PE20081571A1 - Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo - Google Patents

Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo

Info

Publication number
PE20081571A1
PE20081571A1 PE2007001705A PE2007001705A PE20081571A1 PE 20081571 A1 PE20081571 A1 PE 20081571A1 PE 2007001705 A PE2007001705 A PE 2007001705A PE 2007001705 A PE2007001705 A PE 2007001705A PE 20081571 A1 PE20081571 A1 PE 20081571A1
Authority
PE
Peru
Prior art keywords
crystalline acid
preparing
methods
acid
refers
Prior art date
Application number
PE2007001705A
Other languages
English (en)
Inventor
Klaus Bartel
Danja Grossbach
William Guilford
Michael Sander
Gabriele Winter
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of PE20081571A1 publication Critical patent/PE20081571A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN ACIDO CRISTALINO DE FORMULA (II), EN DONDE R1 ES O, S(O)t (DONDE t ES DE 0 A 2) O ALQUILENO; R2 ES ARILO O ARALQUILO OPCIONALMENTE SUSTITUIDOS CON UNO O VARIOS GRUPOS DE ALQUILO, ALCOXI, HALO, ENTRE OTROS. ES PREFERIDO EL ACIDO CRISTALINO: ACIDO ((2S,3R,4E,6E,10E,12S)-13-(4-FLUOROFENOXI)-2,3,12-TRIHIDROXITRIDECA-4,6,10-TRIEN-8-INILOXI)ACETICO, EL CUAL SE PRESENTA EN FORMA ANHIDRA QUE EXHIBE PICOS CARACTERISTICOS a d = 20,48 Å Y a d = 4,34 Å; Y EN FORMA DE HIDRATO QUE EXHIBE PICOS CARACTERISTICOS a d = 9,8 Å Y a d = 4,6 Å. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS ACIDOS SON ANALOGOS DE LIPOXINAS A4, POR LO QUE SON UTILES EN EL TRATAMIENTO DE UN TRASTORNO INFLAMATORIO O AUTOINMUNE
PE2007001705A 2006-12-04 2007-12-03 Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo PE20081571A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87282406P 2006-12-04 2006-12-04

Publications (1)

Publication Number Publication Date
PE20081571A1 true PE20081571A1 (es) 2009-01-04

Family

ID=39060183

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001705A PE20081571A1 (es) 2006-12-04 2007-12-03 Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo

Country Status (2)

Country Link
US (1) US20080182901A1 (es)
PE (1) PE20081571A1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs

Also Published As

Publication number Publication date
US20080182901A1 (en) 2008-07-31

Similar Documents

Publication Publication Date Title
JP2013515822A5 (es)
UA109774C2 (uk) Кристалічні форми саксагліптину та процес його одержання (варіанти)
ECSP055910A (es) Nuevos acidos carboxilicos y sus esteres, medicamentos que contienen estos compuestos y procedimientos para su preparacion
RU2382026C2 (ru) Аналоги липоксина а4
EA200870184A1 (ru) Способы и композиции для кислотной обработки в стволе скважины
BR112013025260A2 (pt) óxido do tipo p, composição para produção de óxido do tipo p, método para produzir óxido do tipo p, dispositivo semicondutor, dispositivo de exibição, aparelho de exibição de imagem, e sistema
FR2910477B1 (fr) Fluxant et ses applications.
BR112012001105A2 (pt) produção de ácido acético por meio de carbonilação com uma reação e vaporização instantânea melhoradas
MY142818A (en) Process for preparing alkyl (meth)acrylates
AR076317A1 (es) Composiciones farmaceuticas que comprenden un compuesto de 1-tio-d-glucitol.
EP2662352A3 (en) Method for Producing Phenylacetamide Compound
MY148096A (en) 4,5-diphenyl-pyrimidinyl-amino substituted carboxylic acids, method for the production and use thereof as medicaments
EA200701810A1 (ru) Производное изоксазолина и новый способ его получения
AR088294A1 (es) Determinacion de polimorfismos de un nucleotido simple utiles para predecir la respuesta clinica al acetato de glatiramero
BR112013030253A2 (pt) compostos com grupos de éster de oxima e/ou acila
WO2008062478A3 (en) Improved process for pure montelukast sodium through pure intermediates as well as novel amine salts
JP2005516094A5 (es)
MX349241B (es) Sal de aluminio que contiene alto porcentaje de ai30 referencia cruzada a solicitudes relacionadas.
NZ708529A (en) Salt and solvates of a tetrahydroisoquinoline derivative
EA200401079A1 (ru) Пестицидная композиция, содержащая эфир молочной кислоты в качестве ингибитора роста кристаллов
RU2013147638A (ru) Новое соединение сложного эфира карбоновой кислоты и способ его получения, и композиция душистых веществ
BR112012029451A2 (pt) composto de amida de poliéster
PE20080175A1 (es) Sales de malato, y polimorfos de acido (3s,5s)-7-[3-amino-5-metil-piperidinil]-1-ciclopropil-1,4-dihidro-8-metoxi-4-oxo-3-quinolincarboxilico
PE20081571A1 (es) Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo
EP1707350A3 (en) Rubber hose for fuel system

Legal Events

Date Code Title Description
FA Abandonment or withdrawal