JP2005506350A - サイトカイン阻害薬としての１，４−二置換ベンゾ−縮合尿素化合物 - Google Patents
サイトカイン阻害薬としての１，４−二置換ベンゾ−縮合尿素化合物 Download PDFInfo
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- JP2005506350A JP2005506350A JP2003535792A JP2003535792A JP2005506350A JP 2005506350 A JP2005506350 A JP 2005506350A JP 2003535792 A JP2003535792 A JP 2003535792A JP 2003535792 A JP2003535792 A JP 2003535792A JP 2005506350 A JP2005506350 A JP 2005506350A
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- Prior art keywords
- alkyl
- branched
- optionally substituted
- unbranched
- pyridinyl
- Prior art date
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- JOZPEVMCAKXSEY-UHFFFAOYSA-N pyrimido[5,4-d]pyrimidine Chemical compound N1=CN=CC2=NC=NC=C21 JOZPEVMCAKXSEY-UHFFFAOYSA-N 0.000 claims description 6
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- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
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| US33025401P | 2001-10-18 | 2001-10-18 | |
| PCT/US2002/032809 WO2003032989A1 (en) | 2001-10-18 | 2002-10-11 | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
Publications (2)
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| JP2005506350A true JP2005506350A (ja) | 2005-03-03 |
| JP2005506350A5 JP2005506350A5 (enExample) | 2006-01-05 |
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| Country | Link |
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| US (1) | US6825184B2 (enExample) |
| EP (1) | EP1438048A1 (enExample) |
| JP (1) | JP2005506350A (enExample) |
| CA (1) | CA2462441A1 (enExample) |
| WO (1) | WO2003032989A1 (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008510164A (ja) * | 2004-08-19 | 2008-04-03 | バイオセプト インコーポレイテッド | ヒドロゲルを用いるマイクロアレイ |
| JP2008535874A (ja) * | 2005-04-14 | 2008-09-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 受容体チロシンキナーゼの活性阻害剤としてのプリン誘導体 |
| JP2009504582A (ja) * | 2005-08-09 | 2009-02-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | チロシンキナーゼ活性を有するピラゾール誘導体 |
| JP2015532287A (ja) * | 2012-09-26 | 2015-11-09 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｉｒｅ１の調節 |
| JP2016539979A (ja) * | 2013-12-09 | 2016-12-22 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体 |
| JP2016539981A (ja) * | 2013-12-09 | 2016-12-22 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体 |
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| AU2002316459A1 (en) * | 2001-07-11 | 2003-01-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methods of treating cytokine mediated diseases |
| EP1455791A1 (en) * | 2001-12-11 | 2004-09-15 | Boehringer Ingelheim Pharmaceuticals Inc. | Method for administering birb 796 bs |
| NZ538029A (en) * | 2002-07-09 | 2006-08-31 | Actelion Pharmaceuticals Ltd | 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives |
| PT1599468E (pt) | 2003-01-14 | 2008-01-14 | Arena Pharm Inc | Derivados de arilo e heteroarilo 1,2,3.-trissubstituídos comomoduladores do metabolismo, e profilaxia e tratamento dedesordens relacionadas tais como diabetes e hiperglicemia |
| CA2517517C (en) | 2003-03-03 | 2012-12-18 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| US7135575B2 (en) * | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| CA2530589A1 (en) | 2003-07-02 | 2005-01-20 | Sugen Inc. | Arylmethyl triazolo and imidazopyrazines as c-met inhibitors |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| EP2287165A3 (en) * | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
| MXPA06001758A (es) * | 2003-08-15 | 2006-08-11 | Irm Llc | Anilino purinas sustituidas en la posicion 6 utiles como inhibidores de rtk. |
| EP1670787B1 (en) * | 2003-09-11 | 2012-05-30 | iTherX Pharma, Inc. | Cytokine inhibitors |
| TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
| TW200538453A (en) | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
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- 2002-10-11 CA CA002462441A patent/CA2462441A1/en not_active Abandoned
- 2002-10-11 EP EP02801703A patent/EP1438048A1/en not_active Withdrawn
- 2002-10-11 JP JP2003535792A patent/JP2005506350A/ja active Pending
- 2002-10-11 WO PCT/US2002/032809 patent/WO2003032989A1/en not_active Ceased
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2008510164A (ja) * | 2004-08-19 | 2008-04-03 | バイオセプト インコーポレイテッド | ヒドロゲルを用いるマイクロアレイ |
| JP2008535874A (ja) * | 2005-04-14 | 2008-09-04 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 受容体チロシンキナーゼの活性阻害剤としてのプリン誘導体 |
| JP2009504582A (ja) * | 2005-08-09 | 2009-02-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | チロシンキナーゼ活性を有するピラゾール誘導体 |
| JP2015532287A (ja) * | 2012-09-26 | 2015-11-09 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | Ｉｒｅ１の調節 |
| JP2016539979A (ja) * | 2013-12-09 | 2016-12-22 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体 |
| JP2016539981A (ja) * | 2013-12-09 | 2016-12-22 | ユーシービー バイオファルマ エスピーアールエル | Ｔｎｆ活性のモジュレーターとしてのイミダゾピリジン誘導体 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1438048A1 (en) | 2004-07-21 |
| US20030162968A1 (en) | 2003-08-28 |
| CA2462441A1 (en) | 2003-04-24 |
| US6825184B2 (en) | 2004-11-30 |
| WO2003032989A1 (en) | 2003-04-24 |
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