CO5580762A2 - Analogos de lipoxina a4 - Google Patents

Analogos de lipoxina a4

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Publication number
CO5580762A2
CO5580762A2 CO04052090A CO04052090A CO5580762A2 CO 5580762 A2 CO5580762 A2 CO 5580762A2 CO 04052090 A CO04052090 A CO 04052090A CO 04052090 A CO04052090 A CO 04052090A CO 5580762 A2 CO5580762 A2 CO 5580762A2
Authority
CO
Colombia
Prior art keywords
alkyl
aralkyl
aryl
halo
optionally substituted
Prior art date
Application number
CO04052090A
Other languages
English (en)
Inventor
John G Bauman
William J Guilford
John F Parkinson
Werner Skuballa
Babu Subramanyam
Original Assignee
Bayer Schering Pharma Ag
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Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23325714&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5580762(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of CO5580762A2 publication Critical patent/CO5580762A2/es

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    • C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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  • Vascular Medicine (AREA)

Abstract

1.- Un compuesto de la fórmula (I) o fórmula (lI): donde: cada R1, R2 y R3 son en forma independiente halo, -OR6, -SR6, - S(O)tR7 (donde t es 1 ó 2) o -N(R7)R8; o R1 y R2 junto con los carbonos a los cuales están unidos forman una estructura monocíclica heterocíclica seleccionada entre las siguientes: o R1 y R2 junto con los carbonos a los cuales están unidos forman la siguiente estructura bicíclica heterocíclica: (donde q es 0 a 3, p es 1 a 4 y cada R15 es hidrógeno, alquilo, aralquilo o arilo); cada R4 es -R9-R12, -R9-R13-R11, -R9-O-R10-R11, -R9-O-R12 -R9-C(O)-R10-R11, -R9-N(R7)-R10-R11, -R9-S(O)T-R10-R11 (donde t es entre 0 y 2), o- R9 -C(F)2-R9 -R11; cada R5 es arilo (sustituido opcionalmente con uno o más sustituyentes seleccionados del grupo que comprende alquilo, alcoxi, halo, haloalquilo y haloalcoxi) o aralquilo (sustituido opcionalmente con uno o más sustituyentes seleccionados del grupo que comprende alquilo, alcoxi, halo, haloalquilo y haloalcoxi); cada R6 es en forma independiente hidrógeno, alquilo, arilo, aralquilo, -C(O)R7, - C(S)R7, -C(O)OR14, -C(S)OR14, -C(O)N(R7)R8, o -C(S)N(R7)R8; cada R7 es en forma independiente hidrógeno, alquilo, cicloalquilo, arilo, o aralquilo; R8 es en forma independiente hidrógeno, alquilo, arilo, aralquilo, -C(O)R7, -C(O)OR14, o cicloalquilo (sustituido opcionalmente con uno o más sustituyentes seleccionados del grupo que comprende alquilo, -N(R7)2, y -C(O)OR7); cada R9 es en forma independiente un enlace simple o una cadena alquileno lineal o ramificada; ...
CO04052090A 2001-11-06 2004-06-03 Analogos de lipoxina a4 CO5580762A2 (es)

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Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1441715B1 (en) * 2001-11-06 2013-02-27 The Brigham And Women's Hospital, Inc. Lipoxins and aspirin-triggered lipoxins and their stable analogs in the treatment of asthma and inflammatory airway diseases
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs
US7327448B2 (en) * 2004-07-29 2008-02-05 Optech Ventures Llc Laser-ultrasonic detection of flip chip attachment defects
US20060154981A1 (en) * 2005-01-12 2006-07-13 Alcon, Inc. Method of reducing intraocular pressure and treating glaucoma
WO2007024589A2 (en) * 2005-08-24 2007-03-01 The Trustees Of Columbia University In The City Of New York Phagocyte enhancement therapy for atherosclerosis
US7687539B1 (en) 2005-11-07 2010-03-30 Alcon Research, Ltd. Method of treating ocular allergy
TW200816991A (en) * 2006-08-23 2008-04-16 Bayer Schering Pharma Ag Treatment and prevention of intestinal fibrosis
US8252749B2 (en) * 2006-09-28 2012-08-28 Follica, Inc. Methods, kits, and compositions for generating new hair follicles and growing hair
TW200829232A (en) * 2006-11-07 2008-07-16 Alcon Mfg Ltd Method of treating asthma, allergic rhinitis, and skin disorders
PE20081571A1 (es) * 2006-12-04 2009-01-04 Bayer Schering Pharma Ag Acido cristalino de analogos de lipoxina a4 y metodos de prepararlo
US20090036530A1 (en) * 2006-12-04 2009-02-05 Bayer Schering Pharma Aktiengesellschaft Crystalline acid of lipoxin A4 analogs and method of making
PE20081200A1 (es) * 2006-12-04 2008-11-06 Bayer Schering Pharma Ag Sal de potasio cristalina de analogos de lipoxina a4
BRPI0811102A2 (pt) * 2007-05-15 2014-09-23 Puretech Ventures Métodos e composições para tratar condições de pele
AU2008301895A1 (en) * 2007-09-14 2009-03-26 Resolvyx Pharmaceuticals, Inc. Oxylipin compounds for treating autoimmune diseases
CA2712970A1 (en) * 2007-10-29 2009-05-07 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Lipoxin a4 protection for retinal cells
EP2209471A4 (en) * 2007-10-30 2010-11-10 Univ Louisiana State PROTECTION OF LIPOXIN A4 FOR ENDOTHELIAL CORNEAL CELLS
CN102036714A (zh) * 2008-05-22 2011-04-27 拜耳先灵医药股份有限公司 晶体2-((2s，3r，4e，6e，10e，12s)-13-(4-氟苯氧基)-2，3，12-三羟基十三碳-4，6，10-三烯-8-炔)氧基)乙酸的无水形式和水合物形式
TW201039815A (en) * 2009-04-13 2010-11-16 Resolvyx Pharmaceuticals Inc Compositions and methods for the treatment of inflammation
US10600073B2 (en) * 2010-03-24 2020-03-24 Innovid Inc. System and method for tracking the performance of advertisements and predicting future behavior of the advertisement
EP2648676A4 (en) 2010-12-06 2016-05-04 Follica Inc METHODS FOR TREATING CALVITIA AND PROMOTING HAIR GROWTH
KR20150036022A (ko) 2012-07-13 2015-04-07 솔베이(소시에떼아노님) 삼중 결합을 포함한 플루오르화 카보닐 화합물, 및 그의 제조 방법과 용도
WO2018144316A1 (en) 2017-01-31 2018-08-09 The Brigham And Women's Hospital, Inc. Alx receptor ligands define a biochemical endotype for inflammation-based diseases
WO2020086704A1 (en) * 2018-10-23 2020-04-30 The Brigham And Women's Hospital, Inc. Lipoxin a4 analogs and uses thereof
KR102086298B1 (ko) * 2019-10-15 2020-03-06 건국대학교 산학협력단 리폭시게나아제 조합반응에 의한 리폭신 유사체의 제조방법 및 이로부터 제조된 리폭신 유사체
CN114890978B (zh) * 2022-04-19 2023-07-25 宿迁医美科技有限公司 酚类化合物及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5650435A (en) 1991-04-01 1997-07-22 Madara; James L. Modulation of inflammation related to columnar epithelia
CA2164951C (en) 1993-06-15 2004-02-10 Charles N. Serhan Lipoxin compounds
US6048897A (en) * 1993-06-15 2000-04-11 Brigham And Women's Hospital Lipoxin compounds and their use in treating cell proliferative disorders
US5441951A (en) 1994-06-15 1995-08-15 Brigham & Women's Hospital Lipoxin compounds
AU7215294A (en) 1993-06-29 1995-01-24 Brigham And Women's Hospital Modulation of inflammation related to columnar epithelia
US5583140A (en) * 1995-05-17 1996-12-10 Bencherif; Merouane Pharmaceutical compositions for the treatment of central nervous system disorders
US6008205A (en) 1997-04-04 1999-12-28 The Brigham & Women's Hospital, Inc. Polyisoprenyl phosphate stable analogs for regulation of neutrophil responses
CA2645558C (en) 1999-03-18 2012-05-15 Brigham And Women's Hospital Regulation of phospholipase d activity
PT1163204E (pt) 1999-03-18 2005-11-30 Brigham & Womens Hospital Compostos a base de lipoxina e sua utilizacao
CA2367909C (en) * 1999-03-18 2008-02-12 Brigham And Women's Hospital Use of lipoxin compounds for inhibiting of tnf-(alpha) initiated neutrophil response
WO2001007664A2 (en) 1999-07-27 2001-02-01 Iowa State University Research Foundation, Inc. Genome analysis
DK1228027T3 (da) 1999-11-09 2004-07-19 Alcon Inc 3-heteroatomsubstituerede og to carbonhomologe af 15-HETE og fremgangsmåder til anvendelse
JP2003514782A (ja) 1999-11-09 2003-04-22 アルコン，インコーポレイテッド ドライアイの処置のためのリポキシンａ４およびそのアナログ
US7700650B2 (en) 2000-03-20 2010-04-20 Trustees Of Boston University Lipoxin analogs and method for the treatment of periodontal disease
US6831186B2 (en) * 2001-11-06 2004-12-14 Schering Aktiengesellschft Lipoxin A4 analogs

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