JP2005504715A - 持続放出特性を有する吸入用粒子 - Google Patents

持続放出特性を有する吸入用粒子 Download PDF

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Publication number
JP2005504715A
JP2005504715A JP2002554139A JP2002554139A JP2005504715A JP 2005504715 A JP2005504715 A JP 2005504715A JP 2002554139 A JP2002554139 A JP 2002554139A JP 2002554139 A JP2002554139 A JP 2002554139A JP 2005504715 A JP2005504715 A JP 2005504715A
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JP
Japan
Prior art keywords
glycero
particles
lipid
delivery
drug
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JP2002554139A
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English (en)
Japanese (ja)
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JP2005504715A5 (enExample
Inventor
バス,スジト,ケイ.
フルカック,ジェフリー,エス.
リップ,マイケル
エルバート,カタリーナ
エドワーズ,デービッド,エイ.
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アドバンスト インハレーション リサーチ,インコーポレイテッド
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Publication of JP2005504715A publication Critical patent/JP2005504715A/ja
Publication of JP2005504715A5 publication Critical patent/JP2005504715A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544Phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002554139A 2000-12-29 2001-12-18 持続放出特性を有する吸入用粒子 Withdrawn JP2005504715A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75210900A 2000-12-29 2000-12-29
PCT/US2001/048956 WO2002053190A2 (en) 2000-12-29 2001-12-18 Particles for inhalation having sustained release properties

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006162862A Division JP2006249099A (ja) 2000-12-29 2006-06-12 持続放出特性を有する吸入用粒子

Publications (2)

Publication Number Publication Date
JP2005504715A true JP2005504715A (ja) 2005-02-17
JP2005504715A5 JP2005504715A5 (enExample) 2009-02-12

Family

ID=25024911

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002554139A Withdrawn JP2005504715A (ja) 2000-12-29 2001-12-18 持続放出特性を有する吸入用粒子
JP2006162862A Withdrawn JP2006249099A (ja) 2000-12-29 2006-06-12 持続放出特性を有する吸入用粒子

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006162862A Withdrawn JP2006249099A (ja) 2000-12-29 2006-06-12 持続放出特性を有する吸入用粒子

Country Status (6)

Country Link
US (2) US7048908B2 (enExample)
EP (1) EP1345629A2 (enExample)
JP (2) JP2005504715A (enExample)
AU (1) AU2002230993B2 (enExample)
CA (1) CA2433335C (enExample)
WO (1) WO2002053190A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2016516062A (ja) * 2013-03-15 2016-06-02 リズム・ファーマシューティカルズ・インコーポレイテッド 医薬組成物

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