CN102198066B - New whitening and freckle eliminating agent for use in cosmetics - Google Patents
New whitening and freckle eliminating agent for use in cosmetics Download PDFInfo
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- CN102198066B CN102198066B CN2011101437746A CN201110143774A CN102198066B CN 102198066 B CN102198066 B CN 102198066B CN 2011101437746 A CN2011101437746 A CN 2011101437746A CN 201110143774 A CN201110143774 A CN 201110143774A CN 102198066 B CN102198066 B CN 102198066B
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Abstract
The invention discloses a new whitening and freckle eliminating agent for use in cosmetics, which contains the following components: 1.0 to 6 percent of glutathione, 10 to 25 percent of liquoric root extract, 10 to 25 percent of tonka bean extract, 1.0 to 10 percent of turmeric, 3.0 to 15 percent of vitamin C(VC)-ethylether, 0.5 to 5.0 percent of intensifier (alpha-lipoic acid and vitamin C ester) and 14 to 55 percent of solvent filling agent. The main freckle eliminating mechanism of the new skin freckle eliminating agent is to inhibit pycocatechol oxidase, prevent melanin from forming by preventing dopa from being oxidized into dopaquinone; the new skin freckle eliminating agent adopts a light wave conversion principle to improve dim complexion; and thus, the new skin freckle eliminating agent has freckle eliminating and whitening effect. Freckle eliminating and whitening products developed by using the whitening and freckle eliminating agent disclosed by the invention have good effects and low toxicity and meet the requirements of China's laws and regulations on cosmetics, overcome the drawbacks of the conventional products and can meet the urgent needs of yellow people with freckles and whitening needs.
Description
[technical field]
The present invention relates to a kind of whitening anti-freckle agent, particularly a kind of novel whitening anti-freckle agent that is applied to cosmetics, it has the facial gloomy colour of skin of improvement, suppresses melanin, and the effect of desalination mottle the invention belongs to cosmetic field.
[background technology]
Beauty treatment skin is sick to be learned as a new branch of science, and Along with people's improves constantly the requirement of U.S.A and embodies its importance day by day in recent years.Because molecular biology, immunologic further investigation, the sick learning of beauty treatment skin obtained some new developments aspect whitening and speckle dispelling.
Gloomy skin and mottle are that melanocyte is in the uneven distribution of skin surface and the result who gathers.Melanin is that to be present in the melanocyte of stratum basale synthetic, and forerunner's tyrosine generates melanin in the melanosome under the tryrosinase effect, and this melanin unusual increasing in epidermis makes the patient that chloasma take place.Melanin is most important pigment in the skin, and it determines our colour of skin.Simultaneously, melanin also is the natural defence system of human body skin, can resist the injury of ultraviolet to skin.But when melanin produces too much or skewness; But can cause pigementation; Form black speck, influence appearance, once skin was dark and gloomy, the fair and clear degree of the increase colour of skin except that the method for speckle is improved with bleaching for people; Mainly be to float black speck on the face, stronger bleaching effect all arranged as retinoic acid, hydroquinone compositions such as (hydroquinone) with powerful ingredient.Yet; Use bleach can destroy the sebum film of skin surface; If during this period, skin receives the stimulation of factors such as ultraviolet radiation, endocrine disturbance again, then the function of its self-protection meeting doubling effect; Make melanocyte discharge more melanin, thereby cause more serious pigementation phenomenon.Along with the progress of modern science and technology, people bring into use milder, effectively Skin whitening care cosmetics reaches and causes the white temporary wish of skin.Through the activity of restraint of tyrosinase, reduce melanic generation, thereby prevent new pigementation, it is dark and gloomy to improve the skin that causes because of Exposure to Sunlight or endocrine disturbance, increases bright and clean degree of the colour of skin and well-balanced degree, and desalinates black speck gradually.
Can be divided into two types from the mechanism of action of known Melanin inhibitor:, suppress melanic generation 1, to the cytotoxicity of melanocyte; 2. melanic generation in the obstruction melanocyte.
Also there is not a kind of generally acknowledged additive of spot-removing function safely and effectively on the China market at present.The freckle effect of nearly all cosmetics is very little; And some speckle dispelling product is for speckle dispelling or light speckle purpose; Add harmful substances such as heavy dose of hydroquinone or aminomercuric chloride, cause part consumer serious allergy or the irreversible hydrargyrum speckle incidents of disfeaturing such as (mercurialism) to occur.
Therefore, the research to safe and effective whitening and speckle dispelling functional additive is the problem that the beauty and make-up industry is paid close attention to always.
[summary of the invention]
The object of the present invention is to provide a kind of cosmetics functional additive with safe speckle dispelling, whitening effect.
The present invention adopts following technical scheme to achieve these goals:
A kind of novel skin whitening anti-freckle agent that is applied to cosmetics is characterized in that containing following component: glutathion, Radix Glycyrrhizae extract, tonka beans extract, Rhizoma Curcumae Longae extract, VC-ethylether.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics, the mass fraction that it is characterized in that said glutathion is 1.0-6%.Said glutathion is 3 aminoacid compositions such as a kind of micromolecule Si Mita, is present in the almost health of each cell.Physiological action is as a kind of important antioxidants in the body; It can dispose the intravital free radical of people, and cleaning and purification human internal environment pollute, thereby promotes people's physical and mental health; The melanin of intravital toxin of homergy and skin makes whole skin health pale.Because reduced glutathion itself is subject to some material oxidation,, thereby let protein and enzyme equimolecular bring into play its physiological function so it can protect sulfydryl in numerous protein and the enzyme equimolecular not by like harmful substance oxidations such as free radicals in vivo.Play anti-allergic effects, also can prevent skin aging and pigmentation, reduce melanic formation, improve the skin oxidation resistance and make skin produce gloss.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics, the mass fraction that it is characterized in that said Radix Glycyrrhizae extract is 10-25%, its effective ingredient is a glabridin.Said glabridin is the main active of licoflavone; Also be the primary product of licoflavone after purifying; Complete plant origin; Glabridin is the natural whiting agent of from the certain species Radix Glycyrrhizae, extracting, it have intensive antibiotic, prevent effects such as UV-induced inflammation, pigmentation and pachylosis, can remove superoxide ion, suppress the haemolysis that causes by hydrogen peroxide; The activity of its ability restraint of tyrosinase; Can suppress dopachrome change and the oxidasic activity of dihydroxy indole carboxylic acid (DHICA) again, be a kind of quick, efficient, green whitening cosmetics additive, can be used for anti-inflammation, antioxidation, defying age, absorption ultraviolet, whiten bright skin, speckle dispelling.Glabridin can go deep into skin inside and keep high activity, effectively suppresses the activity of plurality of enzymes in the melanin generative process.Also have the pachylosis of preventing and antiinflammatory, antimicrobial effect simultaneously.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics, the mass fraction that it is characterized in that said tonka beans extract is 10-25%, its effective ingredient is the tonka beans isoflavone.Said tonka beans isoflavone can absorb sightless ultraviolet light, and produces visible blue light, thereby improves photism, and this visible blue presents penetrating brilliant white under the yellow skin background.And smooth away wrinkles through illuminating shade, the black eye and the colour of skin are uneven; Offset the effect that other wavelength make skin become dark through radiating visible light wave range, increase visible light reflection total amount, make skin seem brilliant white, level and smooth and even.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics, the mass fraction that it is characterized in that said Rhizoma Curcumae Longae extract is 1.0-10%, its effective ingredient is a curcumin.Rhizoma Curcumae Longae is the zingiberaceous plant of polyphenol compound, is a kind of medical material common in the Chinese medicine.Effects such as Rhizoma Curcumae Longae has antiinflammatory, antioxidation, whitens, removes free radical, anticancer, cardiovascular protection.The whitening of Rhizoma Curcumae Longae, effect of dispelling spots more complicated: the maturation of restraint of tyrosinase, quicken tryrosinase decomposition, quicken melanic metabolism, block other signal transport materials, suppress free radical, the factor that blocking-up causes inflammation, the polymerization that reduces the melanin precursor thing etc.Rhizoma Curcumae Longae extract is the natural extract of whitening with comprehensive effect, and the effect of putting forward the bright colour of skin is especially outstanding, has other various skin biological protective actions concurrently.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics, the mass fraction that it is characterized in that said VC-ethylether is 3.0-15%.Vitamin C can effectively prevent melanic generation.But when vitamin C directly was used for skin, it was to the not effect of whitening of skin.Different with VC; The VC-ethylether is best up to now vitamin C derivatives, and it is not only highly stable on chemical property, is invariant color vitamin C derivative truly; And understanding with the mode identical metabolism in vivo behind its entering skin, thereby the effect of the C of performance dimension better with VC.Clinical trial on humans and animals skin proves that the VC-ethylether of interpolation 2% just can be bleached and skin whitening in product.It can improve the glossiness of gloomy skin, makes the skin and the obscure skin Lightening of band black speck.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics is characterized in that also containing the reinforcing agent that mass fraction is 0.5-5.0%.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics is characterized in that described reinforcing agent is made up of VC ester and alpha-lipoic acid.Glutathion must produce cell and precursor (vitamin C and alpha-lipoic acid) thereof, just can play a role effectively.It can dispose the intravital free radical of people alpha-lipoic acid, and cleaning and purification human internal environment pollute, thereby promotes people's physical and mental health, and the melanin of intravital toxin of homergy and skin makes whole skin health pale.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics is characterized in that also containing the solvent filler that mass fraction is 14-55%.
Aforesaid a kind of novel skin whitening anti-freckle agent that is applied to cosmetics is characterized in that described solvent filler comprises propylene glycol and ethyoxyl diethylene glycol (hereinafter to be referred as Carbitol CG).Said propylene glycol and Carbitol CG are commercially available cosmetics-stage raw material.Said Carbitol CG is the solvent of sunlight screening skin-protecting product, personal nursing, essence etc., and potentiation is arranged, and can promote the active matter dermal osmosis, and is safe, non-stimulated, the micro-emulsifier auxiliary agent.
In sum, the invention has the beneficial effects as follows:
Novel skin anti-freckle agent of the present invention, the dominant mechanism of its speckle dispelling are to suppress the catechol oxidase, stop dopa oxidase to become the DOPA quinone to form melanin, utilize the light wave transfer principle simultaneously, improve the obscure colour of skin, thereby carry out speckle dispelling, white-skinned face function.
Use whitening anti-freckle agent of the present invention and be developed to speckle dispelling, skin-lightening cosmetic, effective, toxicity is low, meets China's cosmetics rules requirement, has overcome the deficiency of existing product, can satisfy the urgent needs of suffering from the yellow that mottle and needs whiten in a large number.
[specific embodiment]
The present invention will further detail through embodiment.All compositions are all represented with percent by weight except that specializing.
The present invention is applied to the novel skin whitening anti-freckle agent of cosmetics, is made up of following components in weight percentage content:
Glutathion 1.0-6%, Radix Glycyrrhizae extract 10-25%, tonka beans extract 10-25%; Rhizoma Curcumae Longae extract 1.0-10%; VC-ethylether 3.0-15%, reinforcing agent (alpha-lipoic acid and VC ester) 0.5-5.0%, solvent filler (propylene glycol and Carbitol CG) 14-55%.
Its preparation method:
Step 1: glutathion and VC-ethylether are used pure water (propylene glycol: dissolving water=1: 5) respectively; Again alpha-lipoic acid and VC ester are added glutathion alcohol-water solution, stirring and dissolving;
Step 2: Radix Glycyrrhizae extract with after the Carbitol CG dilution, is added tonka beans extract and Rhizoma Curcumae Longae extract successively, stir;
Step 3: above two kinds of solution (step 1 and step 2) are mixed, stir;
Step 4: remaining propylene glycol and Carbitol CG are added the solution in the step 3, stir.
Below be several specific embodiment of the present invention:
The embodiment table:
| Preparation (%): | 1 | 2 | 3 | 4 | 5 | 6 |
| Glutathion | 1.0 | 2.0 | 3.0 | 4.0 | 5.0 | 6.0 |
| Radix Glycyrrhizae extract | 15 | 10 | 20 | 25 | 13 | 18 |
| The tonka beans extract | 18 | 13 | 10 | 15 | 25 | 10 |
[0033]
| Rhizoma Curcumae Longae extract | 8.5 | 3.0 | 6.0 | 10.0 | 5.5 | 1.0 |
| The VC-ethylether | 8.5 | 6.0 | 9.0 | 15.0 | 12.0 | 3.0 |
| Reinforcing agent | 0.5 | 2.0 | 5.0 | 3.5 | 4.0 | 1.5 |
| The solvent filler | 30 | 55 | 26 | 20 | 14 | 45 |
| Deionized water | Surplus | Surplus | Surplus | Surplus | Surplus | Surplus |
Below further set forth the application of skin-whitening and speckle eliminating agent of the present invention through application implementation of the present invention example, wherein in following prescription skin-whitening and speckle eliminating agent of the present invention with code: Jch.White representes.
Application implementation example 1, face mask for eliminating macula and whitening skin essence (being applicable to paper film or non-woven fabrics facial film)
Production technology: A and B are dissolved respectively, mix, under agitation add C and D successively, stir.
Application implementation example 2, freckle removing and whitening elite breast (being applicable to the Emulsion of speckle dispelling, skin whitening)
Production technology:
1, A is placed the oil phase pot mutually, B places the water pot mutually, respectively with A, B is biphase is heated to 85 ± 3 ℃;
2, A is added to the B phase, stirs and after 5 minutes C is added to mixed solution, homogenizing 5 minutes cools, when temperature to the 50 ℃ left and right sides, with D mutually each component add mixed solution.
Application implementation example 3: whitening and spot eliminating cream A
Production technology: A, B are heated to 80 ℃ mutually respectively, stir; A is slowly added the B phase mutually, and homogenizing 5 minutes stirs cooling; Be cooled to and add the C phase about 50 ℃.
Application implementation example 4: whitening and spot eliminating cream B
Production technology: A, B are heated to 80 ℃ mutually respectively, stir; A is slowly added the B phase mutually, and homogenizing 5 minutes stirs cooling; Add the C phase when being cooled to 50 ℃ of left and right sides.
Application implementation example 5: the maintenance frost of whitening
Production technology: A, B are heated to 80 ℃ mutually respectively, stir; A is slowly added the B phase mutually, and homogenizing 5 minutes stirs cooling; Add the C phase when being cooled to 50 ℃ of left and right sides.
Application implementation example 6: brilliant white vigor eye cream
Production technology: A, B are heated to 80 ℃ mutually respectively, stir; A is slowly added the B phase mutually, and homogenizing 5 minutes stirs cooling; Be cooled to and add the C phase about 50 ℃.
Part raw material sources and model are seen table 1 in the above application implementation example:
Table 1:
The speckle dispelling usefulness contrast experiment of the whitening and spot eliminating cream B of the whitening and spot eliminating cream A of application implementation example 3 of the present invention and application implementation example 4:
To four kinds of common skin types: oily skin, neutral skin, mixed skin, dry skin compare.Four kinds of skin types are embodied in:
1, oily skin: the colour of skin is dark, and most of regional corse sweat pore is obvious in face, the glossy phenomenon of having one's face covered with easily, and skin matter looks that some is coarse.Usually it is not tight to wash face, and 2-3 hour has just had greasy feeling.Blackhead is arranged easily, the puzzlement of acne and pox seal.The formation of oily skin is exactly because sebaceous gland is excessively excited, the secretion excess grease.Usually the adolescence skin can be oily partially, and the male is oil partially.Stay up late and pressure also possibly cause inclined to one side oil.
2, neutral skin: normal skin, seem that pore is tiny, skin has the gloss of penetrating sense.Skin very health and quality is smooth, and isostatic oil content and moisture content are arranged, and small pox and blackhead are seldom arranged.Skin is not oily usually not tight yet.
3, mixed skin: modal skin matter, most of people seem that very health and quality are smooth after the adolescence, only the T block is greasy a bit, and the too greasy even not tight skin matter of two cheeks.Combination skin matter is divided two kinds again, understands Along with season usually and changes, and for example, can mix inclined to one side oil in summer, but in the winter time again can Combination dried partially.
4, dry skin: pore is tiny, almost cannot see, and the sebum secretion amount is few, and skin surface is bellding light not, presents the state of mute light.Form dried stricture of vagina in small, broken bits easily, the expression stricture of vagina is especially with the most obvious around eye and the lip.The dryness skin is easy to generate tight sense, even has the decortication phenomenon.The tight sense of long period is arranged after clean usually easily.The women who has is exactly the dryness skin at an early age, but common most of women after older (50 years old) can become the dryness skin gradually.Live in the more dry skin that is of people in the low humidity weather of sweltering heat or cold in addition.
Object of study:
The face length of in the beauty parlor, selecting above-mentioned four kinds of skin types has the women trier of mottle, as test crowd of the present invention.Specifically be divided into four and organize greatly, its principal character is:
(1) oiliness group; (2) neutral group; (3) Combination group; (4) dryness group.
Every big group is divided into three groups again, and wherein group one is a matched group, and 80 examples are observed by every group.Experimental technique:
Common cosmetics on the group 1 usefulness market, used 1 month continuously at every day 3 times.
The whitening and spot eliminating cream A of group's 2 usefulness application implementation example 3 of the present invention, used 1 month continuously at every day 3 times.
The whitening and spot eliminating cream B of group's 3 usefulness application implementation example 4 of the present invention, used 1 month continuously at every day 3 times.
Result on trial is seen table 2.
Table 2
Conclusion on probation:
Product of the present invention all has good result of use to the mottle problem of the common skin matter of human body, compares all with general cosmetics to have a greater degree of improvement, and about 15～20 days begin to manifest effect, and the effect when using month clearly.
Through the record analysis to experimenter's use, the present invention all has extraordinary effect to various types of mottles, and is especially splendid to light speckle effects such as freckle, chloasma, day sunburn, pox seals.And tangible whitening effect is arranged.
Claims (7)
1. skin-whitening and speckle eliminating agent that is applied to cosmetics; It is characterized in that comprising following components in weight percentage content: glutathion 1.0-6%; Radix Glycyrrhizae extract 10-25%, tonka beans extract 10-25%, Rhizoma Curcumae Longae extract 1.0-10%; VC-ethylether 3.0-15%, reinforcing agent 0.5-5.0%.
2. a kind of skin-whitening and speckle eliminating agent that is applied to cosmetics according to claim 1, the effective ingredient that it is characterized in that said Radix Glycyrrhizae extract is a glabridin.
3. a kind of skin-whitening and speckle eliminating agent that is applied to cosmetics according to claim 1, the effective ingredient that it is characterized in that said tonka beans extract is the tonka beans isoflavone.
4. a kind of skin-whitening and speckle eliminating agent that is applied to cosmetics according to claim 1, the effective ingredient that it is characterized in that said Rhizoma Curcumae Longae extract is a curcumin.
5. a kind of skin-whitening and speckle eliminating agent that is applied to cosmetics according to claim 1 is characterized in that described reinforcing agent is made up of VC ester and alpha-lipoic acid.
6. a kind of skin-whitening and speckle eliminating agent that is applied to cosmetics according to claim 1 is characterized in that said whitening anti-freckle agent also contains the solvent filler that mass fraction is 14-55%.
7. a kind of skin-whitening and speckle eliminating agent that is applied to cosmetics according to claim 6 is characterized in that described solvent filler comprises propylene glycol and ethyoxyl diethylene glycol.
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| CN2011101437746A CN102198066B (en) | 2011-05-31 | 2011-05-31 | New whitening and freckle eliminating agent for use in cosmetics |
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| CN2011101437746A CN102198066B (en) | 2011-05-31 | 2011-05-31 | New whitening and freckle eliminating agent for use in cosmetics |
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| CN102198066B true CN102198066B (en) | 2012-10-31 |
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| CN102772337B (en) * | 2012-08-17 | 2013-06-26 | 珀莱雅化妆品股份有限公司 | Preparation method of composite whitening lipid nanoparticle emulsion |
| CN103932908A (en) * | 2014-04-25 | 2014-07-23 | 北京博辉瑞进生物科技有限公司 | Composition for face whitening and preparation method thereof |
| CN106265197A (en) * | 2015-05-20 | 2017-01-04 | 张俊 | A kind of manufacture method of Rhizoma Zingiberis Recens cream facial cream |
| CN106798654A (en) * | 2015-11-26 | 2017-06-06 | 无限极（中国）有限公司 | The application of glabridin |
| CN105748349A (en) * | 2016-03-02 | 2016-07-13 | 广州丹奇日用化工厂有限公司 | Application of herb extracted composition with whitening effect in cosmetics |
| CN105943448A (en) * | 2016-06-17 | 2016-09-21 | 广州丹奇日用化工厂有限公司 | Black eye removal instant eyelift cream |
| CN106619444A (en) * | 2016-12-01 | 2017-05-10 | 娄强 | Whitening and renewing repairing cream and production method thereof |
| CN106511217A (en) * | 2016-12-28 | 2017-03-22 | 广州市聚吉科绿色化学共性技术研究院有限公司 | Anti-aging composition and application thereof |
| CN108785113B (en) * | 2017-05-04 | 2021-06-15 | 香港科技大学 | Natural molecular composition with whitening effect and application thereof |
| CN107375108A (en) * | 2017-08-29 | 2017-11-24 | 北京军秀咨询有限公司 | A kind of whitening cosmetics containing Herba Lysimachiae foenumgraeci extract |
| CN107397697B (en) * | 2017-08-30 | 2020-05-12 | 永安康健药业（武汉）有限公司 | Whitening and freckle removing composition and application thereof |
| CN108158887A (en) * | 2018-02-08 | 2018-06-15 | 深圳市创艺工业技术有限公司 | A kind of natural cosmetics method with white-skinned face function |
| CN115957158A (en) * | 2021-10-11 | 2023-04-14 | 成都中医药大学附属医院 | Composition for improving pigmentation, fading spots and whitening skin and preparation method and application thereof |
| CN113967174B (en) * | 2021-11-11 | 2023-10-20 | 上海澄穆生物科技有限公司 | Whitening and anti-wrinkle composition and application thereof |
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