JP2005506092A - 肥満細胞培養物からヘパリンを製造する方法。 - Google Patents

肥満細胞培養物からヘパリンを製造する方法。 Download PDF

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JP2005506092A
JP2005506092A JP2003538386A JP2003538386A JP2005506092A JP 2005506092 A JP2005506092 A JP 2005506092A JP 2003538386 A JP2003538386 A JP 2003538386A JP 2003538386 A JP2003538386 A JP 2003538386A JP 2005506092 A JP2005506092 A JP 2005506092A
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Prior art keywords
heparin
culture
cells
mast cells
cell
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JP2003538386A
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English (en)
Japanese (ja)
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JP2005506092A5 (fr
Inventor
キャンス，ピエール
グイルラウメ，ジャン−マルク
リガル，エレン，モニク，マリー
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Aventis Pharma SA
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Aventis Pharma SA
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Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Publication of JP2005506092A publication Critical patent/JP2005506092A/ja
Publication of JP2005506092A5 publication Critical patent/JP2005506092A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2003538386A 2001-10-22 2002-10-22 肥満細胞培養物からヘパリンを製造する方法。 Pending JP2005506092A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0113606A FR2831186B1 (fr) 2001-10-22 2001-10-22 Production d'heparine a partir de cultures de mastocytes
PCT/FR2002/003617 WO2003035886A2 (fr) 2001-10-22 2002-10-22 Preparation d'heparine a partir de cultures de mastocytes

Publications (2)

Publication Number Publication Date
JP2005506092A true JP2005506092A (ja) 2005-03-03
JP2005506092A5 JP2005506092A5 (fr) 2006-01-05

Family

ID=8868558

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003538386A Pending JP2005506092A (ja) 2001-10-22 2002-10-22 肥満細胞培養物からヘパリンを製造する方法。

Country Status (18)

Country Link
US (1) US20050042733A1 (fr)
EP (1) EP1438415A2 (fr)
JP (1) JP2005506092A (fr)
KR (1) KR20040071127A (fr)
CN (1) CN1575341A (fr)
AR (1) AR036915A1 (fr)
BR (1) BR0213478A (fr)
CA (1) CA2462714A1 (fr)
CO (1) CO5570711A2 (fr)
FR (1) FR2831186B1 (fr)
HU (1) HUP0401794A2 (fr)
IL (1) IL161066A0 (fr)
MX (1) MXPA04003740A (fr)
NO (1) NO20041633L (fr)
NZ (1) NZ532414A (fr)
PL (1) PL368599A1 (fr)
WO (1) WO2003035886A2 (fr)
ZA (1) ZA200402304B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2853663B1 (fr) * 2003-04-14 2007-08-31 Aventis Pharma Sa Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
FR2876386B1 (fr) * 2004-10-12 2007-04-06 Aventis Pharma Sa Lignees de mastocytes porcins produisant des molecules de type heparine
KR100688553B1 (ko) * 2005-06-22 2007-03-02 삼성전자주식회사 코어 사이즈를 감소시킨 반도체 메모리 장치
KR101447123B1 (ko) * 2014-02-27 2014-10-06 박상협 헤파린의 추출 방법
KR102104367B1 (ko) 2019-09-02 2020-04-24 팜앤바이오 주식회사 헤파린나트륨의 제조장치 및 제조방법
CN111979193A (zh) * 2019-09-27 2020-11-24 云南洛宇生物科技有限公司 大鼠骨髓源肥大细胞培养方法
CN110592165B (zh) * 2019-10-18 2021-04-27 福州大学 燕窝中硫酸乙酰肝素/肝素的提取方法与结构解析

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3016331A (en) * 1960-01-28 1962-01-09 Ormonoterapia Richter Spa Purification of heparin
AU5810690A (en) * 1989-05-19 1990-12-18 University Of Alabama, The Heparin-producing murine mastocytoma cell lines
JP3507852B2 (ja) * 1993-12-10 2004-03-15 ジェネンテク，インコーポレイテッド アレルギー診断法および抗アレルギー性治療剤のスクリーニング法
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
US6596705B1 (en) * 1998-02-09 2003-07-22 The Regents Of The University Of California Inhibition of L-selectin and P-selection mediated binding using heparin

Also Published As

Publication number Publication date
NZ532414A (en) 2006-12-22
KR20040071127A (ko) 2004-08-11
ZA200402304B (en) 2004-10-07
CA2462714A1 (fr) 2003-05-01
FR2831186A1 (fr) 2003-04-25
NO20041633L (no) 2004-04-21
PL368599A1 (en) 2005-04-04
BR0213478A (pt) 2004-11-03
MXPA04003740A (es) 2005-06-20
IL161066A0 (en) 2004-08-31
FR2831186B1 (fr) 2004-06-18
CO5570711A2 (es) 2005-10-31
WO2003035886A3 (fr) 2004-02-26
EP1438415A2 (fr) 2004-07-21
US20050042733A1 (en) 2005-02-24
HUP0401794A2 (hu) 2004-11-29
AR036915A1 (es) 2004-10-13
CN1575341A (zh) 2005-02-02
WO2003035886A2 (fr) 2003-05-01

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