JP2005506324A5 - - Google Patents
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- Publication number
- JP2005506324A5 JP2005506324A5 JP2003524985A JP2003524985A JP2005506324A5 JP 2005506324 A5 JP2005506324 A5 JP 2005506324A5 JP 2003524985 A JP2003524985 A JP 2003524985A JP 2003524985 A JP2003524985 A JP 2003524985A JP 2005506324 A5 JP2005506324 A5 JP 2005506324A5
- Authority
- JP
- Japan
- Prior art keywords
- disease
- compound according
- specifically
- formula
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 9
- -1 hydroxy-substituted phenyl Chemical class 0.000 claims 6
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 206010003246 Arthritis Diseases 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 200000000018 inflammatory disease Diseases 0.000 claims 3
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 claims 3
- 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- QLSWIGRIBOSFMV-UHFFFAOYSA-N 1H-pyrrol-2-amine Chemical group NC1=CC=CN1 QLSWIGRIBOSFMV-UHFFFAOYSA-N 0.000 claims 1
- 125000004208 3-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C([H])C(*)=C1[H] 0.000 claims 1
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004405 heteroalkoxy group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Chemical group 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrugs Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
Claims (13)
- R1及びR2が水素である、請求項1記載の化合物。
- Ar2が、ハロゲン化物置換フェニルである、請求項1又は2記載の化合物。
- Ar2が4−フルオロフェニルである、請求項1〜3のいずれか1項記載の化合物。
- Ar1が、フェニル、アルコキシ置換フェニル、ヒドロキシ置換フェニル及びヘテロアルコキシ置換フェニルからなる群より選択される、請求項1〜4のいずれか1項記載の化合物。
- Ar1がヘテロアルコキシ置換フェニルである、請求項1〜5のいずれか1項記載の化合物。
- Ar1が、フェニル、3−メトキシフェニル、3−ヒドロキシフェニル及び3−(2,3−ジヒドロキシプロポキシ)フェニルからなる群より選択される、請求項1〜6のいずれか1項記載の化合物
- 請求項1〜7のいずれか1項記載の1つ以上の化合物の治療有効量と賦形剤とを含む組成物。
- 請求項9記載の方法で製造される、請求項1又は3〜7のいずれか1項記載の化合物。
- 具体的には疾患が炎症性疾患であり、より具体的には疾患が関節炎である、特にp38MAPキナーゼインヒビターの投与により処置されうる哺乳動物の疾患を処置するための治療上活性な物質としての、請求項1〜7のいずれか1項記載の化合物。
- 具体的には疾患が炎症性疾患であり、より具体的には疾患が関節炎である、p38MAPキナーゼインヒビターの投与により処置されうる哺乳動物の疾患を処置するための請求項8記載の組成物。
- 具体的には疾患が炎症性疾患であり、より具体的には疾患が関節炎である、p38MAPキナーゼインヒビターの投与により処置されうる哺乳動物の疾患を処置する薬剤の調製のための、請求項1〜7のいずれか1項記載の化合物の使用。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31616901P | 2001-08-30 | 2001-08-30 | |
PCT/EP2002/009505 WO2003020715A1 (en) | 2001-08-30 | 2002-08-26 | Aminopyrrole compounds as antiinflammatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005506324A JP2005506324A (ja) | 2005-03-03 |
JP2005506324A5 true JP2005506324A5 (ja) | 2005-11-17 |
Family
ID=23227809
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003524985A Pending JP2005506324A (ja) | 2001-08-30 | 2002-08-26 | 抗炎症剤としてのアミノピロール化合物 |
Country Status (16)
Country | Link |
---|---|
US (1) | US6696471B2 (ja) |
EP (1) | EP1423378B1 (ja) |
JP (1) | JP2005506324A (ja) |
KR (1) | KR20040029075A (ja) |
CN (1) | CN1281603C (ja) |
AR (1) | AR037140A1 (ja) |
AT (1) | ATE309239T1 (ja) |
AU (1) | AU2002331179B2 (ja) |
BR (1) | BR0212077A (ja) |
CA (1) | CA2458808A1 (ja) |
DE (1) | DE60207273T2 (ja) |
ES (1) | ES2252509T3 (ja) |
MX (1) | MXPA04001810A (ja) |
PL (1) | PL373115A1 (ja) |
RU (1) | RU2315045C2 (ja) |
WO (1) | WO2003020715A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1594459B1 (en) | 2002-12-30 | 2010-02-17 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
US20080113016A1 (en) * | 2004-07-26 | 2008-05-15 | Gary Steven Firestein | Method for Prevention or Treatment of Inflammatory Disease |
EP2131858A4 (en) * | 2007-03-20 | 2011-11-23 | Cadila Pharmaceuticals Ltd | P38 INHIBITORS |
ES2908041T3 (es) | 2015-10-27 | 2022-04-27 | Childrens Hospital Med Ct | Uso de inhibidores de MAPK para reducir la pérdida de células madre hematopoyéticas durante el cultivo ex vivo y la manipulación genética |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
LT3691620T (lt) | 2017-10-05 | 2022-09-26 | Fulcrum Therapeutics, Inc. | P38 kinazės inhibitoriai, sumažinantys dux4 ir pasrovinių genų raišką, skirti fshd gydymui |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6417202B1 (en) | 1996-07-11 | 2002-07-09 | Pfizer Inc. | Pyridylpyrrole compounds useful as interleukin-and TNF antagonists |
WO1998007425A1 (en) * | 1996-08-21 | 1998-02-26 | Smithkline Beecham Corporation | Imidazole compounds, compositions and use |
US5776954A (en) * | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
CA2329065A1 (en) | 1998-05-05 | 1999-11-11 | Francisco Xavier Talamas | Pyrazole derivatives as p-38 map kinase inhibitors |
WO1999058523A1 (en) * | 1998-05-14 | 1999-11-18 | G.D. Searle & Co. | 1,5-DIARYL SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
-
2002
- 2002-08-26 JP JP2003524985A patent/JP2005506324A/ja active Pending
- 2002-08-26 AU AU2002331179A patent/AU2002331179B2/en not_active Ceased
- 2002-08-26 WO PCT/EP2002/009505 patent/WO2003020715A1/en active IP Right Grant
- 2002-08-26 AT AT02767427T patent/ATE309239T1/de not_active IP Right Cessation
- 2002-08-26 DE DE60207273T patent/DE60207273T2/de not_active Expired - Fee Related
- 2002-08-26 PL PL02373115A patent/PL373115A1/xx not_active Application Discontinuation
- 2002-08-26 BR BR0212077-1A patent/BR0212077A/pt not_active IP Right Cessation
- 2002-08-26 EP EP02767427A patent/EP1423378B1/en not_active Expired - Lifetime
- 2002-08-26 ES ES02767427T patent/ES2252509T3/es not_active Expired - Lifetime
- 2002-08-26 KR KR10-2004-7002895A patent/KR20040029075A/ko active IP Right Grant
- 2002-08-26 CN CNB028166310A patent/CN1281603C/zh not_active Expired - Fee Related
- 2002-08-26 RU RU2004109817/04A patent/RU2315045C2/ru not_active IP Right Cessation
- 2002-08-26 CA CA002458808A patent/CA2458808A1/en not_active Abandoned
- 2002-08-26 MX MXPA04001810A patent/MXPA04001810A/es active IP Right Grant
- 2002-08-28 AR ARP020103226A patent/AR037140A1/es unknown
- 2002-08-29 US US10/231,792 patent/US6696471B2/en not_active Expired - Fee Related
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