JP2005500290A - 抗炎症性の、１７β−カルボチオアートアンドロスタン誘導体である１７α複素環エステル - Google Patents

抗炎症性の、１７β−カルボチオアートアンドロスタン誘導体である１７α複素環エステル Download PDF

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Publication number
JP2005500290A
JP2005500290A JP2003503645A JP2003503645A JP2005500290A JP 2005500290 A JP2005500290 A JP 2005500290A JP 2003503645 A JP2003503645 A JP 2003503645A JP 2003503645 A JP2003503645 A JP 2003503645A JP 2005500290 A JP2005500290 A JP 2005500290A
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Prior art keywords
methyl
hydroxy
oxo
difluoro
oxy
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JP2003503645A
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Japanese (ja)
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JP2005500290A5 (enExample
Inventor
ビッガダイク，キース
ジョーンズ，ポール
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Glaxo Group Ltd
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Glaxo Group Ltd
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Priority claimed from GB0114338A external-priority patent/GB0114338D0/en
Priority claimed from GB0202636A external-priority patent/GB0202636D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of JP2005500290A publication Critical patent/JP2005500290A/ja
Publication of JP2005500290A5 publication Critical patent/JP2005500290A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2003503645A 2001-06-12 2002-06-11 抗炎症性の、１７β−カルボチオアートアンドロスタン誘導体である１７α複素環エステル Pending JP2005500290A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0114338A GB0114338D0 (en) 2001-06-12 2001-06-12 Novel compounds
GB0202636A GB0202636D0 (en) 2002-02-05 2002-02-05 Novel compounds
PCT/GB2002/002686 WO2002100879A1 (en) 2001-06-12 2002-06-11 Novel anti-inflammatory 17.alpha.-heterocyclic-esters of 17.beta.carbothioate androstane derivatives

Publications (2)

Publication Number Publication Date
JP2005500290A true JP2005500290A (ja) 2005-01-06
JP2005500290A5 JP2005500290A5 (enExample) 2006-01-05

Family

ID=26246181

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JP2003503645A Pending JP2005500290A (ja) 2001-06-12 2002-06-11 抗炎症性の、１７β−カルボチオアートアンドロスタン誘導体である１７α複素環エステル

Country Status (8)

Country Link
US (1) US20040248867A1 (enExample)
EP (1) EP1395604B1 (enExample)
JP (1) JP2005500290A (enExample)
AR (1) AR034475A1 (enExample)
AT (1) ATE399174T1 (enExample)
DE (1) DE60227254D1 (enExample)
ES (1) ES2307751T3 (enExample)
WO (1) WO2002100879A1 (enExample)

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US20040248867A1 (en) 2004-12-09
ATE399174T1 (de) 2008-07-15
ES2307751T3 (es) 2008-12-01
EP1395604B1 (en) 2008-06-25
DE60227254D1 (de) 2008-08-07

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