WO2000018404A1 - Antibiotic compositions for treatment of the eye, ear and nose - Google Patents
Antibiotic compositions for treatment of the eye, ear and nose Download PDFInfo
- Publication number
- WO2000018404A1 WO2000018404A1 PCT/US1999/022625 US9922625W WO0018404A1 WO 2000018404 A1 WO2000018404 A1 WO 2000018404A1 US 9922625 W US9922625 W US 9922625W WO 0018404 A1 WO0018404 A1 WO 0018404A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- otic
- ophthalmic
- alkyl
- nasal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Definitions
- the preferred non-steroidal anti-inflammatory agents are: prostaglandin H synthetase inhibitors (Cox I or Cox II), also referred to as cyclooxygenase type I and type II inhibitors, such as diclofenac, flurbiprofen, ketorolac, suprofen. nepafenac. amfenac.
- indomethacin naproxen, ibuprofen, bromfenac, ketoprofen, meclofenamate, piroxicam, sulindac, mefanamic acid, diflusinal, oxaprozin, tolmetin, fenoprofen, benoxaprofen, nabumetome, etodolac, phenylbutazone. aspirin, oxyphenbutazone, NCX-4016.
- the ophthalmic, otic and nasal compositions of the present invention will contain one or more compounds of formula (I) and preferably one or more anti-inflammatory agents, in pharmaceutically acceptable vehicles.
- the compositions will typically have a pH in the range of 4.5 to 8.0.
- the ophthalmic compositions must also be formulated to have osmotic values that are compatible with the aqueous humor of the eye and ophthalmic tissues. Such osmotic values will generally be in the range of from about 200 to about 400 milliosmoles per kilogram of water (“mOsm/kg”), but will preferably be about 300 mOsm/kg.
- Ophthalmic, otic and nasal products are typically packaged in multidose form.
- Example 1 The following examples are provided to further illustrate the ophthalmic, otic and nasal compositions of the present invention.
- Example 1
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000571922A JP2002525326A (en) | 1998-09-30 | 1999-09-29 | Antibiotic composition for treatment of eyes, ears and nose |
EP99950008A EP1117406A1 (en) | 1998-09-30 | 1999-09-29 | Antibiotic compositions for treatment of the eye, ear and nose |
CA002344050A CA2344050A1 (en) | 1998-09-30 | 1999-09-29 | Antibiotic compositions for treatment of the eye, ear and nose |
AU62759/99A AU6275999A (en) | 1998-09-30 | 1999-09-29 | Antibiotic compositions for treatment of the eye, ear and nose |
BR9914158-2A BR9914158A (en) | 1998-09-30 | 1999-09-29 | Antibiotic composition for the treatment of eyes, ears and nose |
US09/575,850 US6509327B1 (en) | 1998-09-30 | 2000-05-19 | Compositions and methods for treating otic, ophthalmic and nasal infections |
US09/887,775 US6740664B2 (en) | 1998-09-30 | 2001-06-22 | Methods for treating otic and ophthalmic infections |
HK02100004.2A HK1038692A1 (en) | 1998-09-30 | 2002-01-02 | Antibiotic compositions for treatment of the eye, ear and nose |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10251098P | 1998-09-30 | 1998-09-30 | |
US10251198P | 1998-09-30 | 1998-09-30 | |
US60/102,511 | 1998-09-30 | ||
US60/102,510 | 1998-09-30 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/022624 Continuation WO2000018388A2 (en) | 1998-09-30 | 1999-09-29 | Antibiotic compositions for treatment of the eye, ear and nose |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2000018404A1 true WO2000018404A1 (en) | 2000-04-06 |
Family
ID=26799456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/022625 WO2000018404A1 (en) | 1998-09-30 | 1999-09-29 | Antibiotic compositions for treatment of the eye, ear and nose |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1117406A1 (en) |
JP (1) | JP2002525326A (en) |
AU (1) | AU6275999A (en) |
BR (1) | BR9914158A (en) |
CA (1) | CA2344050A1 (en) |
HK (1) | HK1038692A1 (en) |
WO (1) | WO2000018404A1 (en) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001045679A2 (en) * | 1999-12-22 | 2001-06-28 | Schulz Hans Herrmann | Use of chemotherapeutic agents for topical treatment |
US6284804B1 (en) | 1999-09-24 | 2001-09-04 | Alcon Universal Ltd. | Topical suspension formulations containing ciprofloxacin and dexamethasone |
WO2001089496A2 (en) * | 2000-05-19 | 2001-11-29 | Alcon Laboratories, Inc. | Compositions and methods for treating otic, ophthalmic and nasal infections comprising quinolone antibiotics |
US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
US6462033B2 (en) | 2000-07-26 | 2002-10-08 | Alcon Universal Ltd. | Process for manufacturing compositions containing ciprofloxacin and hydrocortisone |
WO2002085886A2 (en) * | 2001-04-25 | 2002-10-31 | Wockhardt Limited | Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions |
WO2003050107A1 (en) * | 2001-12-13 | 2003-06-19 | Wockhardt Limited | New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US6716830B2 (en) | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
US7164023B2 (en) | 2003-09-04 | 2007-01-16 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
US7638504B2 (en) | 1999-12-23 | 2009-12-29 | Ecolab Inc. | Hepatitis a viricide |
US20140219949A1 (en) * | 2011-06-22 | 2014-08-07 | Jiangsu Deda Pharmaceuticals Co. Ltd | Pharmaceutical compositions comprising iodine and steroid and uses thereof for sinus diseases |
US8846650B2 (en) | 2001-09-21 | 2014-09-30 | Novartis Ag | Method of treating middle ear infections |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005202737B2 (en) * | 1999-12-22 | 2009-01-22 | Bayer Innovation Gmbh | Use of chemotherapeutic agents |
WO2004052236A2 (en) * | 2002-12-06 | 2004-06-24 | Arriva Pharmaceuticals, Inc. | Methods and compositions for treatment of otitis media |
US20090042936A1 (en) * | 2007-08-10 | 2009-02-12 | Ward Keith W | Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
JPS63190826A (en) * | 1987-02-02 | 1988-08-08 | Dai Ichi Seiyaku Co Ltd | Nasal drop |
WO1990001933A1 (en) * | 1988-08-26 | 1990-03-08 | Alcon Laboratories, Inc. | Combination of quinolone antibiotics and steroids for topical ophthalmic use |
US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
WO1996039146A1 (en) * | 1995-06-06 | 1996-12-12 | Bayer Corporation | Non-irritation, non-sensitizing, non-ototoxic otic antibacterial compositions |
JPH10130148A (en) * | 1996-09-04 | 1998-05-19 | Senju Pharmaceut Co Ltd | Composition for nebulizer |
-
1999
- 1999-09-29 AU AU62759/99A patent/AU6275999A/en not_active Abandoned
- 1999-09-29 CA CA002344050A patent/CA2344050A1/en not_active Abandoned
- 1999-09-29 EP EP99950008A patent/EP1117406A1/en not_active Withdrawn
- 1999-09-29 BR BR9914158-2A patent/BR9914158A/en not_active IP Right Cessation
- 1999-09-29 WO PCT/US1999/022625 patent/WO2000018404A1/en not_active Application Discontinuation
- 1999-09-29 JP JP2000571922A patent/JP2002525326A/en active Pending
-
2002
- 2002-01-02 HK HK02100004.2A patent/HK1038692A1/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4551456A (en) * | 1983-11-14 | 1985-11-05 | Merck & Co., Inc. | Ophthalmic use of norfloxacin and related antibiotics |
JPS63190826A (en) * | 1987-02-02 | 1988-08-08 | Dai Ichi Seiyaku Co Ltd | Nasal drop |
US5563138A (en) * | 1987-04-16 | 1996-10-08 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
WO1990001933A1 (en) * | 1988-08-26 | 1990-03-08 | Alcon Laboratories, Inc. | Combination of quinolone antibiotics and steroids for topical ophthalmic use |
WO1996039146A1 (en) * | 1995-06-06 | 1996-12-12 | Bayer Corporation | Non-irritation, non-sensitizing, non-ototoxic otic antibacterial compositions |
JPH10130148A (en) * | 1996-09-04 | 1998-05-19 | Senju Pharmaceut Co Ltd | Composition for nebulizer |
Non-Patent Citations (3)
Title |
---|
"New Antimicrobial Agents Approved by the U.S Food and Drug Administration in 1997 and New Indications for Previously Approved Agents", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 42, no. 4, - 1 April 1998 (1998-04-01), USA, pages 987 - 988, XP000872060 * |
PATENT ABSTRACTS OF JAPAN vol. 012, no. 472 (C - 551) 9 December 1988 (1988-12-09) * |
PATENT ABSTRACTS OF JAPAN vol. 1998, no. 10 31 August 1998 (1998-08-31) * |
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6509327B1 (en) | 1998-09-30 | 2003-01-21 | Alcon Manufacturing, Ltd. | Compositions and methods for treating otic, ophthalmic and nasal infections |
US8673902B2 (en) | 1998-09-30 | 2014-03-18 | Alcon Pharmaceuticals, Ltd. | Method of treating otic infections with moxifloxacin compositions |
US7671070B2 (en) | 1998-09-30 | 2010-03-02 | Alcon, Inc. | Method of treating ophthalmic infections with moxifloxacin compositions |
US6716830B2 (en) | 1998-09-30 | 2004-04-06 | Alcon, Inc. | Ophthalmic antibiotic compositions containing moxifloxacin |
US8993636B2 (en) | 1998-09-30 | 2015-03-31 | Alcon Pharamceuticals, Ltd. | Compositions containing moxifloxacin for treating otic infections |
US6395746B1 (en) | 1998-09-30 | 2002-05-28 | Alcon Manufacturing, Ltd. | Methods of treating ophthalmic, otic and nasal infections and attendant inflammation |
US6359016B2 (en) | 1999-09-24 | 2002-03-19 | Alcon Universal Ltd. | Topical suspension formulations containing ciprofloxacin and dexamethasone |
US6284804B1 (en) | 1999-09-24 | 2001-09-04 | Alcon Universal Ltd. | Topical suspension formulations containing ciprofloxacin and dexamethasone |
EP1408034A1 (en) | 1999-12-22 | 2004-04-14 | Schulz & Schlimbach GbR | Use of Quinoline derivatives as antibacterial agents |
WO2001045679A2 (en) * | 1999-12-22 | 2001-06-28 | Schulz Hans Herrmann | Use of chemotherapeutic agents for topical treatment |
WO2001045679A3 (en) * | 1999-12-22 | 2002-07-18 | Hans-Herrmann Schulz | Use of chemotherapeutic agents for topical treatment |
US8048929B2 (en) | 1999-12-23 | 2011-11-01 | Ecolab Usa Inc. | Hepatitis A viricide |
US7638504B2 (en) | 1999-12-23 | 2009-12-29 | Ecolab Inc. | Hepatitis a viricide |
US8207231B2 (en) | 1999-12-23 | 2012-06-26 | Ecolab Usa Inc. | Hepatitis A virucide |
US6608078B2 (en) | 2000-05-08 | 2003-08-19 | Wockhardt Limited | Antibacterial chiral 8-(substituted piperidino)-benzo [i,j] quinolizines, processes, compositions and methods of treatment |
WO2001089496A3 (en) * | 2000-05-19 | 2002-04-25 | Alcon Lab Inc | Compositions and methods for treating otic, ophthalmic and nasal infections comprising quinolone antibiotics |
WO2001089496A2 (en) * | 2000-05-19 | 2001-11-29 | Alcon Laboratories, Inc. | Compositions and methods for treating otic, ophthalmic and nasal infections comprising quinolone antibiotics |
US6462033B2 (en) | 2000-07-26 | 2002-10-08 | Alcon Universal Ltd. | Process for manufacturing compositions containing ciprofloxacin and hydrocortisone |
US7098219B2 (en) | 2000-08-01 | 2006-08-29 | Wockhart Limited | Inhibitors of cellular efflux pumps of microbes |
WO2002085886A2 (en) * | 2001-04-25 | 2002-10-31 | Wockhardt Limited | Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions |
US7393957B2 (en) | 2001-04-25 | 2008-07-01 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7626032B2 (en) | 2001-04-25 | 2009-12-01 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6964966B2 (en) | 2001-04-25 | 2005-11-15 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US6878713B2 (en) | 2001-04-25 | 2005-04-12 | Wockhardt Limited | Generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
WO2002085886A3 (en) * | 2001-04-25 | 2003-05-22 | Souza Noel J De | Chiral, broad-spectrum antibacterial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation and compositions |
US8846650B2 (en) | 2001-09-21 | 2014-09-30 | Novartis Ag | Method of treating middle ear infections |
US9402805B1 (en) | 2001-09-21 | 2016-08-02 | Alcon Pharmaceuticals Ltd. | Method of treating middle ear infections |
US9149486B2 (en) | 2001-09-21 | 2015-10-06 | Alcon Pharmaceuticals Ltd | Method of treating middle ear infections |
WO2003050107A1 (en) * | 2001-12-13 | 2003-06-19 | Wockhardt Limited | New generation triple-targeting, chiral, broad-spectrum antimicrobial 7-substituted piperidino-quinolone carboxylic acid derivatives, their preparation, compositions and use as medicaments |
US7132541B2 (en) | 2002-05-28 | 2006-11-07 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US6664267B1 (en) | 2002-05-28 | 2003-12-16 | Wockhardt Limited | Crystalline fluoroquinolone arginine salt form |
US7164023B2 (en) | 2003-09-04 | 2007-01-16 | Wockhardt Limited | Benzoquinolizine-2-carboxylic acid arginine salt tetrahydrate |
US20140219949A1 (en) * | 2011-06-22 | 2014-08-07 | Jiangsu Deda Pharmaceuticals Co. Ltd | Pharmaceutical compositions comprising iodine and steroid and uses thereof for sinus diseases |
Also Published As
Publication number | Publication date |
---|---|
BR9914158A (en) | 2001-06-26 |
AU6275999A (en) | 2000-04-17 |
EP1117406A1 (en) | 2001-07-25 |
CA2344050A1 (en) | 2000-04-06 |
JP2002525326A (en) | 2002-08-13 |
HK1038692A1 (en) | 2002-03-28 |
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