CN112022766A - Whitening and acne removing composition and preparation method and application thereof - Google Patents
Whitening and acne removing composition and preparation method and application thereof Download PDFInfo
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- CN112022766A CN112022766A CN202010968870.3A CN202010968870A CN112022766A CN 112022766 A CN112022766 A CN 112022766A CN 202010968870 A CN202010968870 A CN 202010968870A CN 112022766 A CN112022766 A CN 112022766A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention discloses a whitening and acne removing composition which is prepared from the following raw materials in parts by weight: 1-3 parts of nicotinamide, 1-4 parts of cinnamic acid, 0.5-2 parts of glycyrrhiza glabra extract, 0.5-2 parts of pseudo-ginseng extract, 0.5-2 parts of acanthopanax trifoliatus extract, 0.1-0.5 part of magnesium ascorbyl phosphate, 0.8-2.5 parts of transdermal absorption enhancer, 4-8 parts of solubilizer and 55-70 parts of deionized water. The whitening and acne-removing composition disclosed by the invention has a good whitening effect, can obviously inhibit the activity of tyrosinase and inhibit the formation of melanin; the whitening cream acts in multiple directions such as the formation of melanin, the transfer of melanin and the decomposition and elimination of melanin, so that the synergistic whitening effect is achieved; the whitening acne-removing composition has a good acne-removing effect; the trifoliate acanthopanax extract is obtained by water extraction, and can effectively inhibit the activity of tyrosinase, thereby achieving the whitening effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a whitening and acne-removing composition as well as a preparation method and application thereof.
Background
With the improvement of living standard and the improvement of the external image attention of people, and the most demand for whitening in the traditional thought, the development of cosmetic products such as whitening and skin care is excited, the skin care and whitening products are not only rich in people but also can be used by common people, and the people now have gone into the family. Acne, commonly known as whelk, comedo and pimple, is a chronic inflammatory lesion of hair follicle and sebaceous gland related to sebum metabolism, and is frequently generated in abundant sebaceous glands of the head, face, neck, chest and back. Acne can last for many years, and the scars produced by acne not only affect the appearance of the patient, but also further have a serious negative impact on the mind of the patient.
Skin color is determined by the amount and distribution position of melanin in the skin, and it is basically considered that the synthesis of melanin proceeds as follows, in which dopaquinone is produced from intracellular tyrosine as a substrate by tyrosinase, and is further oxidized to 5, 6-dihydroxyindole and 5, 6-dihydroxy-2-hydroxy acid after changing from dopaquinone to dopachrome, and these products are polymerized to finally produce melanin as a polymer. The skin melanocyte tissue transfers melanin into epidermal basal layer cells, is carried into stratum corneum along with the metabolism of the cells, and finally is shed along with the keratinized cells. If the skin melanin grows too fast and is distributed unevenly, local skin hypermelanism and pigmentation can be caused, and the skin melanin appears. At present, the whitening products on the market have different quality, the whitening and acne removing effects need to be further improved, and the overall design of the formula is poor.
Disclosure of Invention
The invention provides a whitening acne-removing composition and a preparation method and application thereof.
The invention adopts the following technical scheme for solving the technical problems:
a whitening and acne removing composition is prepared from the following raw materials in parts by weight: 1-3 parts of nicotinamide, 1-4 parts of cinnamic acid, 0.5-2 parts of glycyrrhiza glabra extract, 0.5-2 parts of pseudo-ginseng extract, 0.5-2 parts of acanthopanax trifoliatus extract, 0.1-0.5 part of magnesium ascorbyl phosphate, 0.8-2.5 parts of transdermal absorption enhancer, 4-8 parts of solubilizer and 55-70 parts of deionized water.
The whitening composition is whitened by using five active ingredients, namely nicotinamide, cinnamic acid, glycyrrhiza glabra extract, acanthopanax trifoliatus extract and magnesium ascorbyl phosphate, can effectively inhibit the formation of tyrosinase, reduce the activity of the tyrosinase, prevent the combination of a substrate and the tyrosinase, block the polymerization of dihydroxyindole into melanin, accelerate the renewal speed of skin cells to promote the cell shedding of the melanin, and inhibit the transfer of melanin particles to keratinocytes from multiple dimensions and multiple directions to achieve the whitening effect, and acts from the formation of the melanin, the transfer of the melanin to the decomposition and removal of the melanin, so that the synergistic whitening effect is achieved; the applicant unexpectedly found that the composition also has a certain acne removing effect in a whitening experiment.
As a preferable scheme, the whitening and acne-removing composition is prepared from the following raw materials in parts by weight: 1-2.5 parts of nicotinamide, 1.5-4 parts of cinnamic acid, 0.5-1.8 parts of glycyrrhiza glabra extract, 0.5-1.5 parts of pseudo-ginseng extract, 0.5-1.5 parts of acanthopanax trifoliatus extract, 0.1-0.4 part of magnesium ascorbyl phosphate, 0.8-2 parts of transdermal absorption enhancer, 4-7 parts of solubilizer and 60-70 parts of deionized water.
As a most preferred scheme, the whitening and acne-removing composition is prepared from the following raw materials in parts by weight: 1.5 parts of nicotinamide, 3 parts of cinnamic acid, 1.2 parts of glycyrrhiza glabra extract, 0.8 part of pseudo-ginseng extract, 0.8 part of acanthopanax trifoliatus extract, 0.2 part of magnesium ascorbyl phosphate, 1.5 parts of transdermal absorption enhancer, 6 parts of solubilizer and 65 parts of deionized water.
As a preferable scheme, the transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 4-8: 20-30 by mixing.
As a most preferred scheme, the transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 5: 24 are mixed together.
As a preferred scheme, the solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to the weight ratio of 1: 4-8, and mixing.
As a most preferred solution, the solubilizer is prepared from polyoxyethylated castor oil, decyl glucoside, in a weight ratio of 1: 5, mixing the components.
As a preferred scheme, the preparation method of the acanthopanax trifoliatus extract comprises the following steps: cleaning and drying the trifoliate acanthopanax stems, grinding the trifoliate acanthopanax stems to 60-90 meshes to obtain trifoliate acanthopanax powder, putting 10-20 parts of trifoliate acanthopanax powder into a round-bottom flask, adding 100-150 parts of deionized water, refluxing for 2-4 h at 80 ℃, filtering, and drying in vacuum to constant weight to obtain the trifoliate acanthopanax extract; the parts are parts by weight.
The trifoliate acanthopanax extract is obtained by extracting trifoliate acanthopanax with water, contains non-alcohol-soluble substances such as polysaccharide, protein and the like, is a whitening active ingredient of the trifoliate acanthopanax, and can effectively inhibit the activity of tyrosinase, thereby achieving the whitening effect.
The invention also provides a preparation method of the whitening and acne removing composition, which comprises the following steps:
(1) adding cinnamic acid, nicotinamide and a solubilizer into deionized water, heating to 85-95 ℃, and uniformly stirring;
(2) cooling to 40-48 ℃, adding the glycyrrhiza glabra extract, the pseudo-ginseng extract, the acanthopanax trifoliatus extract, magnesium ascorbyl phosphate and the transdermal absorption enhancer, and uniformly stirring to obtain the whitening and acne-removing composition.
The invention also provides application of the prepared whitening acne-removing composition in preparation of whitening acne-removing cosmetics, wherein the addition amount of the whitening acne-removing composition is 1-5%.
Nicotinamide: in the traditional safe whitening agent, the nicotinamide can inhibit the transfer of melanin granules to keratinocytes, and the action mechanism of the nicotinamide is as follows: by inhibiting the formation of melanin granules; effectively inhibiting the transfer of melanin to keratinocytes; accelerating the renewal speed of skin cells and promoting the shedding of melanin-containing cells.
Cinnamic acid: is a tyrosinase inhibitor, and can effectively inhibit the formation of tyrosinase.
Glycyrrhiza glabra extract: the Glycyrrhiza glabra extract can reduce the activity of tyrosinase through competitive inhibition, take away a part of tyrosinase from a catalytic loop for melanin synthesis, prevent the combination of a substrate and the tyrosinase, and inhibit the synthesis of melanin.
Radix seu folium Acanthopanax trifoliatus extract: the trifoliate acanthopanax extract extracted by the invention is an trifoliate acanthopanax aqueous extract, and can effectively inhibit the activity of tyrosinase, thereby achieving the whitening effect.
Magnesium ascorbyl phosphate: can reduce melanin to form intermediates, and block dihydroxyindole from polymerizing into melanin.
The solubilizer can increase the solubility of nicotinamide and cinnamic acid.
The skin penetration enhancer can promote penetration and absorption of active substances on skin.
The invention has the beneficial effects that: (1) the whitening and acne-removing composition disclosed by the invention has a good whitening effect, can obviously inhibit the activity of tyrosinase and inhibit the formation of melanin; the whitening cream acts in multiple directions such as the formation of melanin, the transfer of melanin and the decomposition and elimination of melanin, so that the synergistic whitening effect is achieved; (2) the whitening acne-removing composition disclosed by the invention has a good acne-removing effect; (3) the trifoliate acanthopanax extract is obtained by extracting with water, and can effectively inhibit the activity of tyrosinase, thereby achieving the whitening effect.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are a part of the embodiments of the present invention, but not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The raw materials of the invention are all available on the market.
Example 1
The whitening acne-removing composition is prepared from the following raw materials in parts by weight: 1.5 parts of nicotinamide, 3 parts of cinnamic acid, 1.2 parts of glycyrrhiza glabra extract, 0.8 part of pseudo-ginseng extract, 0.8 part of acanthopanax trifoliatus extract, 0.2 part of magnesium ascorbyl phosphate, 1.5 parts of transdermal absorption enhancer, 6 parts of solubilizer and 65 parts of deionized water.
The transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 5: 24 are mixed together.
The solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to a weight ratio of 1: 5, mixing the components.
The preparation method of the acanthopanax trifoliatus extract comprises the following steps: cleaning, drying and grinding to 80 meshes to obtain trifoliate acanthopanax stems, putting 15 parts of trifoliate acanthopanax stems into a round-bottom flask, adding 120 parts of deionized water, refluxing for 2.5 hours at 80 ℃, filtering, and drying in vacuum to constant weight to obtain trifoliate acanthopanax extracts; the parts are parts by weight.
The preparation method of the whitening and acne-removing composition comprises the following steps:
(1) adding cinnamic acid, nicotinamide and a solubilizer into deionized water, heating to 92 ℃, and uniformly stirring;
(2) cooling to 45 ℃, adding the glycyrrhiza glabra extract, the pseudo-ginseng extract, the ilicifolius trifoliate extract, the magnesium ascorbyl phosphate and the transdermal absorption enhancer, and uniformly stirring to obtain the whitening acne-removing composition.
Example 2
A whitening and acne removing composition is prepared from the following raw materials in parts by weight: 1 part of nicotinamide, 1 part of cinnamic acid, 0.5 part of glycyrrhiza glabra extract, 0.5 part of pseudo-ginseng extract, 0.5 part of acanthopanax trifoliatus extract, 0.1 part of magnesium ascorbyl phosphate, 0.8 part of transdermal absorption enhancer, 4 parts of solubilizer and 55 parts of deionized water.
The transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 5: 24 are mixed together.
The solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to a weight ratio of 1: 5, mixing the components.
The preparation method of the acanthopanax trifoliatus extract comprises the following steps: cleaning, drying and grinding to 80 meshes to obtain trifoliate acanthopanax stems, putting 15 parts of trifoliate acanthopanax stems into a round-bottom flask, adding 120 parts of deionized water, refluxing for 2.5 hours at 80 ℃, filtering, and drying in vacuum to constant weight to obtain trifoliate acanthopanax extracts; the parts are parts by weight.
The preparation method of the whitening and acne-removing composition comprises the following steps:
(1) adding cinnamic acid, nicotinamide and a solubilizer into deionized water, heating to 92 ℃, and uniformly stirring;
(2) cooling to 45 ℃, adding the glycyrrhiza glabra extract, the pseudo-ginseng extract, the ilicifolius trifoliate extract, the magnesium ascorbyl phosphate and the transdermal absorption enhancer, and uniformly stirring to obtain the whitening acne-removing composition.
Example 3
A whitening and acne removing composition is prepared from the following raw materials in parts by weight: 3 parts of nicotinamide, 4 parts of cinnamic acid, 2 parts of glycyrrhiza glabra extract, 2 parts of pseudo-ginseng extract, 2 parts of acanthopanax trifoliatus extract, 0.5 part of magnesium ascorbyl phosphate, 2.5 parts of transdermal absorption enhancer, 8 parts of solubilizer and 70 parts of deionized water.
The transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 5: 24 are mixed together.
The solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to a weight ratio of 1: 5, mixing the components.
The preparation method of the acanthopanax trifoliatus extract comprises the following steps: cleaning, drying and grinding to 80 meshes to obtain trifoliate acanthopanax stems, putting 15 parts of trifoliate acanthopanax stems into a round-bottom flask, adding 120 parts of deionized water, refluxing for 2.5 hours at 80 ℃, filtering, and drying in vacuum to constant weight to obtain trifoliate acanthopanax extracts; the parts are parts by weight.
The preparation method of the whitening and acne-removing composition comprises the following steps:
(1) adding cinnamic acid, nicotinamide and a solubilizer into deionized water, heating to 92 ℃, and uniformly stirring;
(2) cooling to 45 ℃, adding the glycyrrhiza glabra extract, the pseudo-ginseng extract, the ilicifolius trifoliate extract, the magnesium ascorbyl phosphate and the transdermal absorption enhancer, and uniformly stirring to obtain the whitening acne-removing composition.
Example 4
The whitening and acne-removing composition is characterized by being prepared from the following raw materials in parts by weight: 2 parts of nicotinamide, 2 parts of cinnamic acid, 1 part of glycyrrhiza glabra extract, 1 part of pseudo-ginseng extract, 0.8 part of acanthopanax trifoliatus extract, 0.3 part of magnesium ascorbyl phosphate, 1.2 parts of transdermal absorption enhancer, 5 parts of solubilizer and 60 parts of deionized water.
The transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 5: 24 are mixed together.
The solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to a weight ratio of 1: 5, mixing the components.
The preparation method of the acanthopanax trifoliatus extract comprises the following steps: cleaning, drying and grinding to 80 meshes to obtain trifoliate acanthopanax stems, putting 15 parts of trifoliate acanthopanax stems into a round-bottom flask, adding 120 parts of deionized water, refluxing for 2.5 hours at 80 ℃, filtering, and drying in vacuum to constant weight to obtain trifoliate acanthopanax extracts; the parts are parts by weight.
The preparation method of the whitening and acne-removing composition comprises the following steps:
(1) adding cinnamic acid, nicotinamide and a solubilizer into deionized water, heating to 92 ℃, and uniformly stirring;
(2) cooling to 45 ℃, adding the glycyrrhiza glabra extract, the pseudo-ginseng extract, the ilicifolius trifoliate extract, the magnesium ascorbyl phosphate and the transdermal absorption enhancer, and uniformly stirring to obtain the whitening acne-removing composition.
Comparative example 1
Comparative example 1 differs from example 1 in that comparative example 1 does not contain niacinamide, all else being the same.
Comparative example 2
Comparative example 2 differs from example 1 in that comparative example 2 does not contain cinnamic acid and is otherwise identical.
Comparative example 3
Comparative example 3 differs from example 1 in that comparative example 3 does not contain glycyrrhiza glabra extract, and the other is the same.
Comparative example 4
Comparative example 4 differs from example 1 in that comparative example 4 does not contain magnesium ascorbyl phosphate, and the other things are the same.
Comparative example 5
Comparative example 5 differs from example 1 in that comparative example 5 does not contain the ilicifolius extract, and the other things are the same.
Comparative example 6
Comparative example 6 is different from example 1 in that the preparation method of the acanthopanax trifoliatus extract in the comparative example 6 is different from that in example 1, and the rest is the same.
The preparation method of the acanthopanax trifoliatus extract comprises the following steps: cleaning, drying and grinding to 80 meshes to obtain trifoliate acanthopanax stems, putting 15 parts of trifoliate acanthopanax stems into a round-bottom flask, adding 120 parts of 70% ethanol, refluxing for 2.5 hours at 80 ℃, filtering, and drying in vacuum to constant weight to obtain trifoliate acanthopanax extracts; the parts are parts by weight.
To further demonstrate the effect of the present invention, the following test methods were provided:
reagents and instruments used for the whitening test: RPMI1640 (Gibco Corp.); calf serum (FCS, Hangzhou Sijiqing Co.); lactate dehydrogenase kit (Nanjing construction Co.); b16 cells (new drug center of the university of chinese pharmacy); BBHF-16CO2 incubator (Shanghai Li Shen Co.); TDL80-2B centrifuge (Shanghai' an pavilion scientific instruments factory); 96-well culture plates (Corning Corp.); DG5031 enzyme linked immunosorbent assay device (east China tube works), other raw materials are common in the market and are not described.
1. Tyrosinase inhibition: adding 500 mu L of 0.1M potassium phosphate solution into 0.3mg/ml tyrosine solution, adding 450 mu L of the test substance of the whitening and acne-removing composition described in examples 1-4 and comparative examples 1-6, uniformly mixing in a test tube, and keeping the temperature at 37 ℃; adding 50 μ L tyrosinase solution (concentration of 1540 unit/ml), and culturing at 37 deg.C for 10 min; the absorbance at 480nm was measured with a UV-VIS spectrophotometer. Tyrosinase inhibition was calculated according to the following formula: inhibition = [ (a-B)/a ] × l 00% wherein "a" is the absorbance of the standard control and "B" is the absorbance of the test solution (or positive control). The results are shown in table 1, and the average value was calculated for each set of three tests.
2. Effect of different materials on inhibition of melanogenesis:
the test method comprises the following steps: selectingSelecting the same generation of cells in logarithmic growth phase, blowing and beating the cells into single cell suspension after conventional pancreatin digestion treatment, counting and quantitatively inoculating the cells into a 96-well plate. After 24 hours, the supernatant was discarded, and the whitening and acne removing compositions (1%) described in examples 1 to 4 and comparative examples 1 to 6 were added, respectively. At 37 deg., 5% volume fraction CO2Culturing under saturated wet condition, adding RPMI1640 culture solution into control well, culturing for three days, and replacing culture solution once in the middle. Discarding the supernatant, counting the cell density after the conventional pancreatin digestion treatment, centrifuging to obtain cell sediment, washing twice with PBS, centrifuging to discard the supernatant, quantitatively adding a 1N NaOH solution containing 10% DMSO, carrying out 80-degree water bath for 50 minutes, and then measuring the light absorption value at 450nm of an enzyme labeling instrument. The melanin production inhibition (%) was 100 (absorbance of each test material/absorbance of the control group), and the specific results are shown in table 1.
TABLE 1 measurement results of tyrosinase and melanin inhibition
As can be seen from table 1, the whitening and acne-removing composition has good tyrosinase and melanin inhibition rates; compared with the examples 1-4, the different proportions of the whitening and acne-removing composition can affect the inhibition rates of tyrosinase and melanin; comparing example 1 with comparative example 1, it can be seen that the nicotinamide does not affect the activity of tyrosinase, but can inhibit the transfer of melanin granules to keratinocytes, and has a good melanin inhibition rate; comparing example 1 with comparative example 2, it can be seen that cinnamic acid can significantly affect tyrosinase and melanin inhibition rates; comparing example 1 with comparative example 3, it can be seen that the glycyrrhiza glabra extract can significantly affect the tyrosinase and melanin inhibition rates; comparing example 1 with comparative example 4, it can be seen that magnesium ascorbyl phosphate can affect the melanin inhibition rate; comparing example 1 with comparative examples 5 and 6, it can be known that the trifoliate acanthopanax extract can significantly affect tyrosinase and melanin inhibition rates; for the preparation method of the trifoliate acanthopanax extract, only the aqueous extract of the trifoliate acanthopanax extract can obviously influence the tyrosinase and melanin inhibition rate, but the alcoholic extract of the trifoliate acanthopanax extract does not have the effect, and the experiments provide scientific theoretical basis for the invention.
3. Example 1 acne treatment efficacy test: the subjects applied the whitening and acne-removing composition observation test described in example 1. Trial objects: the composition is applied to 20-25-year-old face acne-growing people (20 people) once a day for 14 days on continuous trial, other products with acne removing effects are not used in the period, the diet is spicy, and after 14 days, the test result shows that: the composition has the effects of 4 persons, 10 persons and 6 persons, and the effective rate is 70%, which indicates that the whitening acne-removing composition in the embodiment 1 has good acne-removing effect.
In light of the foregoing description of preferred embodiments according to the invention, it is clear that many changes and modifications can be made by the person skilled in the art without departing from the scope of the invention. The technical scope of the present invention is not limited to the contents of the specification, and must be determined according to the scope of the claims.
Claims (10)
1. The whitening and acne-removing composition is characterized by being prepared from the following raw materials in parts by weight: 1-3 parts of nicotinamide, 1-4 parts of cinnamic acid, 0.5-2 parts of glycyrrhiza glabra extract, 0.5-2 parts of pseudo-ginseng extract, 0.5-2 parts of acanthopanax trifoliatus extract, 0.1-0.5 part of magnesium ascorbyl phosphate, 0.8-2.5 parts of transdermal absorption enhancer, 4-8 parts of solubilizer and 55-70 parts of deionized water.
2. The whitening acne-removing composition according to claim 1, which is prepared from the following raw materials in parts by weight: 1-2.5 parts of nicotinamide, 1.5-4 parts of cinnamic acid, 0.5-1.8 parts of glycyrrhiza glabra extract, 0.5-1.5 parts of pseudo-ginseng extract, 0.5-1.5 parts of acanthopanax trifoliatus extract, 0.1-0.4 part of magnesium ascorbyl phosphate, 0.8-2 parts of transdermal absorption enhancer, 4-7 parts of solubilizer and 60-70 parts of deionized water.
3. The whitening acne-removing composition according to claim 1, which is prepared from the following raw materials in parts by weight: 1.5 parts of nicotinamide, 3 parts of cinnamic acid, 1.2 parts of glycyrrhiza glabra extract, 0.8 part of pseudo-ginseng extract, 0.8 part of acanthopanax trifoliatus extract, 0.2 part of magnesium ascorbyl phosphate, 1.5 parts of transdermal absorption enhancer, 6 parts of solubilizer and 65 parts of deionized water.
4. The whitening and acne-removing composition according to claim 1, wherein the transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 4-8: 20-30 by mixing.
5. The whitening and acne-removing composition according to claim 1, wherein the transdermal absorption enhancer is prepared from hydrogenated lecithin, menthol and propylene glycol according to a weight ratio of 1: 5: 24 are mixed together.
6. The whitening acne-removing composition according to claim 1, wherein the solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to a weight ratio of 1: 4-8, and mixing.
7. The whitening acne-removing composition according to claim 1, wherein the solubilizer is prepared from polyoxyethylene castor oil and decyl glucoside according to a weight ratio of 1: 5, mixing the components.
8. The whitening and acne-removing composition according to claim 1, wherein the preparation method of the trifoliate acanthopanax extract comprises the following steps: cleaning and drying the trifoliate acanthopanax stems, grinding the trifoliate acanthopanax stems to 60-90 meshes to obtain trifoliate acanthopanax powder, putting 10-20 parts of trifoliate acanthopanax powder into a round-bottom flask, adding 100-150 parts of deionized water, refluxing for 2-4 h at 80 ℃, filtering, and drying in vacuum to constant weight to obtain the trifoliate acanthopanax extract; the parts are parts by weight.
9. The preparation method of the whitening and acne-removing composition as claimed in any one of claims 1 to 8, which is characterized by comprising the following steps:
(1) adding cinnamic acid, nicotinamide and a solubilizer into deionized water, heating to 85-95 ℃, and uniformly stirring;
(2) cooling to 40-48 ℃, adding the glycyrrhiza glabra extract, the pseudo-ginseng extract, the acanthopanax trifoliatus extract, magnesium ascorbyl phosphate and the transdermal absorption enhancer, and uniformly stirring to obtain the whitening and acne-removing composition.
10. Application of the whitening acne-removing composition prepared according to claim 9 in preparation of whitening acne-removing cosmetics is characterized in that the addition amount of the whitening acne-removing composition is 1-5%.
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| WO2023097326A1 (en) * | 2021-11-29 | 2023-06-01 | The Procter & Gamble Company | Method for treating post-acne marks |
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