CN104523484A - Whitening and balancing eye cream with mild formula - Google Patents
Whitening and balancing eye cream with mild formula Download PDFInfo
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Abstract
The invention provides whitening and balancing eye cream with a mild formula. An effective component of the whitening and balancing eye cream is prepared from 5%-50% of a plant brightener and 0.1%-5% of a plant antioxidant, wherein the plant brightener is arbutin and/or licoflavone; and the plant antioxidant is selected from one or more of a saussurea involucrate extract, a rhodiola rosea extract, a salvia miltiorrhiza extract and a tea extract. The whitening and balancing eye cream does not contain a chemical ultraviolet absorbent, is a natural whitening product employing plant extracts as effective components, is mild in property, and can be applied to sensitive skin of eyes; through nano technical means, the compatibility flexibility, the transdermal absorption ability and the long-term storage stability of arbutin are enhanced; and the arbutin is effectively combined with licoflavone and plant extracts with antioxidant activity, thus compressive nutrients and long-lasting moisture are provided for the eye skin.
Description
Technical field
The invention belongs to cosmetic field, be specifically related to a kind of whitening eye equilibrium cream of formula gentleness.
Background technology
When skin is directly exposed in sunlight, cosmic ray, air and physical chemistry contact scar thing, skin will be made to produce a kind of reactive oxygen free radical, accelerate skin aging.Active oxygen (Reactive Oxygen Species, ROS) be the oxygen-content active material that a kind of activity is very strong, ROS mainly comprises oxygen-derived free radicals (hydroxyl radical free radical, ultra-oxygen anion free radical) and molecular substance (hydrogen peroxide, lipid peroxide), although active oxygen causes the mechanism of skin aging intricate, but the result caused is very simple: degeneration, skin elasticity declines, denature collagen, cell function are low, cutis laxa to cause corium to construct, generation wrinkle and senile plaque (lipofuscin deposition) etc.By adding brightening agent and ultraviolet sunscreen, the effect of skin whitening can be played.Whitening cosmetic on the market, conventional brightening agent mainly contains retinoic acid, mequinol, hydroquinone, ascorbic acid and derivant thereof, kojic acid and derivant, arbutin, Radix Glycyrrhizae extract etc., but for the consideration of safety, the application of kojic acid, mequinol, hydroquinone is subject to restriction (Li Tong in various degree, household chemicals science, 2009 (32): 43-45).
Arbutin (arbutin) is also known as Arbutin, it is the material extracted from ericad Pericarpium Citri tangerinae and other corresponding plants leaves, arbutin stability is bad, its aqueous solution is with ferrum or high price ferrum generate water miscible light/dark balance complex at a low price, can with basic lead acetate generation precipitation, containing arbutin preparation, place for a long time, appearance color can become ash, blackening.Licoflavone, is the effective ingredient by water extraction or the extraction of alcohol extracting method from Chinese herbal medicine Radix Glycyrrhizae, has the biological activity (Liu Jia such as antioxidation, whitening, arrhythmia, blood sugar lowering, Ji Fang, Sun Taoli, etc., Chinese experimental pharmacology of Chinese medical formulae magazine, 2012 (18): 49-52).
Herba Saussureae Involueratae Compositae Genus Saussurea succulent, is mainly distributed in Tianshan Mountains and the alpine region, Kun Lun Mountain of Xinjiang of China.Radix Rhodiolae was once used in traditional herbal medicines, for lessen fatigue and enhancing body to the natural resistivity of various pressure and the treatment for pulmonary tuberculosis and cancer.
Organically being combined by above-mentioned all kinds of Chinese herbal medicine, for improving cosmetics white-skinned face function, is the research that this area is not also carried out.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide a kind of whitening eye equilibrium cream of formula gentleness, brightening agent wherein and antioxidant all extract from plant.
To achieve these goals, concrete technical scheme is as follows:
A whitening eye equilibrium cream for formula gentleness, the effective ingredient of described whitening eye equilibrium cream is made up of plant whitening agent and anioxidant phytochemicals, and described plant whitening agent content is 5 ~ 50%, and described plant anti-oxidation agent content is 0.1 ~ 5%;
Wherein said plant whitening agent is arbutin and/or licoflavone, and described anioxidant phytochemicals is selected from one or more in Herba Saussureae Involueratae extract, Radix Rhodiolae extract, Radix Salviae Miltiorrhizae extract, tea extract.Described anioxidant phytochemicals is preferably low cost vegetable plant water extract.
Wherein, described arbutin take lipid nanoemulsion as carrier, is 0.5 ~ 5% at the content of arbutin lipid nanometer Ruzhong arbutin.
Further, described arbutin lipid nanometer composition of milk is: arbutin 1 ~ 2%, phosphatidase 3 ~ 4% soybean oil 4 ~ 8%, caprylic/capric glyceride 15 ~ 25%, polyglycerol monooleate 1 ~ 3%, sorbester p17 0.5 ~ 0.1%, glycerol 4 ~ 6%, propylene glycol 4 ~ 6%, Tween 80 0.5 ~ 1%, polyoxyethylene castor oil 1 ~ 3%, water is mended to 100%.
Wherein, the preparation method of described arbutin lipid nanoemulsion is: by the component beyond Tween 80, polyoxyethylene castor oil, water, high speed shear under 8000 ~ 15000rpm condition, then Tween 80, polyoxyethylene castor oil, water is added, high speed shear under 8000 ~ 15000rpm condition, colostrum, colostrum through high pressure homogenizer process, pressure 1500 ~ 2500bar used.
The dosage form of described whitening eye equilibrium cream can be emulsion, frost or cream.
When dosage form is emulsion, described whitening eye equilibrium cream is made up of component A, B component and component C, wherein,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 5 ~ 25, Herba Saussureae Involueratae water extract 0.1 ~ 1.5 part, Radix Rhodiolae water extract 0.1 ~ 1.5, glycerol 3 ~ 8, vitamin C 0.1 ~ 3 part, water 60 ~ 92.
B component is grouped into by the one-tenth of following weight portion: licoflavone 0.1 ~ 0.5, ethanol 3 ~ 10,
Component C is grouped into by the one-tenth of following weight portion: almond oil 0.5 ~ 5, silicone oil 2 ~ 4, vitamin E 0.1 ~ 3, PEG ~ 100 stearate 0.5 ~ 1.5, hexadecanol 2 ~ 4, vaseline 4 ~ 8.
Or the dosage form of whitening eye equilibrium cream is frost, it is made up of component A, B component and component C, wherein,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 5 ~ 25, tea polyphenols 0.2 ~ 2, radix Salviae Miltiorrhizae water extract 0.1 ~ 1, vitamin C 0.1 ~ 3, water 5 ~ 10,
B component is grouped into by the one-tenth of following weight portion: glyceryl monostearate 0.5 ~ 5, hexadecanol 2 ~ 5, squalane 3 ~ 7, vaseline 3 ~ 10, white oil 3 ~ 10, lanolin alcohol 0.2 ~ 5, vitamin E 0.1 ~ 3, microwax 0.5 ~ 2,
Component C is grouped into by the one-tenth of following weight portion: water 30 ~ 99.9, polyvinylpyrrolidone 0.2 ~ 1.
Preferably, in described whitening eye equilibrium cream,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 20 ~ 25, tea polyphenols 0.5 ~ 1, radix Salviae Miltiorrhizae water extract 0.1 ~ 0.3, vitamin C 0.1 ~ 1.0, water 5 ~ 8;
B component is grouped into by the one-tenth of following weight portion: glyceryl monostearate 1 ~ 3, hexadecanol 3 ~ 5, squalane 4 ~ 7, vaseline 5 ~ 8, white oil 7 ~ 10, lanolin alcohol 1 ~ 2, vitamin E 1 ~ 2, microwax 1 ~ 2,
Component C is grouped into by the one-tenth of following weight portion: water 40 ~ 99.9, polyvinylpyrrolidone 0.2 ~ 1.
Or the dosage form of whitening eye equilibrium cream is cream, it is made up of component A, B component and component C, wherein,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 5 ~ 25, vitamin C 0.1 ~ 3, rhodioside 0.5 ~ 1.5, tea polyphenols 0.5 ~ 1.5, purified water 0 ~ 95;
B component is grouped into by the one-tenth of following weight portion: licoflavone 0.1 ~ 0.5, ethanol 2 ~ 5;
Component C is grouped into by the one-tenth of following weight portion: titanium dioxide 3 ~ 15, microwax 5 ~ 15, Cera Flava 0.2 ~ 5, vaseline 3 ~ 10, lanoline 3 ~ 10, Squalene 20 ~ 40, oleic acid ethylene oxidic ester 2 ~ 10, adipic acid C
16alkane ester 2 ~ 10.
Preferably, in described whitening eye equilibrium cream,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 8 ~ 12, vitamin C 0.3 ~ 0.6, rhodioside 0.5 ~ 1.0, tea polyphenols 0.5 ~ 1.0, purified water 0 ~ 95;
B component is grouped into by the one-tenth of following weight portion: licoflavone 0.1 ~ 0.5, ethanol 2 ~ 3;
Component C is grouped into by the one-tenth of following weight portion: titanium dioxide 8 ~ 12, microwax 8 ~ 12, Cera Flava 2 ~ 5, vaseline 3 ~ 8, lanoline 6 ~ 8, Squalene 22 ~ 30, oleic acid ethylene oxidic ester 2 ~ 4, adipic acid C
16alkane ester 4 ~ 6.
The preparation method of whitening eye equilibrium cream of the present invention is: component C is heated to 65 ~ 75 DEG C, then is cooled to 45 ~ 52 DEG C and adds B component, stirs 8 ~ 15min, adds component A, homogenizing, to obtain final product after being cooled to room temperature.
Beneficial effect of the present invention is:
The present invention containing chemical ultraviolet absorbers, is not a pure natural whitening product using plant extract as functional component; By nanotechnology means, strengthen the motility of arbutin compatibility, Transdermal absorption ability and long-term shelf-stability; And by arbutin and licoflavone, and there is the plant extract efficient combination of antioxidant activity, provide comprehensive nutrition for eye part skin and moisten for a long time.
Various plants nutritional labeling organically combines by the present invention further, plays the effect of equilibrium water conten and oil content; Skin test results shows, the whitening eye equilibrium cream that the present invention proposes can the generation of check melanin effectively, and character is gentle, is free from side effects to skin, is applicable to eye part skin maintenance.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
In embodiment, if no special instructions, the means used and equipment are means and the equipment of this area routine.
Below in conjunction with embodiment, embodiment of the present invention are described in detail, but it will be understood to those of skill in the art that the following example only for illustration of the present invention, and should not be considered as limiting scope of the present invention.Unreceipted actual conditions person in embodiment, the condition of conveniently conditioned disjunction manufacturer suggestion is carried out.Agents useful for same or the unreceipted production firm person of instrument, being can by the conventional products of commercial acquisition.
The preparation of embodiment 1 arbutin lipid nanoemulsion
Table 1 listed in by the raw material preparing arbutin lipid nanoemulsion.Wherein arbutin is purchased from Rong Sheng bio tech ltd, Xi'an.
Table 1
The preparation method of this lipid nanoemulsion is as follows:
1) by above-mentioned prescription, Part I raw material is added shear mixer, high speed shear under 10000rpm condition, without the visible solid content of naked eyes to system;
3) Part II raw material is added step 1) product, high speed shear under 10000rpm condition, obtain colostrum, colostrum is through high pressure homogenizer (the biological company limited of Guangzhou cumulative, JN30-HC type) process, pressure 2000bar used, circulate 10 times, homogenizing process carries out in 70 DEG C of water-baths; Obtain transparent clear shape arbutin lipid nanoemulsion.
Embodiment 2 whitening eye balance emulsion
The present embodiment proportioning raw materials is in table 2.Wherein arbutin lipid nanoemulsion is prepared by embodiment 1.Herba Saussureae Involueratae water extract is purchased from Yuan Sen bio tech ltd, Xi'an, and Radix Rhodiolae water extract is with the root of Radix Rhodiolae (Rhodiola.rosea.L) and stem for raw material, and water steams and extracts, containing crude drug concentration 1g/mL.
Table 2
The preparation method of this emulsion is as follows:
Component C is heated to 75 DEG C, after waxy substance is melted, add B component when being cooled to 50 DEG C, 300rpm stirs 10min, adds component A after being cooled to room temperature, and homogenizing under pressure 2000bar, to obtain final product.Gained sample is designated as sample 1.
Embodiment 3 whitening eye equilibrium cream
The present embodiment proportioning raw materials is in table 3.Wherein arbutin lipid nanoemulsion is prepared by embodiment 1.Radix Salviae Miltiorrhizae water extract is that after pulverizing with red sage root, water extraction obtains, containing crude drug concentration 1.2g/mL.
Table 3
The preparation method of this whitening eye equilibrium cream is as follows:
B component is heated to 75 DEG C, waxy substance is melted, add component C when being cooled to 50 DEG C, 300rpm stirs 10min, adds component A after being cooled to room temperature, and homogenizing under pressure 2000bar, to obtain final product, and is labeled as sample 2.
Embodiment 4 whitening eye equilibrium cream
The present embodiment proportioning raw materials is in table 4.Raw material and preparation method, with embodiment 3, are labeled as sample 3.
Table 4
Embodiment 5 whitening eye equilibrium cream
The present embodiment proportioning raw materials is in table 5.Wherein arbutin lipid nanoemulsion is prepared by embodiment 1.Rhodioside is the Radix Rhodiolae water extract of embodiment 2.Licoflavone is purchased from the large magnificent great achievement medication chemistry company limited in Wuhan.
Table 5
The preparation method of this whitening eye equilibrium cream is as follows:
Component C is heated to 75 DEG C, after waxy substance is melted, add B component when being cooled to 50 DEG C, 300rpm stirs 10min, adds component A after being cooled to room temperature, and homogenizing under pressure 2000bar, to obtain final product.Be labeled as sample 4.
Embodiment 6 whitening eye equilibrium cream
The present embodiment proportioning raw materials is in table 6.Raw material and preparation method are with embodiment 5.Be labeled as sample 5.
Table 6
Embodiment 7 preparation stability is tested
Test specimen: the sample 1 ~ 5 prepared by embodiment 2 ~ 6;
Control sample: by the prescription of embodiment 2, replaces with the arbutin aqueous solution of 1.5% by arbutin nano-emulsion, all the other compositions and preparation method constant.
Experimental technique:
Sample 1-5 and reference substance are placed 6 months at 4 DEG C, 25 DEG C, 37 DEG C, observes sample appearance.
Experimental result is in table 7.
Table 7: difference is placed and under treatment conditions, sample appearance changes
| Condition | Sample 1 | Sample 2 | Sample 3 | Sample 4 | Sample 5 | Reference substance |
| 4℃ | Milky white | Milky white | Milky white | Milky white | Milky white | Milky white |
| 25℃ | Milky white | Milky white | Milky white | Milky white | Milky white | Graying |
| 37℃ | Milky white | Milky white | Milky white | Milky white | Milky white | Lycoperdon polymorphum Vitt |
From table 7, sample 1-5 places 6 months, and outward appearance still can keep milky, and reference substance, when temperature is raised to 25 DEG C, namely color changes, and the stability reflecting arbutin is damaged.
Embodiment 8 sensitization is tested
Experimental technique: choose 12 Cavia porcelluss of body weight between 350 ~ 450g, be divided at random A, B two groups: A group select embodiment 2,3,5 to prepare totally 6 parts, sample (each embodiment 2 parts); B group is control sample, is according to embodiment 2, arbutin lipid nanoemulsion and licoflavone is changed into the OctMet of Isodose, all the other components and preparation method constant.In test, guinea pig back is shaved hair, respectively about 0.2 gram of sample, reference substance are smeared to 1cm × 1cm region.Observe after 18h and smear cosmetics area skin situation, the results are shown in Table shown in 8:
Guinea pig back change of skin after cosmetics smeared by table 8
| Quantity | No change | Erythema, infiltration or pimple | Edematous erythema, pimple | Remarkable redness, companion's bulla |
| Sample | 6 | 0 | 0 | 0 |
| Reference substance | 1 | 3 | 2 | 0 |
As shown in Table 8, ultraviolet absorber (OctMet) is changed into arbutin lipid nanoemulsion and the licoflavone of same amount, the sensitization of cosmetics significantly declines, and illustrates that the product property that the present invention proposes is gentle, can be used for eye part skin.
Embodiment 9 sun-proof result is tested
Test method: the pertinent regulations detected with reference to spf value in " cosmetics health specification " (version in 2002), slightly changes.30 healthy volunteers are chosen, each 15 of men and women in test, IV type skin (namely seldom tan severely, but easily tanned skin quality), unglazed allergies.30 volunteers are divided into 3 groups, often organize 10 people.
The product of trial target prepared by the embodiment of the present invention 2 ~ 6 is as sample 1 ~ 5; Reference substance 1 ~ 3, respectively according to embodiment 2,3,5, will wherein antioxidation biology bioactive peptide remove, appropriate section with water polishing, all the other prescriptions and preparation method constant.
Experimental result is in table 9:
The different sample spf value of table 9
| Sample 1 | Reference substance 1 | Sample 2 | Sample 3 | Reference substance 2 | Sample 4 | Sample 5 | Reference substance 3 | |
| SPF | 9 | 6.5 | 11.5 | 10.6 | 8 | 16.5 | 15.5 | 11 |
Can be seen by table 9, add the sunscreen product of antioxidation biology bioactive peptide, spf value compared with reference substance, all certain raising.
Embodiment 10 MTT activity test
Take the logarithm the human epidermal cell HEK-n of trophophase, according to 1 × 10
5the concentration of cells/mL inoculates 96 orifice plates, every pore volume 200 μ L, after normal cultivation 24h, in protection group cell culture fluid, adds trial target respectively, after 5min, adopts 1mM H respectively
2o
2carry out oxidative damage process 6h.After oxidative damage process terminates, take out 96 well culture plates, abandon supernatant, carefully with after PBS punching 2 ~ 3 times, then add the fresh medium of 200 μ L containing 0.5mg/mL MTT, continue at 37 DEG C, 5%CO
24h is cultivated under condition.After cultivation terminates, discard MTT solution, every hole adds 100 μ LDMSO, vibration mixing, surveys each hole absorbance (A490) that wavelength is 490nm, calculates cell survival rate, the results are shown in Table 10.
The product of trial target prepared by the embodiment of the present invention 2 ~ 6 is as sample 1 ~ 5; Reference substance 1 ~ 3, respectively according to embodiment 2,3,6, will wherein plant whitening agent and antioxidation biology bioactive peptide remove, appropriate section with water polishing, all the other prescriptions and preparation method constant.
Table 10 MTT activity test
From result table 10, compared with reference substance, containing the sample of plant whitening agent and antioxidation biology bioactive peptide, greatly can improve cell viability.
Embodiment 11 melanin inhibition test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 6 orifice plates.Every hole 3ml, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandons supernatant, and PBS washs, and every hole adds 0.5mL trypsin digestion cell 3min, and every hole adds 2ml maintenance medium and stops digestion.After piping and druming mixing, often kind of concentration is taken out 0.5mL and is made cell counting.All the other cell suspension, with the centrifugal 5min of 2500r/min, abandon supernatant, add sodium hydroxide solution, melanin is dissolved in precipitation, select 490nm wavelength to survey absorbance on enzyme-linked immunosorbent assay instrument, calculate melanin generating suppression, the results are shown in Table 11.
The product of trial target prepared by the embodiment of the present invention 2 ~ 6 is as sample 1 ~ 5; Reference substance 1 ~ 3, respectively according to embodiment 2,3,5, will wherein plant whitening agent remove, appropriate section with water polishing, all the other prescriptions and preparation method constant.
Melanin generating suppression=[1-(medicine hole absorbance ÷ medicine porocyte density) ÷ (control wells absorbance ÷ control wells cell density] × 100%
Table 11 melanin generating suppression %
As shown in Table 11, compared with reference substance, the sample containing plant whitening agent, greatly can strengthen melanin generating suppression.
Embodiment 12 tryrosinase vitality test
By B16 melanocyte with 1 × 10
5the density of individual/mL is inoculated in 96 orifice plates.Every hole 100 μ L, after hatching 24h, abandons supernatant, adds medicine to be measured, after drug effect 3d, abandon supernatant, PBS washing twice, and every hole adds the PBS of 90 μ L containing 1% (volume fraction) Triton X ~ 100.Ultrasonication in ice bath, every hole adds the L ~ dopa of 10 μ L 10mmoL/L, hatches 60min for 37 DEG C, and in 475nm place colorimetric, blank well returns to zero, and surveys each hole absorbance, calculates inhibitory activity against tyrosinase, the results are shown in Table 12.
The product of trial target prepared by the embodiment of the present invention 2 ~ 6 is as sample 1 ~ 5; Reference substance 1 ~ 3, respectively according to embodiment 2,3,5, will wherein plant whitening agent remove, appropriate section with water polishing, all the other prescriptions and preparation method constant.
Suppression ratio=(1-medicine group mean absorbance values ÷ matched group mean absorbance values) × 100%.
Table 12 inhibitory activity against tyrosinase %
As shown in Table 12, compared with reference substance, containing the sample of plant whitening agent, to tyrosinase activity inhibitory action, be significantly improved.
Above embodiment is only be described the preferred embodiment of the present invention; not scope of the present invention is limited; under not departing from the present invention and designing the prerequisite of spirit; the various modification that the common engineers and technicians in this area make technical scheme of the present invention and improvement, all should fall in protection domain that claims of the present invention determine.
Claims (10)
1. the whitening eye equilibrium cream of a formula gentleness, it is characterized in that, the effective ingredient of described whitening eye equilibrium cream is made up of plant whitening agent and anioxidant phytochemicals, and described plant whitening agent content is 5 ~ 50%, and described plant anti-oxidation agent content is 0.1 ~ 5%;
Wherein said plant whitening agent is arbutin and/or licoflavone, and described anioxidant phytochemicals is selected from one or more in Herba Saussureae Involueratae extract, Radix Rhodiolae extract, Radix Salviae Miltiorrhizae extract, tea extract.
2. whitening eye equilibrium cream according to claim 1, is characterized in that, described arbutin take lipid nanoemulsion as carrier, is 0.5 ~ 5% at the content of arbutin lipid nanometer Ruzhong arbutin.
3. whitening eye equilibrium cream according to claim 2, it is characterized in that, described arbutin lipid nanometer composition of milk is: arbutin 1 ~ 2%, phosphatidase 3 ~ 4% soybean oil 4 ~ 8%, caprylic/capric glyceride 15 ~ 25%, polyglycerol monooleate 1 ~ 3%, sorbester p17 0.5 ~ 0.1%, glycerol 4 ~ 6%, propylene glycol 4 ~ 6%, Tween 80 0.5 ~ 1%, polyoxyethylene castor oil 1 ~ 3%, water is mended to 100%.
4. whitening eye equilibrium cream according to claim 3, it is characterized in that, the preparation method of described arbutin lipid nanoemulsion is: by the component beyond Tween 80, polyoxyethylene castor oil, water, high speed shear under 8000 ~ 15000rpm condition, then add Tween 80, polyoxyethylene castor oil, water, high speed shear under 8000 ~ 15000rpm condition, obtains colostrum, colostrum through high pressure homogenizer process, pressure 1500 ~ 2500bar used.
5. whitening eye equilibrium cream according to claim 1, is characterized in that, be made up of component A, B component and component C, wherein,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 5 ~ 25, Herba Saussureae Involueratae water extract 0.1 ~ 1.5 part, Radix Rhodiolae water extract 0.1 ~ 1.5, glycerol 3 ~ 8, vitamin C 0.1 ~ 3 part, water 20 ~ 92,
B component is grouped into by the one-tenth of following weight portion: licoflavone 0.1 ~ 0.5, ethanol 3 ~ 10,
Component C is grouped into by the one-tenth of following weight portion: almond oil 0.5 ~ 5, silicone oil 2 ~ 4, vitamin E 0.1 ~ 3, PEG ~ 100 stearate 0.5 ~ 1.5, hexadecanol 2 ~ 4, vaseline 4 ~ 8.
6. whitening eye equilibrium cream according to claim 1, is characterized in that, be made up of component A, B component and component C, wherein,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 5 ~ 25, tea polyphenols 0.2 ~ 2, radix Salviae Miltiorrhizae water extract 0.1 ~ 1, vitamin C 0.1 ~ 3, water 5 ~ 10,
B component is grouped into by the one-tenth of following weight portion: glyceryl monostearate 0.5 ~ 5, hexadecanol 2 ~ 5, squalane 3 ~ 7, vaseline 3 ~ 10, white oil 3 ~ 10, lanolin alcohol 0.2 ~ 5, vitamin E 0.1 ~ 3, microwax 0.5 ~ 2,
Component C is grouped into by the one-tenth of following weight portion: water 30 ~ 99.9, polyvinylpyrrolidone 0.2 ~ 1.
7. whitening eye equilibrium cream according to claim 6, is characterized in that, in described whitening eye equilibrium cream,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 20 ~ 25, tea polyphenols 0.5 ~ 1, radix Salviae Miltiorrhizae water extract 0.1 ~ 0.3, vitamin C 0.1 ~ 1.0, water 5 ~ 8;
B component is grouped into by the one-tenth of following weight portion: glyceryl monostearate 1 ~ 3, hexadecanol 3 ~ 5, squalane 4 ~ 7, vaseline 5 ~ 8, white oil 7 ~ 10, lanolin alcohol 1 ~ 2, vitamin e1 ~ 2, microwax 1 ~ 2,
Component C is grouped into by the one-tenth of following weight portion: water 40 ~ 99.9, polyvinylpyrrolidone 0.2 ~ 1.
8. whitening eye equilibrium cream according to claim 1, is characterized in that, be made up of component A, B component and component C, wherein,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 5 ~ 25, vitamin C 0.1 ~ 3, rhodioside 0.5 ~ 1.5, tea polyphenols 0.5 ~ 1.5, purified water 0 ~ 95;
B component is grouped into by the one-tenth of following weight portion: licoflavone 0.1 ~ 0.5, ethanol 2 ~ 5;
Component C is grouped into by the one-tenth of following weight portion: titanium dioxide 3 ~ 15, microwax 5 ~ 15, Cera Flava 0.2 ~ 5, vaseline 3 ~ 10, lanoline 3 ~ 10, Squalene 20 ~ 40, oleic acid ethylene oxidic ester 2 ~ 10, adipic acid C
16alkane ester 2 ~ 10.
9. whitening eye equilibrium cream according to claim 8, is characterized in that, in described whitening eye equilibrium cream,
Component A is grouped into by the one-tenth of following weight portion: arbutin lipid nanoemulsion 8 ~ 12, vitamin C 0.3 ~ 0.6, rhodioside 0.5 ~ 1.0, tea polyphenols 0.5 ~ 1.0, purified water 0 ~ 95;
B component is grouped into by the one-tenth of following weight portion: licoflavone 0.1 ~ 0.5, ethanol 2 ~ 3;
Component C is grouped into by the one-tenth of following weight portion: titanium dioxide 8 ~ 12, microwax 8 ~ 12, Cera Flava 2 ~ 5, vaseline 3 ~ 8, lanoline 6 ~ 8, Squalene 22 ~ 30, oleic acid ethylene oxidic ester 2 ~ 4, adipic acid C
16alkane ester 4 ~ 6.
10., according to the arbitrary described whitening eye equilibrium cream of claim 5 ~ 9, it is characterized in that, preparation method is: component C is heated to 65 ~ 75 DEG C, be cooled to 45 ~ 52 DEG C again and add B component, stir 8 ~ 15min, after being cooled to room temperature, add component A, homogenizing, to obtain final product.
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| CN108158958A (en) * | 2018-03-19 | 2018-06-15 | 天马（安徽）国药科技股份有限公司 | A kind of efficient whitening and spot eliminating cream with antianaphylaxis function |
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