CN103989590A - Arbutin herbal essence preparation method and product thereof - Google Patents
Arbutin herbal essence preparation method and product thereof Download PDFInfo
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- CN103989590A CN103989590A CN201410182623.5A CN201410182623A CN103989590A CN 103989590 A CN103989590 A CN 103989590A CN 201410182623 A CN201410182623 A CN 201410182623A CN 103989590 A CN103989590 A CN 103989590A
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- arbutin
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- deionized water
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- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 title claims abstract description 226
- 229960000271 arbutin Drugs 0.000 title claims abstract description 113
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 title claims abstract description 113
- 238000002360 preparation method Methods 0.000 title claims abstract description 74
- 239000007788 liquid Substances 0.000 claims abstract description 74
- 239000013067 intermediate product Substances 0.000 claims abstract description 68
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 60
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 52
- 239000008367 deionised water Substances 0.000 claims abstract description 51
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 51
- 239000002994 raw material Substances 0.000 claims abstract description 39
- 239000003921 oil Substances 0.000 claims abstract description 28
- 235000019198 oils Nutrition 0.000 claims abstract description 28
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 27
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 27
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 27
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims abstract description 13
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 10
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 10
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 10
- 239000004006 olive oil Substances 0.000 claims abstract description 10
- 235000008390 olive oil Nutrition 0.000 claims abstract description 10
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 8
- 239000011709 vitamin E Substances 0.000 claims abstract description 8
- 229940046009 vitamin E Drugs 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 3
- 239000000686 essence Substances 0.000 claims description 61
- 238000000605 extraction Methods 0.000 claims description 50
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims description 26
- 230000032050 esterification Effects 0.000 claims description 23
- 238000005886 esterification reaction Methods 0.000 claims description 23
- 238000010298 pulverizing process Methods 0.000 claims description 23
- 239000000284 extract Substances 0.000 claims description 18
- 239000012528 membrane Substances 0.000 claims description 16
- 238000007598 dipping method Methods 0.000 claims description 14
- 239000011347 resin Substances 0.000 claims description 13
- 229920005989 resin Polymers 0.000 claims description 13
- 240000001987 Pyrus communis Species 0.000 claims description 12
- 235000014443 Pyrus communis Nutrition 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000002068 microbial inoculum Substances 0.000 claims description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- 230000001476 alcoholic effect Effects 0.000 claims description 9
- 239000012141 concentrate Substances 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- 238000003795 desorption Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 238000000227 grinding Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000012163 sequencing technique Methods 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000000108 ultra-filtration Methods 0.000 claims description 7
- 238000001291 vacuum drying Methods 0.000 claims description 7
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 239000000843 powder Substances 0.000 claims description 5
- 229960003600 silver sulfadiazine Drugs 0.000 claims description 5
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 3
- 239000000047 product Substances 0.000 abstract description 11
- 230000002087 whitening effect Effects 0.000 abstract description 11
- 230000003020 moisturizing effect Effects 0.000 abstract description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 2
- 229930003268 Vitamin C Natural products 0.000 abstract 2
- 235000019154 vitamin C Nutrition 0.000 abstract 2
- 239000011718 vitamin C Substances 0.000 abstract 2
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 abstract 1
- 240000000249 Morus alba Species 0.000 abstract 1
- 235000008708 Morus alba Nutrition 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000001649 glycyrrhiza glabra l. absolute Substances 0.000 abstract 1
- 229940051810 licorice root extract Drugs 0.000 abstract 1
- 235000020725 licorice root extract Nutrition 0.000 abstract 1
- 230000003313 weakening effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 22
- 230000000694 effects Effects 0.000 description 12
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 208000037259 Amyloid Plaque Diseases 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
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- 239000000706 filtrate Substances 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 229910052753 mercury Inorganic materials 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010039796 Seborrhoeic keratosis Diseases 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
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- 231100000915 pathological change Toxicity 0.000 description 1
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- 230000019612 pigmentation Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 201000003385 seborrheic keratosis Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
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Abstract
The invention discloses an arbutin herbal essence preparation method. The preparation method comprises the steps of raw material preparation, intermediate product A solution preparation, intermediate product B solution preparation, and herbal essence preparation. The invention also discloses an arbutin herbal essence product prepared through the method. The arbutin herbal essence product is prepared by using 3-7wt% of arbutin, 61-65wt% of deionized water, 0.5-1.5wt% of hydroxyethyl cellulose, 2-4wt% of esterified levorotatory vitamin C, 0.05-0.15wt% of citric acid, 8-12wt% of hyaluronic acid, 3-7wt% of a White Mulberry Root-barkextract liquid, 3-7wt% of a licorice root extract liquid, 2-6wt% of olive oil, 3-7wt% of fructus rosae oil, 1-3wt% of vitamin E, 1-3wt% of water soluble azone and 0.3-0.7wt% of a compound antibacterial agent. The arbutin herbal essence matches arbutin with the levorotatory esterified vitamin C, and can reach deep skin moisturizing, whitening and spot weakening effects.
Description
Technical field
The present invention relates to a kind of cosmetics, relate in particular to a kind of preparation method and Arbutin herbal essences liquid goods thereof of Arbutin herbal essences liquid.
Background technology
Hyperpigmentation in skin and make on skin to occur being referred to as skin splash by the flecks such as brown, yellowish-brown, black, comprises the speckle of many types, in a sense as chloasma, butterfly spot, black speck, senile plaque etc.
Chloasma is a kind of abnormal, calm dermatoses of facial metabolism of pigment that betides.Be more common in middle-aged women, its main manifestations is that yellowish-brown or the greyish black mottle that size shape differs appears in face, is often symmetrically distributed in the positions such as volume, face, cheek, nose and upper lip, does not exceed skin, clear border, the course of disease is slow, long-term existence, and the several years does not take off, after Exposure to Sunlight, often increase the weight of, main cause is female incretion imbalance, and stress is large, and external chemicals etc. causes.
Freckle, is generally distributed in the region that face is arrived by sun exposure easily, is mainly caused by genetic cause.
Black speck, is also butterfly spot, concentrates on two cheeks, seems the butterfly just as an expansion, and main cause is excessive ultraviolet radiation, and skin irriate causes and the propagation of skin bottom melanocyte produces too much melanin, forms black speck.
Senile plaque, a kind of geroderma pathological changes, is medically being called seborrheic keratosis disease.
Sunburn, is after sunlight excessively irradiates, skin generation erythema, edema, the cutaneous pigmentation of appearance.
Except these mottles, also have some other mottle, as due to life-time service mercury cosmetic, cause skin blackout, be called hydrargyrum speckle; Due to the conceived cyasma producing etc.
Whitening and speckle dispelling product is in the market formed by various chemical agents and additive modulation, even contains carcinogenic heavy metal, as plumbous mercury content exceeds standard.These whitening and speckle dispelling products are after short-term is used, although skin is had to certain whitening and speckle dispelling effect, cure the symptoms, not the disease, can not fundamentally reach the effect of protection skin, after life-time service, there will be the following toxic and side effects: gently thinning of skin dies down, cause skin easily irritated; Heavy skin ambustion causes skin to burn out into anabiotic state, absorb less than nutrient substance, make skin hardening; More severe patient also may cause disfeaturing.
Summary of the invention
For the deficiency of existing whitening and speckle dispelling product, the invention provides a kind of preparation method and Arbutin herbal essences goods thereof of the Arbutin herbal essences liquid addressing the above problem.
The present invention for achieving the above object and adopt technical scheme be:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose in step (1), prepared are dissolved in to parts by weight is: in 48%～52% deionized water, carry out heated and stirred, being heated to temperature is 60 DEG C～70 DEG C; Mixing speed is 100r/min～150r/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 45 DEG C～55 DEG C, after dipping 6.5～7.5h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
In described step (21), the leaf of pear tree after drying is placed in the high speed disintegrator of rotating speed >=10000 rev/min and pulverizes, the granularity after it is pulverized is between 80 order～100 orders.
Described high speed disintegrator, it is Chinese medicine high speed disintegrator.
In described step (21), the ultrafilter membrane that the ultrafilter membrane adopting is 3k～10k.
In described step (21), described macroporous resin, it is AB-8NKA-9X-5, HP-20 macroporous resin.
Described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 30～35 DEG C of extraction temperature, pressure 50～60MPa; Separate one-phase temperature: 40～50 DEG C, pressure 20～30MPa;
Separate two-stage temperature: 20～30 DEG C, force value 15～20MPa; Extraction time 3～5 hours, obtains Rosehips oil.
The Arbutin herbal essences liquid that adopts above-mentioned method to prepare, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 48%～52% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out the adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterial silver sulfadiazine powder 70-80%, ethanol 20-30%.
Described Arbutin herbal essences liquid, it is mainly prepared from by the raw material of following parts by weight:
Wherein, in the deionized water that Arbutin, hydroxyethyl-cellulose heating for dissolving are 50% in parts by weight, obtain intermediate product A solution;
It is in 13% deionized water that the left-handed C of esterification is dissolved in parts by weight, then, uses citric acid to carry out the adjusting of pH value, makes pH value in pH=6, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterial silver sulfadiazine powder 70-80%, ethanol 20-30%
Beneficial effect of the present invention:
1. herbal essences liquid of the present invention, it adopts natural Chinese medicinal herb to be prepared from, and the component proportioning of its each component is scientific and reasonable, the essence that preparation generates, no side effects, preparation technology simplifies, and facilitates producer's large-scale production.
2. the present invention has adopted Arbutin, Arbutin has the effect that makes skin bright, can infiltrate skin rapidly and does not affect skin cell, activity that can restraint of tyrosinase (tyrosinase), and then hinder melanic formation, meanwhile, the generation of Mai Laning (melanin) be can effectively block, decomposition and the eliminating of Mai Laning accelerated, thereby, the source producing from speckle, stops the generation of speckle, the problem of profound solution speckle.
3. the Arbutin that the present invention adopts, can also protect skin to exempt from the infringement of what free radical, and hydrophilic is good, therefore often makes an addition in commercially available whitening product.
4. the present invention is ingenious at together with ingenious left-handed to Arbutin and esterification C must collocation, the Cortex Mori, Radix Glycyrrhizae, olive oil, the Rosehips wet goods plant extraction elite that have white-skinned face function concurrently have been added simultaneously, finally add efficient penetrating agent water-solubleazone, help nutrition better bring into play effect again spoke enter the holy product hyaluronic acid of moisturizing, in whitening, deep layer Glycerin, profound Whitening, spot.
5. preparation technology of the present invention simplifies, first Arbutin, hydroxyethyl-cellulose heating for dissolving are obtained to intermediate product A solution, again left-handed esterification C is dissolved in deionized water, use citric acid to carry out the adjusting of pH value, obtain intermediate product B solution, by two above-mentioned steps, ingenious at together with ingenious left-handed to Arbutin and esterification C must collocation, both functions are united two into one.
6. in the extraction of Arbutin of the present invention, adopt Chinese medicine high speed disintegrator to carry out the pulverizing of leaf of pear tree, granularity after it is pulverized is between 80 order～100 orders, reach best crushing effect, therefrom extract better more Arbutin, simultaneously, the present invention adopts alcoholic solution to extract, and first easily extracts than existing employing methanol, makes the Arbutin obtaining, apply in cosmetics, the product of producing is safer, also has, and the present invention adopts the ultrafilter membrane of 3k～10k to filter, make to obtain filtrate, impurity still less.
7. the present invention adopts the mode of vacuum and low temperature high pressure, carries out the extraction of Rosehips oil, first than existing extraction mode, effectively prevent due to high temperature, made the oil extracting occur burning, affected oily quality, meanwhile, adopt the form of high pressure, oil yield is promoted.
Detailed description of the invention
Embodiment 1:
The preparation method of Arbutin herbal essences liquid provided by the invention, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose in step (1), prepared are dissolved in to parts by weight is: in 48%～52% deionized water, carry out heated and stirred, being heated to temperature is 60 DEG C～70 DEG C; Mixing speed is 100r/min～150r/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 45 DEG C～55 DEG C, after dipping 6.5～7.5h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
In described step (21), the leaf of pear tree after drying is placed in the high speed disintegrator of rotating speed >=10000 rev/min and pulverizes, the granularity after it is pulverized is between 80 order～100 orders.
Described high speed disintegrator, it is Chinese medicine high speed disintegrator.
In described step (21), the ultrafilter membrane that the ultrafilter membrane adopting is 3k～10k.
In described step (21), described macroporous resin, it is AB-8NKA-9X-5, HP-20 macroporous resin.
Described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 30～35 DEG C of extraction temperature, pressure 50～60MPa; Separate one-phase temperature: 40～50 DEG C, pressure 20～30MPa;
Separate two-stage temperature: 20～30 DEG C, force value 15～20MPa; Extraction time 3～5 hours, obtains Rosehips oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 48%～52% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out the adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterial silver sulfadiazine powder 70-80%, ethanol 20-30%.
Described Arbutin herbal essences liquid, it is mainly prepared from by the raw material of following parts by weight:
Wherein, in the deionized water that Arbutin, hydroxyethyl-cellulose heating for dissolving are 50% in parts by weight, obtain intermediate product A solution;
It is in 13% deionized water that the left-handed C of esterification is dissolved in parts by weight, then, uses citric acid to carry out the adjusting of pH value, makes pH value in pH=6, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterial silver sulfadiazine powder 70-80%, ethanol 20-30%.
Embodiment 2:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof, it is substantially the same manner as Example 1, and its difference is: this preparation method, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose in step (1), prepared are dissolved in to parts by weight is: in 50% deionized water, carry out heated and stirred, being heated to temperature is 67 DEG C; Mixing speed is 120/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in to parts by weight is: in 13% deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=6.0, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 45 DEG C, after dipping 7h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
In described step (21), the ultrafilter membrane that the ultrafilter membrane adopting is 7k.
Described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 32 DEG C of extraction temperature, pressure 55MPa; Separate one-phase temperature: 40 DEG C, pressure 25MPa; Separate two-stage temperature: 25 DEG C, force value 15MPa; Extraction time 4 hours, obtains Rosehips oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 50% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in parts by weight: in 13% deionized water, then, use citric acid to carry out the adjusting of pH value, make in the scope of pH value in pH=6.0, obtain intermediate product B solution.
Embodiment 3:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof, itself and embodiment 1,2 are basic identical, and its difference is:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose in step (1), prepared are dissolved in to parts by weight is: in 52% deionized water, carry out heated and stirred, being heated to temperature is 60 DEG C; Mixing speed is 150r/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in to parts by weight is: in 13% deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=5.5, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 50 DEG C, after dipping 6.5h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
In described step (21), the ultrafilter membrane that the ultrafilter membrane adopting is 3k.
Described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 30 DEG C of extraction temperature, pressure 60MPa; Separate one-phase temperature: 45 DEG C, pressure 20MPa; Separate two-stage temperature: 20 DEG C, force value 18MPa; Extraction time 5 hours, obtains Rosehips oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 52% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in parts by weight: in 13% deionized water, then, use citric acid to carry out the adjusting of pH value, make in the scope of pH value in pH=5.5, obtain intermediate product B solution.
Embodiment 4:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof, itself and embodiment 1,2,3 are basic identical, and its difference is:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose prepared in step (1) are dissolved in to parts by weight is: 48%～deionized water in, carry out heated and stirred, being heated to temperature is 70 DEG C; Mixing speed is 100r/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=6.5, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 55 DEG C, after dipping 7.5h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
In described step (21), the ultrafilter membrane that the ultrafilter membrane adopting is 10k.
Described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 35 DEG C of extraction temperature, pressure 50MPa; Separate one-phase temperature: 50 DEG C, pressure 30MPa; Separate two-stage temperature: 30 DEG C, force value 20MPa; Extraction time 3 hours, obtains Rosehips oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 48% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out the adjusting of pH value, makes in the scope of pH value in pH=6.5, obtains intermediate product B solution.
Embodiment 5:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof, itself and embodiment 1,2,3,4 are basic identical, and its difference is:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose in step (1), prepared are dissolved in to parts by weight is: in 50% deionized water, carry out heated and stirred, being heated to temperature is 65 DEG C; Mixing speed is 130r/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in to parts by weight is: in 13% deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=6, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 52 DEG C, after dipping 7h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
In described step (21), the ultrafilter membrane that the ultrafilter membrane adopting is 3k～10k.
Described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 33 DEG C of extraction temperature, pressure 56MPa; Separate one-phase temperature: 47 DEG C, pressure 27MPa; Separate two-stage temperature: 26 DEG C, force value 18MPa; Extraction time 4.5 hours, obtains Rosehips oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 50% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in parts by weight: in 13% deionized water, then, use citric acid to carry out the adjusting of pH value, make in the scope of pH value in pH=6.0, obtain intermediate product B solution.
Beneficial effect of the present invention:
1. herbal essences liquid of the present invention, it adopts natural Chinese medicinal herb to be prepared from, and the component proportioning of its each component is scientific and reasonable, the essence that preparation generates, no side effects, preparation technology simplifies, and facilitates producer's large-scale production.
2. the present invention has adopted Arbutin, Arbutin has the effect that makes skin bright, can infiltrate skin rapidly and does not affect skin cell, activity that can restraint of tyrosinase (tyrosinase), and then hinder melanic formation, meanwhile, the generation of Mai Laning (melanin) be can effectively block, decomposition and the eliminating of Mai Laning accelerated, thereby, the source producing from speckle, stops the generation of speckle, the problem of profound solution speckle.
3. the Arbutin that the present invention adopts, can also protect skin to avoid the infringement of free radical, and hydrophilic is good, therefore often adds in the commercially available whitening product of what.
4. the present invention is ingenious at together with ingenious left-handed to Arbutin and esterification C must collocation, the Cortex Mori, Radix Glycyrrhizae, olive oil, the Rosehips wet goods plant extraction elite that have white-skinned face function concurrently have been added simultaneously, finally add efficient penetrating agent water-solubleazone, help nutrition better to bring into play effect, add again the holy product hyaluronic acid of moisturizing, in whitening, can play the Whitening, spot effect of deep skin Glycerin, profound level.
5. preparation technology of the present invention simplifies, first Arbutin, hydroxyethyl-cellulose heating for dissolving are obtained to intermediate product A solution, again left-handed esterification C is dissolved in deionized water, use citric acid to carry out the adjusting of pH value, obtain intermediate product B solution, by two above-mentioned steps, ingenious at together with ingenious left-handed to Arbutin and esterification C must collocation, both functions are united two into one.
6. in the extraction of Arbutin of the present invention, adopt Chinese medicine high speed disintegrator to carry out the pulverizing of leaf of pear tree, granularity after it is pulverized is between 80 order～100 orders, reach best crushing effect, therefrom extract better more Arbutin, simultaneously, the present invention adopts alcoholic solution to extract, and first easily extracts than existing employing methanol, makes the Arbutin obtaining, apply in cosmetics, the product of producing is safer, also has, and the present invention adopts the ultrafilter membrane of 3k～10k to filter, make to obtain filtrate, impurity still less.
7. the present invention adopts the mode of vacuum and low temperature high pressure, carries out the extraction of Rosehips oil, first than existing extraction mode, effectively prevent due to high temperature, made the oil extracting occur burning, affected oily quality, meanwhile, adopt the form of high pressure, oil yield is significantly promoted.
The above embodiments are not all embodiment of the present invention, and the composition range that description is recorded, all can realize the present invention.
As described in the present embodiment of the invention, adopt and the same or analogous step of the present invention and component, and in the scope of listing, the preparation method of the Arbutin herbal essences liquid obtaining and Arbutin herbal essences liquid thereof, all within protection scope of the present invention.
Claims (10)
1. a preparation method for Arbutin herbal essences liquid, is characterized in that: it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethyl-cellulose in step (1), prepared are dissolved in to parts by weight is: in 48%～52% deionized water, carry out heated and stirred, being heated to temperature is 60 DEG C～70 DEG C; Mixing speed is 100r/min～150r/min, until after Arbutin, hydroxyethyl-cellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is the amount of the deionized water of preparation in step (1);
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3), hyaluronic acid, Cortex Mori extract, Radix Glycyrrhizae extract liquid, olive oil, Rosehips oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum that step (1) is prepared, stir, obtain Arbutin herbal essences liquid.
2. the preparation method of Arbutin herbal essences liquid according to claim 1, is characterized in that: described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use alcoholic solution dipping, is, under the temperature conditions of 45 DEG C～55 DEG C, after dipping 6.5～7.5h, to use ultrafiltration membrance filter in temperature, collects filter liquor; Use macroporous resin, filter liquor is carried out to Adsorption and desorption attached, collect stripping liquid, be rotated evaporation, concentrate, vacuum freeze-drying, obtain Arbutin.
3. the preparation method of Arbutin herbal essences liquid according to claim 2, is characterized in that:
In described step (21), the leaf of pear tree after drying is placed in the high speed disintegrator of rotating speed >=10000 rev/min and pulverizes, the granularity after it is pulverized is between 80 order～100 orders.
4. the preparation method of Arbutin herbal essences liquid according to claim 3, is characterized in that: described high speed disintegrator, it is Chinese medicine high speed disintegrator.
5. the preparation method of Arbutin herbal essences liquid according to claim 2, is characterized in that: in described step (21), and the ultrafilter membrane that the ultrafilter membrane adopting is 3k～10k.
6. the preparation method of Arbutin herbal essences liquid according to claim 2, is characterized in that: in described step (21), and described macroporous resin, it is AB-8NKA-9X-5, HP-20 macroporous resin.
7. the preparation method of Arbutin herbal essences liquid according to claim 1, is characterized in that: described step (4), it also comprises the steps:
(41). the extraction of Rosehips oil
Rosehips is placed to vacuum drying oven and dry, moisture Control, 3～8%, is dried rear raw material pulverizing, and degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: 30～35 DEG C of extraction temperature, pressure 50～60MPa; Separate one-phase temperature: 40～50 DEG C, pressure 20～30MPa;
Separate two-stage temperature: 20～30 DEG C, force value 15～20MPa; Extraction time 3～5 hours, obtains Rosehips oil.
8. the Arbutin herbal essences liquid of preparing according to the described method of one of claim 1～7, is characterized in that, it is mainly prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethyl-cellulose heating are dissolved in parts by weight completely and are: in 48%～52% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out the adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution.
9. Arbutin herbal essences liquid according to claim 8, is characterized in that: it is mainly prepared from by the raw material of following parts by weight:
Wherein, in the deionized water that Arbutin, hydroxyethyl-cellulose heating for dissolving are 50% in parts by weight, obtain intermediate product A solution;
It is in 13% deionized water that the left-handed C of esterification is dissolved in parts by weight, then, uses citric acid to carry out the adjusting of pH value, makes pH value in pH=6, obtains intermediate product B solution.
10. Arbutin herbal essences liquid according to claim 8 or claim 9, is characterized in that: the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterial silver sulfadiazine powder 70-80%, ethanol 20-30%.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983611A (en) * | 2015-06-17 | 2015-10-21 | 柳州弘天科技有限公司 | Isolation sunscreen |
| CN105902466A (en) * | 2016-05-20 | 2016-08-31 | 秦瑜 | High-permeability face thinning essence |
| CN108484697A (en) * | 2018-06-05 | 2018-09-04 | 安徽龙润堂生物科技有限公司 | The extraction of ursin and separation method in a kind of leaf of pear tree |
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| JP2005330257A (en) * | 2004-04-19 | 2005-12-02 | Nippon Fine Chem Co Ltd | Cosmetic |
| CN101904809A (en) * | 2010-07-01 | 2010-12-08 | 北京日用化学研究所 | Skin whitening composition |
| CN102813614A (en) * | 2012-08-17 | 2012-12-12 | 天津市中科健新材料技术有限公司 | Cleaning, sunblock and repair wet tissue |
| CN103211717A (en) * | 2012-01-20 | 2013-07-24 | 谢玠扬 | Anti-oxidation composition |
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2014
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005330257A (en) * | 2004-04-19 | 2005-12-02 | Nippon Fine Chem Co Ltd | Cosmetic |
| CN101904809A (en) * | 2010-07-01 | 2010-12-08 | 北京日用化学研究所 | Skin whitening composition |
| CN103211717A (en) * | 2012-01-20 | 2013-07-24 | 谢玠扬 | Anti-oxidation composition |
| CN102813614A (en) * | 2012-08-17 | 2012-12-12 | 天津市中科健新材料技术有限公司 | Cleaning, sunblock and repair wet tissue |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983611A (en) * | 2015-06-17 | 2015-10-21 | 柳州弘天科技有限公司 | Isolation sunscreen |
| CN105902466A (en) * | 2016-05-20 | 2016-08-31 | 秦瑜 | High-permeability face thinning essence |
| CN108484697A (en) * | 2018-06-05 | 2018-09-04 | 安徽龙润堂生物科技有限公司 | The extraction of ursin and separation method in a kind of leaf of pear tree |
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