JP2005330257A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a water-soluble polysaccharide extracted from the fruit body of silver ear (Tremella fusiformis) having excellent application feeling and moisturizing action and to prepare a cosmetic containing the polysaccharide. <P>SOLUTION: The water-soluble polysaccharide extracted from the fruit body of silver ear and having an average molecular weight of 800,000-2,200,000 is compounded to a cosmetic and/or the polysaccharide extracted from the fruit body of silver ear is compounded together with a water-soluble polymer and/or phospholipid to a cosmetic. This invention provides the water-soluble polysaccharide extracted from the fruit body of silver ear having excellent application feeling and moisturizing effect and the cosmetic containing the polysaccharide. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a cosmetic containing a water-soluble polysaccharide extracted from a white jellyfish fruit body, and further, a water-soluble polysaccharide and a water-soluble polymer extracted from a white jellyfish fruit body (however, a water-soluble polysaccharide extracted from a white jellyfish fruit body). The present invention relates to a cosmetic containing a polysaccharide and a phospholipid.

  Conventionally, water-soluble viscous products obtained from fruit jellyfish fruit bodies have been used in skin cosmetics with the expectation of providing a smooth feeling of use and a skin conditioning effect. However, it is difficult to achieve both a moisturizing effect and a feeling of use which are particularly important in cosmetics, and a method for imparting both a high moisturizing effect and an excellent feeling of use to cosmetics has been demanded.

Skin cosmetics containing a viscous extract obtained by extracting a white jellyfish fruit body with water, a water-soluble solvent such as methanol, ethanol, propylene glycol or a mixture thereof are already known. It is also known to blend into a cosmetic material a fruit body extract-like viscous product that is discharged into the culture medium by liquid culture of white jellyfish cells. However, it is difficult to achieve both a moisturizing effect and a feeling of use with these white jellyfish extracts, and there is a need for a technique that can achieve both.
JP-B-1-41121 Japanese Unexamined Patent Publication No. 63-227512 Japanese Examined Patent Publication No. 4-77725

  Provision of a water-soluble polysaccharide excellent in feeling of use and moisturizing effect and a cosmetic containing the same.

  As a result of intensive studies to solve the above-mentioned problems, the present inventors found that a fraction having an average molecular weight of a water-soluble polysaccharide extracted from a white jellyfish fruit body has an excellent moisturizing effect. The present inventors have found that a good feeling of use can be achieved and that it can be preferably used in cosmetics. Further, it has been found that the use of other water-soluble polymers in combination with water-soluble polysaccharides extracted from the fruit bodies of white jellyfish can increase the slime feeling and reduce stickiness, and can exhibit desirable properties as a cosmetic. Furthermore, the present inventors have found that the use of a phospholipid in combination with a water-soluble polysaccharide extracted from a fruit jellyfish fruit body enhances the moisturizing feeling and the dry feeling of slipping, and is preferable as a cosmetic. That is, this invention relates to the cosmetics excellent in the moisturizing effect and usability | use_condition which contain the water-soluble polysaccharide extracted from the white jellyfish fruiting body as an essential component.

  According to the present invention, it is possible to obtain a cosmetic containing a water-soluble polysaccharide extracted from a fruit body of white jellyfish and having excellent usability and moisturizing effect.

White jellyfish is a kind of basidiomycetes, genus Basidiomycetes, and mushrooms belonging to the order of white jellyfish, and the fruiting body is called Shiraki ear and has been prized as a tonic food. As the water-soluble polysaccharide used in the present invention, a substance obtained by extracting a white jellyfish fruit body with water or a mixture of water and a water-soluble solvent can be used. Water-soluble polysaccharides having different average molecular weights can be obtained depending on the type of solvent used for extraction, extraction temperature, extraction time, etc., but those having an average molecular weight of 100,000 to 5,000,000 can be preferably used in the present invention. . More preferably, the average molecular weight is from 800,000 to 2.2 million. The average molecular weight referred to in the present invention is a weight average molecular weight in a gel permeation chromatogram (GPC) using a crosslinked vinyl polymer measured using water as a solvent and polyethylene oxide having a known molecular weight as a standard substance.
The water-soluble polysaccharide extracted from the fruit body of the present invention can control the molecular weight of the extracted polysaccharide to some extent by devising the extraction method. It is also possible to adjust the molecular weight by fractionating the water-soluble polysaccharide obtained by a normal extraction operation such as hot water extraction by a known method such as a dissolution equilibrium method, a gel filtration method, or an adsorption method. is there. As a method for molecular weight fractionation, the dissolution equilibrium method is preferable from the economical viewpoint, and in particular, a fractional precipitation method using a water / water-soluble solvent system such as water / ethanol, water / isopropyl alcohol or the like as a solvent can be preferably used.

In the present invention, a water-soluble polysaccharide and a water-soluble polymer (excluding a water-soluble polysaccharide extracted from a white jellyfish fruit body) extracted from a white jellyfish fruit body, and a feeling of use by using in combination, or a phospholipid, A cosmetic having an excellent moisturizing effect can be obtained.
In the combined use with the water-soluble polymer, a preferable slime feeling at the time of application is increased and at the same time, stickiness can be reduced. As the water-soluble polymer used in the present invention, a nonionic water-soluble polymer and / or an anionic water-soluble polymer can be used. Nonionic water-soluble polymers include polyethylene glycol, polyethylene oxide (PEO), copolymers of ethylene glycol and propylene glycol, dextran, duran gum, quince seed extract, polyvinyl alcohol and its nonionic derivatives, polyglucosyloxyethyl methacrylate ( Poly (meth) acrylic acid derivatives such as p-GEMA), nonionic cellulose derivatives such as polyvinylpyrrolidone, hydroxyethylcellulose, hydroxypropylcellulose, and methylcellulose; nonionic starch derivatives such as hydroxyethyl starch and hydroxypropyl starch; Among them, polyvinyl alcohol, PEO, p-GEMA, dextran, polyvinylpyrrolidone, hydroxyethyl cellulose Scan it can be used particularly preferably.
Examples of the anionic water-soluble polymer used in the present invention include hyaluronic acid, xanthan gum, chondroitin sulfate, polyglutamic acid, polyaspartic acid, carboxymethylcellulose, alkaline generators B-16 polymer, carboxyvinyl polymer (CV), acrylic acid / methacrylic acid. An acid alkyl copolymer can be raised, and among these, hyaluronic acid, polyglutamic acid, and CV can be preferably used. As these anionic water-soluble polymers, their metal salts, ammonium salts, and amine salts can be similarly used. As the types of metal salts, alkali metal salts and alkaline earth metal salts can be used, and among them, sodium salts or potassium salts can be preferably used.
The molecular weight of the water-soluble polymer (excluding the water-soluble polysaccharide extracted from white jellyfish fruiting bodies) used in the present invention is not particularly limited, and those having a molecular weight range usually used can be used.

The combined use with phospholipids is preferable because it enhances the moisturizing feeling and the dry feeling of sliding. Examples of the phospholipid used in the present invention include phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, sphingophospholipid, and their lysates, and the like, or a composition containing these components is used. You can also do things. Examples of the phospholipid composition include soy lecithin, egg yolk lecithin, sunflower lecithin, and the like, and hydrogenated products in which oxidation stability is improved by completely or partially hydrogenating them. In the present invention, these phospholipids can be used alone or in combination of two or more.
When blending phospholipids in cosmetics, it is possible to form liposomes if conditions are selected. When forming liposomes, it is preferable to contain sterols or ceramides in the liposome membrane from the viewpoint of improving the stability of the membrane, and a complex in which those lipids are complexed in advance (for example, Nippon Seika Co., Ltd. ); Presome CS2-101, presome R-3, phytopresome, etc.) can also be used. In such cosmetics, the water-soluble polysaccharide extracted from the fruit body of white jellyfish not only improves the moisturizing feeling and feel as described above, but also contributes to the improvement of the stability of the formed liposomes.

The cosmetic in the present invention is preferably a basic cosmetic such as skin lotion, soft lotion, cosmetic liquid, cream, milky lotion, massage cream, pack, etc. In particular, lotion, cosmetic liquid, cream, and milky lotion are preferable. Examples of hair cosmetics include shampoos, treatments, and hair dyes.
The amount of water jellyfish fruit body extraction water-soluble polysaccharide in the cosmetic is generally 0.01 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 0.3 to 3% by weight. is there.
The amount of the water-soluble polymer used in combination with the water-soluble polysaccharide extracted from white jellyfish fruit bodies in the cosmetic is generally 0 to 5% by weight, preferably 0.05 to 2% by weight.
The amount of the phospholipid used in combination with the white jellyfish fruit body-extracted water-soluble polysaccharide in the cosmetic is generally 0 to 10% by weight, preferably 0.01 to 3% by weight.

  The pH of the cosmetic composition of the present invention is preferably 4 to 8, and more preferably 4.5 to 7.0, because the skin cosmetic composition significantly exhibits high moisture retention. For hair cosmetics, the pH is usually 4 to 10, preferably 4.5 to 9.5.

It is preferable to add a moisturizing agent to the cosmetic of the present invention in order to further enhance the moisturizing effect. Examples of the humectant include polyhydric alcohols, saccharides (excluding polysaccharides), amino acids, betaines, urea, pyrrolidone carboxylic acids or salts thereof, and the like.
Examples of the polyhydric alcohol include glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol, carbitol, methyl carbitol, butyl carbitol, diethyl carbitol and the like. Can do.
Monosaccharides, disaccharides, oligosaccharides, and sugar alcohols can be used as saccharides other than polysaccharides. Glucose, xylose, mannose, galactose, fructose, sucrose, maltose, trehalose, lactose, stachyose, raffinose, Examples include xylitol, sorbitol, erythritol, maltitol, lactitol, α-cyclodextrin, β-cyclodextrin, γ-cyclodextrin, methyl-β-cyclodextrin, maltosyl-β-cyclodextrin, and their derivatives. .
Examples of amino acids include glycine, serine, threonine, alanine, aspartic acid, tyrosine, valine, leucine, arginine, glutamine, proline, methionine, cysteine, trimethylglycine, tryptophan, hydroxyproline, taurine, and hypotaurine.
In addition, organic acids and salts thereof such as lactic acid and its alkali metal salts, citric acid and its alkali metal salts, hydrolysates of yeast and yeast extract, yeast culture fluid, fermentation metabolites such as lactic acid bacteria culture fluid, eggshell membrane protein, Water-soluble protein such as albumin, collagen, elastin, keratin, sericin, collagen hydrolyzate, elastin degrading peptide, keratin degrading peptide, conchiolin degrading peptide, soybean proteolytic peptide, wheat proteolytic peptide, casein degrading peptide, silk hydrolyzate Peptides and their salts, sesame lignan glycosides, bovine submandibular gland mucin, placenta extract, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, etc. Can be raised.
The amount of the moisturizing agent is preferably 0.001 to 40% by weight, more preferably 0.01 to 20% by weight.

  The cosmetic composition of the present invention includes a natural extract obtained by extraction from animals or plants or microorganisms using one or more selected from the group consisting of organic solvents, alcohols, and water in order to enhance the moisturizing effect. It is preferable to include one or more selected. These natural extracts include yeasts such as Saccharomyces, filamentous fungi, bacteria, cow placenta, human placenta, human umbilical cord, yeast, cow collagen, milk derived protein, silk, wheat, soybean, cow blood, pig blood, chicken crown, cucumber, Rice, Shea butter, Birch, Tea, Tomato, Garlic, Clam, Rose, Loofah, Hop, Peach, Apricot, Lemon, Kiwi, Dokudami, Pepper, Clara, Gigigishi, Kouhone, Sage, Sawtooth, Zeniaoi, Senkyu, Assembly, Thyme, Spruce, Spruce, Birch, Horsetail, Loofah, Maronie, Yukinoshita, Arnica, Lily, Artemisia, Peonies, Aloe, Aloe Vera, Ogon, Awesome, Safflower, Sanshishi, Shikon, Tycho, Chimpi, Carrot, Yakuinin, Sycaen Sawara, Melissa, Biwa, Licorice Nishikawa willow, organic solvent from animals and plants, microorganisms and a part thereof such as Jatoba, alcohols, polyhydric alcohols, water, natural extracts and the like obtained by extraction or hydrolysis in aqueous alcohol. When the natural extract is contained, the blending amount is preferably 0.001 to 10% by weight, more preferably 0.005 to 5% by weight.

In the cosmetic of the present invention, it is preferable to blend vitamins and derivatives thereof to further enhance the skin conditioning effect. Vitamins and their derivatives include vitamin A, vitamin B group, vitamin D, vitamin E, pantothenic acid, biotin and the like; ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl magnesium phosphate, ascorbine Examples thereof include sodium acid, tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate and the like.
The amount of vitamins and derivatives thereof to be incorporated is preferably 0.001 to 20% by weight, more preferably 0.01 to 10% by weight.

The skin cosmetic of the present invention can be added with a whitening effect by adding a whitening agent. As whitening agents, ascorbic acid such as arbutin and its derivatives, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate, ascorbic acid, sodium ascorbate, ascorbic acid 2-glucoside And derivatives thereof, kojic acid, glutathione, ellagic acid, placenta extract, oryzanol, butylresorcinol, chamomile extract and the like.
When the whitening agent is included, the blending amount is preferably 0.01 to 20% by weight, more preferably 0.1 to 10% by weight.

  In addition to the above, the cosmetics of the present invention, other than those described above, are usually added to the cosmetics as needed, for example, lower alcohols, silicones, oils and fats, ester oils, as long as the preferred effects of the present invention are not impaired. -Oil components such as sterols and their derivatives-hydrocarbons, emulsifying / solubilizing agents, thickening / gelling agents, antioxidants, preservatives, bactericides, chelating agents, pH adjusters, acids, alkalis, ultraviolet rays Absorbent, solvent, exfoliating / dissolving agent, anti-inflammatory agent, refreshing agent, astringent, stimulant, hair restorer, polymer powder, hydroxy acids / vitamins and their derivatives, enzymes, nucleic acids, hormones Organic acids, enzymes, inorganic powders, fragrances, pigments and the like can be blended.

  Examples of these additives include oils and fats, hydrocarbon oils such as liquid paraffin, squalane, hydrogenated polyisobutene; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil , Tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, Vegetable oils such as linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef fat, milk fat, horse fat, Animal fats and oils such as egg yolk oil, mink oil, turtle oil, whale wax, lanolin, orange luffy oil; liquid lanolin, reduced ras Lanolins such as phosphorus, adsorption purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; cetyl octanoate Octyl palmitate, octyldodecyl myristate, hexyldecyl myristate, oleyl oleate, octyldodecyl oleate, lanolin fatty acid octyldodecyl, hexyldecyl octanoate, isononyl isononanoate, isotridecyl isononanoate, isostearyl neopentanoate, octyl neodecanoate Dodecyl, ethyl oleate, avocado oil fatty acid ethyl, isopropyl palmitate, isopropyl myristate, isoptearate Fatty acid esters such as pill, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dioctyl succinate; oxyesters such as cetyl lactate, diisostearyl malate; glyceryl trioctanoate, Glyceryl trioleate, glyceryl triisostearate, glyceryl tri (capryl / caprate), hydrogenated rosin glyceryl (hydrogenated ester gum), pentaoctyl ritylyl tetraoctanoate, hydrogenated rosin pentaerythrityl, propylene glycol dioleate, dioctane Acid neopentyl glycol, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, (hydroxystearic acid / stearic acid / rosinic acid) dipentaeri Polyhydric alcohol fatty acid esters such as srityl, diglyceryl diisostearate, polyglyceryl tetraisostearate; dimer dilinoleic acid dimer dilinoleyl, dimer dilinoleic acid di (isostearyl / phytosteryl), dimer dilinoleic acid (phytosteryl / isostearyl) / Cetyl / stearyl / behenyl), diisostearyl dimer dilinoleate, diisopropyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer acid hydrogenated castor oil, hydroxyalkyl dimer Dimer acids such as linoleyl ether, dimer acid, hydrogenated dimer acid, dimer diol or dimer diol derivatives; cholesteryl acetate, cholesteryl nonanoate, stear Cholesteryl acid, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L- Glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), 12-hydroxystearate cholesteryl, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, soft sanolate phytosteryl fatty acid Stero such as cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl Sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol; ceramides such as natural ceramide (type 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, etc. Petrolatum, solid paraffin, candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene propylene copolymer Waxes such as: phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, sphingomyelin, phosphati Phospholipids such as acid and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid and hydrogenated egg yolk phospholipid; perfluoropolyether; alcohol derivatives such as jojoba alcohol, chimyl alcohol, and batyl alcohol; lauric acid, Myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecane Acids, higher fatty acids such as anteisoheneicosanoic acid, long-chain branched fatty acids and salts thereof; coconut oil fatty acid monoethanolamide, coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, lauric acid diethanolamide, palmitic acid Bruno ethanolamide, can be exemplified fatty acid alkanolamides, such as palmitic acid diethanol amide. Further, if necessary, it can be used in combination with silicones. Silicones include low-viscosity dimethylpolysiloxane, high-viscosity dimethylpolysiloxane, cyclic dimethylsiloxane (decamethylcyclopentasiloxane), methylphenylpolysiloxane, diphenylpolysiloxane, silicone resin, silicone rubber, amino-modified polysiloxane, and cation-modified. Examples thereof include polysiloxane, polyether-modified polysiloxane, polyglycerin-modified polysiloxane, sugar-modified polysiloxane, alkyl-modified polysiloxane, fatty acid-modified polysiloxane, and fluorine-modified polysiloxane.

  Surfactants include fatty acid salts, alkyl sulfate salts, alkylbenzene sulfonate salts, polyoxyethylene alkyl sulfate salts, polyoxyethylene fatty amine sulfate salts, acyl N-methyl taurate salts, alkyl ether phosphate ester salts, N- Anionic surfactants such as acylamino acid salts; polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene alkyl ether sorbitan fatty acid partial ester, polyhydric alcohol fatty acid partial ester, polyglycerin fatty acid ester, polyoxyethylene Nonionic surfactants such as fatty acid esters, alkyldimethylamine oxides, alkylpolyglycosides, alkylglucosides; alkyltrimethylammonium salts, dialkyldimethylammonium Cationic surfactants such as salts, benzalkonium salts, alkyldimethylbenzylammonium salts, alkyldimethylaminopropylamides; alkyldimethylaminoacetic acid betaines, alkylamidodimethylaminoacetic acid betaines, 2-alkyl-N-carboxy-N-hydroxys Examples include amphoteric surfactants such as imidazolinium betaine.

  Thickeners and gelling agents include guar gum, carrageenan, alginic acid, tragacanth gum, curdlan, amphoteric methacrylate copolymer, cationized cellulose, nitrocellulose; 12-hydroxystearic acid and its salts, dextrin fatty acid ester, anhydrous silica Examples include acids, metal soaps, organically modified clay minerals, sucrose fatty acid esters, fructooligosaccharide fatty acid esters and the like.

  Examples of antioxidants include vitamin E (tocopherol) and / or derivatives thereof, vitamin C (ascorbic acid) and / or derivatives thereof, BHT, BHA, propyl gallate, sulfites, bisulfites, and the like. it can. Examples of preservatives include p-hydroxybenzoic acid esters, phenoxyethanol, 1,2-pentanediol, 1,2-hexanediol, quaternary ammonium salts and the like. Examples of the disinfectant include trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, chlorhexidine, halocarban, hinokitiol, phenol, isopropylphenol, and photosensitizers. Examples of chelating agents include edetate, phytic acid, phosphonic acids, polyamino acids and the like. Examples of pH adjusters / acids / alkalis include citric acid, lactic acid, glycolic acid, succinic acid, hydrochloric acid, monoethanolamine, diethanolamine, triethanolamine, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, etc. Can do. Examples of the solvents include lower alcohols such as ethanol and 2-propanol; acetone, ethyl acetate, ethylene glycol monoethyl ether, and the like. Examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, and sodium bromate.

  Examples of ultraviolet absorbers include benzophenone derivatives, paraaminobenzoic acid derivatives, paramethoxycinnamic acid derivatives, salicylic acid derivatives, urocanic acid, ethyl urocanate, 4-tert-butyl-4'-methoxydibenzoylmethane, 2- (2'- Examples thereof include hydroxy-5′-methylphenyl) benzotriazole, methyl anthranilate, rutin and derivatives thereof. Examples of the anti-inflammatory agent include glycyrrhizic acid and its derivatives, guaiazulene, hydrocortisone acetate, prednisone, salicylic acid derivatives and the like. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the antihistamine include diphedramine hydrochloride, chlorpheniramine maleate, glycyrrhetinic acid derivatives and the like. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of the stimulant include cantalis tincture, ginger tincture, chili pepper tincture, benzyl nicotinate and the like. Examples of hair growth agents include assembly extract, cephalanthin, vitamin E and derivatives thereof, γ-oryzanol, capsicum tincture, ginger tincture, cantalis tincture, nicotinic acid benzyl ester, allantoin, photosensitizer 301, photosensitizer 401, and the like. be able to.

  Examples of α-hydroxy acids and derivatives thereof include lactic acid, glycolic acid, fruit acid, hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl and the like. Examples of enzymes include lysozyme chloride, papain, pancreatin, protease, and the like. Examples of nucleic acids include adenosine triphosphate disodium. Examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.

  Inorganic powders include mica, talc, kaolin, montmorillonite, sericite, kaolinite, calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium dioxide, zinc oxide, alumina, silica. Examples include fumed silica, mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorine phlogopite, fine particle composite powder, gold, aluminum, etc. can do. Examples of the polymer powder include starch, nylon powder, polyethylene powder, polymethyl methacrylate, polyethylene terephthalate / polymethyl methacrylate laminate powder, and the like, and these asserted powders.

  Examples of the fragrance include limonene, linanol, citral, β-ionone, benzyl benzoate, indole, eugenol, auranthiol, geraniol, rilal, damascon, benzyl acetate, jasmine lactone, galac solid, essential oil and the like. Examples of the pigment include natural pigments such as β-carotene, calsamine, rutin, cochineal, chlorophyll; legal pigments, basic dyes, lakes, organic pigments, and the like.

  In addition, other components used in known cosmetics, pharmaceuticals, foods and the like can be appropriately blended as long as the effects of the present invention are not impaired.

The cosmetics of the present invention include cleansing cosmetics, hair cosmetics, basic cosmetics, makeup cosmetics, aromatic cosmetics, tan / sunscreen cosmetics, nail cosmetics, eyeliner cosmetics, lip cosmetics, oral cosmetics, and bath cosmetics. Is done. In addition, as the dosage form of the skin cosmetic of the present invention, a lotion, a water-in-oil emulsion, an oil-in-water emulsion, a liposome preparation, a solid form, a sheet form, a powder form, a gel form, a mousse form, a spray form, etc. A well-known dosage form can be used and it can manufacture according to a normal method.
The cosmetic composition of the present invention can be used as a medicinal cosmetic composition having an excellent whitening effect, a topical skin preparation for moisturizing preparations, a freckle, a melanosis, a liver patch, etc. Can be produced according to the usual methods.

  Hereinafter, the present invention will be described in more detail with reference to examples and comparative examples, but the present invention is not limited to these examples. The amounts of the components to be blended are all by weight unless otherwise specified.

Production and production of water-soluble polysaccharides extracted from fruit bodies of white jellyfish-1
50 g of a dried product of a commercially available white jellyfish fruit body was pulverized and extracted at 90 to 95 ° C. for 5 hours with 1000 mL of water. After the residue was filtered off, the residue was further extracted in the same manner, and the insoluble residue was filtered off. The extracts were combined, centrifuged at 2000 Gal to remove the precipitate, and then lyophilized to obtain 23.2 g of dry powder. As a result of GPC analysis, the average molecular weight of this product was 2.5 million.
The molecular weight was measured with GPC 8020 manufactured by Tosoh Corporation (the same applies hereinafter).
Column: TSK-GEL α-3000 + α-6000
Eluent: 1M acetic acid-sodium acetate buffer water (PH4.5)

Production Example-2
50 g of dried dried white jellyfish fruiting bodies were pulverized and extracted with 1000 mL of water at 50 to 55 ° C. for 5 hours. The residue was filtered off and centrifuged at 2000 Gal to remove the precipitate, and then freeze-dried to obtain 12.3 g of a dry powder. As a result of GPC analysis, the average molecular weight of this product was 600,000.

Production Example 3
20 g of Extract-1 was dissolved in 1000 mL of water, and 2000 mL of isopropyl alcohol was further added and mixed with stirring. Next, this was centrifuged at 2000 Gal to remove the precipitate, and then 3000 mL of isopropyl alcohol was further added and mixed with stirring. The white precipitate generated by this operation was collected by centrifugation, vacuum dried and pulverized to obtain 12.8 g of a pale white powder. As a result of GPC analysis, the average molecular weight of this product was 1.7 million.

Production Example 4
10 g of Extract-2 was dissolved in 500 mL of water, and further 1500 mL of acetone was added and mixed with stirring. The white precipitate produced by this operation was collected by centrifugation, vacuum dried and pulverized to obtain 4.0 g of a pale white powder. As a result of GPC analysis, the average molecular weight of this product was 900,000.

  Various cosmetics were produced according to the formulations of Examples 1 to 24 and Comparative Examples 1 to 13 shown in Tables 1 to 5, and the feeling of use and the moisturizing effect were evaluated. The test and evaluation methods for the feeling of use and the moisturizing effect are as follows.

Usability and moisturizing effect :
About 0.5 g of each sample was taken and applied to the face, and the feeling after use and the moisturizing effect were evaluated in the following stages.
Feeling of use ◯: Good feeling of use (less stickiness, preferable slime feeling at the time of application, dry feeling of slipping)
(Triangle | delta): It is not in the state which can satisfy any of stickiness, the slime feeling at the time of application | coating, and the dry feeling of a slipping up.
x: At least one of stickiness, slime feeling at the time of application, and slipping feeling after drying is bad, and the feeling of use is not good.
Moisturizing effect O: Moisturizing effect is felt.
Δ: A slight moisturizing effect is felt.
x: A moisturizing effect is hardly felt.

Moisturizing test :
About 1 mg of each sample was taken, applied to a 2 × 2 cm range of the forearm inner part, the skin conductance after 2 hours was measured, and the moisturizing effect was evaluated in the following stage. Measuring instrument: SKICON-200 (manufactured by IBS)
◯: Skin conductance is more than twice that before application.
Δ: Skin conductance is 1.5 to 2 times that before application.
x: Skin conductance is almost the same as before application.

Examples 1 to 5 and Comparative Examples 1 to 3 Lotion (Production Method)
According to the recipe in Table 1, A is mixed and dissolved uniformly. Mix B and dissolve uniformly. After adding B to A and stirring, the pH was adjusted to about 6.0 with sodium citrate to obtain a skin lotion.
The evaluation results are shown in Table 1.

Examples 6 to 10 and Comparative Examples 4 to 6 Lotion (Production Method)
According to the formulation in Table 2, A is mixed and dissolved uniformly. Mix B and dissolve uniformly. After adding B to A and stirring, the pH was adjusted to about 6.0 with sodium lactate to obtain a skin lotion.
The evaluation results are shown in Table 2.

Examples 11 to 15 and Comparative Example 7 Cosmetic liquid (manufacturing method)
According to the prescription in Table 3,
1. Dissolve B in a part of D to make a viscous liquid.
2. Mix C and the remaining D, dissolve uniformly, and warm to about 70 ° C.
3.2. After adding A to the mixture and stirring with a homomixer, And cooled to 40 ° C. to obtain a serum.
The evaluation results are shown in Table 3.

尚、いずれの処方例においてもリポソームが形成されている事を偏光顕微鏡観察、及び、電子顕微鏡観察により確認した。また、製品の経時安定性は以下の基準により評価した；
Ａ：４０℃３ヶ月、及び、４℃３ヶ月の経時でオリの発生を認めない。
Ｂ：４０℃３ヶ月、及び、４℃３ヶ月の経時で若干のオリの発生を認める。
Ｃ：４０℃１週間の経時でオリの発生を認める。

In any of the prescription examples, the formation of liposomes was confirmed by observation with a polarizing microscope and an electron microscope. The stability of the product over time was evaluated according to the following criteria;
A: No occurrence of orientation is observed over time of 3 months at 40 ° C. and 3 months at 4 ° C.
B: The generation | occurrence | production of some sediment is recognized by time-lapse | temporality of 40 degreeC 3 months and 4 degreeC 3 months.
C: The occurrence of orientation is observed over a period of one week at 40 ° C.

Examples 16 to 20 and Comparative Examples 8 to 10 Cream (Production method)
According to the prescription in Table 4,
1. Mix A, dissolve uniformly, and warm to about 80 ° C.
2. Mix B, dissolve uniformly, and warm to about 80 ° C.
3.2. 1. The mixture was stirred and emulsified with a homomixer at 3000 rpm for 3 minutes, and then cooled to about 40 ° C. to obtain a cream.
The evaluation results are shown in Table 4.

Examples 21-24 and Comparative Examples 11-13 Nutritional Cream
(Production method)
According to the prescription in Table 5,
1. Mix A, dissolve uniformly, and warm to about 80 ° C.
2. Mix B, dissolve uniformly, and warm to about 80 ° C.
3.2. 1. The mixture was stirred and emulsified with a homomixer at 3000 rpm for 3 minutes, and then cooled to about 40 ° C. to obtain a nutritional cream.
The evaluation results are shown in Table 5.

As mentioned above, the cosmetics which mix | blended the polysaccharide with the molecular weight of the specific range extracted from the white jellyfish fruiting body of this invention are excellent in a usability | use_condition and a moisturizing effect from Tables 1-5. In addition, cosmetics containing polysaccharides extracted from white jellyfish fruit bodies and water-soluble polymers and / or phospholipids are excellent in feeling of use and moisturizing effect.
As shown in the comparative examples, those not containing a polysaccharide extracted from a white jellyfish fruit body and those containing a polysaccharide extracted from a white jellyfish fruit body having an average molecular weight of 600,000 had a low moisturizing effect. Moreover, although what mixed the polysaccharide extracted from the white jellyfish fruiting body with an average molecular weight of 2.5 million was excellent in the moisturizing effect, it was sticky and inferior in the feeling of use. In addition, it is more effective to use a polysaccharide extracted from a white jellyfish fruit body together with a water-soluble polymer and / or phospholipid, and contains a polysaccharide extracted from a white jellyfish fruit body in a molecular weight range that cannot achieve both the feeling of use and the moisturizing effect. Even in this case, it is possible to achieve both a feeling of use and a moisturizing effect by using a water-soluble polymer and / or phospholipid in combination. Furthermore, the polysaccharide extracted from the fruit body of a white jellyfish is effective in stabilizing the liposome over time using phospholipids.

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to obtain a water-soluble polysaccharide extracted from a white jellyfish fruit body having excellent usability and moisturizing effect and a skin cosmetic containing the same.

Claims (12)

Cosmetics containing water-soluble polysaccharides and water-soluble polymers (excluding water-soluble polysaccharides extracted from white jellyfish fruiting bodies) and / or phospholipids extracted from white jellyfish fruiting bodies The cosmetic according to claim 1, wherein the water-soluble polymer (excluding the water-soluble polysaccharide extracted from the fruit body of white jellyfish) is a nonionic water-soluble polymer and / or an anionic water-soluble polymer. Nonionic water-soluble polymers are poly (meth) such as polyethylene glycol, polyethylene oxide, copolymers of ethylene glycol and propylene glycol, dextran, duran gum, quince seed extract, polyvinyl alcohol and its nonionic derivatives, polyglucosyloxyethyl methacrylate, etc. An acrylic acid derivative, polyvinyl pyrrolidone, hydroxyethyl cellulose, hydroxypropyl cellulose, nonionic cellulose derivatives such as methylcellulose, and one or more selected from nonionic starch derivatives such as hydroxyethyl starch and hydroxypropyl starch. Cosmetics according to 2 Anionic water-soluble polymer is hyaluronic acid, xanthan gum, chondroitin sulfate, polyglutamic acid, polyaspartic acid, carboxymethylcellulose, alkali generators B-16 polymer, carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, and The cosmetic according to claim 2, wherein the cosmetic is one or more selected from metal salts, ammonium salts, and amine salts. The cosmetic according to claim 1, wherein the phospholipid is a liposome. Water-soluble polysaccharides having an average molecular weight of 800,000 to 2,200,000, extracted from fruit jellyfish fruiting bodies A cosmetic comprising the water-soluble polysaccharide according to claim 6. The cosmetic according to any one of claims 1 to 5, wherein the water-soluble polysaccharide extracted from the fruit body of white jellyfish is the water-soluble polysaccharide according to claim 6. 2. One or more moisturizing agents selected from the group consisting of polyhydric alcohols, saccharides (excluding polysaccharides), betaine, urea, pyrrolidone carboxylic acid or salts thereof, and amino acids. ~ 5 or cosmetics according to claims 7-8 2. One or more selected from the group consisting of natural extracts obtained by extracting from animals and plants or microorganisms using one or more selected from the group consisting of organic solvents, alcohols, and water. Cosmetics given in any 1 of -5 or 7-9 Vitamin A, vitamin B group, vitamin D, vitamin E, pantothenic acid, one or more vitamins selected from the group consisting of tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, etc. Cosmetics according to any one of claims 1 to 5 or 7 to 10, characterized in that the cosmetics and derivatives thereof are contained. Arbutin and its derivatives, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl teraisopalmitate, magnesium ascorbyl phosphate, ascorbic acid, sodium ascorbate, ascorbic acid 2-glucoside and the like, koji It contains at least one whitening agent selected from the group consisting of acid, glutathione, ellagic acid, placenta extract, oryzanol, butylresorcinol, and chamomile extract, any one of claims 1-5 or 7-11 Cosmetics according to item