JP2005504715A5 - - Google Patents
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- JP2005504715A5 JP2005504715A5 JP2002554139A JP2002554139A JP2005504715A5 JP 2005504715 A5 JP2005504715 A5 JP 2005504715A5 JP 2002554139 A JP2002554139 A JP 2002554139A JP 2002554139 A JP2002554139 A JP 2002554139A JP 2005504715 A5 JP2005504715 A5 JP 2005504715A5
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- JP
- Japan
- Prior art keywords
- particles
- drug
- tap density
- aerosol
- particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002245 particle Substances 0.000 claims description 31
- 239000003814 drug Substances 0.000 claims description 11
- 229940079593 drug Drugs 0.000 claims description 10
- 210000002345 respiratory system Anatomy 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 230000002685 pulmonary effect Effects 0.000 claims description 2
- 150000002632 lipids Chemical class 0.000 claims 3
- 239000012867 bioactive agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 150000002484 inorganic compounds Chemical class 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 description 9
- 239000000443 aerosol Substances 0.000 description 6
- 230000008021 deposition Effects 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 230000009977 dual effect Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 238000002664 inhalation therapy Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75210900A | 2000-12-29 | 2000-12-29 | |
| PCT/US2001/048956 WO2002053190A2 (en) | 2000-12-29 | 2001-12-18 | Particles for inhalation having sustained release properties |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006162862A Division JP2006249099A (ja) | 2000-12-29 | 2006-06-12 | 持続放出特性を有する吸入用粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005504715A JP2005504715A (ja) | 2005-02-17 |
| JP2005504715A5 true JP2005504715A5 (enExample) | 2009-02-12 |
Family
ID=25024911
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002554139A Withdrawn JP2005504715A (ja) | 2000-12-29 | 2001-12-18 | 持続放出特性を有する吸入用粒子 |
| JP2006162862A Withdrawn JP2006249099A (ja) | 2000-12-29 | 2006-06-12 | 持続放出特性を有する吸入用粒子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006162862A Withdrawn JP2006249099A (ja) | 2000-12-29 | 2006-06-12 | 持続放出特性を有する吸入用粒子 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7048908B2 (enExample) |
| EP (1) | EP1345629A2 (enExample) |
| JP (2) | JP2005504715A (enExample) |
| AU (1) | AU2002230993B2 (enExample) |
| CA (1) | CA2433335C (enExample) |
| WO (1) | WO2002053190A2 (enExample) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| US20060171899A1 (en) * | 1998-12-10 | 2006-08-03 | Akwete Adjei | Water-stabilized aerosol formulation system and method of making |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7678364B2 (en) * | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| AU2002230993B2 (en) * | 2000-12-29 | 2006-02-02 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| WO2004033620A2 (en) | 2001-11-02 | 2004-04-22 | Insert Therapeutics, Inc. | Methods and compositions for therapeutic use of rna interference |
| AU2002346424A1 (en) * | 2001-11-19 | 2003-06-10 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
| CA2500065A1 (en) * | 2002-09-30 | 2004-04-15 | Acusphere, Inc. | Sustained release porous microparticles for inhalation |
| BRPI0414907A (pt) * | 2003-09-30 | 2006-11-07 | Acusphere Inc | formulações farmacêuticas com liberação sustentada injetáveis, orais ou tópicas |
| US7625865B2 (en) | 2004-03-26 | 2009-12-01 | Universita Degli Studi Di Parma | Insulin highly respirable microparticles |
| DK1786784T3 (da) | 2004-08-20 | 2011-02-14 | Mannkind Corp | Katalyse af diketopiperazinsyntese |
| BR122019022692B1 (pt) | 2004-08-23 | 2023-01-10 | Mannkind Corporation | Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo |
| JP2008537551A (ja) | 2005-03-31 | 2008-09-18 | カランド ファーマシューティカルズ， インコーポレイテッド | リボヌクレオチドレダクターゼサブユニット２の阻害剤およびその使用 |
| US20090142303A1 (en) * | 2005-08-11 | 2009-06-04 | David Edwards | Methods and compositions for dried cellular forms |
| WO2007033372A2 (en) | 2005-09-14 | 2007-03-22 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| US20070197460A1 (en) | 2005-11-01 | 2007-08-23 | Alnylam Pharmaceuticals, Inc. | Rnai inhibition of influenza virus replication |
| WO2007070843A2 (en) * | 2005-12-15 | 2007-06-21 | Acusphere, Inc. | Processes for making particle-based pharmaceutical formulations for oral administration |
| DK1986679T3 (da) | 2006-02-22 | 2017-11-20 | Mannkind Corp | Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof |
| WO2007109097A2 (en) | 2006-03-16 | 2007-09-27 | Alnylam Pharmaceuticals, Inc. | RNAi MODULATION OF TGF-BETA AND THERAPEUTIC USES THEREOF |
| AU2007253803B2 (en) | 2006-05-19 | 2012-05-24 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of Aha and therapeutic uses thereof |
| DK2148691T3 (en) | 2007-02-05 | 2015-08-17 | Apellis Pharmaceuticals Inc | Compstatinanaloger for use in the treatment of inflammatory states of the respiratory system |
| AU2009232355A1 (en) | 2008-04-04 | 2009-10-08 | Calando Pharmaceuticals, Inc. | Compositions and use of EPAS1 inhibitors |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| CA3153292A1 (en) | 2008-06-13 | 2009-12-17 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
| CN102065942B (zh) | 2008-06-20 | 2013-12-11 | 曼金德公司 | 用于对吸入工作进行实时描绘的交互式设备和方法 |
| TWI532497B (zh) | 2008-08-11 | 2016-05-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| PL2405963T3 (pl) | 2009-03-11 | 2014-04-30 | Mannkind Corp | Urządzenie, układ i sposób pomiaru oporu inhalatora |
| FR2943538B1 (fr) | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| US9018190B2 (en) | 2009-03-27 | 2015-04-28 | Adocia | Functionalized oligosaccharides |
| EP2435025B1 (en) | 2009-05-29 | 2016-07-06 | Pearl Therapeutics, Inc. | Respiratory delivery of active agents |
| KR20180036807A (ko) | 2009-06-12 | 2018-04-09 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| CA2778698A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| RU2571331C1 (ru) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Системы и способы доставки сухих порошковых лекарств |
| KR101940832B1 (ko) | 2011-04-01 | 2019-01-21 | 맨카인드 코포레이션 | 의약 카트리지용 블리스터 패키지 |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| EP3524258B1 (en) | 2011-06-22 | 2025-10-01 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
| EP2776053A1 (en) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Methods and compositions for treating pain |
| US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
| EP2819672A1 (en) * | 2012-02-29 | 2015-01-07 | Pulmatrix, Inc. | Inhalable dry powders |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| EP2911690A1 (en) | 2012-10-26 | 2015-09-02 | MannKind Corporation | Inhalable influenza vaccine compositions and methods |
| EP2912045A4 (en) * | 2012-10-29 | 2016-07-13 | Molecular Transfer Inc | POLYCATION METHYL PHOSPHOLIPIDES FOR IMPROVED RELEASE OF NUCLEIC ACIDS IN EUKARYOTIC CELLS |
| WO2014074797A1 (en) | 2012-11-09 | 2014-05-15 | Civitas Therapeutics, Inc. | Ultra low density pulmonary powders |
| EP2919804B1 (fr) | 2012-11-13 | 2018-01-31 | Adocia | Formulation à action rapide d'insuline comprenant un composé anionique substitué |
| EP3778623A1 (en) * | 2013-03-15 | 2021-02-17 | Rhythm Pharmaceuticals, Inc. | Pharmaceutical compositions |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| CA2918369C (en) | 2013-07-18 | 2021-06-29 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
| WO2015021064A1 (en) | 2013-08-05 | 2015-02-12 | Mannkind Corporation | Insufflation apparatus and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US9795678B2 (en) | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| FR3020947B1 (fr) | 2014-05-14 | 2018-08-31 | Adocia | Composition aqueuse comprenant au moins une proteine et un agent solubilisant, sa preparation et ses utilisations |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| DK3212212T3 (da) | 2014-10-31 | 2020-12-21 | Univ Monash | Pulverformulering |
| MA40910A (fr) | 2014-11-07 | 2017-09-12 | Civitas Therapeutics Inc | Poudres de rapamycine pour administration pulmonaire |
| WO2017004501A1 (en) | 2015-07-02 | 2017-01-05 | Civitas Therapeutics, Inc. | Triptan powders for pulmonary delivery |
| KR20180050320A (ko) * | 2015-09-09 | 2018-05-14 | 노파르티스 아게 | 분무-건조된 제제의 폐로의 표적화된 전달 |
| MX392574B (es) | 2015-10-07 | 2025-03-24 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada para usarse en el tratamiento de trastornos oculares |
| FR3043557B1 (fr) | 2015-11-16 | 2019-05-31 | Adocia | Composition a action rapide d'insuline comprenant un citrate substitue |
| US10067160B2 (en) | 2016-11-16 | 2018-09-04 | CBN Nano Technologies, Inc. | Sequential tip systems and methods for positionally controlled chemistry |
| KR20190139931A (ko) | 2017-04-07 | 2019-12-18 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 및 관련 조성물 및 방법 |
| CA3059449A1 (en) | 2017-04-24 | 2018-11-01 | Cocrystal Pharma, Inc. | Pyrrolopyrimidine derivatives useful as inhibitors of influenza virus replication |
| KR102813547B1 (ko) | 2018-07-27 | 2025-05-27 | 코크리스탈 파마, 아이엔씨. | 인플루엔자바이러스 복제 억제제로서의 피롤로[2,3-b]피리딘 유도체 |
| ES2937837T3 (es) | 2018-09-10 | 2023-03-31 | Cocrystal Pharma Inc | Inhibidores de piridopirazina y piridotriazina de la replicación del virus de la gripe |
| CN112969457B (zh) | 2018-10-17 | 2025-10-28 | 共晶制药公司 | 流感病毒复制抑制剂的组合 |
| WO2020112716A1 (en) | 2018-11-26 | 2020-06-04 | Cocrystal Pharma, Inc. | Inhibitors of influenza virus replication |
| WO2021188620A1 (en) | 2020-03-17 | 2021-09-23 | Cocrystal Pharma Inc. | Peptidomimetic n5-methyl-n2-(nonanoyl-l-leucyl)-l-glutaminate derivatives, triazaspiro[4.14]nonadecane derivatives and similar compounds as inhibitors of norovirus and coronavirus replication |
| BR112022019557A2 (pt) | 2020-04-10 | 2022-12-06 | Cocrystal Pharma Inc | Inibidores de replicação de norovírus e coronavírus |
| CA3210753A1 (en) | 2021-02-09 | 2022-08-18 | University Of Georgia Research Foundation, Inc. | Human monoclonal antibodies against pneumococcal antigens |
| TW202321196A (zh) | 2021-08-03 | 2023-06-01 | 美商共結晶製藥公司 | 冠狀病毒抑制劑 |
| WO2023198757A1 (en) | 2022-04-14 | 2023-10-19 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Alpha-1-antitrypsin for treating paramyxoviridae or orthomyxoviridae infections |
Family Cites Families (124)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2533065A (en) | 1947-03-08 | 1950-12-05 | George V Taplin | Micropulverized therapeutic agents |
| US2470296A (en) | 1948-04-30 | 1949-05-17 | Abbott Lab | Inhalator |
| US2992645A (en) | 1958-05-06 | 1961-07-18 | Benger Lab Ltd | Disperser for powders |
| US3957965A (en) | 1967-08-08 | 1976-05-18 | Fisons Limited | Sodium chromoglycate inhalation medicament |
| AU439432B2 (en) | 1968-11-28 | 1972-08-15 | Dulux Australia Ltd | Polymer and coating composition |
| US3781230A (en) | 1968-12-23 | 1973-12-25 | Champion Int Corp | Microcapsular opacifier system |
| US4173488A (en) | 1968-12-23 | 1979-11-06 | Champion International Corporation | Oil-in-water emulsions containing hydropholeic starch |
| GB1410588A (en) | 1971-08-10 | 1975-10-22 | Fisons Ltd | Composition |
| US4089800A (en) | 1975-04-04 | 1978-05-16 | Ppg Industries, Inc. | Method of preparing microcapsules |
| US4161516A (en) | 1975-07-25 | 1979-07-17 | Fisons Limited | Composition for treating airway disease |
| US4272398A (en) | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
| US4743545A (en) | 1984-08-09 | 1988-05-10 | Torobin Leonard B | Hollow porous microspheres containing biocatalyst |
| US4352883A (en) | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| US4391909A (en) | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| US4276885A (en) | 1979-05-04 | 1981-07-07 | Rasor Associates, Inc | Ultrasonic image enhancement |
| DE3274065D1 (de) | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| DE3268533D1 (en) | 1981-07-24 | 1986-02-27 | Fisons Plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
| US5260306A (en) | 1981-07-24 | 1993-11-09 | Fisons Plc | Inhalation pharmaceuticals |
| DE3141641A1 (de) | 1981-10-16 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Ultraschall-kontrastmittel und dessen herstellung |
| US4480041A (en) | 1982-07-09 | 1984-10-30 | Collaborative Research, Inc. | Use of phosphotriester intermediates for preparation of functionalized liposomes |
| US4572203A (en) | 1983-01-27 | 1986-02-25 | Feinstein Steven B | Contact agents for ultrasonic imaging |
| US4718433A (en) | 1983-01-27 | 1988-01-12 | Feinstein Steven B | Contrast agents for ultrasonic imaging |
| EP0501523B1 (en) | 1983-11-14 | 1997-04-09 | Columbia Laboratories, Inc. | Bioadhesive compositions |
| US4865789A (en) | 1983-11-14 | 1989-09-12 | Akzo Nv | Method for making porous structures |
| US4818542A (en) | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
| CA1215922A (en) | 1984-05-25 | 1986-12-30 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| US4679555A (en) | 1984-08-07 | 1987-07-14 | Key Pharmaceuticals, Inc. | Method and apparatus for intrapulmonary delivery of heparin |
| SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
| WO1987003197A1 (en) | 1985-11-29 | 1987-06-04 | Fisons Plc | Pharmaceutical composition including sodium cromoglycate |
| GB8601100D0 (en) | 1986-01-17 | 1986-02-19 | Cosmas Damian Ltd | Drug delivery system |
| US5160745A (en) | 1986-05-16 | 1992-11-03 | The University Of Kentucky Research Foundation | Biodegradable microspheres as a carrier for macromolecules |
| US4741872A (en) | 1986-05-16 | 1988-05-03 | The University Of Kentucky Research Foundation | Preparation of biodegradable microspheres useful as carriers for macromolecules |
| EP0257915B1 (en) | 1986-08-11 | 1993-03-10 | Innovata Biomed Limited | Pharmaceutical formulations comprising microcapsules |
| ATE76311T1 (de) | 1986-08-19 | 1992-06-15 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen. |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| DE3637926C1 (de) | 1986-11-05 | 1987-11-26 | Schering Ag | Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen |
| JPS63122620A (ja) | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| US4897256A (en) | 1986-11-25 | 1990-01-30 | Abbott Laboratories | LHRH analog formulations |
| NZ222907A (en) | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
| US5204113A (en) | 1987-04-09 | 1993-04-20 | Fisons Plc | Pharmaceutical compositions containing pentamidine |
| US4861627A (en) | 1987-05-01 | 1989-08-29 | Massachusetts Institute Of Technology | Preparation of multiwall polymeric microcapsules |
| GB8712176D0 (en) | 1987-05-22 | 1987-06-24 | Cosmas Damian Ltd | Drug delivery system |
| US5690954A (en) | 1987-05-22 | 1997-11-25 | Danbiosyst Uk Limited | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material |
| US5069936A (en) | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
| US4857311A (en) | 1987-07-31 | 1989-08-15 | Massachusetts Institute Of Technology | Polyanhydrides with improved hydrolytic degradation properties |
| GB8723846D0 (en) | 1987-10-10 | 1987-11-11 | Danbiosyst Ltd | Bioadhesive microsphere drug delivery system |
| US4855144A (en) | 1987-10-23 | 1989-08-08 | Advanced Polymer Systems | Synthetic melanin aggregates |
| IE61591B1 (en) | 1987-12-29 | 1994-11-16 | Molecular Biosystems Inc | Concentrated stabilized microbubble-type ultrasonic imaging agent and method of production |
| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| AU3073789A (en) | 1988-03-31 | 1989-10-05 | Abbott Laboratories | Drug delivery using pulmonary surfactant to facilitate absorption |
| US5064650A (en) | 1988-04-19 | 1991-11-12 | Southwest Research Institute | Controlled-release salt sensitive capsule for oral use and adhesive system |
| US4917119A (en) | 1988-11-30 | 1990-04-17 | R. J. Reynolds Tobacco Company | Drug delivery article |
| GB8900267D0 (en) | 1989-01-06 | 1989-03-08 | Riker Laboratories Inc | Narcotic analgesic formulations and apparatus containing same |
| US4976968A (en) | 1989-02-24 | 1990-12-11 | Clinical Technologies Associates, Inc. | Anhydrous delivery systems for pharmacological agents |
| DK0471036T4 (da) | 1989-05-04 | 2004-07-19 | Southern Res Inst | Indkapslingsfremgangsmåde |
| US5176132A (en) | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
| US5174988A (en) | 1989-07-27 | 1992-12-29 | Scientific Development & Research, Inc. | Phospholipid delivery system |
| WO1991004732A1 (en) | 1989-10-03 | 1991-04-18 | Advanced Polymer Systems, Inc. | Erodible macroporous hydrogel particles and preparation thereof |
| IT1237118B (it) | 1989-10-27 | 1993-05-18 | Miat Spa | Inalatore multidose per farmaci in polvere. |
| US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
| US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| EP0550436A1 (en) | 1989-11-06 | 1993-07-14 | Alkermes Controlled Therapeutics, Inc. | Protein microspheres and methods of using them |
| WO1991006286A1 (en) | 1989-11-06 | 1991-05-16 | Enzytech, Inc. | Method for producing protein microspheres |
| US5123414A (en) | 1989-12-22 | 1992-06-23 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5334381A (en) | 1989-12-22 | 1994-08-02 | Unger Evan C | Liposomes as contrast agents for ultrasonic imaging and methods for preparing the same |
| US5352435A (en) | 1989-12-22 | 1994-10-04 | Unger Evan C | Ionophore containing liposomes for ultrasound imaging |
| GB9003821D0 (en) | 1990-02-20 | 1990-04-18 | Danbiosyst Uk | Diagnostic aid |
| AU636481B2 (en) | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| SE9002017D0 (sv) | 1990-06-06 | 1990-06-06 | Kabivitrum Ab | Process for manufacture of matrices |
| SK392592A3 (en) | 1990-06-29 | 1994-07-06 | Fisons Plc | Pressure aerosol composition |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| SE9302777D0 (sv) | 1993-08-27 | 1993-08-27 | Astra Ab | Process for conditioning substances |
| US5327883A (en) | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
| FI935394L (fi) | 1991-06-03 | 1993-12-02 | Nycomed Imaging As | Foerbaettringar i betraeffande kontrastmedel |
| ATE134509T1 (de) | 1991-06-10 | 1996-03-15 | Schering Corp | Fluorchlorkohlenwasserstoffreie aerosolformulierungen |
| US5409688A (en) | 1991-09-17 | 1995-04-25 | Sonus Pharmaceuticals, Inc. | Gaseous ultrasound contrast media |
| DE69232034T2 (de) | 1991-12-18 | 2002-06-06 | Minnesota Mining And Mfg. Co., Saint Paul | Aerosolzusammensetzungen für Arzneimittelsuspensionen |
| US5169871A (en) | 1991-12-19 | 1992-12-08 | Hoechst Celanese Corp. | Highly porous compressible polymeric powders |
| JPH07507806A (ja) | 1992-06-11 | 1995-08-31 | アルカーメス コントロールド セラピューティクス，インコーポレイテッド | エリスロポエチン薬物送達システム |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| GB2269992A (en) | 1992-08-14 | 1994-03-02 | Rh Ne Poulenc Rorer Limited | Powder inhalation formulations |
| DK0679088T3 (da) | 1992-09-29 | 2002-10-28 | Inhale Therapeutic Syst | Pulmonal levering af aktive fragmenter af parathyreoideaea hormon |
| GB9221329D0 (en) | 1992-10-10 | 1992-11-25 | Delta Biotechnology Ltd | Preparation of further diagnostic agents |
| US5698721A (en) | 1992-12-17 | 1997-12-16 | Megabios Corporation | Catonic amphiphiles |
| CN1068230C (zh) | 1993-01-25 | 2001-07-11 | 索纳斯药品有限公司 | 用作超声造影剂的相转变胶体 |
| GB9301629D0 (en) | 1993-01-27 | 1993-03-17 | Scotia Holdings Plc | Formulations containing unsaturated fatty acids |
| US5994314A (en) | 1993-04-07 | 1999-11-30 | Inhale Therapeutic Systems, Inc. | Compositions and methods for nucleic acid delivery to the lung |
| US5456917A (en) | 1993-04-12 | 1995-10-10 | Cambridge Scientific, Inc. | Method for making a bioerodible material for the sustained release of a medicament and the material made from the method |
| TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9313650D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| DE4323636A1 (de) | 1993-07-15 | 1995-01-19 | Hoechst Ag | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| HUT74509A (en) | 1993-09-09 | 1997-01-28 | Schering Ag | Active principles and gas containing microparticles, their use for realising active principles in ultrasonically controlled manner, and process for preparing them |
| SG48049A1 (en) | 1993-10-01 | 1998-04-17 | Astra Ab | Process i |
| CA2183577C (en) | 1994-03-07 | 2007-10-30 | John S. Patton | Methods and compositions for pulmonary delivery of insulin |
| GB9412273D0 (en) | 1994-06-18 | 1994-08-10 | Univ Nottingham | Administration means |
| GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| JPH10506406A (ja) | 1994-09-29 | 1998-06-23 | アンダリス、リミテッド | 治療用ビヒクルとしての噴霧乾燥させた微細粒子 |
| GB9423419D0 (en) | 1994-11-19 | 1995-01-11 | Andaris Ltd | Preparation of hollow microcapsules |
| GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
| US5830430A (en) * | 1995-02-21 | 1998-11-03 | Imarx Pharmaceutical Corp. | Cationic lipids and the use thereof |
| US5612053A (en) | 1995-04-07 | 1997-03-18 | Edward Mendell Co., Inc. | Controlled release insufflation carrier for medicaments |
| US5932241A (en) * | 1995-06-07 | 1999-08-03 | Valentis, Incorporated | Cationic lipid DNA complexes for gene targeting |
| US5811406A (en) * | 1995-06-07 | 1998-09-22 | Regents Of The University Of California | Dry powder formulations of polynucleotide complexes |
| GB9606677D0 (en) | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| USRE37053E1 (en) | 1996-05-24 | 2001-02-13 | Massachusetts Institute Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5985309A (en) | 1996-05-24 | 1999-11-16 | Massachusetts Institute Of Technology | Preparation of particles for inhalation |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US20020052310A1 (en) * | 1997-09-15 | 2002-05-02 | Massachusetts Institute Of Technology The Penn State Research Foundation | Particles for inhalation having sustained release properties |
| WO1998006437A2 (en) * | 1996-08-13 | 1998-02-19 | Chiron Corporation | Compositions and methods for polynucleotide delivery |
| JP2001502666A (ja) * | 1996-09-12 | 2001-02-27 | ジェネメディシン，インコーポレイテッド | 肺遺伝子送達のための組成物および方法 |
| US6077543A (en) | 1996-12-31 | 2000-06-20 | Inhale Therapeutic Systems | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| ATE287257T1 (de) * | 1997-01-16 | 2005-02-15 | Massachusetts Inst Technology | Zubereitung von partikelhaltigen arzneimitteln zur inhalation |
| US5898028A (en) * | 1997-03-20 | 1999-04-27 | Novo Nordisk A/S | Method for producing powder formulation comprising an insulin |
| EP1027033B1 (en) * | 1997-05-14 | 2009-07-22 | The University Of British Columbia | High efficiency encapsulation of nucleic acids in lipid vesicles |
| WO1999016420A1 (en) | 1997-09-29 | 1999-04-08 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in nebulizers |
| AU750567B2 (en) | 1997-09-29 | 2002-07-25 | Novartis Ag | Stabilized preparations for use in nebulizers |
| US6956021B1 (en) * | 1998-08-25 | 2005-10-18 | Advanced Inhalation Research, Inc. | Stable spray-dried protein formulations |
| US20030125236A1 (en) * | 2000-12-29 | 2003-07-03 | Advenced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| AU2002230993B2 (en) * | 2000-12-29 | 2006-02-02 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
-
2001
- 2001-12-18 AU AU2002230993A patent/AU2002230993B2/en not_active Ceased
- 2001-12-18 WO PCT/US2001/048956 patent/WO2002053190A2/en not_active Ceased
- 2001-12-18 JP JP2002554139A patent/JP2005504715A/ja not_active Withdrawn
- 2001-12-18 CA CA2433335A patent/CA2433335C/en not_active Expired - Fee Related
- 2001-12-18 EP EP01991253A patent/EP1345629A2/en not_active Withdrawn
-
2002
- 2002-07-23 US US10/202,616 patent/US7048908B2/en not_active Expired - Lifetime
-
2006
- 2006-05-18 US US11/436,404 patent/US20080039366A1/en not_active Abandoned
- 2006-06-12 JP JP2006162862A patent/JP2006249099A/ja not_active Withdrawn
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