JP2005504729A5 - - Google Patents
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- Publication number
- JP2005504729A5 JP2005504729A5 JP2002583413A JP2002583413A JP2005504729A5 JP 2005504729 A5 JP2005504729 A5 JP 2005504729A5 JP 2002583413 A JP2002583413 A JP 2002583413A JP 2002583413 A JP2002583413 A JP 2002583413A JP 2005504729 A5 JP2005504729 A5 JP 2005504729A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- substituted
- aralkyl
- unsubstituted
- alkanoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 7
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 claims 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 125000001589 carboacyl group Chemical group 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 3
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- -1 1-aminocyclohexylcarbonyl Chemical group 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 125000004442 acylamino group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000005098 aryl alkoxy carbonyl group Chemical group 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000010586 diagram Methods 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 125000003147 glycosyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000004385 trihaloalkyl group Chemical group 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28629101P | 2001-04-25 | 2001-04-25 | |
| US28710401P | 2001-04-27 | 2001-04-27 | |
| US34116501P | 2001-12-13 | 2001-12-13 | |
| PCT/IN2002/000111 WO2002085886A2 (en) | 2001-04-25 | 2002-04-24 | Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005504729A JP2005504729A (ja) | 2005-02-17 |
| JP2005504729A5 true JP2005504729A5 (https=) | 2006-01-05 |
| JP4342797B2 JP4342797B2 (ja) | 2009-10-14 |
Family
ID=27403606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002583413A Expired - Fee Related JP4342797B2 (ja) | 2001-04-25 | 2002-04-24 | 新世代三重照準、キラル、広域スペクトラム抗菌、７位置換ピペリジノ−キノロンカルボン酸誘導体の調製、組成、および薬剤としての使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6964966B2 (https=) |
| EP (1) | EP1392677A2 (https=) |
| JP (1) | JP4342797B2 (https=) |
| AU (1) | AU2002302963A1 (https=) |
| CA (1) | CA2445888A1 (https=) |
| WO (1) | WO2002085886A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8163769B2 (en) | 2002-03-12 | 2012-04-24 | Abbott Laboratories | Antibacterial compounds |
| MXPA05009688A (es) * | 2003-03-12 | 2005-12-05 | Abbott Lab | Derivados de naftiridina como agentes antibacterianos. |
| WO2005026145A2 (en) * | 2003-09-12 | 2005-03-24 | Warner-Lambert Company Llc | Quinolone antibacterial agents |
| TW200526626A (en) * | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| GB0321509D0 (en) * | 2003-09-13 | 2003-10-15 | Astrazeneca Ab | Chemical compounds |
| ATE423117T1 (de) | 2003-09-22 | 2009-03-15 | Janssen Pharmaceutica Nv | Heterocyclische 7-aminoalkylidenylchinolone und - naphthyridone |
| WO2005066154A2 (en) * | 2003-11-20 | 2005-07-21 | Wockhardt Limited | Polymorphs of 1-cyclopropyl-6-fuoro-8-methoxy-7-(4-amino-3, 3-dimethylpiperidin-1-yl) -1, 4-dihydro-4-oxo-quinoline-3-carboxylic acid hydrochloride and mesalyte salts |
| DE102004035203A1 (de) | 2004-07-21 | 2006-02-16 | Bayer Healthcare Ag | Substituierte Chinolone |
| US7732612B2 (en) | 2004-09-09 | 2010-06-08 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| NZ561613A (en) | 2005-02-18 | 2010-12-24 | Astrazeneca Ab | Antibacterial piperidine derivatives |
| DE102005030524A1 (de) * | 2005-06-30 | 2007-01-18 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone II |
| DE102006005861A1 (de) * | 2006-02-09 | 2007-08-23 | Aicuris Gmbh & Co. Kg | Substituierte Chinolone III |
| WO2008038122A2 (en) * | 2006-09-29 | 2008-04-03 | Wockhardt Research Centre | Processes for the preparation of 7-substituted 3,3-dimethyl-4-amino-piperidino-quinolone carboxylic acid derivatives |
| US7902227B2 (en) | 2007-07-27 | 2011-03-08 | Janssen Pharmaceutica Nv. | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents |
| CN101952252A (zh) * | 2008-02-27 | 2011-01-19 | 住友化学株式会社 | 哌啶-3-基氨基甲酸烷基酯的光学拆分方法及其中间体 |
| US8658648B2 (en) | 2008-12-05 | 2014-02-25 | Designmedix, Inc. | Modified chloroquines with single ring moiety or fused ring moiety |
| WO2011034971A1 (en) * | 2009-09-15 | 2011-03-24 | Designmedix, Inc. | Modified fluoroquinolone compounds and methods of using the same |
| EP3692991A1 (de) | 2015-06-09 | 2020-08-12 | Bayer Pharma Aktiengesellschaft | Positiv allosterische modulatoren des muskarinergen m2 rezeptors |
| CN109689654A (zh) | 2016-07-11 | 2019-04-26 | 拜耳医药股份有限公司 | 7-取代的1-吡啶基-萘啶-3-甲酰胺类及其用途 |
| JOP20190045A1 (ar) | 2016-09-14 | 2019-03-14 | Bayer Ag | مركبات أميد حمض 1- أريل-نفثيريدين-3-كربوكسيليك مستبدلة في الموضع 7 واستخدامها. |
| EP3296298A1 (de) | 2016-09-14 | 2018-03-21 | Bayer Pharma Aktiengesellschaft | 7-substituierte 1-aryl-naphthyridin-3-carbonsäureamide und ihre verwendung |
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| US6514986B2 (en) * | 2000-11-22 | 2003-02-04 | Wockhardt Limited | Chiral fluoroquinolone arginine salt forms |
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| AU7866701A (en) | 2000-05-08 | 2001-11-20 | Shiv Kumar Agarwal | Antibacterial chiral 8-(substituted piperidino)-benzo (i, j) quinolizines, processes, compositions and methods of treatment |
| AU2001280091A1 (en) | 2000-08-01 | 2002-02-13 | Wockhardt Limited | Inhibitors of cellular efflux pumps of microbes |
-
2002
- 2002-04-23 US US10/128,996 patent/US6964966B2/en not_active Expired - Fee Related
- 2002-04-24 WO PCT/IN2002/000111 patent/WO2002085886A2/en not_active Ceased
- 2002-04-24 AU AU2002302963A patent/AU2002302963A1/en not_active Abandoned
- 2002-04-24 CA CA002445888A patent/CA2445888A1/en not_active Abandoned
- 2002-04-24 JP JP2002583413A patent/JP4342797B2/ja not_active Expired - Fee Related
- 2002-04-24 EP EP02730678A patent/EP1392677A2/en not_active Withdrawn
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