PE20030566A1 - Analogos de lipoxina a4 - Google Patents

Analogos de lipoxina a4

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Publication number
PE20030566A1
PE20030566A1 PE2002001079A PE2002001079A PE20030566A1 PE 20030566 A1 PE20030566 A1 PE 20030566A1 PE 2002001079 A PE2002001079 A PE 2002001079A PE 2002001079 A PE2002001079 A PE 2002001079A PE 20030566 A1 PE20030566 A1 PE 20030566A1
Authority
PE
Peru
Prior art keywords
aralkyl
aryl
alkyl
alkylene
cor7
Prior art date
Application number
PE2002001079A
Other languages
English (en)
Inventor
Werner Skuballa
John G Bauman
John F Parkinson
Babu Subramanyam
William J Guilford
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23325714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20030566(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20030566A1 publication Critical patent/PE20030566A1/es

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    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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Abstract

SE REFIERE A ANALOGOS DE LIPOXINA DE FORMULA I Y II DONDE R1, R2, R3 SON HALO, OR6, SR6, S(O)tR7, NR7R8; T ES 1-2; R1 Y R2 FORMAN UN HETEROCICLO TAL COM IMIDAZOLIL-2-ONA, OXAZOLIL-2-ONA; TIAZOLIL-2-ONA; TIOXAZOLIL, DITIAZOLIL, ENTRE OTROS; R1 Y R2 FORMAN UN GRUPO a; q ES 0-3; p ES 1-4; R15 ES H, ALQUILO, ARALQUILO, ARILO; R4 ES R9R12, R9R13R11, R9OR10R11, ENTRE OTROS; R5 ES ARILO, ARALQUILO, ENTRE OTROS; R6 ES H, ALQUILO, ARILO, ARALQUILO, COR7, CSR7, ENTRE OTROS; R7 ES H, ALQUILO, CICLOALQUILO, ENTRE OTROS; R8 ES H, ALQUILO, ARILO, ARALQUILO, COR7; R8 ES H, ALQUILO, ARILO, ARALQUILO, COR7; R9 ES ALQUILENO; R10 ES ALQUILENO, ALQUINILENO; R11 ES COOR7, CON(R7)2, PO(OR7)2, ENTRE OTROS; R12 ES ARILO, ARALQUILO, ENTRE OTROS; R13 ES ALQUILENO, ALQUENILENO, CICLOALQUILENO; R14 ES ALQUILO, ARILO, ARALQUILO. UN COMPUESTO PREFERIDO ES METILESTER DEL ACIDO (5S,6R,7E,9E,13E,15S)-16-(4-FLUOROFENOXI)-5,6,15-TRIHIDROXI-3-OXAHEXADECA-7,9,13-TRIEN-11-INOICO; LOS COMPUESTOS SON ANALOGOS DE LIPOXINAS (EICOSANOIDES) Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS COMO DERMATITIS DE CONTACTO, ALERGICA, RINITIS ALERGICA, URTICARIA, DERMATITIS ATOPICA, PSORIASIS, ISQUEMIA, INFARTO AGUDO DEL MIOCARDIO, ATAQUE HEMORRAGICO
PE2002001079A 2001-11-06 2002-11-06 Analogos de lipoxina a4 PE20030566A1 (es)

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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4652685B2 (ja) * 2001-11-06 2011-03-16 ザ ブライハム アンド ウイメンズ ホスピタル， インコーポレイテッド 喘息および炎症性気道疾患の治療におけるリポキシンおよびアスピリン誘発リポキシンおよびそれらの安定な類似物
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
US7327448B2 (en) * 2004-07-29 2008-02-05 Optech Ventures Llc Laser-ultrasonic detection of flip chip attachment defects
US20060154981A1 (en) * 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
WO2007024589A2 (en) * 2005-08-24 2007-03-01 The Trustees Of Columbia University In The City Of New York Phagocyte enhancement therapy for atherosclerosis
US7687539B1 (en) 2005-11-07 2010-03-30 Alcon Research, Ltd. Method of treating ocular allergy
TW200816991A (en) * 2006-08-23 2008-04-16 Bayer Schering Pharma Ag Treatment and prevention of intestinal fibrosis
CA2664697A1 (en) * 2006-09-28 2008-04-10 Follica, Inc. Methods, kits, and compositions for generating new hair follicles and growing hair
BRPI0718540A2 (pt) * 2006-11-07 2013-11-19 Alcon Res Ltd Método de tratamento de asma, rinite alérgica, e distúrbios de pele
US20090036530A1 (en) * 2006-12-04 2009-02-05 Bayer Schering Pharma Aktiengesellschaft Crystalline acid of lipoxin A4 analogs and method of making
PE20120395A1 (es) * 2006-12-04 2012-05-23 Bayer Ip Gmbh Sal de potasio cristalina de analogos de lipoxina a4
PE20081571A1 (es) * 2006-12-04 2009-01-04 Bayer Schering Pharma Ag Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo
US20100278784A1 (en) * 2007-05-15 2010-11-04 Puretech Ventures Methods and compositions for treating skin conditions
JP2010539167A (ja) * 2007-09-14 2010-12-16 リゾルヴィクス・ファーマシューティカルズ・インコーポレイテッド 免疫機能を調節する組成物および方法
WO2009058815A2 (en) * 2007-10-29 2009-05-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Lipoxin a4 protection for retinal cells
AU2008318646B2 (en) * 2007-10-30 2014-09-25 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Lipoxin A4 protection for cornea endothelial cells
WO2009140984A1 (en) * 2008-05-22 2009-11-26 Bayer Schering Pharma Aktiengesellschaft Anhydrous and hydrate forms of crystalline 2- ( (2s, 3r, 4e, 6e, 1oe, 12s) -13- (4-fluorophenoxy) -2,3, 12- (trihydroxytrideca-4, 6, 10-trien-8-ynyl) oxy) acetic acid
TW201039815A (en) * 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
US10600073B2 (en) * 2010-03-24 2020-03-24 Innovid Inc. System and method for tracking the performance of advertisements and predicting future behavior of the advertisement
BR112013014021A8 (pt) 2010-12-06 2017-10-03 Follica Inc Métodos para tratamento de calvície e promoção de crescimento de cabelos
US10106492B2 (en) 2012-07-13 2018-10-23 Solvay Sa Fluorinated carbonyl compounds comprising a triple bond, methods for their manufacture and uses thereof
US11519911B2 (en) 2017-01-31 2022-12-06 The Brigham And Women's Hospital, Inc. ALX receptor ligands define a biochemical endotype for inflammation-based diseases
US20210401798A1 (en) * 2018-10-23 2021-12-30 The Brigham And Women's Hospital, Inc. Lipoxin a4 analogs and uses thereof
KR102086298B1 (ko) * 2019-10-15 2020-03-06 건국대학교 산학협력단 리폭시게나아제 조합반응에 의한 리폭신 유사체의 제조방법 및 이로부터 제조된 리폭신 유사체
CN114890978B (zh) * 2022-04-19 2023-07-25 宿迁医美科技有限公司 酚类化合物及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650435A (en) 1991-04-01 1997-07-22 Madara; James L. Modulation of inflammation related to columnar epithelia
US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
AU692453B2 (en) * 1993-06-15 1998-06-11 Brigham And Women's Hospital Lipoxin compounds
US5441951A (en) 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
AU7215294A (en) 1993-06-29 1995-01-24 Brigham And Women's Hospital Modulation of inflammation related to columnar epithelia
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
US6008205A (en) 1997-04-04 1999-12-28 The Brigham & Women's Hospital, Inc. Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses
WO2000055109A1 (en) * 1999-03-18 2000-09-21 Brigham And Women's Hospital Lipoxin compounds and their use
ES2249257T3 (es) 1999-03-18 2006-04-01 The Brigham And Women's Hospital, Inc. Utilizacion de compuestos de lipoxina para la inhibicion de la respuesta de los neutrofilos inducida por tnf-alfa.
ATE466582T1 (de) 1999-03-18 2010-05-15 Brigham & Womens Hospital 16-phenoxy-lipoxin analoge zur medizinischen verwendung
WO2001007664A2 (en) 1999-07-27 2001-02-01 Iowa State University Research Foundation, Inc. Genome analysis
BR0015392A (pt) 1999-11-09 2002-06-25 Alcon Inc Lipoxina a4 e seus análogos para o tratamento de olho ressecado
DE60010503T2 (de) 1999-11-09 2004-09-23 Alcon, Inc. Tri-heteroatom-substituierte und zwei kohlenstoff homologe von 15-hete und verfahren zur verwendung
EP1268393A2 (en) 2000-03-20 2003-01-02 Trustees Of Boston University Lipoxin analogs and methods for the treatment of periodontal disease
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs

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