JP2005504795A5 - - Google Patents
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- Publication number
- JP2005504795A5 JP2005504795A5 JP2003526921A JP2003526921A JP2005504795A5 JP 2005504795 A5 JP2005504795 A5 JP 2005504795A5 JP 2003526921 A JP2003526921 A JP 2003526921A JP 2003526921 A JP2003526921 A JP 2003526921A JP 2005504795 A5 JP2005504795 A5 JP 2005504795A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- group
- unsubstituted
- alkyl
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 125000001931 aliphatic group Chemical group 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000003107 substituted aryl group Chemical group 0.000 claims 6
- 229910017489 Cu I Inorganic materials 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims 4
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 239000002243 precursor Substances 0.000 claims 4
- 239000007858 starting material Substances 0.000 claims 4
- 125000000547 substituted alkyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 1
- 229910021591 Copper(I) chloride Inorganic materials 0.000 claims 1
- 229910021595 Copper(I) iodide Inorganic materials 0.000 claims 1
- -1 N-morpholino, pyrimidyl Chemical group 0.000 claims 1
- 230000002862 amidating effect Effects 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 150000003512 tertiary amines Chemical class 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32202001P | 2001-09-13 | 2001-09-13 | |
| PCT/US2002/029154 WO2003022846A1 (en) | 2001-09-13 | 2002-09-13 | 1-glyoxlylamide indolizines for treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504795A JP2005504795A (ja) | 2005-02-17 |
| JP2005504795A5 true JP2005504795A5 (enExample) | 2006-01-05 |
Family
ID=23253054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003526921A Pending JP2005504795A (ja) | 2001-09-13 | 2002-09-13 | 癌処置のための１−グリオキシリルアミドインドリジン類 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US6861436B2 (enExample) |
| EP (1) | EP1432709B8 (enExample) |
| JP (1) | JP2005504795A (enExample) |
| KR (1) | KR20040053125A (enExample) |
| CN (1) | CN1568324A (enExample) |
| AT (1) | ATE300542T1 (enExample) |
| AU (1) | AU2002333626B2 (enExample) |
| BR (1) | BR0212794A (enExample) |
| CA (1) | CA2459886A1 (enExample) |
| DE (1) | DE60205265T2 (enExample) |
| ES (1) | ES2245747T3 (enExample) |
| IL (1) | IL160810A0 (enExample) |
| IS (1) | IS7176A (enExample) |
| MX (1) | MXPA04002323A (enExample) |
| NO (1) | NO20041035L (enExample) |
| NZ (1) | NZ531700A (enExample) |
| PT (1) | PT1432709E (enExample) |
| WO (1) | WO2003022846A1 (enExample) |
| ZA (1) | ZA200401996B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040116462A1 (en) * | 2002-12-12 | 2004-06-17 | Mitsunori Ono | Indolizine compounds |
| PT1432709E (pt) * | 2001-09-13 | 2005-10-31 | Synta Pharmaceuticals Corp | Indolizinas de 1-glioxilamida para o trtamento do cancro |
| JP2006504692A (ja) * | 2002-09-13 | 2006-02-09 | シンタ ファーマシューティカルズ コーポレーション | インドリジンの合成方法 |
| DE10318611A1 (de) | 2003-04-24 | 2004-11-11 | Elbion Ag | 4-, 6- oder 7-Hydroxyindole mit N-Oxidgruppen und deren Verwendung als Therapeutika |
| WO2005099824A1 (en) * | 2004-03-30 | 2005-10-27 | Synta Pharmaceuticals, Corp. | 1-glyoxylamide indolizines for treating lung and ovarian cancer |
| GB0413605D0 (en) | 2004-06-17 | 2004-07-21 | Addex Pharmaceuticals Sa | Novel compounds |
| US20070293456A9 (en) * | 2004-12-30 | 2007-12-20 | Anthony Hayford | Method for the synthesis of 3-substituted indolizine and benzoindolizine compounds |
| WO2006128184A2 (en) * | 2005-05-20 | 2006-11-30 | Alantos-Pharmaceuticals, Inc. | Pyrimidine or triazine fused bicyclic metalloprotease inhibitors |
| US20070155738A1 (en) | 2005-05-20 | 2007-07-05 | Alantos Pharmaceuticals, Inc. | Heterobicyclic metalloprotease inhibitors |
| CA2733247C (en) * | 2008-08-14 | 2018-04-03 | Beta Pharma Canada Inc. | Heterocyclic amide derivatives as ep4 receptor antagonists |
| EP4008327A1 (en) | 2009-04-29 | 2022-06-08 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| AR077428A1 (es) * | 2009-07-29 | 2011-08-24 | Sanofi Aventis | (aza) indolizinacarboxamidas ciclicas su preparacion y su uso como agentes farmaceuticos |
| CN113603694B (zh) * | 2021-07-16 | 2022-07-22 | 浙江工业大学 | 一种1,2-二酮类化合物及其制备方法和应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2287706A (en) * | 1994-03-21 | 1995-09-27 | Fujisawa Pharmaceutical Co | Indolizine derivatives |
| FR2757166B1 (fr) * | 1996-12-12 | 1999-01-29 | Rhone Poulenc Rorer Sa | Derives du pyrrole, leur preparation et les compositions pharmaceutiques qui les contiennent |
| WO1998047507A1 (en) * | 1997-04-24 | 1998-10-29 | Shionogi & Co., Ltd. | Method for the treatment of stroke using n-heterocyclic glyoxylamide compounds |
| US6472389B1 (en) | 1998-05-21 | 2002-10-29 | Shionogi & Co., Ltd. | Pyrrolo[1,2-b] pyridazine derivatives having sPLA2 inhibitory effect |
| CA2346334A1 (en) | 1998-10-14 | 2000-04-20 | Shionogi & Co., Ltd. | Composition for treating or preventing ischemia reperfusion injury |
| US6461538B2 (en) * | 1999-12-16 | 2002-10-08 | Fuji Photo Film Co., Ltd. | Production process for indolizine compounds and their use in organic light-emitting devices |
| PT1432709E (pt) * | 2001-09-13 | 2005-10-31 | Synta Pharmaceuticals Corp | Indolizinas de 1-glioxilamida para o trtamento do cancro |
| US20040116462A1 (en) * | 2002-12-12 | 2004-06-17 | Mitsunori Ono | Indolizine compounds |
-
2002
- 2002-09-13 PT PT02798231T patent/PT1432709E/pt unknown
- 2002-09-13 ES ES02798231T patent/ES2245747T3/es not_active Expired - Lifetime
- 2002-09-13 AU AU2002333626A patent/AU2002333626B2/en not_active Ceased
- 2002-09-13 US US10/244,088 patent/US6861436B2/en not_active Expired - Fee Related
- 2002-09-13 WO PCT/US2002/029154 patent/WO2003022846A1/en not_active Ceased
- 2002-09-13 DE DE60205265T patent/DE60205265T2/de not_active Expired - Fee Related
- 2002-09-13 CN CNA028202848A patent/CN1568324A/zh active Pending
- 2002-09-13 BR BR0212794-6A patent/BR0212794A/pt not_active IP Right Cessation
- 2002-09-13 KR KR10-2004-7003754A patent/KR20040053125A/ko not_active Withdrawn
- 2002-09-13 EP EP02798231A patent/EP1432709B8/en not_active Expired - Lifetime
- 2002-09-13 AT AT02798231T patent/ATE300542T1/de not_active IP Right Cessation
- 2002-09-13 IL IL16081002A patent/IL160810A0/xx unknown
- 2002-09-13 MX MXPA04002323A patent/MXPA04002323A/es unknown
- 2002-09-13 JP JP2003526921A patent/JP2005504795A/ja active Pending
- 2002-09-13 NZ NZ531700A patent/NZ531700A/en unknown
- 2002-09-13 CA CA002459886A patent/CA2459886A1/en not_active Abandoned
-
2004
- 2004-03-11 IS IS7176A patent/IS7176A/is unknown
- 2004-03-11 ZA ZA200401996A patent/ZA200401996B/xx unknown
- 2004-03-11 NO NO20041035A patent/NO20041035L/no not_active Application Discontinuation
- 2004-05-20 US US10/849,978 patent/US20040214850A1/en not_active Abandoned
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