CN111643396B - Moisturizing skin care lotion containing icodextrin and application thereof - Google Patents
Moisturizing skin care lotion containing icodextrin and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention belongs to the field of cosmetics, and relates to a moisturizing skin care lotion containing icodextrin and application of the moisturizing skin care lotion. The skin moisturizer comprises icodextrin, and the content of the icodextrin is 3% -8%. The icodextrin used as the moisturizing component of the moisturizing skin care lotion disclosed by the invention is alpha-glucan, and has a smaller molecular weight than ordinary glucan, so that the moisturizing skin care lotion has good water solubility, can be added in a larger amount, exerts a larger moisturizing effect, and keeps the texture of the skin care lotion fresh. Solves the problems that the moisturizing components of the moisturizing skin care lotion on the market mainly comprise beta-glucan, the water solubility is poor, and the moisturizing skin care lotion is viscous when the addition amount is about 1 percent.
Description
Technical Field
The invention belongs to the field of cosmetics, and relates to a moisturizing skin care lotion containing icodextrin and application of the moisturizing skin care lotion.
Technical Field
The glucan is homotypic polysaccharide composed of glucose as monosaccharide, and is divided into alpha-glucan and beta-glucan, and each glucan is combined by multiple bond positions. Dextran has a long history in the western world as an active ingredient in skin care products. Families in many European and American countries are used to bath the infants with water soaked with oat to relieve and prevent eczema; the elderly are also used to wash their face with oat water in winter to relieve dry skin. This is mainly due to the fact that the substances extracted from oats contain vitamin E and glucan components, both of which have a certain repairing and protecting effect on the skin.
Icodextrin is a glucan hydrolyzed by starch, has molecular weight of 19000-25000, and has good water solubility, safety and biocompatibility. The pharmaceutical preparation taking the icodextrin as the raw material is approved to be on the market in more than 30 countries and regions, and has good safety, biocompatibility and stability; the colloidal solution prepared from the icodextrin has good ultrafiltration effect and hydration floating effect, can be used as peritoneal dialysis solution and surgical anti-adhesion flushing solution, and Cooker shows that the icodextrin has good biocompatibility in a paper published in 2002; the paper published by Mistry in 1994 shows that icodextrin solutions proved safe and effective for long-term use as peritoneal dialysis solutions in a randomized multicenter clinical trial; the patent paper published by Catena in 2012 indicated that in a single-center, prospective randomized trial, the use of 4% icodextrin was safe in patients with small intestinal obstruction, reducing the risk of intra-abdominal adhesions forming and reoccluding.
In the process of studying icodextrin, we find that a colloidal solution formed by icodextrin has the efficacy of moisturizing, and probably because the icodextrin solution is a colloidal solution, a protective film can be formed on the surface of skin, so that the loss of water is reduced, and the icodextrin can be used for moisturizing and skin-care liquid. At present, the moisturizing skin care lotion on the market mainly takes beta-glucan as a main component, has poor water solubility, is viscous when the addition amount is about 1 percent, and the icodextrin is alpha-glucan and has smaller molecular weight than common glucan, so the moisturizing skin care lotion has good water solubility, can be added with more amount, and plays a larger moisturizing effect to keep the texture of the skin care lotion fresh.
The alpha-glucan oligosaccharide is a product obtained by acting glucose transferase on maltose, the polymerization degree of the alpha-glucan oligosaccharide is 4~6 glucose units, the molecular weight of the alpha-glucan oligosaccharide is far less than that of icodextrin, the alpha-glucan oligosaccharide is mainly used as a skin conditioner and enhances the natural barrier of skin, and the principle of the alpha-glucan oligosaccharide is that harmful bacteria are reduced by increasing healthy bacteria on the skin, namely the alpha-glucan oligosaccharide is just like yoghurt to intestinal tracts. The alpha-glucan oligosaccharide has a small molecular weight, cannot form an effective protective film on the surface of skin, and has a moisturizing effect weaker than that of icodextrin.
In the research, the film forming effect is found to play a role in isolating the outside and the pollution of makeup foundation besides enhancing the moisturizing effect, so that the makeup removal is more convenient, and the alpha-glucan oligosaccharide does not have the effect.
Disclosure of Invention
The invention provides a moisturizing skin care lotion containing icodextrin, which can form a layer of protective film on the surface of skin and reduce the loss of water. Icodextrin is prepared by hydrolyzing starch and has good biocompatibility. At present, the moisturizing components of the moisturizing skin care lotion on the market mainly comprise beta-glucan, the water solubility is poor, the moisturizing skin care lotion is viscous when the addition amount is about 1%, and the icodextrin is alpha-glucan and has a smaller molecular weight than ordinary glucan, so the moisturizing skin care lotion has good water solubility, can be added in more amount, and can exert a larger moisturizing effect to keep the texture of the moisturizing skin care lotion fresh.
The technical scheme adopted by the invention is as follows:
a moisturizing skin care lotion containing icodextrin is characterized in that: the moisturizing skin care lotion contains icodextrin.
Further, the content of the icodextrin is 0.003-8%.
Further, the moisturizing skin care lotion contains icodextrin, a thickening agent, a humectant, a skin protective agent, an emulsifier, an antioxidant, a preservative, essence and purified water;
further, the thickener can be any one or more of carbomer, xanthan gum, hydrolyzed sclerotium rolfsii gum, sodium acrylate/sodium acryloyldimethyl taurate copolymer, glycerol polyacrylate and hydroxyethyl cellulose, but is not limited to the above; the humectant can be any one or more of glycerol, sodium hyaluronate, 1,2-propylene glycol, 1,3-propylene glycol, 1,3-butanediol and 1,2-pentanediol, but is not limited to the above; the skin protectant may be one or more of D-panthenol, ethylhexyl methoxycinnamate, bisabolol, dipotassium glycyrrhizinate, lysine, and histidine, but is not limited thereto; the emulsifier can be any one or more of glycerol stearate, cetearyl alcohol, cetearyl glucoside, lecithin, polysorbate-20 and sorbitan stearate, but is not limited to the components; the antioxidant can be any one or more of tocopherol (vitamin E), BHT, ascorbyl tetraisopalmitate, ascorbic acid and 3-o-ethyl ascorbic acid, but is not limited to the above; the preservative can be any one or more of phenoxyethanol, chlorphenesin, methylparaben, propylparaben and methylisothiazolinone, but is not limited to the above; the essence can be any one or more of rose scent, lily scent, cardamom scent, small black skirt scent, grapefruit scent and non-scent, but is not limited to the above.
Further, the skin lotion comprises the following components: icodextrin, hyaluronic acid, corn gluten amino acids, sclerotium rolfsii gum, glycerol, propylene glycol, phenoxyethanol, 1,2-hexanediol and purified water.
Further, the skin moisturizer comprises the following components in percentage by mass: 0.003-8% of icodextrin, 0.5-2% of hyaluronic acid, 2-5% of corn gluten amino acids, 0.1-0.5% of sclerotium rolfsii gum, 0.1-3% of glycerol, 2-5% of propylene glycol, 0.1-0.5% of phenoxyethanol, 0.1-0.5% of 1,2-hexanediol and the balance of purified water.
Furthermore, other active ingredients can be added into the skin moisturizer to prepare the skin moisturizer with corresponding efficacy.
Further, other active ingredients added into the skin moisturizer are selected from one or more of carnitine, caffeine, niacinamide, ascorbic acid, arbutin, astaxanthin and resveratrol.
The invention also provides the application of the moisturizing skin care lotion containing the icodextrin, the skin care lotion can be prepared into products containing the icodextrin, and the products are moisturizing skin care facial masks containing the icodextrin, moisturizing skin care water containing the icodextrin and moisturizing skin care essence containing the icodextrin, but are not limited to the products.
The skin moisturizer of the icodextrin can be prepared by the following steps:
according to the technical scheme, the icodextrin, the hyaluronic acid, the sclerotium rolfsii gum, the glycerol and the propylene glycol are weighed according to the component proportion, the components are dissolved in a proper amount of purified water under the condition of stirring to be used as a component A, the corn gluten amino acids and a proper amount of purified water are added into a main pot, the component A which is dispersed in advance is added, the temperature is heated to 80-85 ℃, the temperature is kept for 10min, the vacuum stirring is carried out for 20-35r/min, the temperature is reached, the temperature is reduced to 45-50 ℃ after the dissolution and the mixing are uniform, the phenoxyethanol and 8978 zft 8978-hexanediol are added, the temperature is kept for 10min, the temperature is reduced to below 35 ℃, the filling and the packaging are carried out, and the finished product is obtained after the detection is qualified.
The invention has the beneficial effects that: the moisturizing components of the moisturizing skin care lotion on the market at present mainly comprise beta-glucan, the water solubility is poor, and the moisturizing skin care lotion is viscous when the addition amount is about 1%, while the icodextrin used by the moisturizing skin care lotion is alpha-glucan and has a smaller molecular weight than ordinary glucan, so the moisturizing skin care lotion has good water solubility, can be added with more amount, exerts a larger moisturizing effect, and keeps the texture of the moisturizing skin care lotion fresh and cool. The addition of the beta-glucan in the same proportion is thick paste, so that the feeling of use is greasy and thick.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention.
Example 1
A skin moisturizer containing icodextrin comprises the following components in percentage by mass: 5% of icodextrin, 2% of hyaluronic acid, 5% of corn gluten amino acids, 0.3% of sclerotium rolfsii gum, 0.3% of glycerol, 2% of propylene glycol, 0.1% of phenoxyethanol and 0.1% of 1,2-hexanediol, weighing the mass of each substance according to the formula, dissolving icodextrin, hyaluronic acid, sclerotium rolfsii gum, glycerol and propylene glycol in a proper amount of purified water under stirring to obtain a component A, adding the corn gluten amino acids and a proper amount of purified water into a main pot, adding the dispersed component A, heating to 80-85 ℃, keeping the temperature for 10min, stirring under vacuum for 20-35r/min, cooling to 45-50 ℃ after the temperature is up to and uniformly mixed, adding phenoxyethanol and 1,2-hexanediol, keeping the temperature for 10min, cooling to below 35 ℃, filling, packaging, and obtaining the skin care lotion containing icodextrin after passing detection.
Example 2
A skin moisturizer containing icodextrin comprises the following components in percentage by mass: 0.003% of icodextrin, 0.5% of hyaluronic acid, 2% of corn gluten amino acids, 0.1% of sclerotium rolfsii gum, 0.1% of glycerol, 3% of propylene glycol, 0.3% of phenoxyethanol and 0.3% of 1,2-hexanediol, weighing the mass of each substance according to the formula, dissolving icodextrin, hyaluronic acid, micronucleus gum, glycerol and propylene glycol in a proper amount of purified water under stirring to obtain a component A, adding the corn gluten amino acids and a proper amount of purified water into a main pot, adding the component A dispersed in advance, heating to 80-85 ℃, preserving heat for 10min, stirring under vacuum for 20-35r/min, cooling to 45-50 ℃ after the temperature is reached and dissolved and mixed uniformly, adding phenoxyethanol and 1,2-hexanediol, preserving heat for 10min, cooling to below 35 ℃, filling, packaging, and obtaining the skin care lotion containing icodextrin after detection is qualified.
Example 3
A skin moisturizer containing icodextrin comprises the following components in percentage by mass: 8% of icodextrin, 1% of hyaluronic acid, 3% of corn gluten amino acids, 0.5% of sclerotium rolfsii gum, 3% of glycerol, 5% of propylene glycol, 0.5% of phenoxyethanol and 0.5% of 1,2-hexanediol, weighing the mass of each substance according to the formula, dissolving icodextrin, hyaluronic acid, micronucleus gum, glycerol and propylene glycol in a proper amount of purified water under stirring to obtain a component A, adding the corn gluten amino acids and a proper amount of purified water into a main pot, adding the dispersed component A, heating to 80-85 ℃, keeping the temperature for 10min, stirring under vacuum for 20-35r/min, cooling to 45-50 ℃ after the temperature is reached and the mixture is uniformly dissolved, adding phenoxyethanol and 1,2-hexanediol, keeping the temperature for 10min, cooling to below 35 ℃, filling and packaging, and obtaining the skin care lotion containing icodextrin after the detection is qualified.
Example 4
Adding 89% of the skin care solution of example 1 and a proper amount of purified water into 0.3% of carbomer, adding into a main pot, heating to 80-85 deg.C, keeping the temperature for 10min to obtain a uniform transparent state, cooling to 55-60 deg.C, adding 0.3% triethanolamine, measuring pH to 5-7, keeping the temperature for 10min, cooling to 45 deg.C, adding 10% flos Rosae Rugosae water, keeping the temperature for 10min, and cooling to 35 deg.C. Folding and packaging the non-woven fabric patch into a bag, automatically filling and subpackaging the liquid, sealing, and detecting to be qualified to obtain the mask containing the icodextrin.
Comparative example 1
A skin moisturizer containing beta-glucan comprises the following components in percentage by mass: 1% of beta-glucan, 1% of hyaluronic acid, 3% of corn gluten amino acids, 0.5% of sclerotium rolfsii gum, 3% of glycerol, 5% of propylene glycol, 0.5% of phenoxyethanol, 0.5% of 1,2-hexanediol, and the mass of each substance is weighed according to the formula, icodextrin, hyaluronic acid, sclerotium rolfsii gum, glycerol and propylene glycol are dissolved in a proper amount of purified water under the condition of stirring to form a component A, the corn gluten amino acids and a proper amount of purified water are added into a main pot, the component A which is dispersed in advance are added, the temperature is increased to 80-85 ℃, the temperature is kept for 10min, the vacuum stirring is carried out for 20-35r/min, the temperature is increased to 45-50 ℃, phenoxyethanol and 1,2-hexanediol are added after the dissolution and the mixing are uniform, the temperature is kept for 10min, the filling and the packaging are carried out after the temperature is reduced to below 35 ℃, and the skin care lotion containing the beta-glucan is obtained after the detection is qualified.
The lotion prepared in this comparative example was thick, creamy and experienced greasy feel in use, and the lotion prepared in example 3 was still a fresh liquid texture as compared to example 3.
Comparative example 2
The skin moisturizer containing the beta-glucan comprises the following components in percentage by mass: 0.003% of beta-glucan, 1% of hyaluronic acid, 3% of corn gluten amino acids, 0.5% of sclerotium rolfsii gum, 3% of glycerol, 5% of propylene glycol, 0.5% of phenoxyethanol and 0.5% of 1,2-hexanediol, weighing the mass of each substance according to the formula, dissolving icodextrin, hyaluronic acid, sclerotium rolfsii gum, glycerol and propylene glycol in a proper amount of purified water under stirring to obtain a component A, adding the corn gluten amino acids and a proper amount of purified water into a main pot, adding the component A which is dispersed in advance, heating to 80-85 ℃, keeping the temperature for 10min, stirring under vacuum for 20-35r/min, cooling to 45-50 ℃ after the temperature reaches and is dissolved and mixed uniformly, adding phenoxyethanol and 1,2-hexanediol, keeping the temperature for 10min, cooling to below 35 ℃, filling and packaging, and obtaining the skin care lotion containing the beta-glucan after detection is qualified.
Comparative example 3
A skin moisturizer containing alpha-glucan oligosaccharide comprises the following components in percentage by mass: 8% of alpha-glucan oligosaccharide, 1% of hyaluronic acid, 3% of corn gluten amino acids, 0.5% of sclerotium rolfsii gum, 3% of glycerol, 5% of propylene glycol, 0.5% of phenoxyethanol and 0.5% of 1,2-hexanediol, weighing the mass of each substance according to the formula, dissolving icodextrin, hyaluronic acid, micronucleus gum, glycerol and propylene glycol in a proper amount of purified water under stirring to obtain a component A, adding the corn gluten amino acids and a proper amount of purified water into a main pot, adding the dispersed component A, heating to 80-85 ℃, keeping the temperature for 10min, stirring under vacuum for 20-35r/min, cooling to 45-50 ℃ after the temperature is up to and uniformly mixed, adding phenoxyethanol and 1,2-hexanediol, keeping the temperature for 10min, cooling to below 35 ℃, filling, packaging, and obtaining the skin care lotion containing the alpha-glucan oligosaccharide after the detection is qualified.
Skin moisture test
The subjects required a uniform rinsing of the inner forearm of both hands before the test using a German Comeometer CM 825 skin moisture tester at a temperature of 20 ℃ and a relative humidity of 50%. After washing, five test areas were marked on the left and right forearms of the examinee at intervals of 1cm, each test area being 5X 5cm 2 . The samples obtained in example 1, example 2, example 3, comparative example 1, comparative example 2 and comparative example 3 were applied to the paint in an amount of 0.2g, respectively. After the subject was rested in a constant environment for 30 minutes, the test site blank value was measured using a Corneometer, and 5 points were fixedly measured for each area in a certain order to obtain an average value thereof. The application of the sample was then handled by the specialist and the timing was started, measuring a total of 2 hours. Average each detectionSubtracting the blank value from the value to obtain the change of the MMV value in the time period, and obtaining the growth rate of the MMV value after removing the blank value
The skin moisture content increase rate calculation formula is as follows:
skin moisture content increase rate% = (MMVt-MMV) 0 ）/MMV 0 ×100%
In the formula: MMV 0 MMV of skin before application
MMVt-time period t after application skin MMV
The results are as follows:
TABLE 1 test results of moisturizing fluids of inventive examples and comparative examples
As can be seen from the above table, compared with the skin moisturizer containing the alpha-glucan oligosaccharide, the skin moisturizer containing the icodextrin is superior to the skin moisturizer containing the alpha-glucan oligosaccharide. Compared with the skin moisturizer containing the beta-glucan, the skin moisturizer containing the icodextrin is superior to the skin moisturizer containing the beta-glucan in moisturizing effect, and the skin moisturizer containing the icodextrin is fresh in texture and good in use body feeling. The moisture retention effect was greatly impaired although the texture was kept fresh at a β -glucan content of 0.003%. Therefore, the skin care lotion containing the icodextrin can keep fresh texture and also can exert good moisturizing capability.
The above embodiments are provided for illustrative purposes to enable persons skilled in the art to understand the present invention and implement the present invention, and the protection scope of the present invention is not limited thereby. The invention is within the scope of the claims, unless otherwise indicated herein or clearly indicated by the context of the claims.
Claims (7)
1. A moisturizing skin care lotion containing icodextrin is characterized in that:
the moisturizing skin care lotion contains icodextrin;
the content of the icodextrin is 0.003-8%.
2. The icodextrin-containing moisturizing lotion according to claim 1, characterized in that: the moisturizing skin care lotion contains icodextrin, a thickening agent, a humectant, a skin protective agent, an emulsifier, an antioxidant, a preservative, essence and purified water.
3. The moisturizing lotion containing icodextrin of claim 1, wherein: the skin lotion comprises the following components: icodextrin, hyaluronic acid, corn gluten amino acids, sclerotium rolfsii gum, glycerol, propylene glycol, phenoxyethanol, 1,2-hexanediol and purified water.
4. The moisturizing lotion containing icodextrin of claim 1, wherein: the skin moisturizer comprises the following components in percentage by mass: icodextrin 0.003-8%, hyaluronic acid 0.5-2%, corn gluten amino acids 2-5%, sclerotium rolfsii gum 0.1-0.5%, glycerin 0.1-3%, propylene glycol 2-5%, phenoxyethanol 0.1-0.5%,1,2-hexanediol 0.1-0.5%, and the balance of purified water.
5. The moisturizing lotion containing icodextrin of claim 1, wherein: the skin moisturizer can be added with other active ingredients to prepare a moisturizing skin moisturizer with corresponding effects.
6. The moisturizing lotion containing icodextrin of claim 5, wherein: the other active ingredients added into the skin lotion are selected from one or more of carnitine, caffeine, nicotinamide, ascorbic acid, arbutin, astaxanthin and resveratrol.
7. Use of the icodextrin-containing moisturizing lotion according to any one of claims 1-5, characterized in that: the moisturizing skin care lotion containing the icodextrin can be prepared into products containing the icodextrin, and the products are moisturizing skin care facial masks containing the icodextrin, moisturizing skin care water containing the icodextrin and moisturizing skin care essence containing the icodextrin.
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| CN112245346A (en) * | 2020-09-30 | 2021-01-22 | 华仁健康产业(青岛)有限公司 | Moisture mask and preparation method thereof |
| CN112263508A (en) * | 2020-09-30 | 2021-01-26 | 华仁健康产业(青岛)有限公司 | Mask powder with moisturizing function |
| CN112294673A (en) * | 2020-09-30 | 2021-02-02 | 华仁健康产业(青岛)有限公司 | Whitening mask and preparation method thereof |
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