JP2005503411A5 - - Google Patents
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- Publication number
- JP2005503411A5 JP2005503411A5 JP2003528768A JP2003528768A JP2005503411A5 JP 2005503411 A5 JP2005503411 A5 JP 2005503411A5 JP 2003528768 A JP2003528768 A JP 2003528768A JP 2003528768 A JP2003528768 A JP 2003528768A JP 2005503411 A5 JP2005503411 A5 JP 2005503411A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- hydrogen
- alkyl
- arylalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000005127 aryl alkoxy alkyl group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- 206010014561 Emphysema Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32296201P | 2001-09-18 | 2001-09-18 | |
| PCT/EP2002/010181 WO2003024920A1 (en) | 2001-09-18 | 2002-09-11 | Substituted urea retinoid agonists ii |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005503411A JP2005503411A (ja) | 2005-02-03 |
| JP2005503411A5 true JP2005503411A5 (enExample) | 2006-01-05 |
| JP4410562B2 JP4410562B2 (ja) | 2010-02-03 |
Family
ID=23257206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528768A Expired - Fee Related JP4410562B2 (ja) | 2001-09-18 | 2002-09-11 | 置換尿素レチノイド作用薬ｉｉ |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6838472B2 (enExample) |
| EP (1) | EP1430023B1 (enExample) |
| JP (1) | JP4410562B2 (enExample) |
| KR (1) | KR100891224B1 (enExample) |
| CN (1) | CN1301968C (enExample) |
| AR (1) | AR036532A1 (enExample) |
| AT (1) | ATE427929T1 (enExample) |
| AU (1) | AU2002340886B2 (enExample) |
| BR (1) | BR0212607A (enExample) |
| CA (1) | CA2458266C (enExample) |
| DE (1) | DE60231888D1 (enExample) |
| ES (1) | ES2325063T3 (enExample) |
| MX (1) | MXPA04002305A (enExample) |
| PL (1) | PL209697B1 (enExample) |
| RU (1) | RU2303027C2 (enExample) |
| WO (1) | WO2003024920A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1889830A1 (en) | 2006-07-10 | 2008-02-20 | Pharmeste S.r.l. | Biarylcarboxyarylamides as vanilloid-1 receptor modulators |
| EP1889837A1 (en) * | 2006-07-10 | 2008-02-20 | Pharmeste S.r.l. | VR1 vanilloid receptor antagonists with a iononic substructure |
| CN103200937B (zh) | 2010-09-01 | 2020-07-03 | 托马斯杰弗逊大学 | 用于肌肉修复和再生的组合物和方法 |
| CN105188753B (zh) | 2012-11-08 | 2018-12-18 | 国立大学法人山口大学 | 角结膜病症的治疗剂 |
| DK3000466T3 (en) | 2013-05-22 | 2018-11-26 | Univ Yamaguchi | INHIBITOR FOR RETINOCHOROIDAL DISEASES |
| MX390115B (es) | 2016-06-08 | 2025-03-20 | Clementia Pharmaceuticals Inc | Metodos para tratar la osificacion heterotopica. |
| JP7018957B2 (ja) | 2016-11-16 | 2022-02-14 | クレメンティア ファーマシューティカルズ インコーポレイテッド | 多発性骨軟骨腫（ｍｏ）を処置するための方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU87821A1 (fr) * | 1990-10-12 | 1992-05-25 | Cird Galderma | Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique |
| HUT62558A (en) * | 1991-07-01 | 1993-05-28 | Sandoz Ag | Process for producing n-phenylthiourea derivaties and pharmaceutical compositions comprising same |
| US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
| US5648514A (en) * | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| JO2178B1 (en) | 1999-10-19 | 2003-04-23 | اف . هوفمان لاروش ايه جي | Treatment of invasive diseases, using selected anti-PAR materials |
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2002
- 2002-09-11 MX MXPA04002305A patent/MXPA04002305A/es active IP Right Grant
- 2002-09-11 BR BR0212607-9A patent/BR0212607A/pt not_active IP Right Cessation
- 2002-09-11 KR KR1020047003921A patent/KR100891224B1/ko not_active Expired - Fee Related
- 2002-09-11 AT AT02774599T patent/ATE427929T1/de active
- 2002-09-11 PL PL370459A patent/PL209697B1/pl not_active IP Right Cessation
- 2002-09-11 JP JP2003528768A patent/JP4410562B2/ja not_active Expired - Fee Related
- 2002-09-11 RU RU2004111789/04A patent/RU2303027C2/ru not_active IP Right Cessation
- 2002-09-11 CA CA2458266A patent/CA2458266C/en not_active Expired - Fee Related
- 2002-09-11 WO PCT/EP2002/010181 patent/WO2003024920A1/en not_active Ceased
- 2002-09-11 DE DE60231888T patent/DE60231888D1/de not_active Expired - Lifetime
- 2002-09-11 CN CNB028178327A patent/CN1301968C/zh not_active Expired - Fee Related
- 2002-09-11 ES ES02774599T patent/ES2325063T3/es not_active Expired - Lifetime
- 2002-09-11 AU AU2002340886A patent/AU2002340886B2/en not_active Ceased
- 2002-09-11 EP EP02774599A patent/EP1430023B1/en not_active Expired - Lifetime
- 2002-09-16 AR ARP020103489A patent/AR036532A1/es not_active Application Discontinuation
- 2002-09-17 US US10/244,885 patent/US6838472B2/en not_active Expired - Fee Related