CN102614104B - Skin-whitening and freckle-dispelling essence and preparation method thereof - Google Patents
Skin-whitening and freckle-dispelling essence and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a skin-whitening and freckle-dispelling essence and a preparation method thereof. The skin-whitening and freckle-dispelling essence contains the following active ingredients which are selected in the aspects of eight factors according to the latest skin-whitening and freckle-dispelling mechanism: nano-wrapped supercritical bee glue, sunscreen algae (helionori), a lytic keratinase complex (protease complex), multiex bsasm, skin-whitening polypeptide (melanostatine DM), skin neogenesis energy algae (AOAINE), epidermal growth factor bionic peptide (CG IDP-5) and a brazzil tourmaline extracting solution (tourmalina). Compared with the prior art, the skin-whitening and freckle-dispelling essence is clear in mechanism, natural and efficient in sorting, and has the advantages of inhibiting melanin, screening sun, promoting metabolism, diminishing inflammation, reducing genuine melanin, accelerating the metabolism of the melanin, improving obscuration caused by wrinkle spots and the like; after skin-whitening and freckle-dispelling essence is used, skin is the fair and tender and white lucent; and the preparation method is scientific.
Description
Technical field
The present invention relates to a kind of Whitening, spot essence, especially relate to a kind of Whitening, spot essence that contains nano-encapsulated supercritical propolis isoreactivity composition and preparation method thereof.
Background technology
Modern Whitening, spot skin care item, the principle of most foundations is that the activity by restraint of tyrosinase reduces melanic generation, or melanin catabolism, reduction by having generated, reach the effect of Whitening, spot, the active component that adopts mainly is synthetic chemistry preparations such as arbutin, ascorbic acid phosphoric acid esters sodium (vitamin C), kojic dipalmitate, action effect is limited, easily bounce-back.
Existing technology is whitened, light speckle mechanism: mainly consider from two factor aspects, act on limitedly, easily rebound.As shown in Figure 1.
Summary of the invention
Purpose of the present invention is exactly in order to overcome the defective that above-mentioned prior art exists, according to up-to-date Whitening, spot mechanism, innovatively from eight factor aspects, comprehensive selected active component, provide a kind of based on natural origin, safer, more effective, become Whitening, spot essence of assignment system and preparation method thereof by nano-encapsulated supercritical propolis isoreactivity.
Purpose of the present invention can be achieved through the following technical solutions: a kind of Whitening, spot essence is characterized in that the raw material of this Whitening, spot essence comprises the component of following weight percent content:
The raw material of described Whitening, spot essence comprises the component of following weight percent content:
The raw material of described Whitening, spot essence comprises the component of following weight percent content:
The raw material of described Whitening, spot essence comprises the component of following weight percent content:
A kind of Whitening, spot essence and preparation method thereof is characterized in that, this method may further comprise the steps:
(1) weighs deionized water in the water pot, add the measured EDTA disodium of accurate scale, hyaluronate sodium, carbomer more successively, and heating mixes while stirring, 60 ℃ abundant stirring and dissolving is even down for temperature, add propylene glycol, 1 more successively, 3-butanediol, methyl hydroxybenzoate, allantoin, brazil tourmaline stone extracting solution, sun-proof algae stirring and dissolving are even, and 60 ℃ of temperature are incubated 30 minutes;
(2) when 60 ℃ of temperature, in water pot material suction vacuum emulsifying pot, stir afterwards and add nano-encapsulated supercritical propolis, dissolved ceratinase compound enzyme, composite plant antiallergic liquid, the polypeptide of whitening, the newborn energy algae of skin, the bionical peptide of epidermal growth factor down successively, stirred 30 minutes, fully mix homogeneously;
(3) cool, when temperature descends 45 ℃, add PEG-40 castor oil hydrogenated, caprylin, and stir;
(4) continue cooling, when temperature descends 35 ℃, add aminomethyl propanol, and stir;
(5) cooling again, when 30 ℃ of temperature declines, i.e. discharging obtains product.
According to up-to-date Whitening, spot mechanism, innovatively from eight factor aspects, comprehensive selected not only safety, but also effective natural source nano active composition, that is:
1, suppresses melanic synthetic, eliminate melanin source---nano-encapsulated supercritical propolis.Adopt low temperature supercritical extraction (SUPERCRITICAL EXTRACTING) technology and technology that natural propolis is extracted, purifies, the propolis that obtains, the purity height, lighter color, pass through phospholipid nano-encapsulated technology (Phospholipids) again and be treated as the nano-encapsulated supercritical propolis, make it water-soluble, and be easy to infiltration and absorption, successfully solved the compatibility problem with other composition.The nano-encapsulated supercritical propolis has the effect of powerful antioxidation, restraint of tyrosinase activity, and tryrosinase is the reason (exogenous and endogenous oxygen-derived free radicals corrodes skin → tryrosinase and generates → produce DOPA → melanin → mottle) that causes excessive melanin to generate.
2, UV sunlight or electromagnetic radiation are tanned and bring out one of mottle " arch-criminal "; so; sun-proof very important to Whitening, spot---sun-proof algae (PHYCOCORAIL); extracted by Sargassum; ultraviolet or electromagnetic radiation are reduced the injury of horn cell; prevent the formation of injured cell, protection cell membrane lipid and DNA.Therefore have anti-solarization, preserve moisture, repair the remarkable effect of radiation damage.
3, enhancing metabolism just can be white---keratin-dissolving multienzyme complex (PROTEASE COMPLEX), extracted by natural goodses such as Fructus Chaenomeliss, and be the best substitute of fruit acid AHA.Can gentlely remove the dead cutin (dead bark) of skin epidermis, promotion group cell new life, and it is active to promote blood circulation, it is unimpeded to strengthen capillary blood flow, thereby accelerates skin cell metabolism, reaches the effect that gentle shining skin is whitened.
4, want the first antiinflammatory of light speckle, antiinflammatory, this listens seemingly somewhat mysterious theory, but is to have the knack of doing sth greatly in fact! So-called " inflammation " refers to skin sensitivity inflammation such as allergy, general red, pruritus, red blood streak.Suppose scytitis is regarded as one " courier " that the content of this courier's reception and registration is exactly so: generate melanin or mottle.So, antiinflammatory is to reinforce the skin defence line, the approach of Whitening, spot---composite plant antiallergic liquid (MULTIEX BSASM) is the compound herb extract by 7 kind of plant, and this 7 kind of plant is: Herba Rosmarini Officinalis, foreign glycosides chrysanthemum, green tea, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Radix Scutellariae and Herba Centellae.Has multiple efficacies, as immunomodulating, anti-inflammatory and antioxidative pharmacological action.
5, reduce true property melanin, regulated and control the melanin ratio, just can reach the even penetrating in vain of skin.Black have two kinds of different types: yellow extremely red false melanin and black are to brown true property melanin, and they all are the important pigment celles who determines the colour of skin, and undue minimizing all is harmful to.Effectively reduce eumelanin content, increase false melanin content simultaneously, to put forward the bright colour of skin very important to all even to have regulated and control the melanin ratio, work along both lines, it is penetrating to make that skin and muscles are fair---the polypeptide of whitening (MELANOSTATINE DM), and a kind of by the agouti signal protein that extracts behind the lactic acid bacteria fermentation, can control melanic total growing amount, and false melanic ratio in the increase melanin, thereby make skin whiten and to desalinate the effect of mottle faster.
6, energy promotes, accelerates the melanin metabolism, gives Whitening, spot a bit " acceleration ".Discover how skin maintains again, but still lack anger and vigor.This mainly is to cause skin to lack energy because of pressure, ultraviolet, wear out etc., causes how maintaining also being difficult to get a desired effect again.Come to encourage to skin with what? a yes energy! Give in addition energy supplement of skin, can not only accelerate melanic metabolism, can also promote cell viability, promote white-skinned face function---the newborn energy algae (AOAINE) of skin, extracted by brown seaweed (zigzag Fucus Vesiculosus).Can provide the fast rapid regeneration of skin and cell normal growth required essential natural nutrient, the loss of extra-nutrition promotes skin metabolism, and it is synthetic to increase the plain ATP of skin energy; Protect the skin cell mitochondrion and keep mitochondrial function; Promote skin new life, help skin to reply health and vigor.
7, improving obscure that the wrinkle shade causes, also is the important content of whitening.Nowadays people no longer are one-side bleaching for the concern of whitening, begin to recognize that the skin that makes us becomes obscure, except melanism generates the flaw cause, follow microgroove that skin aging occurs, lax, corse sweat pore and rough be one of main cause equally.If skin is no wrinkle, soft and smooth, consolidation, as glass bead, affirm the reflectance height than withered, wrinkle, rough skin, distribute pale beautiful gloss, present young breath---the bionical peptide of epidermal growth factor (CG IDP-5), utilize the synthetic bionical peptide of micromolecule of biotechnology, can produce the physiological signal that is similar to epidermal growth factor, excite horn cell, the healthy hyperplasia of prostate of fibroblast, and promote keratin, various collagen protein and mucinous synthetic, strengthen skin elasticity and smoothness, resist wrinkle and produce.
8, no longer simple whiten more want fair and tender in vain---brazil tourmaline stone (TOURMALINA), a kind of tourmaline that originates from Brazil is called red tourmaline stone (TOURMALINA) again.This gem is released far infrared at the Shi Huire that is heated, and can promote blood circulation of skin and oxygen supply, makes the colour of skin appear how fair and tender gloss from inside to outside, can also can play the effect of loosening, reduce pressure, promote reparation to skin.
The supercritical propolis of nano-encapsulated described in the present invention is extracted and preparation by supercritical extraction unit and nanometer emulsified machine.
Sun-proof algae described in the present invention (PHYCOCORAIL) is produced by French SECMA company.
The multienzyme complex of keratin-dissolving described in the present invention (PROTEASE COMPLEX) is produced by Belgian ENZYBEL company.
The antiallergic of composite plant described in the present invention liquid (MULTIEX BSASM) is produced by Korea S BIOSPECTRUM company.
The polypeptide (MELANOSTATINE DM) of whitening described in the present invention is produced by French VINCIENCE company.
The newborn energy algae of skin described in the present invention (AOAINE) is produced by French SECMA company.
The bionical peptide of epidermal growth factor described in the present invention (CG IDP-5) is produced by Korea S GARAGEN company.
The tourmaline of brazil described in the present invention stone (TOURMALINA) is produced by French Soliance company.
Carbomer described in the present invention, it mainly acts on: gelling thickener, form smear salubrious, silk is sliding, absorbability is good stablizes translucent mastic.
Aminomethyl propanol described in the present invention, it mainly acts on: in the carbomer special use and thickening agent.
This propylene glycol described in the present invention, 1,2 one butanediol, it mainly acts on and is: the efficient moisture-retention agent, moisten, strengthen nano-encapsulated propolis isoreactivity composition emulsifying dispersivity and promotion infiltration and absorb.
The castor oil hydrogenated of PEG-40 described in the present invention, it mainly acts on and is: solubilizing agent increases dissolubility and the product appearance transparency of each component raw material, and has the moisturizing effect concurrently.
Caprylin described in the present invention, it mainly acts on and is: gentle, non-stimulated antiseptic.
Methyl hydroxybenzoate described in the present invention, it mainly acts on and is: antioxidant.
Allantoin described in the present invention, it mainly acts on: be to promote cutin to upgrade, antiallergic is preserved moisture.
The disodium of EDTA described in the present invention, it mainly acts on: be ion chelating agent, the protection active component is promoted the product effect.
Saturating hyaluronate sodium described in the present invention, it mainly acts on: efficient physiology wetting agent, strengthen the skin moisture-retaining capacity.
Preparation method of the present invention adopts " cryogenic vacuum emulsifying preparation technology " to realize this preparation method advantage: low temperature--and it is active that the protection active matter is not subjected to high temperature to destroy attenuating; Vacuum--prevent active matter oxidation forfeiture effect; The high speed shear emulsifying of emulsifying--2800-3200rmp (per minute commentaries on classics) is stirred, and obtains fine and smooth, stable mastic.
Compared with prior art, Whitening, spot mechanism of the present invention: consider from eight factor aspects, and active component selected natural origin, that produced by the nano-encapsulated technology, easy Transdermal absorption, effect significantly, lasting, and safer, do not rebound.Possess technical originality:
1, antioxidation suppresses melanic synthetic source---nano-encapsulated supercritical propolis
2, sun-proof very important to whitening---sun-proof algae (HELIONORI)
3, enhancing metabolism just can be white---keratin-dissolving multienzyme complex (PROTEASE COMPLEX)
4, want first antiinflammatory---the composite plant antiallergic liquid (MULTIEX BSASM) of light speckle
5, reduce true property melanin---the polypeptide of whitening (MELANOSTATINE DM)
6, energy promoter is accelerated the melanin metabolism---the newborn energy algae (AOAINE) of skin
7, improve obscure that the wrinkle shade causes---the bionical peptide of epidermal growth factor (CG IDP-5)
8, no longer simple whiten more want fair and tender in vain---brazil tourmaline stone extracting solution (TOURMALINA).
Description of drawings
Fig. 1 is prior art Whitening, spot mechanism figure;
Fig. 2 is Whitening, spot mechanism figure of the present invention;
Fig. 3 is process chart of the present invention.
The specific embodiment
For technological means, creation characteristic that the present invention is realized, reach purpose and effect is easy to understand, below in conjunction with specific embodiment, further set forth the present invention.
Embodiment 1
A kind of Whitening, spot essence that contains nano-encapsulated supercritical propolis isoreactivity composition is characterized in that: this Whitening, spot essence is prepared from by its weight % proportioning by following raw material:
Present embodiment preparation technology flow chart as shown in Figure 3.The preparation manipulation step is as follows:
1, accurately weighs deionized water in the water pot, add the measured EDTA disodium of accurate scale, hyaluronate sodium, carbomer more successively, and heating mixes while stirring, 60 ℃ abundant stirring and dissolving is even down for temperature, add propylene glycol, 1 more successively, 3-butanediol, methyl hydroxybenzoate, allantoin, brazil tourmaline stone extracting solution (TOURMALINA), sun-proof algae (HELIONORI) stirring and dissolving are even, and 60 ℃ of temperature are incubated 30 minutes.
2, accurately weigh the newborn energy algae (AOAINE) of nano-encapsulated supercritical propolis, dissolved ceratinase compound enzyme (PROTEASE COMPLEX), composite plant antiallergic liquid (MULTIEX BSASM), the polypeptide of whitening (MELANOSTATINE DM), skin, the bionical peptide of epidermal growth factor (CG IDP-5) respectively in container separately, standby.
3, when 60 ℃ of temperature, in water pot material suction vacuum emulsifying pot, stir afterwards and add nano-encapsulated supercritical propolis, dissolved ceratinase compound enzyme (PROTEASE COMPLEX), composite plant antiallergic liquid (MULTIEX BSASM), the polypeptide of whitening (MELANOSTATINE DM), the newborn energy algae (AOAINE) of skin, the bionical peptide of epidermal growth factor (CG IDP-5) down successively, stirred 30 minutes, fully mix homogeneously.
4, cool, when temperature descends 45 ℃, add PEG-40 castor oil hydrogenated, caprylin, and stir.
5, continue cooling, when temperature descends 35 ℃, add aminomethyl propanol, stir, and start homogenizing, fully mix homogeneously.
7, cooling again, when temperature descends 30 ℃, i.e. discharging, sampling observation semi-finished product (physics and chemistry and sanitary indexs such as denseness, color and luster, abnormal smells from the patient, heat-resisting, cold-resistant stability, total number of bacteria), qualified is fill, packing, checks finished product again, detects and can put in storage after qualified.Preparation is finished.
Embodiment 2
A kind of Whitening, spot essence that contains nano-encapsulated supercritical propolis isoreactivity composition, this Whitening, spot essence is prepared from by its weight % proportioning by following raw material:
Present embodiment preparation technology flow chart is identical with embodiment 1 with the preparation manipulation step.
Embodiment 3
A kind of Whitening, spot essence that contains nano-encapsulated supercritical propolis isoreactivity composition, this Whitening, spot essence is prepared from by its weight % proportioning by following raw material:
Present embodiment preparation technology flow chart is identical with embodiment 1 with the preparation manipulation step.
Embodiment 4
A kind of Whitening, spot essence that contains nano-encapsulated supercritical propolis isoreactivity composition, this Whitening, spot essence is prepared from by its weight % proportioning by following raw material:
Present embodiment preparation technology flow chart is identical with embodiment 1 with the preparation manipulation step.
Embodiment 5
A kind of Whitening, spot essence that contains nano-encapsulated supercritical propolis isoreactivity composition, this Whitening, spot essence is prepared from by its weight % proportioning by following raw material:
Present embodiment preparation technology flow chart is identical with embodiment 1 with the preparation manipulation step.
Claims (5)
1. a Whitening, spot essence is characterized in that, the raw material of this Whitening, spot essence comprises the component of following weight percent content:
2. a kind of Whitening, spot essence according to claim 1 is characterized in that, the raw material of described Whitening, spot essence comprises the component of following weight percent content:
3. a kind of Whitening, spot essence according to claim 1 is characterized in that, the raw material of described Whitening, spot essence comprises the component of following weight percent content:
4. a kind of Whitening, spot essence according to claim 1 is characterized in that, the raw material of described Whitening, spot essence comprises the component of following weight percent content:
5. the preparation method of a Whitening, spot essence according to claim 1 is characterized in that, this method may further comprise the steps:
(1) weighs deionized water in the water pot, add the measured EDTA disodium of accurate scale, hyaluronate sodium, carbomer more successively, and heating mixes while stirring, 60 ℃ abundant stirring and dissolving is even down for temperature, add propylene glycol, 1 more successively, 3-butanediol, methyl hydroxybenzoate, allantoin, brazil tourmaline stone extracting solution, sun-proof algae stirring and dissolving are even, and 60 ℃ of temperature are incubated 30 minutes;
(2) when 60 ℃ of temperature, in water pot material suction vacuum emulsifying pot, stir afterwards and add nano-encapsulated supercritical propolis, dissolved ceratinase compound enzyme, composite plant antiallergic liquid, the polypeptide of whitening, the newborn energy algae of skin, the bionical peptide of epidermal growth factor down successively, stirred 30 minutes, fully mix homogeneously;
(3) cool, when temperature descends 45 ℃, add PEG-40 castor oil hydrogenated, caprylin, and stir;
(4) continue cooling, when temperature descends 35 ℃, add aminomethyl propanol, and stir;
(5) cooling again, when 30 ℃ of temperature declines, i.e. discharging obtains product.
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| CN109464365A (en) * | 2018-12-20 | 2019-03-15 | 北京蜜慕科技有限公司 | The novel processing step of propolis active ingredients and its application in cosmetics |
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| CN105687090A (en) * | 2016-03-14 | 2016-06-22 | 芜湖华海生物工程有限公司 | Allantoin skin-care compound |
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| CN108743432A (en) * | 2018-08-04 | 2018-11-06 | 芜湖慧宇商贸有限公司 | A kind of preparation method of the anti-wrinkle Essence containing ooze extract |
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