CN101904809A - Skin whitening composition - Google Patents
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- CN101904809A CN101904809A CN 201010214873 CN201010214873A CN101904809A CN 101904809 A CN101904809 A CN 101904809A CN 201010214873 CN201010214873 CN 201010214873 CN 201010214873 A CN201010214873 A CN 201010214873A CN 101904809 A CN101904809 A CN 101904809A
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Abstract
The invention discloses a skin whitening composition which comprises a white mulberry root-bark extract, a chamomile extract, a rhodiola rosea extract, a grape seed extract, a licorice extract, a morus australis extract, arbutin, kojic acid dipalmitate, nicotinamide, tetrahydrodiferuloylmethane, a moisturizer and a preservative. The effective skin whitening ingredients of the skin whitening composition can inhibit the activity of tyrosinase, can block the transportation of melanin and can inhibit the formation of melanin; the skin whitening composition can be applied to skin whitening cosmetics and is safe and effective.
Description
One, technical field
The present invention relates to skin lightening compositions, have outstanding skin-whitening effect and do not cause the skin lightening compositions of any side effect, comprising various plants extract and synthetic.
Two, background technology:
People more and more pursue healthy pale skin, make that the demand of lightening compositions is more and more big.Skin histology is people's a ground floor protection barrier, and broad sense is divided into three parts: epidermis, corium and subcutaneous tissue.The color of skin mainly is to contain melanic quantity according to Skin Cell, and size determines with distributing.To carry out from two aspects for the skin-whitening problem, the one, intracellular whitening, the 2nd, the whitening of cell.
Whiten for intracellular, we should at first stop melanin synthetic, and are many at the active research of restraint of tyrosinase on the one hand at this.Tryrosinase is a kind of polyphenol enzyme, belongs to redox enzymes, and this enzyme can catalytic tyrosine be oxidized into DOPA and DOPA quinone and generates 5 by dopachrome, and 6-dihydroxy indole carboxylic acid generates melanin.Because this enzyme when catalytic reaction, must have bivalent cupric ion and the participation of oxygen-derived free radicals is arranged, so clear have oxygen-derived free radicals or complex copper ion that tryrosinase is lost activity, can't synthesis of melanin.Activity problems in conjunction with tryrosinase, modern society is mainly from two approach researchs, and the one, the damage type of tryrosinase suppresses, and can directly modify the active site of tryrosinase, the problem of modification makes tryrosinase lose the effect to melanocyte precursor-tyrosine; The 2nd, the non-damage type of tryrosinase suppresses, and by the biosynthesis of restraint of tyrosinase or by being at war with substrate tyrosine, suppresses melanic formation thereby reach.Secondly should stop melanic transmission.Some material can suppress the process that melanin granule shifts to horn cell from melanocyte.At last, should accelerate melanic metabolism.After melanin granule is synthetic; it can be reduced on the one hand; make the oxidation state melanin granule reduction of black become the reproducibility melanin granule of white, secondly, be transferred to melanin granule in the skin corium and mainly be lysosome by cell; by with lysosome in some enzyme have an effect; final catabolism falls, so, but produce lysosomal material by adding irritation cell; shorten the cutin metabolism cycle, thereby accelerate cuticular coming off.
For cell, the cell-melanocyte effect for producing melanin granule suppresses its activity, also can reach the purpose that obvious suppression melanin produces.As suppressing melanocytic growth, propagation all can play the effect that melanin generates that suppresses.
Recently, there is mechanism of action unicity in the prior art, the monistic problem of whitening composition.(early stage disclosed document NO.99-002109 of Korean Patent and NO.97-021273) acts on tryrosinase so that suppress melanic generation as Cortex Mori (Souhakuhi) extract, thereby reaches the effect of whitening.As the obviously active and melanic generation of restraint of tyrosinase of Rhizoma Polygoni Cuspidati extract (NO.CN101357114), remove various free radicals, reach the effect of whitening.Have the effect of the tyrosinase activity of obstruction as Vaccinium bracteatum Thunb. resin alcohols (NO.CN101102744), hinder the melanocyte nucleus formation.Present stage, the model of action of whitening agent remains with the restraint of tyrosinase activity and takes as the leading factor.
At present, use more whitening composition by sources can simply be divided into synthetic class and plant extract class on the market, this two big class whitening composition shows pluses and minuses separately, synthetic constituents general cost is low, low price, better with the compatibility of other compositions, but it is single relatively that shortcoming is the effect aspect, the effect scope is narrow, and plant extract class natural component, safety, himself containing multiple analog structure makes it can a plurality of angles, number of ways is brought into play its function, plays good cooperative effect, will surpass synthetic constituents far away but its shortcoming is cost.
Three, summary of the invention:
At the problem that prior art exists, the invention provides a kind ofly according to the different mechanism of action, the multiple component of whitening will reach the lightening compositions of optimal balance point between cost and the effect.
For achieving the above object, a kind of lightening compositions of the present invention.Comprising: contain plant extract class (A component) by composition total weight percent: Cortex Mori extract 7-10%, camomile extract 7-10%, Radix Rhodiolae extract 8-10%, Semen Vitis viniferae extract 8-10%, Radix Glycyrrhizae extract 7-10%, chicken Mulberry extract 3-5%; Synthetic class (B component): contain arbutin 7-10%, Kojic Acid Dipalmitate 3-5%, nicotiamide 2-3%, tetrahydrocurcumin 1-2%; The polyhydric alcohol solutions of C component 46.6-24.6% and D component antiseptic methyl hydroxybenzoate 0.2% and Jie Ma 0.2%.
Further, described A component is that chicken Mulberry extract, Cortex Mori extract, Radix Glycyrrhizae extract, camomile extract, Radix Rhodiolae extract and Semen Vitis viniferae extract are for extracting the class whitening composition.
Further, described B component is that arbutin, Kojic Acid Dipalmitate, nicotiamide and tetrahydrocurcumin are synthetic class whitening composition.
Further, described C component is the polyhydric alcohol 1,3 butylene glycol.
Further, described D component is antiseptic methyl hydroxybenzoate and Jie Ma.
A kind of preparation method of as the above-mentioned component of whitening: 1) with in the C component 1, when the 3-butanediol is heated to 50 ℃-60 ℃, B component Kojic Acid Dipalmitate uniform dissolution is complete, after adding D component antiseptic methyl hydroxybenzoate uniform dissolution is complete, when solution is reduced to 30 ℃, add other composition arbutin in the B component successively, nicotiamide, the tetrahydrocurcumin uniform dissolution is complete, with A component Cortex Mori extract, camomile extract (endothelin antagonist), Radix Rhodiolae extract, Semen Vitis viniferae extract, after Radix Glycyrrhizae extract and chicken Mulberry extract add successively, stir, add the prompt horse of D component antiseptic and evenly stir fully, get final product discharging.
The present invention is a kind of lightening compositions, wherein add plant extract and synthetic constituents is composite forms, have type speckles such as desalination melanin deposition, black speck, sunburn, can also dispel obscure pigment rapidly, increase skin brilliant white elasticity, in addition, have good antioxidation, can decompose melanin, skin whitening, the prevention mottle forms, and increases skin to ultraviolet resistivity, improves the effect of whitening composition to skin greatly.Plant extract constituents and the combined effect of synthetic constituents compatibility make whitening composition easier of skin absorbs, and reaching increases the effect of whitening.
Plant extract class chicken Mulberry extract in the lightening compositions of the present invention, Cortex Mori extract and Kojic Acid Dipalmitate can be directly to tryrosinase modify, modification, make it to lose effect, suppress the purpose that melanin forms thereby reach to melanin precursor tyrosine;
Synthetic class arbutin in the lightening compositions of the present invention is to utilize tyrosine analog and tyrosine competition tryrosinase, effectively suppresses melanin and forms.
Plant extract class Radix Glycyrrhizae extract in the lightening compositions of the present invention, to the synthetic middle active inhibition of dopachrome tautomerase of participation melanin with to 5, the obstruction of 6-dihydroxy indole polymer.
Synthetic class nicotiamide can suppress the formation of melanin granule in the lightening compositions of the present invention, effectively suppress melanin to the horn cell transmission, promote to contain melanic cell detachment by the renewal speed of quickening Skin Cell, improve the effect of skin matter, clean white muscle skin from inside to outside.
After plant extract class camomile extract (endothelin antagonist) can suppress Endothelin competitively and the melanocyte membrane receptor combines in the lightening compositions of the present invention, suppress the purpose that melanocyte is bred and melanin generates that ultraviolet radiation causes thereby reach, evenly the colour of skin reaches whitening effect.
Therefore, be devoted to provide the multiple mechanism of action among the present invention in one aspect, the skin lightening compositions of multiple whitening composition.
Four, specific implementation method:
Embodiment 1:
Lightening compositions of the present invention, comprise A component, B component, C component and D component, wherein contain: A component Cortex Mori extract 10% by composition total weight percent, camomile extract (endothelium antagonist) 10%, Radix Rhodiolae extract 10%, Semen Vitis viniferae extract 10%, Radix Glycyrrhizae extract 8%, chicken Mulberry extract 5%; B component: arbutin 9%, Kojic Acid Dipalmitate 5%, nicotiamide 3%, tetrahydrocurcumin 2%; The prompt horse 0.2% of the 1,3 butylene glycol solution of C component 27.6% and D component antiseptic, methyl hydroxybenzoate 0.2%.
The present invention adopts chicken Mulberry extract, Cortex Mori extract and Kojic Acid Dipalmitate can be directly to tryrosinase modify, modification, make it to lose effect to melanin precursor tyrosine, suppress the purpose that melanin forms thereby reach; Arbutin utilizes tyrosine analog and tyrosine competition tryrosinase, effectively suppresses melanin and forms; Radix Glycyrrhizae extract, to the synthetic middle active inhibition of dopachrome tautomerase of participation melanin with to 5, the obstruction of 6-dihydroxy indole polymer; Nicotiamide can suppress the formation of melanin granule, effectively suppresses melanin to the horn cell transmission, promotes to contain melanic cell detachment by the renewal speed of quickening Skin Cell, improves the effect of skin matter, clean white muscle skin from inside to outside; After camomile extract (interior degree element is picked up anti-agent) can suppress Endothelin competitively and the melanocyte membrane receptor combines, suppress the purpose that melanocyte is bred and melanin generates that ultraviolet radiation causes thereby reach, evenly the colour of skin reaches whitening effect; Radix Rhodiolae extract and Semen Vitis viniferae extract have extremely strong antioxidation, can prevent the effect to skin injury that free radical produced of ultraviolet induction.
Experiment showed, that this compositions has good whitening effect, can be added in the class cosmetics of whitening that dissolubility, compatibility are fine, easy operating.
Embodiment 2:
Lightening compositions of the present invention, comprise A component, B component, C component and D component, wherein contain: A component Cortex Mori extract 7% by composition total weight percent, camomile extract (endothelium antagonist) 7%, Radix Rhodiolae extract 8%, Semen Vitis viniferae extract 8%, Radix Glycyrrhizae extract 7%, chicken Mulberry extract 3%; B component: arbutin 7%, Kojic Acid Dipalmitate 3%, nicotiamide 2%, tetrahydrocurcumin 1%; The prompt horse 0.2% of C component 1,3 butylene glycol 46.6% and D component antiseptic, methyl hydroxybenzoate 0.2%.
Embodiment 3:
Lightening compositions of the present invention, comprise A component, B component, C component and D component, wherein contain: A component Cortex Mori extract 8.5% by composition total weight percent, camomile extract (endothelium antagonist) 8.5%, Radix Rhodiolae extract 8.5%, Semen Vitis viniferae extract 8.5%, Radix Glycyrrhizae extract 10%, chicken Mulberry extract 4%; B component: arbutin 8%, Kojic Acid Dipalmitate 4%, nicotiamide 2.5%, tetrahydrocurcumin 1.5%; The prompt horse 0.2% of C component 1,3 butylene glycol 35.6% and D component antiseptic, methyl hydroxybenzoate 0.2%.
The whiten preparation method of component of the present invention, concrete steps: 1) with in the C component 1, when the 3-butanediol is heated to 50 ℃-60 ℃, Kojic Acid Dipalmitate uniform dissolution in the B component is complete, after adding D component antiseptic methyl hydroxybenzoate uniform dissolution is complete, when reducing to solution to 30 ℃, add B component arbutin successively, nicotiamide, the tetrahydrocurcumin uniform dissolution is complete, with A component Cortex Mori extract, and camomile extract (endothelin antagonist), Radix Rhodiolae extract, Semen Vitis viniferae extract after Radix Glycyrrhizae extract and chicken Mulberry extract add successively, stirs, add the prompt horse of D component antiseptic and evenly stir fully, get final product discharging.
Claims (8)
1. lightening compositions, the mixture that comprises plant extract class and synthetic class is as effective ingredient.
2. according to the described lightening compositions of claim 1, comprise: contain plant extract class (A component) by composition total weight percent: Cortex Mori extract 7-10%, camomile extract 7-10%, Radix Rhodiolae extract 8-10%, Semen Vitis viniferae extract 8-10%, Radix Glycyrrhizae extract 7-10%, chicken Mulberry extract 3-5%; Synthetic class (B component): contain arbutin 7-10%, Kojic Acid Dipalmitate 3-5%, nicotiamide 2-3%, tetrahydrocurcumin 1-2%; The polyhydric alcohol solutions of C component 46.6-24.6% and D component antiseptic methyl hydroxybenzoate 0.2% and Jie Ma 0.2%.
3. according to the described lightening compositions of claim 2, it is characterized in that plant extract class melanin inhibitor is chicken Mulberry extract, Cortex Mori extract, Radix Glycyrrhizae extract.
4. according to the described lightening compositions of claim 2, it is characterized in that synthetic class melanin inhibitor is selected from arbutin, Kojic Acid Dipalmitate, tetrahydrocurcumin.
5. according to the described lightening compositions of claim 2, it is characterized in that the skin exfoliation agent that the synthetic class is quickened skin cell renewal is selected from nicotiamide.
6. according to the described lightening compositions of claim 2, it is characterized in that plant extract class endothelin antagonist is selected from camomile extract.
7. according to the described lightening compositions of claim 2, it is characterized in that plant extract class antioxidant is selected from Radix Rhodiolae extract and Semen Vitis viniferae; The synthetic kind antioxidant is selected from tetrahydrocurcumin.
8. according to the described lightening compositions of claim 2, after the wherein said lightening compositions preparation, add in the skin-lightening cosmetic, be used to the human body skin of whitening.
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| CN2010102148734A CN101904809B (en) | 2010-07-01 | 2010-07-01 | Skin whitening composition |
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| CN2010102148734A CN101904809B (en) | 2010-07-01 | 2010-07-01 | Skin whitening composition |
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| CN101904809A true CN101904809A (en) | 2010-12-08 |
| CN101904809B CN101904809B (en) | 2012-02-15 |
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Cited By (21)
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| CN102772337A (en) * | 2012-08-17 | 2012-11-14 | 珀莱雅(湖州)化妆品有限公司 | Preparation method of composite whitening lipid nanoparticle emulsion |
| CN102871898A (en) * | 2012-09-05 | 2013-01-16 | 福建泉州恒泉化妆品有限公司 | Yellowness-improving and lightening and whitening lotion product and preparation method |
| CN102961296A (en) * | 2012-12-19 | 2013-03-13 | 成都山信药业有限公司 | Composition with skin whitening function and application of composition |
| CN103340785A (en) * | 2013-07-05 | 2013-10-09 | 上海珍馨化工科技有限公司 | Chamomile toning lotion |
| CN103932954A (en) * | 2014-05-21 | 2014-07-23 | 张贺 | Cosmetic for whitening and tendering skin and fining pores and preparation method thereof |
| CN103989590A (en) * | 2014-04-30 | 2014-08-20 | 吴雪琴 | Arbutin herbal essence preparation method and product thereof |
| CN104027293A (en) * | 2014-06-27 | 2014-09-10 | 王忠良 | Whitening cosmetic and preparation method thereof |
| CN104523484A (en) * | 2014-12-10 | 2015-04-22 | 唯美度科技（北京）有限公司 | Whitening and balancing eye cream with mild formula |
| CN104771353A (en) * | 2015-05-08 | 2015-07-15 | 山东友励商贸有限责任公司 | Cream used for deep cleaning and caring of face skin |
| CN105943433A (en) * | 2016-05-11 | 2016-09-21 | 杭州西顿生物科技有限公司 | Skin-whitening composition as well as preparation method and applications thereof |
| CN106236671A (en) * | 2016-08-31 | 2016-12-21 | 祖亚宾 | Freckle whitening makeup and preparation method thereof |
| CN106860209A (en) * | 2017-01-17 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment whitening emulsion |
| CN107496319A (en) * | 2017-08-04 | 2017-12-22 | 兰新全 | Moisturizing whitening is releived essence lotion and preparation method thereof |
| CN107982196A (en) * | 2017-12-30 | 2018-05-04 | 广州市中通生化制品有限公司 | A kind of composition with white-skinned face function and preparation method and application |
| CN109464366A (en) * | 2019-01-02 | 2019-03-15 | 吉林大学 | A kind of composition and its preparation method and application for removing skin splash |
| CN111617025A (en) * | 2020-06-12 | 2020-09-04 | 洋浦吉商生物科技有限公司 | Fermentation product cosmetic for whitening, removing freckles and resisting saccharification |
| CN112022766A (en) * | 2020-09-15 | 2020-12-04 | 广州科盈化妆品有限公司 | Whitening and acne removing composition and preparation method and application thereof |
| CN112386552A (en) * | 2020-12-08 | 2021-02-23 | 广州名妆化妆品制造有限公司 | Preparation method of compound freckle-removing and whitening composition |
| CN113041177A (en) * | 2019-12-27 | 2021-06-29 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, eye essence containing the same and preparation method thereof |
| US11311593B2 (en) * | 2017-10-06 | 2022-04-26 | Plant Advanced Technologies Pat | Root extracts from plants of the Morus genus and uses of same |
| CN116370378A (en) * | 2023-03-31 | 2023-07-04 | 广东诗漾医疗科技有限公司 | Licorice root extract skin care product composition and preparation method thereof |
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| CN102772337B (en) * | 2012-08-17 | 2013-06-26 | 珀莱雅化妆品股份有限公司 | Preparation method of composite whitening lipid nanoparticle emulsion |
| CN102772337A (en) * | 2012-08-17 | 2012-11-14 | 珀莱雅(湖州)化妆品有限公司 | Preparation method of composite whitening lipid nanoparticle emulsion |
| CN102871898A (en) * | 2012-09-05 | 2013-01-16 | 福建泉州恒泉化妆品有限公司 | Yellowness-improving and lightening and whitening lotion product and preparation method |
| CN102961296A (en) * | 2012-12-19 | 2013-03-13 | 成都山信药业有限公司 | Composition with skin whitening function and application of composition |
| CN102961296B (en) * | 2012-12-19 | 2014-06-11 | 成都山信药业有限公司 | Composition with skin whitening function and application of composition |
| CN103340785A (en) * | 2013-07-05 | 2013-10-09 | 上海珍馨化工科技有限公司 | Chamomile toning lotion |
| CN103989590B (en) * | 2014-04-30 | 2016-05-25 | 吴雪琴 | Preparation method and the goods of Arbutin herbal essences liquid |
| CN103989590A (en) * | 2014-04-30 | 2014-08-20 | 吴雪琴 | Arbutin herbal essence preparation method and product thereof |
| CN103932954A (en) * | 2014-05-21 | 2014-07-23 | 张贺 | Cosmetic for whitening and tendering skin and fining pores and preparation method thereof |
| CN104027293A (en) * | 2014-06-27 | 2014-09-10 | 王忠良 | Whitening cosmetic and preparation method thereof |
| CN104027293B (en) * | 2014-06-27 | 2018-07-13 | 高宝化妆品（中国）有限公司 | A kind of skin-lightening cosmetic and preparation method thereof |
| CN104523484A (en) * | 2014-12-10 | 2015-04-22 | 唯美度科技（北京）有限公司 | Whitening and balancing eye cream with mild formula |
| CN104771353A (en) * | 2015-05-08 | 2015-07-15 | 山东友励商贸有限责任公司 | Cream used for deep cleaning and caring of face skin |
| CN104771353B (en) * | 2015-05-08 | 2017-10-17 | 山东友励商贸有限责任公司 | It is a kind of to be used for the solidifying frost of skin of face deep layer cleaning and nursing |
| CN105943433A (en) * | 2016-05-11 | 2016-09-21 | 杭州西顿生物科技有限公司 | Skin-whitening composition as well as preparation method and applications thereof |
| CN106236671A (en) * | 2016-08-31 | 2016-12-21 | 祖亚宾 | Freckle whitening makeup and preparation method thereof |
| CN106860209A (en) * | 2017-01-17 | 2017-06-20 | 长沙协浩吉生物工程有限公司 | A kind of compound method of ferment whitening emulsion |
| CN107496319A (en) * | 2017-08-04 | 2017-12-22 | 兰新全 | Moisturizing whitening is releived essence lotion and preparation method thereof |
| US11311593B2 (en) * | 2017-10-06 | 2022-04-26 | Plant Advanced Technologies Pat | Root extracts from plants of the Morus genus and uses of same |
| CN107982196A (en) * | 2017-12-30 | 2018-05-04 | 广州市中通生化制品有限公司 | A kind of composition with white-skinned face function and preparation method and application |
| CN109464366A (en) * | 2019-01-02 | 2019-03-15 | 吉林大学 | A kind of composition and its preparation method and application for removing skin splash |
| CN113041177A (en) * | 2019-12-27 | 2021-06-29 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, eye essence containing the same and preparation method thereof |
| CN113041177B (en) * | 2019-12-27 | 2023-10-27 | 广州市科能化妆品科研有限公司 | Collagenase inhibitor, eye essence containing collagenase inhibitor and preparation method of eye essence |
| CN111617025A (en) * | 2020-06-12 | 2020-09-04 | 洋浦吉商生物科技有限公司 | Fermentation product cosmetic for whitening, removing freckles and resisting saccharification |
| CN112022766A (en) * | 2020-09-15 | 2020-12-04 | 广州科盈化妆品有限公司 | Whitening and acne removing composition and preparation method and application thereof |
| CN112386552A (en) * | 2020-12-08 | 2021-02-23 | 广州名妆化妆品制造有限公司 | Preparation method of compound freckle-removing and whitening composition |
| CN116370378A (en) * | 2023-03-31 | 2023-07-04 | 广东诗漾医疗科技有限公司 | Licorice root extract skin care product composition and preparation method thereof |
| CN116370378B (en) * | 2023-03-31 | 2023-10-13 | 广东诗漾医疗科技有限公司 | Licorice root extract skin care product composition and preparation method thereof |
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