CN103989590B - Preparation method and the goods of Arbutin herbal essences liquid - Google Patents
Preparation method and the goods of Arbutin herbal essences liquid Download PDFInfo
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- CN103989590B CN103989590B CN201410182623.5A CN201410182623A CN103989590B CN 103989590 B CN103989590 B CN 103989590B CN 201410182623 A CN201410182623 A CN 201410182623A CN 103989590 B CN103989590 B CN 103989590B
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- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 title claims abstract description 218
- 229960000271 arbutin Drugs 0.000 title claims abstract description 109
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 title claims abstract description 109
- 238000002360 preparation method Methods 0.000 title claims abstract description 70
- 239000007788 liquid Substances 0.000 title claims abstract description 69
- 239000000686 essence Substances 0.000 title claims abstract description 65
- 239000013067 intermediate product Substances 0.000 claims abstract description 62
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 51
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 48
- 239000008367 deionised water Substances 0.000 claims abstract description 46
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 46
- 239000002994 raw material Substances 0.000 claims abstract description 40
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 27
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 27
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 27
- 239000010667 rosehip oil Substances 0.000 claims abstract description 24
- 230000032050 esterification Effects 0.000 claims abstract description 23
- 238000005886 esterification reaction Methods 0.000 claims abstract description 23
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 239000002068 microbial inoculum Substances 0.000 claims abstract description 15
- 239000004006 olive oil Substances 0.000 claims abstract description 10
- 235000008390 olive oil Nutrition 0.000 claims abstract description 10
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 8
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229940069445 licorice extract Drugs 0.000 claims abstract description 8
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 8
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 8
- 229940046009 vitamin E Drugs 0.000 claims abstract description 8
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 8
- 239000011709 vitamin E Substances 0.000 claims abstract description 8
- 229940084084 white mulberry extract Drugs 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 3
- 238000000605 extraction Methods 0.000 claims description 41
- 238000010298 pulverizing process Methods 0.000 claims description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 238000007598 dipping method Methods 0.000 claims description 14
- 240000001987 Pyrus communis Species 0.000 claims description 12
- 235000014443 Pyrus communis Nutrition 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 12
- 239000011347 resin Substances 0.000 claims description 11
- 229920005989 resin Polymers 0.000 claims description 11
- 238000013019 agitation Methods 0.000 claims description 7
- 238000001816 cooling Methods 0.000 claims description 7
- 238000003795 desorption Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 7
- 230000008020 evaporation Effects 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000012163 sequencing technique Methods 0.000 claims description 7
- 238000001179 sorption measurement Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 238000000108 ultra-filtration Methods 0.000 claims description 7
- 238000001291 vacuum drying Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 2
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 claims 4
- 229940124530 sulfonamide Drugs 0.000 claims 4
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 3
- 230000002421 anti-septic effect Effects 0.000 claims 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 12
- 230000002087 whitening effect Effects 0.000 abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract description 6
- 235000011187 glycerol Nutrition 0.000 abstract description 3
- 239000012263 liquid product Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 17
- 239000000047 product Substances 0.000 description 13
- 238000001035 drying Methods 0.000 description 8
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 5
- 102000003425 Tyrosinase Human genes 0.000 description 4
- 108060008724 Tyrosinase Proteins 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 229910052738 indium Inorganic materials 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 235000019198 oils Nutrition 0.000 description 4
- 206010027146 Melanoderma Diseases 0.000 description 3
- 208000003351 Melanosis Diseases 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 229940048368 flamazine Drugs 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
- 229910052753 mercury Inorganic materials 0.000 description 3
- UEJSSZHHYBHCEL-UHFFFAOYSA-N silver(1+) sulfadiazinate Chemical compound [Ag+].C1=CC(N)=CC=C1S(=O)(=O)[N-]C1=NC=CC=N1 UEJSSZHHYBHCEL-UHFFFAOYSA-N 0.000 description 3
- 208000037259 Amyloid Plaque Diseases 0.000 description 2
- 206010008570 Chloasma Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 206010025421 Macule Diseases 0.000 description 2
- 240000000249 Morus alba Species 0.000 description 2
- 235000008708 Morus alba Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000011031 large-scale manufacturing process Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 210000004927 skin cell Anatomy 0.000 description 2
- 230000010148 water-pollination Effects 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000012641 Pigmentation disease Diseases 0.000 description 1
- 206010039796 Seborrhoeic keratosis Diseases 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000013043 chemical agent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 208000000069 hyperpigmentation Diseases 0.000 description 1
- 230000003810 hyperpigmentation Effects 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
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- 230000005855 radiation Effects 0.000 description 1
- 201000003385 seborrheic keratosis Diseases 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The preparation method who the invention discloses a kind of Arbutin herbal essences liquid, it comprises the steps: the preparation of (1) raw material; (2) preparation of intermediate product A solution; (3) preparation of intermediate product B solution; (4) preparation of herbal essences liquid. The invention also discloses Arbutin herbal essences liquid product prepared by the method, it is mainly prepared from by the raw material of following parts by weight: Arbutin: 3%～7%; Deionized water: 61%～65%; Hydroxyethylcellulose: 0.5%～1.5%; Left-handed C:2%～4% of esterification; Citric acid: 0.05%～0.15%; Sodium hyaluronate: 8%～12%; Root bark of white mulberry extract: 3%～7%; Licorice extract: 3%～7%; Olive oil: 2%～6%; Rose hip oil: 3%～7%; Vitamin E: 1%～3%; Water-solubleazone: 1%～3%; Compound Resisting microbial inoculum: 0.3%～0.7%. Together with the present invention arranges in pairs or groups left-handed to Arbutin and esterification C, can reach the effect of deep layer Glycerin, Whitening, spot.
Description
Technical field
The present invention relates to a kind of cosmetics, relate in particular to a kind of Arbutin herbal essences liquid preparation method andIts Arbutin herbal essences liquid goods.
Background technology
Hyperpigmentation in skin and make on skin to occur the flecks such as brown, yellowish-brown, black, is referred to asFor skin splash, comprise in a sense the spot of many types, as chloasma, butterfly macules, blackspot,Senile plaque expelling etc.
Chloasma is a kind of abnormal, calm dermatoses of facial metabolism of pigment that betides. In being more common inYear women, its main manifestations is that yellowish-brown or the greyish black color spot that size shape differs appears in face, often symmetricalBe distributed in the positions such as volume, face, cheek, nose and upper lip, do not exceed skin, clear border, the course of disease is slow,Long-term existence, the several years does not take off, and after Exposure to Sunlight, often increases the weight of, and main cause is female incretion imbalance, spiritPressure is large, and external application chemicals etc. causes.
Freckle, is generally distributed in the region that face is arrived by solar radiation easily, is mainly caused by genetic cause.
Blackspot, is also butterfly macules, concentrates on two cheeks, seems the butterfly just as an expansion, mainly formerBecause being that excessive ultraviolet ray is irradiated, skin irriate, causes the propagation of skin bottom melanocyte, producesRaw too much melanin, forms blackspot.
Senile plaque expelling, a kind of geroderma pathology, is medically being called seborrheic keratosis disease.
Sunburn, is after sunlight excessively irradiates, skin generation erythema, oedema, the cutaneous pigmentation of appearance.
Except these color spots, also have some other color spot, as due to the long-term mercury cosmetic that uses, leadCause skin blackout, be called mercury spot; Due to the conceived cyasma producing etc.
Whitening spot-removing product is in the market formed by various chemical agents and additive modulation, even containsCarcinogenic heavy metal, as plumbous mercury content exceeds standard. These whitening spot-removing products short-term use after, althoughSkin is had to certain whitening spot-removing effect, but cure the symptoms, not the disease, can not fundamentally reach protection skinEffect, after long-term use, there will be the following toxic and side effect: gently thinning of skin dies down, and causesSkin is easily irritated; Heavy skin ambustion causes skin to burn out into anabiotic state, absorb less than nutrientsMatter, makes skin hardening; More severe patient also may cause disfeaturing.
Summary of the invention
For the deficiency of existing whitening spot-removing product, the invention provides a kind of Arbutin addressing the above problemThe preparation method of herbal essences liquid and Arbutin herbal essences goods thereof.
The present invention for achieving the above object and adopt technical scheme be:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is: 48%～In 52% deionized water, add thermal agitation, being heated to temperature is 60 DEG C～70 DEG C; Mixing speed is100r/min～150r/min, until after Arbutin, hydroxyethylcellulose dissolve completely, cooling, obtainIntermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, addThe citric acid that enters step (1) preparation carries out the adjusting of pH value, makes pH value in pH=5.5～6.5Scope in, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is accurate in step (1)The amount of standby deionized water;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3),Sodium hyaluronate, root bark of white mulberry extract, licorice extract, olive oil, rose hip oil that step (1) is prepared,Vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir, and obtains Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is 45 DEG C～55 DEG C in temperatureTemperature conditions under, dipping 6.5～7.5h after, use ultrafiltration membrance filter, collect filter liquor; Use macroporeResin, carries out Adsorption and desorption to filter liquor attached, collects stripping liquid, is rotated evaporation, concentrated, veryEmpty freeze-drying, obtains Arbutin.
In described step (21), the leaf of pear tree after drying is placed on to the high speed of rotating speed >=10000 rev/minIn pulverizer, pulverize, make its pulverize after granularity between 80 order～100 orders.
Described high speed disintegrator, it is Chinese medicine high speed disintegrator.
In described step (21), the milipore filter that the milipore filter adopting is 3k～10k.
In described step (21), described macroreticular resin, it is AB-8NKA-9X-5, HP-20Macroreticular resin.
Described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, and after drying, raw material is pulverized, powderBroken degree, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: extraction30～35 DEG C of temperature, pressure 50～60MPa; Separate one-phase temperature: 40～50 DEG C, pressure 20～30MPa；
Separate two-stage temperature: 20～30 DEG C, force value 15～20MPa; Extraction time 3～5 hours, obtainsObtain rose hip oil.
The Arbutin herbal essences liquid that adopts above-mentioned method to prepare, it is mainly by the raw material of following parts by weightBe prepared from:
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 48%～52%In deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out the tune of pH valueJoint, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterialAgent flamazine pulvis 70-80%, ethanol 20-30%.
Described Arbutin herbal essences liquid, it is mainly prepared from by the raw material of following parts by weight:
Wherein, in the deionized water that Arbutin, hydroxyethylcellulose heating for dissolving are 50% in parts by weight,Obtain intermediate product A solution;
It is in 13% deionized water that the left-handed C of esterification is dissolved in parts by weight, then, uses citric acid to enterThe adjusting of row pH value, makes pH value in pH=6, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antisepticFlamazine pulvis 70-80%, ethanol 20-30%
Beneficial effect of the present invention:
1. herbal essences liquid of the present invention, it adopts natural Chinese medicinal herb to be prepared from, and the component of its each component is joinedRatio, scientific and reasonable, the Essence that preparation generates, no side effects, preparation technology simplifies, and facilitates factoryFamily's large-scale production.
2. the present invention has adopted Arbutin, and Arbutin has the effect that makes skin bright, can infiltrate rapidly fleshSkin and do not affect skin cell, activity that can restraint of tyrosinase (tyrosinase), and then hinder blackThe formation of element, meanwhile, can effectively block the generation of Mai Laning (melanin), accelerates dividing of Mai LaningSeparate and get rid of, thereby the source producing from spot, stops the generation of spot, profound solution spotProblem.
3. the Arbutin that the present invention adopts, can also protect skin to exempt from the infringement of what free radical, and hydrophily is good, because ofThis often makes an addition in commercially available whitening product.
4. the present invention is ingenious at together with ingenious left-handed to Arbutin and esterification C must collocation, has added simultaneously and has held concurrentlyThe root bark of white mulberry of tool white-skinned face function, Radix Glycyrrhizae, olive oil, fructus rosae wet goods plant extraction elite, finally addEfficient penetrating agent water-solubleazone, help nutrition better bring into play effect again spoke enter the holy product glass urine of moisturizingAcid, in whitening, deep layer Glycerin, profound Whitening, spot.
5. preparation technology of the present invention simplifies, in first Arbutin, hydroxyethylcellulose heating for dissolving being obtainedBetween product A solution, more left-handed esterification C is dissolved in deionized water, use citric acid to carry out pH valueAdjusting, obtain intermediate product B solution, by two above-mentioned steps, ingenious at Arbutin and esterificationLeft-handed C is ingenious must arrange in pairs or groups together, and both functions are united two into one.
6. in the extraction of Arbutin of the present invention, adopt Chinese medicine high speed disintegrator to carry out the pulverizing of leaf of pear tree,Granularity after it is pulverized, between 80 order～100 orders, has reached best crushing effect, betterTherefrom extract more Arbutin, meanwhile, the present invention adopts ethanolic solution to extract, first than existingAdopt methyl alcohol easily to extract, make the Arbutin of acquisition, apply in cosmetics the product of producingProduct are safer, also have, and the present invention adopts the milipore filter of 3k～10k to filter, and makes to obtain filtered fluid,Impurity still less.
7. the present invention adopts the mode of vacuum and low temperature high pressure, carries out the extraction of rose hip oil, first than existingExtraction mode, has effectively prevented due to high temperature, make the oil extracting occur burning, has affected oilQuality, meanwhile, adopts the form of high pressure, and oil yield is promoted.
Detailed description of the invention
Embodiment 1:
The preparation method of Arbutin herbal essences liquid provided by the invention, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is: 48%～In 52% deionized water, add thermal agitation, being heated to temperature is 60 DEG C～70 DEG C; Mixing speed is100r/min～150r/min, until after Arbutin, hydroxyethylcellulose dissolve completely, cooling, obtainIntermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, addThe citric acid that enters step (1) preparation carries out the adjusting of pH value, makes pH value in pH=5.5～6.5Scope in, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is accurate in step (1)The amount of standby deionized water;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3),Sodium hyaluronate, root bark of white mulberry extract, licorice extract, olive oil, rose hip oil that step (1) is prepared,Vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir, and obtains Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is 45 DEG C～55 DEG C in temperatureTemperature conditions under, dipping 6.5～7.5h after, use ultrafiltration membrance filter, collect filter liquor; Use macroporeResin, carries out Adsorption and desorption to filter liquor attached, collects stripping liquid, is rotated evaporation, concentrated, veryEmpty freeze-drying, obtains Arbutin.
In described step (21), the leaf of pear tree after drying is placed on to the high speed of rotating speed >=10000 rev/minIn pulverizer, pulverize, make its pulverize after granularity between 80 order～100 orders.
Described high speed disintegrator, it is Chinese medicine high speed disintegrator.
In described step (21), the milipore filter that the milipore filter adopting is 3k～10k.
In described step (21), described macroreticular resin, it is AB-8NKA-9X-5, HP-20Macroreticular resin.
Described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, and after drying, raw material is pulverized, powderBroken degree, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: extraction30～35 DEG C of temperature, pressure 50～60MPa; Separate one-phase temperature: 40～50 DEG C, pressure 20～30MPa；
Separate two-stage temperature: 20～30 DEG C, force value 15～20MPa; Extraction time 3～5 hours,Obtain rose hip oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, itsMainly be prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 48%～52%Deionized water in, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out pH valueRegulate, make in the scope of pH value in pH=5.5～6.5, obtain intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterialAgent flamazine pulvis 70-80%, ethanol 20-30%.
Described Arbutin herbal essences liquid, it is mainly prepared from by the raw material of following parts by weight:
Wherein, in the deionized water that Arbutin, hydroxyethylcellulose heating for dissolving are 50% in parts by weight,Obtain intermediate product A solution;
It is in 13% deionized water that the left-handed C of esterification is dissolved in parts by weight, then, uses citric acid to enterThe adjusting of row pH value, makes pH value in pH=6, obtains intermediate product B solution.
Wherein, the component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antibacterialAgent flamazine pulvis 70-80%, ethanol 20-30%.
Embodiment 2:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof,It is substantially the same manner as Example 1, and its difference is: this preparation method, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is: 50%In deionized water, add thermal agitation, being heated to temperature is 67 DEG C; Mixing speed is 120/min, straightAfter dissolving completely to Arbutin, hydroxyethylcellulose, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in to parts by weight is: in 13% deionized water;Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes pH value in pH=6.0Scope in, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is accurate in step (1)The amount of standby deionized water;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3),Sodium hyaluronate, root bark of white mulberry extract, licorice extract, olive oil, rose hip oil that step (1) is prepared,Vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir, and obtains Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is the temperature of 45 DEG C in temperatureUnder condition, after dipping 7h, use ultrafiltration membrance filter, collect filter liquor; Use macroreticular resin, to leachingIt is attached that liquid carries out Adsorption and desorption, collects stripping liquid, is rotated evaporation, concentrated, vacuum freeze-drying, obtainsArbutin.
In described step (21), the milipore filter that the milipore filter adopting is 7k.
Described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, and after drying, raw material is pulverized, powderBroken degree, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: extraction32 DEG C of temperature, pressure 55MPa; Separate one-phase temperature: 40 DEG C, pressure 25MPa; Separate second orderDuan Wendu: 25 DEG C, force value 15MPa; Extraction time 4 hours, obtains rose hip oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, itsMainly be prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 50% deionizationIn water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in parts by weight: in 13% deionized water, then, use citric acidCarry out the adjusting of pH value, make in the scope of pH value in pH=6.0, obtain intermediate product B solution.
Embodiment 3:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof,Itself and embodiment 1,2 are basic identical, and its difference is:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is: 52%In deionized water, add thermal agitation, being heated to temperature is 60 DEG C; Mixing speed is 150r/min, straightAfter dissolving completely to Arbutin, hydroxyethylcellulose, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in to parts by weight is: in 13% deionized water;Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes pH value in pH=5.5Scope in, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is accurate in step (1)The amount of standby deionized water;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3),Sodium hyaluronate, root bark of white mulberry extract, licorice extract, olive oil, rose hip oil that step (1) is prepared,Vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir, and obtains Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is the temperature of 50 DEG C in temperatureUnder condition, after dipping 6.5h, use ultrafiltration membrance filter, collect filter liquor; Use macroreticular resin, to filterIt is attached that fluid is carried out Adsorption and desorption, collects stripping liquid, is rotated evaporation, concentrated, vacuum freeze-drying,To Arbutin.
In described step (21), the milipore filter that the milipore filter adopting is 3k.
Described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, and after drying, raw material is pulverized, powderBroken degree, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: extraction30 DEG C of temperature, pressure 60MPa; Separate one-phase temperature: 45 DEG C, pressure 20MPa; Separate second orderDuan Wendu: 20 DEG C, force value 18MPa; Extraction time 5 hours, obtains rose hip oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, itsMainly be prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 52% deionizationIn water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in parts by weight: in 13% deionized water, then, use citric acidCarry out the adjusting of pH value, make in the scope of pH value in pH=5.5, obtain intermediate product B solution.
Embodiment 4:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof,Itself and embodiment 1,2,3 are basic identical, and its difference is:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is: 48%～Deionized water in, add thermal agitation, being heated to temperature is 70 DEG C; Mixing speed is 100r/min,Until after Arbutin, hydroxyethylcellulose dissolve completely, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; Then, addThe citric acid that enters step (1) preparation carries out the adjusting of pH value, makes the scope of pH value in pH=6.5In, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is accurate in step (1)The amount of standby deionized water;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3),Sodium hyaluronate, root bark of white mulberry extract, licorice extract, olive oil, rose hip oil that step (1) is prepared,Vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir, and obtains Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is the temperature of 55 DEG C in temperatureUnder condition, after dipping 7.5h, use ultrafiltration membrance filter, collect filter liquor; Use macroreticular resin, to filterIt is attached that fluid is carried out Adsorption and desorption, collects stripping liquid, is rotated evaporation, concentrated, vacuum freeze-drying,To Arbutin.
In described step (21), the milipore filter that the milipore filter adopting is 10k.
Described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, and after drying, raw material is pulverized, powderBroken degree, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: extraction35 DEG C of temperature, pressure 50MPa; Separate one-phase temperature: 50 DEG C, pressure 30MPa; Separate second orderDuan Wendu: 30 DEG C, force value 20MPa; Extraction time 3 hours, obtains rose hip oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, itsMainly be prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 48% deionizationIn water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry out the tune of pH valueJoint, makes in the scope of pH value in pH=6.5, obtains intermediate product B solution.
Embodiment 5:
The preparation method of the Arbutin herbal essences liquid that the present embodiment provides and Arbutin herbal essences liquid thereof,Itself and embodiment 1,2,3,4 are basic identical, and its difference is:
A preparation method for Arbutin herbal essences liquid, it comprises the steps:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is: 50%In deionized water, add thermal agitation, being heated to temperature is 65 DEG C; Mixing speed is 130r/min, straightAfter dissolving completely to Arbutin, hydroxyethylcellulose, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in to parts by weight is: in 13% deionized water;Then, the citric acid that adds step (1) to prepare carries out the adjusting of pH value, makes pH value in pH=6Scope in, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is accurate in step (1)The amount of standby deionized water;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Intermediate product A solution prepared by step (2), intermediate product B solution prepared by step (3),Sodium hyaluronate, root bark of white mulberry extract, licorice extract, olive oil, rose hip oil that step (1) is prepared,Vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir, and obtains Arbutin herbal essences liquid.
Described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is the temperature of 52 DEG C in temperatureUnder condition, after dipping 7h, use ultrafiltration membrance filter, collect filter liquor; Use macroreticular resin, to leachingIt is attached that liquid carries out Adsorption and desorption, collects stripping liquid, is rotated evaporation, concentrated, vacuum freeze-drying, obtainsArbutin.
In described step (21), the milipore filter that the milipore filter adopting is 3k～10k.
Described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, and after drying, raw material is pulverized, powderBroken degree, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle, and extraction conditions is: extraction33 DEG C of temperature, pressure 56MPa; Separate one-phase temperature: 47 DEG C, pressure 27MPa; Separate second orderDuan Wendu: 26 DEG C, force value 18MPa; Extraction time 4.5 hours, obtains rose hip oil.
The Arbutin herbal essences liquid that adopts the preparation method of above-mentioned Arbutin herbal essences liquid to prepare, itsMainly be prepared from by the raw material of following parts by weight:
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 50% deionizationIn water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in parts by weight: in 13% deionized water, then, use citric acidCarry out the adjusting of pH value, make in the scope of pH value in pH=6.0, obtain intermediate product B solution.
Beneficial effect of the present invention:
1. herbal essences liquid of the present invention, it adopts natural Chinese medicinal herb to be prepared from, and the component of its each component is joinedRatio, scientific and reasonable, the Essence that preparation generates, no side effects, preparation technology simplifies, and facilitates factoryFamily's large-scale production.
2. the present invention has adopted Arbutin, and Arbutin has the effect that makes skin bright, can infiltrate rapidly fleshSkin and do not affect skin cell, activity that can restraint of tyrosinase (tyrosinase), and then hinder blackThe formation of element, meanwhile, can effectively block the generation of Mai Laning (melanin), accelerates dividing of Mai LaningSeparate and get rid of, thereby the source producing from spot, stops the generation of spot, profound solution spotProblem.
3. the Arbutin that the present invention adopts, can also protect skin to avoid the infringement of free radical, and hydrophily is good, because ofThis normal interpolation in the commercially available whitening product of what.
4. the present invention is ingenious at together with ingenious left-handed to Arbutin and esterification C must collocation, has added simultaneously and has held concurrentlyThe root bark of white mulberry of tool white-skinned face function, Radix Glycyrrhizae, olive oil, fructus rosae wet goods plant extraction elite, finally addEfficient penetrating agent water-solubleazone, helps nutrition better to bring into play effect, then adds the holy product glass of moisturizingUric acid, in whitening, can play the Whitening, spot effect of deep skin Glycerin, profound level.
5. preparation technology of the present invention simplifies, in first Arbutin, hydroxyethylcellulose heating for dissolving being obtainedBetween product A solution, more left-handed esterification C is dissolved in deionized water, use citric acid to carry out pH valueAdjusting, obtain intermediate product B solution, by two above-mentioned steps, ingenious at Arbutin and esterificationLeft-handed C is ingenious must arrange in pairs or groups together, and both functions are united two into one.
6. in the extraction of Arbutin of the present invention, adopt Chinese medicine high speed disintegrator to carry out the pulverizing of leaf of pear tree,Granularity after it is pulverized, between 80 order～100 orders, has reached best crushing effect, betterTherefrom extract more Arbutin, meanwhile, the present invention adopts ethanolic solution to extract, first than existingAdopt methyl alcohol easily to extract, make the Arbutin of acquisition, apply in cosmetics the product of producingProduct are safer, also have, and the present invention adopts the milipore filter of 3k～10k to filter, and makes to obtain filtered fluid,Impurity still less.
7. the present invention adopts the mode of vacuum and low temperature high pressure, carries out the extraction of rose hip oil, first than existingExtraction mode, has effectively prevented due to high temperature, make the oil extracting occur burning, has affected oilQuality, meanwhile, adopts the form of high pressure, and oil yield is significantly promoted.
The above embodiments are not all embodiment of the present invention, the composition range that description is recorded,All can realize the present invention.
As described in the present embodiment of the invention, adopt and the same or analogous step of the present invention and component, and instituteIn the scope of listing, preparation method and the Arbutin herbal essences thereof of the Arbutin herbal essences liquid obtainingLiquid, all within protection scope of the present invention.
Claims (10)
1. a preparation method for Arbutin herbal essences liquid, is characterized in that: it comprise asLower step:
(1). the preparation of raw material
Prepare raw material according to following parts by weight:
The component that described Compound Resisting microbial inoculum is following percentage by weight mixes: antiseptic sulfanilamide (SN) is phoneticPyridine silver powder agent 70-80%, ethanol 20-30%;
(2). the preparation of intermediate product A solution
Arbutin, the hydroxyethylcellulose in step (1), prepared are dissolved in to parts by weight is:In 48%～52% deionized water, add thermal agitation, being heated to temperature is 60 DEG C～70DEG C; Mixing speed is 100r/min～150r/min, until Arbutin, hydroxyethylcellulose are completeAfter CL, cooling, obtain intermediate product A solution, for subsequent use;
(3). the preparation of intermediate product B solution
The left-handed C of esterification preparing in step (1) is dissolved in remaining deionized water; SoAfter, add step (1) prepare citric acid carry out the adjusting of pH value, make pH value inIn the scope of pH=5.5～6.5, obtain intermediate product B solution; For subsequent use;
The total amount of the deionized water using in described step (2) and step (3) is step (1)The amount of the deionized water of middle preparation;
Between described step (2), step (3) without sequencing;
(4). the preparation of herbal essences liquid
Middle producing prepared by intermediate product A solution, step (3) prepared by step (2)Thing B solution, sodium hyaluronate, root bark of white mulberry extract, licorice extract that step (1) is prepared,Olive oil, rose hip oil, vitamin E, water-solubleazone, Compound Resisting microbial inoculum, stir,Obtain Arbutin herbal essences liquid.
2. the preparation method of Arbutin herbal essences liquid according to claim 1, its spyLevy and be: described step (2), it also comprises the steps:
(21). the extraction of Arbutin
Leaf of pear tree being dried, pulverizing, being sieved, use ethanolic solution dipping, is 45 in temperatureDEG C～temperature conditions of 55 DEG C under, after dipping 6.5～7.5h, use ultrafiltration membrance filter, collectFilter liquor; Use macroreticular resin, filter liquor carried out to Adsorption and desorption attached, collect stripping liquid,Be rotated evaporation, concentrated, vacuum freeze-drying, obtain Arbutin.
3. the preparation method of Arbutin herbal essences liquid according to claim 2, its featureBe: in described step (21), dried leaf of pear tree is placed on to rotating speed >=10000 rev/minIn the high speed disintegrator of clock, pulverize, make its pulverize after granularity in 80 order～100 ordersBetween.
4. the preparation method of Arbutin herbal essences liquid according to claim 3, its spyLevy and be: described high speed disintegrator, it is Chinese medicine high speed disintegrator.
5. the preparation method of Arbutin herbal essences liquid according to claim 2, its spyLevy and be: in described step (21), the milipore filter that the milipore filter adopting is 3k～10k.
6. the preparation method of Arbutin herbal essences liquid according to claim 2, its spyLevy and be: in described step (21), described macroreticular resin, its be AB-8, NKA-9,X-5, HP-20 macroreticular resin.
7. the preparation method of Arbutin herbal essences liquid according to claim 1, its spyLevy and be: described step (4), it also comprises the steps:
(41). the extraction of rose hip oil
Fructus rosae is placed to vacuum drying oven and dry, moisture is controlled at 3～8%, raw material after dryingPulverize, degree of grinding, between 80～100 orders, installs to the raw material after pulverizing in extraction kettle extractionThe condition of getting is: 30～35 DEG C of extraction temperature, pressure 50～60MPa; Separate one-phase temperature:40～50 DEG C, pressure 20～30MPa;
Separate two-stage temperature: 20～30 DEG C, force value 15～20MPa; Extraction time 3～5 hours, obtain rose hip oil.
8. the Arbutin herbal essences liquid of preparing according to the described method of one of claim 1～7,It is characterized in that, it is mainly prepared from by the raw material of following parts by weight:
The component that described Compound Resisting microbial inoculum is following percentage by weight mixes: antiseptic sulfanilamide (SN) is phoneticPyridine silver powder agent 70-80%, ethanol 20-30%;
Wherein, Arbutin, hydroxyethylcellulose heating are dissolved in parts by weight completely and are: 48%～In 52% deionized water, obtain intermediate product A solution;
The left-handed C of esterification is dissolved in remaining deionized water, then, uses citric acid to carry outThe adjusting of pH value, makes in the scope of pH value in pH=5.5～6.5, obtains intermediate productB solution.
9. Arbutin herbal essences liquid according to claim 8, is characterized in that: itsMainly be prepared from by the raw material of following parts by weight:
What wherein, Arbutin, hydroxyethylcellulose heating for dissolving were 50% in parts by weight go fromIn sub-water, obtain intermediate product A solution;
It is in 13% deionized water that the left-handed C of esterification is dissolved in parts by weight, then, usesCitric acid carries out the adjusting of pH value, makes pH value in pH=6, obtains intermediate product BSolution.
10. Arbutin herbal essences liquid according to claim 8 or claim 9, is characterized in that:The component that described Compound Resisting microbial inoculum is specially following percentage by weight mixes: antiseptic sulphurAmic metadiazine silver powder agent 70-80%, ethanol 20-30%.
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| CN105902466A (en) * | 2016-05-20 | 2016-08-31 | 秦瑜 | High-permeability face thinning essence |
| CN108484697B (en) * | 2018-06-05 | 2020-06-05 | 安徽龙润堂生物科技有限公司 | Extraction and separation method of arbutin in pear leaves |
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| CN101904809A (en) * | 2010-07-01 | 2010-12-08 | 北京日用化学研究所 | Skin whitening composition |
| CN102813614A (en) * | 2012-08-17 | 2012-12-12 | 天津市中科健新材料技术有限公司 | Cleaning, sunblock and repair wet tissue |
| CN103211717A (en) * | 2012-01-20 | 2013-07-24 | 谢玠扬 | Anti-oxidation composition |
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| CN101904809A (en) * | 2010-07-01 | 2010-12-08 | 北京日用化学研究所 | Skin whitening composition |
| CN103211717A (en) * | 2012-01-20 | 2013-07-24 | 谢玠扬 | Anti-oxidation composition |
| CN102813614A (en) * | 2012-08-17 | 2012-12-12 | 天津市中科健新材料技术有限公司 | Cleaning, sunblock and repair wet tissue |
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