 2005508380 A5 JP2005508380 A5 JP 2005508380A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- linear
- aryl
- aralkyl
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims description 112
- 125000003118 aryl group Chemical group 0.000 claims description 72
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 70
- 125000001475 halogen functional group Chemical group 0.000 claims description 58
- 125000001424 substituent group Chemical group 0.000 claims description 54
- 229910052739 hydrogen Inorganic materials 0.000 claims description 52
- 239000001257 hydrogen Substances 0.000 claims description 52
- 125000003545 alkoxy group Chemical group 0.000 claims description 46
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 46
- 125000001188 haloalkyl group Chemical group 0.000 claims description 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 150000002431 hydrogen Chemical class 0.000 claims 43
- 125000002947 alkylene group Chemical group 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 31
- 125000004450 alkenylene group Chemical group 0.000 claims 23
- 125000002993 cycloalkylene group Chemical group 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 20
- 125000004419 alkynylene group Chemical group 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 15
- 241000124008 Mammalia Species 0.000 claims 10
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 7
- 208000023275 Autoimmune disease Diseases 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 6
- 229920000858 Cyclodextrin Polymers 0.000 claims 5
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 5
- 150000003536 tetrazoles Chemical class 0.000 claims 5
- 206010061218 Inflammation Diseases 0.000 claims 4
- 230000004054 inflammatory process Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 230000001154 acute effect Effects 0.000 claims 3
- 230000002757 inflammatory effect Effects 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 150000004702 methyl esters Chemical class 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- 208000011231 Crohn disease Diseases 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 206010040070 Septic Shock Diseases 0.000 claims 2
- 206010065899 Tracheal inflammation Diseases 0.000 claims 2
- 206010044302 Tracheitis Diseases 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000031104 Arterial Occlusive disease Diseases 0.000 claims 1
- 206010003210 Arteriosclerosis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 201000005488 Capillary Leak Syndrome Diseases 0.000 claims 1
- 206010007513 Cardiac aneurysm Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010012442 Dermatitis contact Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- 206010014824 Endotoxic shock Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010061459 Gastrointestinal ulcer Diseases 0.000 claims 1
- 206010018785 Gingival infections Diseases 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 208000032382 Ischaemic stroke Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000019693 Lung disease Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000022873 Ocular disease Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 206010034576 Peripheral ischaemia Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 208000004403 Prostatic Hyperplasia Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000033626 Renal failure acute Diseases 0.000 claims 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010049771 Shock haemorrhagic Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 208000031932 Systemic capillary leak syndrome Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 206010044541 Traumatic shock Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 208000024780 Urticaria Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 206010000891 acute myocardial infarction Diseases 0.000 claims 1
- 208000012998 acute renal failure Diseases 0.000 claims 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 claims 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims 1
- 208000002029 allergic contact dermatitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002619 cancer immunotherapy Methods 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 206010014599 encephalitis Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 230000007574 infarction Effects 0.000 claims 1
- 208000001875 irritant dermatitis Diseases 0.000 claims 1
- 208000023569 ischemic bowel disease Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000031225 myocardial ischemia Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 208000028169 periodontal disease Diseases 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 claims 1
- 0 C*(C)C(C(C)S1)OC1=O Chemical compound C*(C)C(C(C)S1)OC1=O 0.000 description 5
- LWLOKSXSAUHTJO-UHFFFAOYSA-N CC(C(C)O1)OC1=O Chemical compound CC(C(C)O1)OC1=O LWLOKSXSAUHTJO-UHFFFAOYSA-N 0.000 description 2
- SWMIQHDRPJPYJM-UHFFFAOYSA-N CC(C(C(C)(C)C)N1)OC1=O Chemical compound CC(C(C(C)(C)C)N1)OC1=O SWMIQHDRPJPYJM-UHFFFAOYSA-N 0.000 description 1
- ZDXCVVOLHJFBMT-UHFFFAOYSA-N CC(C(C(C)(C)C)S1)SC1=O Chemical compound CC(C(C(C)(C)C)S1)SC1=O ZDXCVVOLHJFBMT-UHFFFAOYSA-N 0.000 description 1
- FEVSXQMJLWVHDA-UHFFFAOYSA-N CC(C(C)N1)NC1=O Chemical compound CC(C(C)N1)NC1=O FEVSXQMJLWVHDA-UHFFFAOYSA-N 0.000 description 1
- DXRZFYKVFKAPCE-UHFFFAOYSA-N CC(C(C)O1)NC1=O Chemical compound CC(C(C)O1)NC1=O DXRZFYKVFKAPCE-UHFFFAOYSA-N 0.000 description 1
- BQNBCJVFHWANQK-UHFFFAOYSA-N CC(C(C)S1)OC1=O Chemical compound CC(C(C)S1)OC1=O BQNBCJVFHWANQK-UHFFFAOYSA-N 0.000 description 1
- CQUCRFYNCROOIS-UHFFFAOYSA-N CC(C(C)S1)SC1=O Chemical compound CC(C(C)S1)SC1=O CQUCRFYNCROOIS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33868401P | 2001-11-06 | 2001-11-06 | |
| PCT/US2002/035318 WO2003040080A2 (en) | 2001-11-06 | 2002-11-05 | Lipoxin a4 analogs |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009035743A Division JP5065315B2 (ja) | 2001-11-06 | 2009-02-18 | リポキシンａ４類似体 |
| JP2009142783A Division JP4510919B2 (ja) | 2001-11-06 | 2009-06-15 | リポキシンａ４類似体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005508380A JP2005508380A (ja) | 2005-03-31 |
| JP2005508380A5 true JP2005508380A5 (cg-RX-API-DMAC7.html) | 2009-04-09 |
Family
ID=23325714
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003542128A Withdrawn JP2005508380A (ja) | 2001-11-06 | 2002-11-05 | リポキシンａ４類似体 |
| JP2009035743A Expired - Fee Related JP5065315B2 (ja) | 2001-11-06 | 2009-02-18 | リポキシンａ４類似体 |
| JP2009142783A Expired - Fee Related JP4510919B2 (ja) | 2001-11-06 | 2009-06-15 | リポキシンａ４類似体 |
| JP2012125762A Expired - Fee Related JP5457501B2 (ja) | 2001-11-06 | 2012-06-01 | リポキシンａ４類似体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009035743A Expired - Fee Related JP5065315B2 (ja) | 2001-11-06 | 2009-02-18 | リポキシンａ４類似体 |
| JP2009142783A Expired - Fee Related JP4510919B2 (ja) | 2001-11-06 | 2009-06-15 | リポキシンａ４類似体 |
| JP2012125762A Expired - Fee Related JP5457501B2 (ja) | 2001-11-06 | 2012-06-01 | リポキシンａ４類似体 |
Country Status (30)
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1441715B1 (en) * | 2001-11-06 | 2013-02-27 | The Brigham And Women's Hospital, Inc. | Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
| US7327448B2 (en) * | 2004-07-29 | 2008-02-05 | Optech Ventures Llc | Laser-ultrasonic detection of flip chip attachment defects |
| US20060154981A1 (en) * | 2005-01-12 | 2006-07-13 | Alcon, Inc. | Method of reducing intraocular pressure and treating glaucoma |
| WO2007024589A2 (en) * | 2005-08-24 | 2007-03-01 | The Trustees Of Columbia University In The City Of New York | Phagocyte enhancement therapy for atherosclerosis |
| US7687539B1 (en) | 2005-11-07 | 2010-03-30 | Alcon Research, Ltd. | Method of treating ocular allergy |
| TW200816991A (en) * | 2006-08-23 | 2008-04-16 | Bayer Schering Pharma Ag | Treatment and prevention of intestinal fibrosis |
| WO2008042216A2 (en) * | 2006-09-28 | 2008-04-10 | Follica, Inc. | Methods, kits, and compositions for generating new hair follicles and growing hair |
| MX2009004962A (es) * | 2006-11-07 | 2009-05-21 | Alcon Res Ltd | Metodo para tratar asma, rinitis alergia y trastornos de la piel. |
| PE20081571A1 (es) * | 2006-12-04 | 2009-01-04 | Bayer Schering Pharma Ag | Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo |
| PE20081200A1 (es) * | 2006-12-04 | 2008-11-06 | Bayer Schering Pharma Ag | Sal de potasio cristalina de analogos de lipoxina a4 |
| US20090036530A1 (en) * | 2006-12-04 | 2009-02-05 | Bayer Schering Pharma Aktiengesellschaft | Crystalline acid of lipoxin A4 analogs and method of making |
| US20100278784A1 (en) * | 2007-05-15 | 2010-11-04 | Puretech Ventures | Methods and compositions for treating skin conditions |
| US20090137527A1 (en) * | 2007-09-14 | 2009-05-28 | Resolvyx Pharmaceuticals, Inc. | Compositions and methods for modulating immune function |
| CA2712970A1 (en) * | 2007-10-29 | 2009-05-07 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Lipoxin a4 protection for retinal cells |
| US8729128B2 (en) * | 2007-10-30 | 2014-05-20 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Lipoxin A4 protection for cornea endothelial cells |
| CN102036714A (zh) * | 2008-05-22 | 2011-04-27 | 拜耳先灵医药股份有限公司 | 晶体2-((2s，3r，4e，6e，10e，12s)-13-(4-氟苯氧基)-2，3，12-三羟基十三碳-4，6，10-三烯-8-炔)氧基)乙酸的无水形式和水合物形式 |
| TW201039815A (en) * | 2009-04-13 | 2010-11-16 | Resolvyx Pharmaceuticals Inc | Compositions and methods for the treatment of inflammation |
| US10600073B2 (en) * | 2010-03-24 | 2020-03-24 | Innovid Inc. | System and method for tracking the performance of advertisements and predicting future behavior of the advertisement |
| EP2648676A4 (en) | 2010-12-06 | 2016-05-04 | Follica Inc | METHODS FOR TREATING CALVITIA AND PROMOTING HAIR GROWTH |
| MY169104A (en) | 2012-07-13 | 2019-02-18 | Solvay | Fluorinated carbonyl compounds comprising a triple bond, methods for their manufacture and uses thereof |
| CA3052271A1 (en) | 2017-01-31 | 2018-08-09 | The Brigham And Women's Hospital, Inc. | Alx receptor ligands define a biochemical endotype for inflammation-based diseases |
| US20210401798A1 (en) * | 2018-10-23 | 2021-12-30 | The Brigham And Women's Hospital, Inc. | Lipoxin a4 analogs and uses thereof |
| KR102086298B1 (ko) * | 2019-10-15 | 2020-03-06 | 건국대학교 산학협력단 | 리폭시게나아제 조합반응에 의한 리폭신 유사체의 제조방법 및 이로부터 제조된 리폭신 유사체 |
| CN114890978B (zh) * | 2022-04-19 | 2023-07-25 | 宿迁医美科技有限公司 | 酚类化合物及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5650435A (en) | 1991-04-01 | 1997-07-22 | Madara; James L. | Modulation of inflammation related to columnar epithelia |
| US6048897A (en) * | 1993-06-15 | 2000-04-11 | Brigham And Women's Hospital | Lipoxin compounds and their use in treating cell proliferative disorders |
| US5441951A (en) * | 1994-06-15 | 1995-08-15 | Brigham & Women's Hospital | Lipoxin compounds |
| EP1657233A1 (en) | 1993-06-15 | 2006-05-17 | The Brigham & Women's Hospital, Inc. | Lipoxin compounds |
| WO1995001179A1 (en) | 1993-06-29 | 1995-01-12 | Brigham & Women's Hospital | Modulation of inflammation related to columnar epithelia |
| US5583140A (en) * | 1995-05-17 | 1996-12-10 | Bencherif; Merouane | Pharmaceutical compositions for the treatment of central nervous system disorders |
| US6008205A (en) | 1997-04-04 | 1999-12-28 | The Brigham & Women's Hospital, Inc. | Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses |
| DE60044335D1 (de) | 1999-03-18 | 2010-06-17 | Brigham & Womens Hospital | 16-phenoxy-lipoxin analoge zur medizinischen verwendung |
| PT1163204E (pt) | 1999-03-18 | 2005-11-30 | Brigham & Womens Hospital | Compostos a base de lipoxina e sua utilizacao |
| AU775140B2 (en) | 1999-03-18 | 2004-07-22 | Brigham And Women's Hospital | Use of lipoxin compounds for inhibiting of TNF-(alfa) initiated neutrophil response |
| AU6382000A (en) | 1999-07-27 | 2001-02-13 | Iowa State University Research Foundation Inc. | Genome analysis |
| PT1228027E (pt) | 1999-11-09 | 2004-08-31 | Alcon Inc | Derivados de 15-hete com heteroatomo substituinte em posicao 3 e homologos com dois carbonos e metodos de utilizacao |
| PT1237549E (pt) | 1999-11-09 | 2004-06-30 | Alcon Inc | Lipoxina a4 e seus analogos para o tratamento de olho seco |
| AU2001249329A1 (en) | 2000-03-20 | 2001-10-03 | Brigham And Women's Hospital | Lipoxin analogs and methods for the treatment of periodontal disease |
| US6831186B2 (en) * | 2001-11-06 | 2004-12-14 | Schering Aktiengesellschft | Lipoxin A4 analogs |
-
2002
- 2002-10-22 US US10/279,084 patent/US6831186B2/en not_active Expired - Lifetime
- 2002-11-05 PT PT02784388T patent/PT1472209E/pt unknown
- 2002-11-05 CA CA2706661A patent/CA2706661C/en not_active Expired - Fee Related
- 2002-11-05 AR ARP020104224A patent/AR037252A1/es not_active Application Discontinuation
- 2002-11-05 TW TW091132580A patent/TWI331992B/zh not_active IP Right Cessation
- 2002-11-05 PL PL371928A patent/PL207597B1/pl unknown
- 2002-11-05 MX MXPA04004300A patent/MXPA04004300A/es active IP Right Grant
- 2002-11-05 RS YUP-384/04A patent/RS51005B/sr unknown
- 2002-11-05 RU RU2004117546/04A patent/RU2382026C2/ru not_active IP Right Cessation
- 2002-11-05 SI SI200230826T patent/SI1472209T1/sl unknown
- 2002-11-05 CN CNA028268539A patent/CN1612852A/zh active Pending
- 2002-11-05 CA CA2706872A patent/CA2706872C/en not_active Expired - Fee Related
- 2002-11-05 CA CA2466418A patent/CA2466418C/en not_active Expired - Fee Related
- 2002-11-05 JP JP2003542128A patent/JP2005508380A/ja not_active Withdrawn
- 2002-11-05 EP EP02784388A patent/EP1472209B1/en not_active Expired - Lifetime
- 2002-11-05 ES ES02784388T patent/ES2323769T3/es not_active Expired - Lifetime
- 2002-11-05 AU AU2002348167A patent/AU2002348167B2/en not_active Ceased
- 2002-11-05 AT AT02784388T patent/ATE424380T1/de active
- 2002-11-05 CN CN2007101081453A patent/CN101054344B/zh not_active Expired - Fee Related
- 2002-11-05 WO PCT/US2002/035318 patent/WO2003040080A2/en not_active Ceased
- 2002-11-05 KR KR1020047006775A patent/KR100958216B1/ko not_active Expired - Fee Related
- 2002-11-05 DE DE60231435T patent/DE60231435D1/de not_active Expired - Lifetime
- 2002-11-05 NZ NZ532672A patent/NZ532672A/en not_active IP Right Cessation
- 2002-11-05 BR BR0213940-5A patent/BR0213940A/pt not_active Application Discontinuation
- 2002-11-05 IL IL16181102A patent/IL161811A0/xx active IP Right Grant
- 2002-11-05 DK DK02784388T patent/DK1472209T3/da active
- 2002-11-06 PE PE2002001079A patent/PE20030566A1/es not_active Application Discontinuation
- 2002-11-06 UY UY27531A patent/UY27531A1/es unknown
-
2004
- 2004-02-18 US US10/782,024 patent/US7223798B2/en not_active Expired - Lifetime
- 2004-05-06 IL IL161811A patent/IL161811A/en not_active IP Right Cessation
- 2004-06-03 CO CO04052090A patent/CO5580762A2/es active IP Right Grant
- 2004-06-03 ZA ZA2004/04393A patent/ZA200404393B/en unknown
- 2004-06-04 NO NO20042336A patent/NO329004B1/no not_active IP Right Cessation
-
2006
- 2006-10-23 US US11/585,501 patent/US7928255B2/en not_active Expired - Lifetime
- 2006-11-03 US US11/592,448 patent/US7994346B2/en not_active Expired - Lifetime
-
2008
- 2008-12-03 EC EC2008005137A patent/ECSP085137A/es unknown
-
2009
- 2009-02-18 JP JP2009035743A patent/JP5065315B2/ja not_active Expired - Fee Related
- 2009-06-04 CY CY20091100596T patent/CY1110472T1/el unknown
- 2009-06-15 JP JP2009142783A patent/JP4510919B2/ja not_active Expired - Fee Related
-
2012
- 2012-06-01 JP JP2012125762A patent/JP5457501B2/ja not_active Expired - Fee Related
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