JP2008526692A5 - - Google Patents

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Publication number
JP2008526692A5
JP2008526692A5 JP2007548675A JP2007548675A JP2008526692A5 JP 2008526692 A5 JP2008526692 A5 JP 2008526692A5 JP 2007548675 A JP2007548675 A JP 2007548675A JP 2007548675 A JP2007548675 A JP 2007548675A JP 2008526692 A5 JP2008526692 A5 JP 2008526692A5
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JP
Japan
Prior art keywords
methyl
amino
pyridinyl
pyridyl
pyrimidinyl
Prior art date
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Application number
JP2007548675A
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English (en)
Japanese (ja)
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JP2008526692A (ja
JP4698681B2 (ja
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Priority claimed from CNA2005101074022A external-priority patent/CN1939910A/zh
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Publication of JP2008526692A publication Critical patent/JP2008526692A/ja
Publication of JP2008526692A5 publication Critical patent/JP2008526692A5/ja
Application granted granted Critical
Publication of JP4698681B2 publication Critical patent/JP4698681B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2007548675A 2004-12-31 2005-12-26 アミノピリミジン類の化合物及びその塩の調製方法と薬物の用途 Expired - Fee Related JP4698681B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN200410103077 2004-12-31
CN200410103077.8 2004-12-31
CNA2005101074022A CN1939910A (zh) 2004-12-31 2005-09-30 氨基嘧啶类化合物及其盐和其制备方法与药物用途
CN200510107402.2 2005-09-30
PCT/CN2005/002308 WO2006069525A1 (en) 2004-12-31 2005-12-26 Aminopyrimidine compounds and their salts, process for preparation and pharmaceutical use thereof

Publications (3)

Publication Number Publication Date
JP2008526692A JP2008526692A (ja) 2008-07-24
JP2008526692A5 true JP2008526692A5 (enExample) 2011-03-10
JP4698681B2 JP4698681B2 (ja) 2011-06-08

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ID=36614492

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007548675A Expired - Fee Related JP4698681B2 (ja) 2004-12-31 2005-12-26 アミノピリミジン類の化合物及びその塩の調製方法と薬物の用途

Country Status (7)

Country Link
US (1) US8183242B2 (enExample)
EP (1) EP1840122B1 (enExample)
JP (1) JP4698681B2 (enExample)
CN (1) CN1939910A (enExample)
CA (1) CA2602738C (enExample)
ES (1) ES2436758T3 (enExample)
WO (1) WO2006069525A1 (enExample)

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US8367686B2 (en) 2007-06-07 2013-02-05 Intra-Cellular Therapies, Inc. Heterocycle compounds and uses thereof
US9062023B2 (en) * 2007-06-07 2015-06-23 Intra-Cellular Therapies, Inc. Heterocycle compounds and uses thereof
US8735417B2 (en) 2009-12-17 2014-05-27 Merck Sharp & Dohme Corp. Aminopyrimidines as Syk inhibitors
CN102796079B (zh) * 2011-05-27 2016-06-29 江苏豪森药业集团有限公司 一种甲磺酸氟马替尼的制备方法
CN102816147B (zh) * 2011-06-09 2016-06-08 江苏豪森药业集团有限公司 甲磺酸氟马替尼晶型b及其制备方法和用途
CN102816146A (zh) * 2011-06-10 2012-12-12 江苏豪森医药集团连云港宏创医药有限公司 甲磺酸氟马替尼晶型a及其制备方法和用途
CN103709147A (zh) * 2012-10-09 2014-04-09 江苏豪森医药集团连云港宏创医药有限公司 甲磺酸氟马替尼晶型及其制备方法和用途
CN103396395B (zh) * 2013-07-26 2014-09-03 天津法莫西医药科技有限公司 一种合成n-（5-硝基-2-甲基吡啶基-3-）-4-（3-吡啶基）-2-嘧啶胺及其中间体的方法
CN103360366B (zh) * 2013-07-26 2015-04-01 天津禾盛医药技术开发有限公司 N-(5-硝基-2-甲基吡啶基-3-)-4-(3-吡啶基)-2-嘧啶胺及其中间体的制备方法
CN105884746B (zh) * 2016-05-05 2018-09-21 江苏豪森药业集团有限公司 氟马替尼的合成方法
CN107652269A (zh) * 2016-07-26 2018-02-02 江苏豪森药业集团有限公司 甲磺酸氟马替尼中间体纯化方法
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
CN109438365B (zh) * 2018-12-06 2022-04-05 华南师范大学 N-(3-((4-三氟甲基)-2-嘧啶基)氨基苯基)-2,6-二氟苯磺酰胺衍生物
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
TW202100520A (zh) 2019-03-05 2021-01-01 美商英塞特公司 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物
CA3132730A1 (en) * 2019-03-05 2020-09-10 Hongyi & Associates Llc Compounds for treating neurodegenerative diseases and cancers
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
TW202115024A (zh) 2019-08-14 2021-04-16 美商英塞特公司 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物
CN119930610A (zh) 2019-10-11 2025-05-06 因赛特公司 作为cdk2抑制剂的双环胺
CN111072636B (zh) * 2019-12-16 2022-08-23 江苏豪森药业集团有限公司 氟马替尼的合成方法
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
IL312506A (en) 2021-11-08 2024-07-01 Progentos Therapeutics Inc Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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