JP2005504782A5 - - Google Patents
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- Publication number
- JP2005504782A5 JP2005504782A5 JP2003524580A JP2003524580A JP2005504782A5 JP 2005504782 A5 JP2005504782 A5 JP 2005504782A5 JP 2003524580 A JP2003524580 A JP 2003524580A JP 2003524580 A JP2003524580 A JP 2003524580A JP 2005504782 A5 JP2005504782 A5 JP 2005504782A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- pharmaceutical composition
- gabapentin
- aminoamide
- acceptable derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapen Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 6
- 229960002870 gabapentin Drugs 0.000 claims 6
- AYXYPKUFHZROOJ-ZETCQYMHSA-N (3S)-3-(aminomethyl)-5-methylhexanoic acid Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 4
- 229960001233 pregabalin Drugs 0.000 claims 4
- PFZGGJTWPMATOE-HSZRJFAPSA-N (2R)-N-methyl-3-phenyl-2-[(4-phenylmethoxyphenyl)methylamino]propanamide Chemical compound C([C@H](C(=O)NC)NCC=1C=CC(OCC=2C=CC=CC=2)=CC=1)C1=CC=CC=C1 PFZGGJTWPMATOE-HSZRJFAPSA-N 0.000 claims 1
- -1 3-fluorobenzyloxy Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
Claims (6)
- ガバペンチンまたはプレガバリンまたはそれらの薬剤として許容される誘導体と、（Ｓ）−（＋）−２−［４−（２−フルオロベンジルオキシ）ベンジルアミノ］プロパンアミド、（Ｒ）−（−）−２−［４−ベンジルオキシベンジルアミノ］−３−フェニル−Ｎ−メチルプロパンアミド、および（Ｓ）−（＋）−２−［４−（３−フルオロベンジルオキシ）−ベンジルアミノ］−Ｎ−メチル−プロパンアミドの、場合により、単一異性体またはその混合物またはその薬剤として許容される誘導体からなる群より選択されるα−アミノアミドとを含む薬剤組成物であって、
α−アミノアミドおよびガバペンチンまたはプレガバリンまたはそれらの薬剤として許容される誘導体は、それぞれのＥＤ５０値の割合に基づく比で存在し、その比が、それぞれ、約１：１から約３０：１または約１：１から約１：３０の範囲にある、薬剤組成物。 - α−アミノアミドおよびガバペンチンまたはプレガバリンは、それぞれのＥＤ５０値の割合に基づく比にあり、その比が、それぞれ、約１：１から約９：１または約１：１から約１：９の範囲にある請求項１に記載の薬剤組成物。
- α−アミノアミドおよびガバペンチンまたはプレガバリンは、それぞれのＥＤ５０値の割合に基づく比にあり、その比が、それぞれ、約１：１から約３：１または１：１から約１：３の範囲にある請求項１または２に記載の薬剤組成物。
- ガバペンチンまたはその薬剤として許容される誘導体、およびα−アミノアミドまたはその薬剤として許容される誘導体を含む請求項１から３のいずれかに記載の薬剤組成物。
- ガバペンチンまたはその薬剤として許容される誘導体を含み、α−アミノアミドが、（Ｓ）−（＋）−２−［４−（２−フルオロベンジルオキシ）ベンジルアミノ］プロパンアミドまたはその薬剤として許容される誘導体である請求項１から４のいずれかに記載の薬剤組成物。
- 疼痛症状を処置するための医薬を調製するための請求項１から５のいずれかに記載の薬剤組成物の使用。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01121069 | 2001-09-03 | ||
| PCT/EP2002/008910 WO2003020273A2 (en) | 2001-09-03 | 2002-08-09 | Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005504782A JP2005504782A (ja) | 2005-02-17 |
| JP2005504782A5 true JP2005504782A5 (ja) | 2005-11-17 |
| JP4350508B2 JP4350508B2 (ja) | 2009-10-21 |
Family
ID=8178510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003524580A Expired - Lifetime JP4350508B2 (ja) | 2001-09-03 | 2002-08-09 | ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8084447B2 (ja) |
| EP (1) | EP1423168B1 (ja) |
| JP (1) | JP4350508B2 (ja) |
| KR (1) | KR100890875B1 (ja) |
| CN (1) | CN1274306C (ja) |
| AT (1) | ATE317280T1 (ja) |
| AU (1) | AU2002333374B2 (ja) |
| BR (1) | BRPI0212298B8 (ja) |
| CA (1) | CA2459470C (ja) |
| DE (1) | DE60209152T2 (ja) |
| DK (1) | DK1423168T3 (ja) |
| ES (1) | ES2253579T3 (ja) |
| HK (1) | HK1070305A1 (ja) |
| IL (2) | IL160523A0 (ja) |
| MX (1) | MXPA04002009A (ja) |
| NO (1) | NO331298B1 (ja) |
| NZ (1) | NZ531586A (ja) |
| PT (1) | PT1423168E (ja) |
| RU (1) | RU2295337C2 (ja) |
| SI (1) | SI1423168T1 (ja) |
| WO (1) | WO2003020273A2 (ja) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| EP1169060B1 (en) | 1999-04-09 | 2005-08-31 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| JP4350508B2 (ja) | 2001-09-03 | 2009-10-21 | ニユーロン・フアーマシユーテイカルズ・エツセ・ピー・アー | ガバペンチンまたはその類似体とα−アミノアミドとを含む薬剤組成物およびその鎮痛用途 |
| EP1438956A1 (en) * | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| AU2004207010A1 (en) * | 2003-01-30 | 2004-08-12 | Dynogen Pharmaceuticals, Inc. | Methods of treating lower urinary tract disorders using sodium channel modulators |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
| CA2536764C (en) * | 2003-08-25 | 2013-09-17 | Newron Pharmaceuticals, S.P.A. | .alpha.-aminoamide derivatives useful as anti-inflammatory agents |
| EP1533302A1 (en) * | 2003-11-21 | 2005-05-25 | Newron Pharmaceuticals S.p.A. | Histidine derivatives |
| EP1557166A1 (en) | 2004-01-21 | 2005-07-27 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful in the treatment of lower urinary tract disorders |
| BRPI0515154A (pt) * | 2004-09-10 | 2008-07-08 | Newron Pharm Spa | uso de (halobenzilóxi)benzilamino-propanamidas para a fabricação de medicamentos ativos, compostos e composição farmacêutica |
| MX2007014129A (es) * | 2005-05-10 | 2008-01-11 | Teva Pharma | Resolucion optica del acido 3-carbamoilmetil-5-metil hexanoico. |
| CN100410242C (zh) * | 2005-06-23 | 2008-08-13 | 江苏恩华药业股份有限公司 | 普瑞巴林中间体及其制备方法 |
| KR20080034205A (ko) | 2005-09-19 | 2008-04-18 | 테바 파마슈티컬 인더스트리즈 리미티드 | (ｓ)-프레가발린의 신규한 합성을 위한 주요 중간체인 키랄3-카르바모일메틸-5-메틸 헥산산 |
| EP1798236A1 (en) * | 2005-12-13 | 2007-06-20 | EOS Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ti Caret A.S. | Process for the preparation of 3-pyridyl-1-hydroxyethylidene-1,1- biphosphonic acid and hydrated forms thereof |
| EP1963280B1 (en) | 2005-12-22 | 2015-10-28 | Newron Pharmaceuticals S.p.A. | 2-phenylethylamino derivatives as calcium and/or sodium channel modulators |
| PT2029524E (pt) * | 2006-06-19 | 2015-03-09 | Newron Pharm Spa | Processo para a produção de 2-[4-(3- e 2-fluorobenziloxi benzilamino]propanamidas |
| AU2008261325B2 (en) | 2007-06-15 | 2012-12-06 | Newron Pharmaceuticals S.P.A. | Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators |
| CN104523668B (zh) * | 2007-12-11 | 2020-06-09 | 纽朗制药有限公司 | 高纯度的2-[4-(3-或2-氟苄氧基)苄氨基]丙酰胺类及其用途 |
| EP2400989B1 (en) | 2009-02-24 | 2016-08-10 | Nektar Therapeutics | Gabapentin-peg conjugates |
| WO2011134763A1 (en) | 2010-04-27 | 2011-11-03 | Newron Pharmaceuticals S.P.A. | Process for the production of ralfinamide methanesulfonate salts or their r-enantiomers |
| BR112021004030A2 (pt) * | 2018-09-04 | 2021-06-22 | Minerva Neurosciences, Inc. | métodos de uso de um composto de fenoxipropilamina para tratar a dor |
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-
2002
- 2002-08-09 JP JP2003524580A patent/JP4350508B2/ja not_active Expired - Lifetime
- 2002-08-09 KR KR1020047003189A patent/KR100890875B1/ko active IP Right Grant
- 2002-08-09 WO PCT/EP2002/008910 patent/WO2003020273A2/en active IP Right Grant
- 2002-08-09 ES ES02797573T patent/ES2253579T3/es not_active Expired - Lifetime
- 2002-08-09 DK DK02797573T patent/DK1423168T3/da active
- 2002-08-09 EP EP02797573A patent/EP1423168B1/en not_active Expired - Lifetime
- 2002-08-09 NZ NZ531586A patent/NZ531586A/en not_active IP Right Cessation
- 2002-08-09 MX MXPA04002009A patent/MXPA04002009A/es active IP Right Grant
- 2002-08-09 PT PT02797573T patent/PT1423168E/pt unknown
- 2002-08-09 CA CA2459470A patent/CA2459470C/en not_active Expired - Lifetime
- 2002-08-09 CN CNB028185897A patent/CN1274306C/zh not_active Expired - Lifetime
- 2002-08-09 US US10/487,931 patent/US8084447B2/en active Active
- 2002-08-09 AU AU2002333374A patent/AU2002333374B2/en not_active Expired
- 2002-08-09 RU RU2004110041/15A patent/RU2295337C2/ru active
- 2002-08-09 SI SI200230290T patent/SI1423168T1/sl unknown
- 2002-08-09 DE DE60209152T patent/DE60209152T2/de not_active Expired - Lifetime
- 2002-08-09 BR BRPI0212298A patent/BRPI0212298B8/pt not_active IP Right Cessation
- 2002-08-09 IL IL16052302A patent/IL160523A0/xx active IP Right Grant
- 2002-08-09 AT AT02797573T patent/ATE317280T1/de active
-
2004
- 2004-02-23 IL IL160523A patent/IL160523A/en unknown
- 2004-03-02 NO NO20040907A patent/NO331298B1/no not_active IP Right Cessation
-
2005
- 2005-04-08 HK HK05102974A patent/HK1070305A1/xx not_active IP Right Cessation
-
2011
- 2011-12-07 US US13/313,627 patent/US8710040B2/en not_active Expired - Lifetime
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