JP2019214537A - Phosphatidylinositol-containing cosmetic or external preparation for skin - Google Patents

Abstract

To provide cosmetics or external preparations for skin in which phosphatidylinositol is simply and stably dispersed in water without using a synthetic surfactant.SOLUTION: A cosmetic or an external preparation for skin containing the following components (A) to (C) is used. The cosmetic or the external preparation for skin of the present invention can easily and stably disperse phosphatidylinositol in water without using a synthetic surfactant, and further a cosmetic or an external preparation for skin excellent in transparency and dispersion stability can be obtained by using a specific polyhydric alcohol. (A) A phospholipid composition comprising the following components (A1) and (A2): (A1) phosphatidylinositol; and (A2) lecithin. (B) Polyhydric alcohol. (C) Water.SELECTED DRAWING: None

Description

  The present invention relates to a cosmetic or skin external preparation containing a phospholipid composition comprising phosphatidylinositol and lecithin, a polyhydric alcohol, and water.

  Lecithin is a general term for glycerophospholipids obtained from animals or plants, and is widely used as a natural emulsifier in foods, cosmetics, pharmaceuticals and the like. The components of lecithin are classified according to the structure of a polar group bonded to a phosphate group, and include phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidic acid (PA), and the like. Is known to be a major component. In recent years, studies focusing on the function and efficacy of each of these have been made, and it is known that PI is deeply involved in the intracellular and extracellular information transmission functions, and that triglyceride concentration in blood due to PI ingestion Physiological effects such as a decrease and an increase in HDL cholesterol have been reported. As cosmetics, physiological effects such as increasing the amount of hyaluronic acid in the skin (Patent Document 1) and enhancing Nrf2 activity (Patent Document 2) have been reported. In using PI as an active ingredient in various applications, it is important to obtain a composition containing PI at a high concentration. As a technique for this, lecithin has been used for a long time as a solvent separation (eg, Patent Document 3) or column purification. However, there are problems in terms of manufacturing complexity and cost. On the other hand, recently, a method for efficiently producing PI using phospholipase B that specifically acts on a phospholipid other than PI (Patent Documents 4 and 5) has been developed, and a composition containing a high concentration of PI has been industrially manufactured. It has become possible to obtain PI at a reasonable cost, and further applications of PI are expected. However, PI is inferior to other phospholipids in emulsifying power, and it is very difficult to disperse PI alone and uniformly in water. As a method for solving such a problem, for example, a method using a polyoxyethylene-based surfactant or the like in combination (Patent Document 6) is known. Due to concerns, a method that does not use a synthetic surfactant has been desired.

  Techniques for dispersing phospholipids in water using polyhydric alcohols are already known (for example, Patent Documents 7 and 8), but techniques for dispersing phosphatidylinositol using polyhydric alcohols are not known. . In addition, when phosphatidylinositol was dispersed using a polyhydric alcohol, the effect of the specific polyhydric alcohol on the transparency and dispersion stability was not known at all.

International Publication No. 2009/110205 JP 2011-168541 A JP-A-60-246305 International Publication No. 2007/010892 JP-A-2015-27260 JP 2012-77000A JP-A-60-153938 JP H11-13065A

  The present inventors have conducted various studies on phosphatidylinositol, which has not been widely used as a cosmetic use, and have various physiological activities including a previously unknown action, as an active ingredient of the cosmetic. I found it very useful. On the other hand, it has been found that it is very difficult to mix it into cosmetics due to its low dispersibility in water. Therefore, an object of the present invention is to provide a cosmetic or external preparation for skin in which phosphatidylinositol is simply and stably dispersed in water without using a synthetic surfactant.

The present inventors have conducted intensive studies to solve the above problems, and as a result, have found that a cosmetic or an external preparation for skin containing the following components (A) to (C) solves the above problems. Was completed.
(A) Phospholipid composition comprising the following components (A1) and (A2) (A1) phosphatidylinositol (A2) lecithin (B) polyhydric alcohol (C) water

  By using the present invention, phosphatidylinositol can be easily and stably dispersed in water without using a synthetic surfactant, and excellent transparency and dispersion stability can be obtained by using a specific polyhydric alcohol. It is possible to easily obtain a cosmetic or a skin external preparation. Further, the cosmetic or external preparation for skin of the present invention exerts excellent physiological activities such as hyaluronic acid production promoting action, intracellular active oxygen scavenging action, whitening action and collagen production promoting action.

The present invention is a cosmetic or a skin external preparation containing the following components (A) to (C) as essential components.
(A) Phospholipid composition comprising the following components (A1) and (A2) (A1) phosphatidylinositol (A2) lecithin (B) polyhydric alcohol (C) water

  The phosphatidylinositol (hereinafter also referred to as PI) as the component (A1) used in the present invention is one of the phospholipids present in plants such as soybean, rapeseed, sunflower, corn, and palm in nature. Included in lecithin extracted from. By fractionating from such lecithin by solvent fractionation or column purification or by a method using an enzyme to be described later, it is possible to obtain a composition containing a high concentration of PI. A PI-containing composition can be used as component (A1). As the high-concentration PI-containing composition, a composition having a PI content of 40% by weight or more, preferably 50% by weight or more may be used. As a method for producing a high-concentration PI-containing composition, a phospholipase B that specifically acts on a phospholipid other than PI is used in addition to the solvent separation and column purification that have been known for a long time, and a PI such as PC, PE, or PA is used. After selectively hydrolyzing other phospholipids, a method of extracting the remaining PI with a solvent (Patent Documents 4 and 5) has been developed. For this reason, a high-concentration PI-containing composition can be industrially and inexpensively obtained, and Soybrain PI50 (manufactured by Unitech Foods) is sold as a commercial product. In the present invention, such commercially available products can be preferably used.

  The lecithin of the component (A2) used in the present invention includes natural lecithin obtained from plants such as soybean, rapeseed, sunflower, safflower, peanut, cottonseed, corn, rice, barley and egg yolk, and hydrogenated products thereof. Can be exemplified. Further, these may be derivatives modified with a polyoxyalkylene group such as polyethylene glycol. These may be used alone or as a mixture of two or more. In general, natural plant-derived lecithin contains about 30% by weight of phosphatidylcholine (hereinafter also referred to as PC), but those in which the PC content is increased by solvent fractionation are commercially available. In the present invention, from the viewpoint of improving dispersibility, it is preferable to use one having an increased PC content, and the PC content in the component (A2) is 50 to 99% by weight, more preferably 70 to 99% by weight. Good to be. As described above, plant-derived lecithin contains about 10 to 20% of PI, but lecithin in which the PC content has been increased by solvent separation contains almost no PI because it is removed during the separation process. Therefore, in order to obtain a phospholipid composition having a high PC content and containing PI, it is necessary to mix a high-concentration PI-containing composition with lecithin having an increased PC content. Since lecithin obtained from egg yolk naturally contains about 70% by weight of PC (not including PI), it can be preferably used as the component (A2). However, in view of the natural consciousness of consumers, it is possible to use plant-derived lecithin. preferable. From the viewpoint of improving the feeling of use of the cosmetic or external preparation for skin of the present invention, it is preferable to use a mixture of hydrogenated lecithin and unhydrogenated lecithin as the component (A2). The mixing ratio of hydrogenated lecithin to unhydrogenated lecithin may be 99: 1 to 70:30, more preferably 97: 3 to 80:20 by weight.

  In the present invention, the component (A2) is used for the purpose of assisting the dispersion of the component (A1). The mixing ratio of the components (A1) and (A2) in the present invention is not particularly limited, but may be mixed at a weight ratio of 5:95 to 50:50, preferably 10:90 to 40:60.

  The amount of the component (A) used in the present invention is not particularly limited, but is preferably 0.001 to 5% by weight from the viewpoint of dispersion stability and transparency of the obtained cosmetic or external preparation for skin. Is preferably 0.005 to 2% by weight, most preferably 0.01 to 1% by weight.

  The polyhydric alcohol of the component (B) used in the present invention is used for the purpose of easily and stably dispersing the component (A) in water. Specific examples of component (B) include ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 2-methyl-1, 3-propanediol, 3-methyl-1,3-butanediol (isopentyldiol), tetramethylene glycol, hexylene glycol, caprylyl glycol, 1,2-pentanediol (pentylene glycol), 1,2-hexane Dihydric alcohols such as diol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol; trihydric alcohols such as glycerin, trimethylolpropane, 1,2,6-hexanetriol Sorbitol, xylitol, erythritol, maltitol, Sugar alcohols such as mannitol and pentaerythritol; glyceryl ethers such as ethyl glycerin, butyl glycerin, hexyl glycerin, and ethylhexyl glycerin; diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycol Examples include polyhydric alcohol polymers such as glycerin, triglycerin, tetraglycerin, and polyglycerin. These may be used alone or as a mixture of two or more. Among these, from the viewpoint of dispersibility of the component (A) in water, glycerin, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, hexylene glycol, 2-pentanediol and 1,2-hexanediol are preferred. From the viewpoint of the transparency and dispersion stability of the obtained cosmetic or external preparation for skin, in particular, one or more kinds selected from hexylene glycol, 1,2-pentanediol and 1,2-hexanediol are essential. It is preferable to include as. By incorporating such an essential polyhydric alcohol, it is possible to obtain a cosmetic or a skin external preparation excellent in not only initial dispersibility but also transparency and dispersion stability. In order to obtain a cosmetic or skin external preparation having transparency in appearance, such an essential polyhydric alcohol is contained in the component (B) in an amount of 20% by weight or more, preferably 25% by weight or more, and most preferably 28% by weight. It is desirable to contain at the above concentration.

  In the cosmetic or external preparation for skin of the present invention, "transparent in appearance" means that when a sample is placed in a glass bottle having a diameter of 3.5 cm and observed from the side, the transparency behind the liquid can be seen through. To tell. When measuring turbidity with a spectrophotometer, the transmittance is 60% or more when a sample is placed in a cell having a thickness of 1 cm and measured at a wavelength of 600 nm.

  The mixing ratio of the components (A) and (B) used in the present invention is from 1: 5 to 1: 200 in terms of weight ratio from the viewpoint of obtaining a cosmetic or a skin external preparation having excellent transparency and dispersion stability. , Preferably in a ratio of 1:10 to 1: 150.

  The water of the component (C) used in the present invention is not particularly limited as long as it can be generally used for cosmetics. Purified water, ion-exchanged water, distilled water, natural water, deep sea water, hydrogen water, etc. Can be used. Further, the pH may be adjusted with an acid, an alkali, a buffer, a chelating agent or the like, or a preservative may be added.

  The cosmetic or external preparation for skin of the present invention may further contain sterols or triterpenes as component (D) for the purpose of improving dispersion stability. Specific examples of the component (D) include sterols derived from animals such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, and desmosterol; stigmasterol, sitosterol, campesterol, brassicasterol, and phytosterol as a mixture thereof. Sterols derived from plants; sterols derived from microorganisms such as ergosterol; γ-oryzanol; ursolic acid; glycyrrhetinic acid; These may be used alone or as a mixture of two or more. Of these, cholesterol, phytosterol and γ-oryzanol are preferred. The blending amount of the component (D) is not particularly limited, but the blending ratio of the components (A) and (D) is 200: 1 to 1: 1, preferably 100: 1 to 2: 1 by weight. It is good to mix in a ratio.

  As a method for producing the cosmetic or external preparation for skin of the present invention, first, the components (A) and (B) or the components (A), (B) and (D) are stirred and mixed while being heated, and the polyhydric alcohol is mixed. The dispersion can be prepared by a method in which water is added to the obtained polyhydric alcohol dispersion while stirring, or a polyhydric alcohol dispersion is added to water while stirring. By such a method, phosphatidylinositol, which is difficult to disperse alone in water, can be easily and stably dispersed in water, and an aqueous dispersion excellent in transparency and dispersion stability can be obtained. .

  The phosphatidylinositol which is the component (A1) of the present invention is excellent in hyaluronic acid production promoting action, intracellular active oxygen scavenging action, whitening action, collagen production promoting action and the like as described in Japanese Patent Application No. 2018-083875. The cosmetic or external preparation for skin of the present invention containing this PI also has an excellent physiological activity.

  The cosmetic or external preparation for skin of the present invention may contain, if necessary, water and additional components usually incorporated into cosmetics, such as oily bases, surfactants, alcohols, humectants, polymers, thickeners and gels. Agents, antioxidants, preservatives, bactericides, chelating agents, pH adjusters / acids / alkali, ultraviolet absorbers, whitening agents, solvents, exfoliants / dissolvents, antipruritics, anti-inflammatory agents, antiperspirants, refreshing agents Agents, antihistamines, astringents, stimulants, hair growth agents / blood circulation promoters, reducing agents / oxidants, polymer powders, hydroxy acids, vitamins and their derivatives, sugars and their derivatives, organic acids, enzymes , Nucleic acids, hormones, inorganic powders, fragrances, dyes and the like may be contained to such an extent that the effects of the present invention are not impaired.

  Oil bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, kimyl alcohol, seraky alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linoleic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Higher fatty acids such as canic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acids and hydrogenated dimer acids and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, potassium, sodium salts thereof. And nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid Hydrocarbons such as paraffin; candelilla wax, carnauba wax, rice wax, wood wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, fisher Waxes such as tropsch wax, polyethylene wax, ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut Oil, hazelnut oil, kukuinut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, flaxseed oil, cottonseed oil, soybean oil, peanut oil, rice bran Vegetable oils such as oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal properties such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil and turtle oil Oils and fats; animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanolin Lanolins such as adsorbed and purified lanolin, lanolin acetate, lanolin acetate liquid, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, Phospholipids such as phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof, and phospholipids such as lysolecithin; hydrogenated soybean phospholipids, partially hydrogenated soybean phosphorus Phospholipid derivatives such as lipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; sapogenins; saponins; cholesteryl acetate, nonanoic acid Resteryl, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, di-N-lauroyl-L-glutamate (cholesteryl / behenyl / octyldodecyl), di-N-lauroyl-L-glutamate (cholesteryl / octyldodecyl), N-lauroyl- L-glutamic acid di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di (phytosteryl / octyldodecyl), acyl sarcosine alkyl ester such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid Cholesteryl, macadamia nut oil fatty acid phytosteryl, sunflower seed oil fatty acid phytosteryl, phytosteryl isostearate, soft lano Sterol esters such as cholesteryl phosphate fatty acid, cholesteryl hard lanolin fatty acid, cholesteryl long chain fatty acid, and cholesteryl long chain α-hydroxy fatty acid; lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex; octyl myristate Dodecyl, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanate, Isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyl oleate Dodecyl, octyldodecyl ricinoleate, octyldodecyl lanolin fatty acid, dicaprylyl carbonate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, palmitin Octyl acid, isopropyl isostearate, isopropyl lanolin fatty acid, methyl heptyl laurate, methyl heptyl myristate, methyl heptyl palmitate, methyl heptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyl sebacate Octyl, diisobutyl adipate, dioctyl adipate, dioctyl succinate, citric acid Monoalcohol carboxylic esters such as triethyl; oxyesters such as cetyl lactate, diisostearyl malate, hydrogenated castor oil monoisostearate, and γ-elcalactone; glyceryl trioctanoate, glyceryl trioleate, and triisostearic acid Glyceryl, glyceryl diisostearate, glyceryl tri (caprylic / capric acid), tri (caprylic / capric / myristic / stearic) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), Glyceryl eicosane diacid behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol octanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (isostearic acid / sebacic acid) Ditrimethylolpropane, pentaerythrityl triethylhexanoate, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonisostearate, deca (erucic acid / isostearic acid / ricinolein) Acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoester, glycol distearate (ethylene distearate) Polyglycol fatty acid esters such as lenglycol), 3-methyl-1,5-pentanediol dineopentanoate and 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; Diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, di (isostearyl / phytosteryl) dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl) ), Dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, hydrogenated rosin condensate of dimer dilinoleyl, dimer dilinoleic acid-hardened castor oil, hydroxyalkyl dimer relinole Derivatives of dimer acids or dimer diols such as diethers; coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA) Fatty acid alkanolamides, such as lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethyl) Polysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclope) Siloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, (aminoethylaminopropyl methicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyl dimethicone and amodimethicone, cation Modified silicone, polyether-modified silicone such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid Modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone Silicones such as corn, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amide alkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, polysiloxane / oxyalkylene copolymer; perfluorodecane; Fluorinated oils such as perfluorooctane and perfluoropolyether are preferred.

  Examples of humectants / feel improvers include glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, Polyethylenes such as trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol / propylene glycol copolymers, and polymers thereof; diethylene glycol monoethyl ether (Ethoxydiglycol), glycol alkyl ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether and diethylene glycol dibutyl ether Water-soluble esters such as (eicosane diacid / tetradecandioic acid) polyglyceryl-10, polyglyceryl-10 tetradecandioate and bisethoxydiglycol cyclohexanedicarboxylate; sugars such as sorbitol, xylitol, erythritol, mannitol and maltitol Alcohols: glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ- Cyclodextrins and modified cyclodextrins such as maltosylation and hydroxyalkylation), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabino Saccharides such as galactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer and derivatives thereof; hyaluronic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoitin sulfate, caronine sulfate, kerato sulfate, dermatan Sulfuric acid; white jellyfish extract, white jellyfish polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, a naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid and lactic acid and salts thereof; urea; 2-pyrrolidone-5 -Carboxylic acids and salts thereof such as sodium; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine Amino acids such as glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen-degrading peptide, Hydrolyzed Collagen, Hydroxypropylammonium Chloride Hydrolyzed Collagen, Elastin Degraded Peptide, Keratin Degraded Peptide, Hydrolyzed Keratin, Conchiolin Degraded Peptide, Hydrolyzed Conchiolin, Silk Proteolytic Peptide, Hydrolyzed Silk, Lauroyl Hydrolyzed Silk Sodium, Soy Proteolysis Protein peptides such as peptides, wheat proteolytic peptides, hydrolyzed wheat proteins, casein degrading peptides, acylated peptides and the like Derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture, yeast extract, eggshell membrane protein, bovine submandibular mucin, hypotaurine, sesame lignan glycoside, Glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerastin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk extract, Izayobara extract, Achillea millefolium extract, Animal / plant extract components such as eucalyptus extract, melilot extract, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudo-ceramide, glycosphingolipid, ceramide and sugar-ceramide-containing extract, etc. Ceramides can be mentioned as preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. The HLB of the surfactant is not particularly limited, and can be used from as low as about 1 to as high as about 20, and it is also preferable to combine low and high HLB. Preferred examples of the surfactant include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amines and sodium lauroylglutamate methylalanine sodium; Acyl amino acid salts such as sodium silicate, triethanolamine cocoylglutamate, sodium lauroylglutamate, sodium myristoylglutamate, sodium stearoylglutamate, ditriethanolamine palmitoylaspartate, cocoylalanine triethanolamine, lysine sodium dilauroylglutamate; sodium laureth acetate; Polyoxyethylene alkyl ether acetate; succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylate; acyl lactate; polyoxyethylene fatty amine sulfate; fatty acid alkanolamide sulfate; Fatty acid glyceride sulfates such as coconut oil fatty acid sodium glycerin sulfate; Oxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate; monolauroyl monoethanolamide polyoxyethylene sulfosuccinate Alkyl ether sulfosuccinates such as sodium silicate, lauryl polypropylene glycol sodium sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkyl naphthalene sulfonates; alkane sulfonates; α-sulfofatty acid methyl ester salt; acyl isethionate salt; alkyl glycidyl ether sulfonate Alkyl sulfoacetic acid salts; Alkyl ether phosphates such as sodium laureth phosphate, sodium dilaurate phosphate, sodium trilaureth phosphate, sodium monooleate phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphorus Acid salts; fatty acid amide ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, cyclic lysophosphatidic acid or salts thereof; silicone-based shades such as carboxylic acid-modified silicone, phosphoric acid-modified silicone, and sulfuric acid-modified silicone Ionic surfactants and the like; examples of nonionic surfactants include laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), and stearee. (Polyoxyethylene stearyl ether), behenes (polyoxyethylene behenyl ether), isosteareth (polyoxyethylene isostearyl ether), octyl dodeces (polyoxyethylene octyl dodecyl ether) Polyoxyethylene alkyl ethers; polyoxyethylene alkyl phenyl ether; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, Castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene hydrogenated castor oil maleic acid; poly Polyoxyethylene cholesterol; polyoxyethylene cholesterol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether; polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether; Polyoxyethylene / polyoxypropylene alkyl ether such as polyoxyethylene / polyoxypropylene monobutyl ether, polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol (Poly) glycerin polyoxypropylene glycol such as PPG-9 diglyceryl; Ryl, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil, glyceryl mono-cottonseed oil, glyceryl monoerucate, glyceryl sesquioleate, glycerin α, α'-pyroglutamate oleate, monostearin Glycerin fatty acid partial esters such as acid glycerin malic acid; 2, polyglyceryl-10 decasterate, polyglyceryl-2 isostearate, 3, 4, 5, 6, 8, 8, 10, diglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 3 , Polyglyceryl-2 triisostearate, polyglyceryl-2 tetraisostearate, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 5, 6, 8, 10, polyglyceryl dioleate 6, polyglycerin fatty acid esters such as polyglyceryl-2 trioleate and polyglyceryl-10 decaoleate; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol moiety Fatty acid ester; sorbitol partial fatty acid ester; maltitol partial fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate Sorbitan fatty acid esters such as sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol penta-2-ethylhexylate sorbitan, and diglycerol sorbitan tetra-2-ethylhexylate; Sugar derivative partial esters such as sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; Stearates, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene dioleate, etc. Polyoxyethylene fatty acid monoesters and diesters; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate Polyoxyethylene glycerin fatty acid esters such as ethate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene sorbitan tetraoleate; poly Oxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol fatty acid esters such as bitol pentaoleate and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax Alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, serakyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; Natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amide; coconut oil fatty acid monoethano Luamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide Fatty acid alkanolamides such as (partamide MEA), palmitic acid diethanolamide (partamide DEA), and coconut oil fatty acid methylethanolamide (cocamide methyl MEA); alkyls such as lauramine oxide, cocamine oxide, stearamine oxide and behenamine oxide Dimethylamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; polyethers such as dimethicone copolyol Silicone-based nonionic surfactants such as silicone-modified silicone, polysiloxane / oxyalkylene copolymer, polyglycerin-modified silicone, and sugar-modified silicone; cationic surfactants include behentrimonium chloride and stearyltrimonium chloride Alkyltrimethylammonium chlorides such as cetrimonium chloride and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicicodimmonium chloride; stearamide propyldimethylamine; Fatty acid amidoamines such as stearamidoethyldiethylamine and salts thereof; alkyl etheramines such as stearoxypropyldimethylamine and Or quaternary salts of fatty acids; fatty acid amide-type quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and lanolin ethyl sulfate aminopropylethyldimethylammonium; polyoxyethylene alkylamine and the like. Salts or quaternary salts; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine monium salts; alkyltrialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts Alkyl isoquinolinium salts; dialkyl morphonium salts; polyamine fatty acid derivatives; amino-modified silicones such as aminopropyl dimethicone and amodimethicone; cation-modified silicones; And silicone-based cationic surfactants such as polyether-modified silicone, amino-modified and polyether-modified silicone; and amphoteric surfactants include N-alkyl-N, N- such as lauryl betaine (lauryl dimethylamino acetate betaine). Dimethylamino acid betaine; fatty acid amide alkyl-N, N-dimethylamino acid betaine such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline type betaine such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaine such as alkyldimethyltaurine; alkyl Sulfate betaines such as dimethylaminoethanol sulfate; phosphate betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine, phosphatidylethanolamine , Phosphatidylserine, sphingomyelin and other sphingolipids, lysolecithin, hydrogenated soybean phospholipids, partially hydrogenated soybean phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, phospholipids such as hydroxylated lecithin; silicones Preferred examples of the polymeric amphoteric surfactant include polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymer, and various silicone surfactants.

  Guar gum, locust bean gum, queen seeded, carrageenan, galactan, gum arabic, tara gum, tamarind, furceleran, karaya gum, troloi, chara gum, tragacanth gum, pectin, pectic acid and sodium Salts such as salts, salts such as alginic acid and sodium salt, mannan; starches such as rice, corn, potato, wheat, etc .; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, licorice extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl Cellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, cellulose sodium sulfate, dialkyldimethylammonium cellulose cellulose, crystalline cellulose, cellulose such as cellulose powder and derivatives thereof; soluble starch, carboxymethyl starch, methylhydroxypropyl starch; Starch polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride starch, and corn starch aluminum octenylsuccinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA); Vinyl pidolidone / vinyl alcohol copolymer, polyvinyl methylate Amphoteric methacrylic acid such as polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate) copolymer (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester; water-dispersible polyester; Acrylamide; polyacrylic acid ester copolymer such as polyethyl acrylate; carboxyvinyl polymer; polyacrylic acid and salts thereof such as sodium salt; acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylate copolymer, acrylic acid / cationized methacrylamide copolymer, polyquaternium Cationized oligosaccharides, cationized polysaccharides such as cationized dextran, guar hydroxypropyltrimonium chloride, etc .; acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer; Polyethyleneimine; cationic polymer; copolymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and copolymer with butyl methacrylate; acrylic resin emulsion, polyethyl acrylate emulsion, polyacryl alkyl ester emulsion; Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; Classes; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and salts thereof; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride; Fumed silica (ultrafine silica anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal dialkyl phosphate, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester Preferred are mentioned.

  Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol. Classes: diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as acetate, diethylene glycol monoethyl ether acetate and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, and dialkyl carbonate , Acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation chlorofluorocarbon; and propellants such as LPG, dimethyl ether, and carbon dioxide.

  As antioxidants, tocopherol derivatives such as tocopherol (vitamin E) and tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; Sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride are preferred As Preferred examples of the reducing agent include thioglycolic acid, cysteine, and cysteamine. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, percarbonate and the like.

  Examples of antibacterial agents or preservatives include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-pentanediol, 1,2-hexanediol, and 1,2-octane. 1,2-alkanediols such as diols; alkylglyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; sodium benzoate; isothiazolineone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazo Linium urea; dehydroacetic acid and salts thereof; phenols; halogenated bisphenols such as triclosan, acid amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, ben chloride Ruconium, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and phenylphenol sodium; phenylethyl alcohol , Photosensitizers, antibacterial zeolites and silver ions are preferred. When used as an antiseptic or antiseptic for antiseptic purposes, phenoxyethanol from the viewpoint of safety of cosmetics or external preparations for skin; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol and 1,2-octanediol; alkyl glyceres such as 2-ethylhexyl glyceryl ether It is more preferred to use ethers.

  Examples of the chelating agent include edetates (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; etidronic acid and the like Sodium oxalate; polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine , Gluconic acid, ascorbic acid, succinic acid and tartaric acid are preferred. pH adjusters ・ Acids and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferred.

  Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, biotite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluoroapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metallic soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, navy blue, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine particles and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Inorganic powders of various sizes and shapes such as body, gold, aluminum, etc., and treated with various surface treatment agents such as hydrogen silicone, silicone such as cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powder such as powder that has been hydrophobized or hydrophilized; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate / polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate laminate powder, polyethylene terephthalate / aluminum / epoxy laminate powder, urethane powder, silicone powder, Teflon (registered trademark) powder, and organic-inorganic composite powder Are preferred. As inorganic salts, sodium chloride-containing salts such as common salt, normal salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum potassium potassium sulfate (alum), aluminum ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na / 2Na / 3Na phosphate, phosphoric acid Potassiums, calcium phosphates, and magnesium phosphates are preferred.

  Examples of the ultraviolet absorber include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, N, N-dimethylparaaminoethyl ethyl ester Benzoic acid-based ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid And salicylic acid purples such as sodium salts thereof, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc. Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxysi Cinnamic acid-based ultraviolet absorbers such as namate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone; 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4′-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone and the like Benzophenone purple Linear absorber; 3- (4'-methylbenzylidene) -d, l-camphor; 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5- Methylphenylbenzotriazole; 2- (2'-hydroxy-5'-t-octylphenyl) benzotriazole; 2- (2'-hydroxy-5'-methylphenylbenzotriazole; dibenzarazine; dianisoylmethane; 5- (3 2,3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyltriazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2'-hydroxy-5'-methylphenyl) benzotriazole, 1- ( , 4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, hydantoin derivatives such as 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidine propionate, phenylbenzimidazozole sulfonic acid, terephthalidene dicane fursulfone Preferred are acids, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

  As vitamins and derivatives thereof, vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide / benzyl nicotinate, vitamin Bs such as choline; vitamin Cs such as ascorbic acid and salts thereof such as sodium; vitamin D; Vitamin E such as β, γ, δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate salts such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt; Fatty acid esters of ascorbic acid, such as tetraisopalmitic acid ester, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate; ascorbic acid alkyl ethers, such as ethyl ascorbic acid; ascorbic acid glucosides, such as ascorbic acid-2-glucoside; Ascorbic acid derivatives such as fatty acid esters and tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate and tocopherol phosphate; tocotrienol; and other various vitamin derivatives Are preferred.

  Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramin hydrochloride, chlorpheniramine maleate; And a plant extract such as Yongba extract are preferred. Examples of hair-growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as assembly extract, pepper tincture, ginger tincture, ginger extract, and cantharis tincture; capsaicin, nonylate valenylamide, zingerone, ictamol, tannic acid , Borneol, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthin, γ-oryzanol, cepharanthin, vitamin E and derivatives such as tocopherol nicotinate / tocopherol acetate, γ-oryzanol, nicotinic acid and nicotinamide / benzyl nicotinate Derivatives such as ester inositol hexanicotinate, nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, Flavanonol derivatives, stigmasterol or stigmasteranol and glycosides thereof, and minoxidil are preferred. Preferred examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone, and the like. Other therapeutic agents such as anti-wrinkle agents, anti-aging agents, tightening agents, cooling agents, warming agents, wound healing promoters, stimulants, analgesics, cell activators, etc. include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives of lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, hydroxy-capric acid, long-chain α-hydroxy fatty acid, α- such as long-chain α-hydroxy fatty acid cholesteryl, etc. β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine, and derivatives thereof; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein, α-lipoic acid, platinum nanocolloid, fullerenes, etc. Catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; tannins, sesamin, protoanthocyanidins, chlorogenic acid, polyphenols such as apple polyphenols; rutin and glycosides; Derivatives of hesperidin and glycosides; lignan glycosides; licorice extract-related substances such as glabridine, glabrene, liquiritin, isoliquiritin; lactoferrin; gingerol, gingerol; fragrance substances such as menthol, camphor, cedrol and derivatives thereof. Preferred are capsaicin, vanillin and the like and derivatives; insect repellents such as diethyltoluamide; complexes of a physiologically active substance and cyclodextrins.

  Plant / animal / microbial extracts include iris extract, ashitaba extract, asnaro extract, asparagus extract, avocado extract, amateur extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot nucleus extract, and ginkgo extract , Inchiko extract, Fennel extract, Turmeric extract, Oolong tea extract, Owaurushi extract, Eijitsu extract, Echinashi leaf extract, Emisoso extract, Japanese gourd extract, Oubaku extract, Ouren extract, Barley extract, Panax ginseng extract, Hypericum perforatum extract, Odorikosou extract, Ononisu extract , Dutch mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed Luk, cuckoo extract, chamomile extract, oil-soluble chamomile extract, carrot extract, sagebrush extract, oak wheat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kio extract, jellyfish extract, kina extract, cucumber extract, kiri leaf extract, Guanosine, Guava extract, Kujin extract, Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentian extract, Gennoshoko extract, Black tea Extract, yeast extract, kouboku extract, coffee extract, burdock extract, rice extract, rice fermented extract, rice bran fermented extract, rice germ oil, comfrey extract, Lagen, lingonberry extract, Psychic extract, Psychoextract, Saitai extract, saffron extract, Salvia extract, Sabonso extract, Sasa extract, Hawthorn extract, Sansha extract, Sansho extract, Shiitake extract, Jio extract, Shikon extract, Perilla extract, Shinanoki extract, Shimotsubesou Extract, Jatoba extract, Peony extract, Ginger extract, Shobu root extract, Birch extract, White jellyfish extract, Japanese horse chestnut extract, Stevia extract, Stevia fermented product, Nishikawayanagi extract, Sekiyu suta extract, Scotch hawthorn extract, Syringa serrata extract, Scotch extract , Mint extract, sage extract, mallow extract, senkyu extract, assembly extract, soybean extract, rhubarb extract, die Extract, syrup extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, scotch extract, chimpanzee extract, tea tree oil, tea bean extract, capsicum extract, eucalyptus extract, calendula extract, spruce extract, spruce extract, dokudami extract, tomato Extract, natto extract, carrot extract, garlic extract, nobara extract, hibiscus extract, Bacmondou extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, Parietaria extract, Hioki sorghum extract, bisabolol, hinoki extract, bifidobacterium extract, Loquat extract, coltsfoot extract, fukinotou extract, bakuria extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, Safflower extract, Peppermint extract, Bodaiju extract, Button extract, Hop extract, Maikaika extract, Pine extract, Maronie extract, Mizubasho extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, roman chamomile extract, royal jelly Extracts and extracts such as Warmoko extract are preferred.

  Examples of the antipruritic include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, and pyridoxine. Examples of antiperspirants include chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate, and the like. Examples of the cooling agent include menthol and methyl salicylate. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid, and the like. Examples of the enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease and the like. Preferred nucleic acids include ribonucleic acid and its salts, deoxyribonucleic acid and its salts, and disodium adenosine triphosphate.

  As the fragrance, acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, IsoE super, isobutyl quinoline, iris oil, iron, indole, ylang-ylang oil, undecanaal, undecenal, γ-undecalactone, Estragole, Eugenol, Okemos, Opoponax Resinoid, Orange Oil, Eugenol, Orlanthol, Garrack Solid, Carvacrol, L-Carbon, Camphor, Cannon, Carrot Seed Oil, Clove Oil, Methyl Cinnarate, Geraniol, Geranilnitrile , Isobornyl acetate, geranyl acetate, dimethylbenzylcarbinyl acetate, styralyl acetate, ceryl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiveryl acetate, benzyl acetate, vinegar Linalyl, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, styrax resinoid, cedarwood oil, cedren, cedrol, celery seed oil, thyme oil, damascon, damacenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, Tripral, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla absolute , Vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperiton, phenethyl alcohol, phenylacetaldehyde, petitgren oil, hexylcinnamaldehyde, cis-3-hexenol, peruval balsam, vetiver oil, vetiverol, peppermint oil, Pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menthon, eucalyptus oil, β-yonone, lime oil, lavender oil, Synthetic and natural flavors such as D-limonene, linalool, linal, liliar, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various compounded flavors It is mentioned as preferred.

  Examples of the pigment / colorant / dye / pigment are Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204 Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, Green No. 402, Red No. 102, Red 104-1, red 105-1, red 106, red 2, red 3, red 201, red 202, red 203, red 204, red 205, red 206, red 207 Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 227 No. 28, Red 230-1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503 Red 504, Red 505, Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow Legal pigments such as No. 405, Yellow 406, Yellow 407, Yellow No. 5, etc .; Other acidic dyes such as Acid Red 14; Base dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; Two , Nitro dyes such as HC Yellow 5, HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26; dispersion Dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and loess Pigments; inorganic black pigments such as black iron oxide and lower titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; ultramarine, navy blue, etc. Inorganic blue pigments: pearl pigments such as titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil; aluminum powder Metal powder pigments such as powdered powders and gold; astaxanthin, anthraquinones such as alizarin, anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, curcumin, cochineal, naphthoquinones such as shikonin, bixin, Flavones, betacyanidins, henna, hemoglobin, lycopene, riboflavin, rutin, and other natural pigments and dyes; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylene Oxidation dye intermediates and couplers such as diamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and the like; salts; autoxidation dyes such as indoline; dihydroxyacetone; And the like as correct ones.

  Preferred examples of the water include hard water, soft water, natural water, deep sea water, electrolytic alkali ion water, electrolytic acidic ion water, ion water, and cluster water, in addition to ordinary water and purified water.

  In addition to these, cosmetic raw material standards, cosmetic varieties compounding component standards, Japanese Cosmetic Industry Federation ingredient label list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), quasi-drug raw material standards, Japanese Pharmacopoeia, pharmaceutical additives Ingredients listed in the standards, official compendiums of food additives, etc., and Japanese and foreign patent publications and patent publications (including published publications and republication) that belong to the international patent classification IPC A61K7 and A61K8 Known cosmetic components, pharmaceutical components, food components, and the like, such as the components described, can be contained in a known combination and in a blending ratio and blending amount.

  Examples of the types of the cosmetics of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, aromatic cosmetics, body cosmetics, and external skin preparations such as ointments. The cosmetic of the present invention can be produced according to a usual method.

  The types of the cosmetic or the external preparation for skin of the present invention will be described in further detail.Examples of hair cosmetics include oil shampoos, cream shampoos, conditioning shampoos, dandruff shampoos, shampoos for hair coloring, and shampoos with integrated rinse. Rinsing, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, chick, hair cream, hair blow, split ends coat , Hair oil, permanent wave agent, straight perm agent, oxidative hair dye, hair bleach, hair color pre-treatment, hair color after treatment, perm pre-treatment, perm Terpolymers treatments, hair manicure, and as hair growth agents are preferred.

  As skin cosmetics, lotions such as soft lotion, astringent lotion, washing lotion, and multi-layer lotion; emollient lotion, moisturizing lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer -Emulsions, massage lotions, cleansing lotions, protect emulsions, sun protects, sun protectors, UV care milk, sun screens, make-up lotions, keratin smoothers, elbow lotions, hand lotions, body lotions, etc .; emollient creams, nutritional creams, Nourishing cream, burnishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream Creams, such as creams, pre-make-up creams, sunscreen creams, suntan creams, depilatory creams, deodorant creams, shaving creams, keratin softening creams; gels, such as moisture gels; essences, such as moisturizing essences, whitening essences, ultraviolet protection essences; Liposomal cosmetics such as liposome serum and liposome lotion; pack masks such as peel-off pack, powder pack, washing pack, oil pack, cleansing mask; cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing Oil, cleansing mask, washing powder, facial cleansing powder, etc .; toilet soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic toilet soap Soap can be mentioned as preferred.

  As make-up cosmetics, preferred are white powder and powdered powders, foundations, lipsticks, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrows, eyebrow, nail enamel, enamel remover, nail treatment. .

  Preferred examples of the aromatic cosmetics include perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, condensed fragrance, aromatic powder, perfume soap, body lotion, and bath oil.

  Examples of body cosmetics include body cleaning products such as body shampoos, deodorant lotions, deodorant powders, deodorant sprays, deodorant cosmetics such as deodorant sticks, decolorizing agents, depilatory and depilatory agents, bath agents, and insect repellent sprays. Repellers are preferred.

  The external preparation for skin can be used in the form of ointments, patches, lotions, liniments, liquid coatings and the like. In addition, it can be used as an oral cosmetic such as toothpaste and mouthwash.

  As the dosage form of the cosmetic or external preparation for skin of the present invention, emulsification such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, O / W / O type, etc. Type cosmetics, oily cosmetics, solid cosmetics, liquid cosmetics, kneaded cosmetics, stick cosmetics, volatile oil cosmetics, powdery cosmetics, jelly cosmetics, gel cosmetics, pastes Preferred forms include cosmetics, emulsion polymer type cosmetics, sheet type cosmetics, mist type cosmetics, spray type cosmetics and the like.

  The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

Lotions containing the components (A) to (C) of the present invention with the compositions shown in Tables 1 to 5 were prepared by the following methods. For the obtained lotion, the initial dispersibility, transparency and dispersion stability were evaluated by the following methods, and the results are shown in the lower column of each table.

<Preparation method>
The components (A) and (B) were previously stirred and mixed at 80 ° C. to prepare a polyhydric alcohol dispersion. The resulting polyhydric alcohol dispersion is added to an aqueous solution of methylparaben and the component (C) heated and dissolved at 80 ° C. while stirring, and the mixture is stirred with a homomixer (75 ° C., 5000 rpm, 15 minutes). And cooled.

<Initial dispersibility>
About the obtained lotion, the dispersion state immediately after preparation was visually observed, and the initial dispersibility was evaluated according to the following evaluation criteria.

○ ... uniformly dispersed × ... not uniformly dispersed

<Transparency>
The transmittance of the lotion was measured using a spectrophotometer (cell thickness 1 cm, wavelength 600 nm). In addition, the lotion was placed in a glass bottle having a diameter of 3.5 cm, the external appearance was visually observed from the side, and the transparency was evaluated according to the following evaluation criteria.

○ ・ ・ ・ The back of the liquid can be seen through. △ ・ ・ ・ The back of the liquid can be seen slightly. × ・ ・ ・ The back of the liquid cannot be seen through.

<Dispersion stability>
The obtained lotion was subjected to a storage stability test at 50 ° C. for one month, and the dispersion stability was evaluated according to the following evaluation criteria.

・ ・ ・: Evenly dispersed after storage △: Almost uniformly dispersed after storage ×: Not uniformly dispersed or precipitated after storage

  From the results of Tables 1 to 3, it was found that the component (A) can be easily dispersed in water using the component (B). In particular, when 1,2-pentanediol, 1,2-hexanediol, and hexylene glycol (essential polyhydric alcohol) were used as the component (B), it was found that transparency and dispersion stability were extremely excellent (implementation). Examples 1-3). In addition, when the essential polyhydric alcohol is used alone, transparency and dispersion stability are excellent when used in combination with other polyhydric alcohols having poor transparency and dispersion stability. (Examples 7 to 11). In addition, in order to obtain a lotion having excellent transparency, it was found that these essential polyhydric alcohols should be contained in the component (B) in an amount of 25% by weight or more (Examples 12 to 14).

  From the results in Table 4, it was found that when the component (A1) ratio in the component (A) was high, initial dispersion was not possible (Comparative Example 2). It was also found that the initial dispersion was not possible even when the ratio of component (B) to component (A) was low (Comparative Example 3). Furthermore, from the results in Table 5, it was found that the higher the PC content in the component (A2), the better the transparency and dispersion stability (Examples 19 to 21).

  The cosmetics described below were prepared. The obtained cosmetic was excellent in moisturizing property and permeation, prevented fine lines and rough skin, and made the skin look bright and plump.

Example 22 Moisturizing lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.02
Hydrogenated lecithin (PC content 97%) 0.05
Lecithin (PC content 92%) 0.01
BG 2.0
Glycerin 3.0
1,2-pentanediol 3.0
Part B Purified water 40.0
Part C Neosolue-Aqulio (Nippon Seika) 1.0
Neosolue-AquaS (Nippon Seika) 1.0
Glucosylceramide 0.5
Tremoist-TP (Nippon Seika) 0.1
EDTA-2Na 0.05
Phenoxyethanol 0.2
Methyl paraben 0.15
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Part A and Part B were heated to 70 ° C., and Part A was added while stirring Part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, after cooling, part C previously mixed was added to make a uniform liquid.

Example 23 Moisturizing lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.04
Hydrogenated lecithin (PC content 97%) 0.09
Lecithin (PC content 92%) 0.01
Polyglycerin-10 1.0
Diglycerin 2.0
Glycerin 8.0
1,2-pentanediol 4.0
Planool-LG2 (Nippon Seika) 0.01
Planool-ISS (Nippon Seika) 0.01
Part B Purified water 50.0
Part C Maltitol liquid 1.0
Betaine 0.5
α-glucan oligosaccharide 0.1
Hyaluronate Na 0.5
Tuberose polysaccharide 0.01
Hydroxypropyl methylcellulose stearoxy ether 0.05
(Acrylates / alkyl acrylate (C10-30)) crosspolymer 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methyl paraben 0.15
Purified water Amount that totals 100 ----------------------------------------------------------------------------------
(Preparation method)
Part A and Part B were heated to 70 ° C., and Part A was added while stirring Part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, it was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industry). After cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 24 Moisturizing lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.04
Hydrogenated lecithin (PC content 97%) 0.09
Lecithin (PC content 92%) 0.01
Phytopresome-MEL (Nippon Seika) 0.05
BG 5.0
Glycerin 10.0
1,2-hexanediol 5.0
Part B Purified water 40.0
Part C Neosolue-Aqulio (Nippon Seika) 1.0
Neosolue-AquaS (Nippon Seika) 1.0
PEG / PPG / polybutylene glycol-8 / 5/3 glycerin 0.5
Xanthan gum 0.05
Glucosyl trehalose 0.5
Polyquaternium-51 0.5
Hydrolyzed yeast extract 1.0
Licorice extract 0.05
Aloe extract 0.05
Sohakuhi Extract 0.2
Pentetate 5Na 0.05
Phenoxyethanol 0.2
Methyl paraben 0.15
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Part A and Part B were heated to 70 ° C., and Part A was added while stirring Part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, after cooling, part C previously mixed was added to make a uniform liquid.

Example 25 Moisturizing lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.04
Hydrogenated lecithin (PC content 97%) 0.09
Lecithin (PC content 92%) 0.01
Glycerin 8.0
Hexylene glycol 5.0
Lysolecithin 0.03
Phytopresome Cera23 (Nippon Seika) 0.05
Part B Purified water 60.0
Part C Hydrolyzed collagen 0.05
Hydrolyzed sodium hyaluronate 0.05
Citric acid 0.01
Na citrate 0.09
Neosolue-Aqulio (Nippon Seika) 1.0
Pyrrolidone carboxylate Na 0.1
Inositol 0.2
Arginine 0.1
Alanine 0.1
Betaine 0.1
EDTA-2Na 0.05
Phenoxyethanol 0.4
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Parts A and B were each heated to 70 ° C., and part A was added while stirring part B with a propeller (500 rpm) to prepare an aqueous dispersion. Further, after cooling, part C previously mixed was added to make a uniform liquid.

Example 26 Moisturizing lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.08
Hydrogenated lecithin (PC content 97%) 0.18
Lecithin (PC content 92%) 0.02
Propanediol 5.0
Glycerin 10.0
1,2-pentanediol 10.0
Phytopresome Lipo-Q (Nippon Seika) 0.05
Phytopresome Asta (Nippon Seika) 0.05
LUSPLAN PI-DA (Nippon Seika) 0.05
Planool-DP (Nippon Seika) 0.05
Phytosterol 0.05
Tocopherol 0.02
Part B Purified water 60.0
Part C Mannitol 1.0
PEG-30 1.0
Hydrolyzed collagen 0.1
Urea 0.1
Chondroitin sulfate Na 0.05
Hydroxyethyl cellulose 0.03
Carboxyvinyl polymer 0.05
Sorbitol 0.5
Phenoxyethanol 0.2
Purified water Amount that totals 100 ----------------------------------------------------------------------------------
(Preparation method)
Part A and Part B were heated to 70 ° C., and Part A was added while stirring Part B with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, it was dispersed with a high-pressure emulsifier (Microfluidizer manufactured by Mizuho Industry). After cooling, part C mixed in advance was added to obtain a uniform liquid.

Example 27 Whitening lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.08
Hydrogenated lecithin (PC content 97%) 0.18
Lecithin (PC content 92%) 0.02
Phytosterol 0.05
Glycerin 8.0
1,2-pentanediol 8.0
Part B 3-O-ethylascorbic acid (Nippon Seika) 1.0
Arbutin (Nippon Seika) 1.0
Purified water 30.0
Neosolue-Aqulio (Nippon Seika) 1.0
Ethanol 3.0
Inulin 2.0
Methyl gluces-10 2.0
Glycyrrhizic acid 2K 0.05
Tremoist-TP (Nippon Seika) 0.02
Xanthan gum 0.03
Phenoxyethanol 0.2
Methyl paraben 0.15
Na edetate 0.2
Citric acid 0.1
Na Citrate Amount that pH becomes 4.5 Part C Purified water Amount that becomes 100 in total ---------------------------------------- −−−−−−−−−−−
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and Part C were heated to 70 ° C., and Part A was added while stirring Part C with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, after cooling, part B previously mixed was added to obtain a uniform liquid.

Example 28 Whitening lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A phosphatidylinositol (Soybrain PI50) 0.08
Hydrogenated lecithin (PC content 97%) 0.18
Lecithin (PC content 92%) 0.02
1,2-pentanediol 5.0
Oryzanol 0.1
Part B Tranexamic acid (Nippon Seika) 2.0
3-O-ethylascorbic acid (Nippon Seika) 1.0
Ascorbic acid 2-glucoside 1.0
Phytic acid 0.30
Purified water 20.0
Ohgon Extract 0.2
Peony extract 0.2
Tripropylene glycol 2.0
DPG 2.0
Maltose 1.0
Carbomer 0.01
Glutamic acid 0.2
Phenoxyethanol 0.2
Methyl paraben 0.15
Citric acid 0.1
Na citrate proper amount C part Purified water Amount to be 100 in total --------------------------------------------------- −−−−−
(Preparation method)
Part B was mixed to prepare a viscous liquid. Part A and Part C were heated to 70 ° C., and Part A was added while stirring Part C with a homomixer (7000 rpm) to prepare an aqueous dispersion. Further, after cooling, part B previously mixed was added to obtain a uniform liquid.

Example 29 Gel lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 10.0
1,2-pentanediol 5.0
Sorbitol solution (70%) 5.0
Polyglyceryl laurate-10 0.4
Part B Niacinamide 1.0
Neosolue-Aqulio (Nippon Seika) 1.0
Neosolue-Aqua (Nippon Seika) 1.0
Diglycerin 3.0
Tripropylene glycol 3.0
PEG-60 3.0
Purified water 10.0
Part C Pullulan 0.2
Ethylhexyl glycerin 0.2
Polymethacryloyl lysine 0.05
Tremoist-SL (Nippon Seika) 1.0
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Xanthan gum 0.05
Na hyaluronate 0.01
Carbomer 0.06
Hydroxide K 0.05
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 70 ° C. and uniformly dispersed. Part C was mixed, stirred well, and made uniform, and then heated to about 70 ° C. Part B was stirred with a propeller to prepare a mixed solution. Part C was added to Part A, the mixture was stirred at about 70 ° C. using a homomixer, cooled to about 40 ° C., and the mixture of Part B was added.

Example 30 Transparent gel

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 5.0
1,2-hexanediol 3.0
PPG-6 decyltetradeceth-30 0.2
PEG-30 phytosterol 0.3
Phytopresomeme MEL (Nippon Seika) 0.8
Purified water 40.0
Part B PEG-4M 0.2
Methyl gluces-10 1.0
Pyridoxine hydrochloride 0.05
Ethylhexyl glycerin 0.2
Phenoxyethanol 0.4
Tremoist-TP (Nippon Seika) 0.01
Hydrolyzed collagen 0.01
Purified water Total amount to be 100 Part C Pentetate 5Na 0.05
(Dimethylammonium acrylate / vinylpyrrolidone) copolymer 0.05
(Acrylates / alkyl acrylate (C10-30)) crosspolymer 0.15
Arginine 0.25
Purified water 20.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was stirred with a propeller to prepare a nanovesicle liquid. Part C was mixed to obtain a viscous liquid. Part B was mixed to obtain a uniform liquid. Part A and Part B were added to Part C to make the mixture uniform.

Example 31 Skull Proration

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Phytosterol 0.01
Glycerin 6.0
1,2-hexanediol 1.0
Part B Purified water 50.0
Part C Neosolue-Aqulio (Nippon Seika) 1.0
Tocopherol acetate 0.05
Menthol 0.1
Betaine 0.2
Assembly extract 0.1
Tamasakitsu Lafuji Root Extract 0.003
Hinokitiol 0.1
PCA-Na 0.1
Carbomer 0.01
Hydroxide K 0.01
Pentetate 5Na 0.05
Methyl paraben 0.1
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Part A and Part B were heated to 70 ° C., and Part A was added while stirring Part B with a homomixer (7000 rpm) to prepare a nanovesicle liquid. Further, after cooling, part C previously mixed was added to make a uniform liquid.

Example 32 Hair restorer

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
1,2-pentanediol 5.0
Phytopresome MEL (Nippon Seika) 1.0
Part B Neosolu-Aqulio (Nippon Seika) 0.5
DPG 2.0
Lactic acid 0.1
Tremoist-TP (Nippon Seika) 0.01
Purified water 50.0
Part C Ethanol 10.0
Menthol 0.1
Menthyl glyceryl ether 0.15
Panthenyl ethyl ether 0.2
Camphor 0.1
Cordyceps Extract 1.0
Assembly extract 1.0
Loquat Leaf Extract 1.0
Hydrolyzed hyaluronic acid 0.02
Cyclic lysophosphatidic acid Na 0.001
Capsicum extract 0.01
Betaine 0.3
Trehalose 0.2
Cimen-5-ol 0.1
Tocopherol acetate 0.05
β-glycyrrhetinic acid 0.05
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Part A and Part B were heated to 70 ° C., and Part A was added while stirring Part B with a propeller (500 rpm) to prepare a nanovesicle liquid. Further, after cooling, part C previously mixed was added to make a uniform liquid.

Example 33 Whitening milky lotion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Planpool-H (Nippon Seika) 1.0
Planool-LG3 (Nippon Seika) 1.0
Planool-DP (Nippon Seika) 1.0
LUSPLAN DD-DA5 (Nippon Seika) 0.2
LUSPLAN DD-DA7 (Nippon Seika) 0.2
Cetyl ethylhexanoate (Nippon Seika) 7.0
Diethylhexyl succinate (Nippon Seika) 3.0
Cetanol 1.2
Myristyl alcohol 2.0
Oleyl alcohol 1.0
Part B Stearoxyhydroxypropyl methylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
Part C Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Phytocompo-C (Nippon Seika) 1.0
1,2-pentanediol 3.0
Glycerin 8.0
Part D 3-O-ethylascorbic acid (Nippon Seika) 1.0
Tranexamic acid (Nippon Seika) 2.0
Purified water 5.0
Part E Phenoxyethanol 0.2
Methyl paraben 0.15
Phytic acid 0.5
Citric acid 0.1
Amount of Na citrate to reach pH 4.5 Purified water Amount to be 100 in total ----------------- −−−−−−
(Preparation method)
Parts A and E were each heated to about 70 ° C. and uniformly dissolved. Part B was stirred to obtain a viscous liquid. Part C was heated to about 70 ° C. and uniformly dispersed. Part A was added while stirring part C with a homodisper, and then part E was added while stirring. Part D and Part B were added at about 50 ° C., and the mixture was stirred and uniformly dissolved.

Example 34 Emulsion

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Glycerin 3.0
1,2-pentanediol 5.0
BG 3.0
LP70H (Nippon Seika) 0.1
Phytocompo-PP (Nippon Seika) 1.5
Part B Triethylhexanoin (Nippon Seika) 3.0
LUSPLAN SR-DM4 (Nippon Seika) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl alcohol 1.0
Aralkyl alcohol 0.1
Jojoba alcohol 3.0
Kimyl alcohol 0.3
Seraquil alcohol 0.1
Hexyldecanol 0.5
C part BG 5.0
(Hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer
0.2
Tremoist-TP (Nippon Seika) 0.03
Carbomer 0.1
Purified water 30.0
D part Neosolue-Aqua (Nippon Seika) 0.5
Polyquaternium-51 1.0
Ascorbyl glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methyl paraben 0.15
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part C was mixed and stirred to make it viscous. Part A was added while stirring Part A with a homodisper, and then Part D was added and emulsified. At about 50 ° C., part C was added, and the mixture was stirred and cooled to about 40 ° C.

Example 35 Skin care cream

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Sugar squalane 10.0
Stearic acid 1.0
Planool-ISS (Nippon Seika) 1.0
Planool-SUN (Nippon Seika) 1.0
Jojoba oil 3.0
Behenyl alcohol 2.0
PEG-20 glyceryl isostearate 1.0
Olive oil fatty acid sorbitan 0.8
Polyglyceryl oleate-10 1.0
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(Acryloyldimethyl taurine ammonium /
Behenes methacrylate-25) Crosspolymer 0.2
Tremoist-SL (Nippon Seika) 1.0
Purified water 20.0
Hydrolyzed poly γ-glutamic acid K 0.1
Polyglutamate Na 0.1
Oligopeptide-24 0.05
Part C Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 9.0
1,2-pentanediol 10.0
PEG-8 5.0
PEG-2M 2.0
Ethylhexyl glyceryl 0.8
DPG 1.5
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Parts A and C were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part B was mixed and stirred to obtain a viscous liquid. Part A was added and emulsified while stirring Part C with a homomixer. After cooling, at about 50 ° C., Part B was added, and the mixture was stirred and cooled to about 40 ° C.

Example 36 Skin care cream

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Olive oil 1.5
Shea butter 1.0
Dimethicone 10cSt 1.0
Pentaerythrityl tetraethylhexanoate (Nippon Seika) 3.0
Diisostearyl malate (Nippon Seika) 5.0
LUSPLAN DD-DHR (Nippon Seika) 1.0
LUSPLAN DD-IS (Nippon Seika) 1.0
Cholesteryl 12-hydroxystearate 0.1
Cetearyl glucoside 1.2
Behenyl alcohol 1.5
Ascorbyl tetrahexyldecanoate 7.0
Cetanol 2.5
Polyglyceryl distearate-20.8
Sorbitan stearate 0.3
PEG-60 hydrogenated castor oil 1.0
Polyglyceryl oleate-10 1.0
Part B Acrylic acid / alkyl methacrylate copolymer 0.1
Hydroxide K 0.07
(VP / eicosene) copolymer 0.2
Tremoist-SL (Nippon Seika) 1.0
Purified water 20.0
Hyaluronate Na 0.1
Panthenol 0.05
Glycyrrhizic acid 2K 0.1
Succinoyl atelocollagen 0.01
Part C Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
Lysolecithin 0.02
Glycerin 9.0
1,2-hexanediol 3.0
1,2-pentanediol 1.5
Sorbitol 2.0
Multitose 2.0
Glyceryl caprylate 0.8
Purified water Amount to be 100 in total ------------------------------------------------------------------------------------------
(Preparation method)
Parts A and C were mixed, heated to about 70 ° C., and uniformly dissolved and dispersed. Part B was mixed and stirred to obtain a viscous liquid. Part A was added and emulsified while stirring Part C with a homomixer. After cooling, at about 50 ° C., Part B was added, and the mixture was stirred and cooled to about 40 ° C.

Example 37 Cleansing cream

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Planpool-LG2 (Nippon Seika) 1.0
LUSPLAN SR-DP4 (Nippon Seika) 0.2
Neosolue-MP (Nippon Seika) 0.2
Diethylhexyl adipate (Nippon Seika) 0.5
Diisobutyl adipate (Nippon Seika) 0.5
Diethylhexyl succinate (Nippon Seika) 1.0
PEG-12 isostearate 3.0
Solves 30 Tetraisostearate-30 1.5
Polyoxyethylene sorbitan oleate 0.3
Polyglyceryl laurate-10 0.3
Microcrystalline wax 2.0
PPG-9 diglyceryl 1.0
Ceresin 3.0
Tocopherol 0.05
Part B Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
Glycerin 9.0
Diglycerin 3.0
1,2-pentanediol 3.0
Neosolue-Aqua (Nippon Seika) 0.5
Neosolue-Aqulio (Nippon Seika) 0.5
DPG 5.0
Edetate 3Na 0.02
Phenoxyethanol 0.5
Purified water Amount to be 100 in total ---------------------------------------------------------------------------------
(Preparation method)
Part A was dissolved by heating to about 80 ° C. Part B was heated to about 80 ° C. Part B was gradually added to Part A while stirring, and the mixture was cooled to 40 ° C after mixing.

Example 38 Facial cleansing foam

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Stearic acid K 10.0
Palmitic acid K 10.0
Myristate K 10.0
Lauric acid K 4.0
Lauroyl sarcosine isopropyl 0.8
Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
Planool-G (Nippon Seika) 0.05
PEG-150 10.0
1,2-pentanediol 10.0
Glyceryl monostearate 1.0
PEG-40 hydrogenated castor oil 0.5
Part B Tremoist-SL (Nippon Seika) 1.0
Inulin 0.3
Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methyl paraben 0.1
Purified water Amount to be 100 in total ---------------------------------------------------------------------------------
(Preparation method)
Part A was dissolved by heating to about 80 ° C. Part B was heated to about 80 ° C. Part B was gradually added to Part A while stirring, and the mixture was cooled to 40 ° C after mixing.

Example 39 Facial cleansing foam

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Lecithin (PC content 92%) 0.01
(Coconut fatty acid / hydrogenated tallow fatty acid) Glutamate Na 20.0
Cocoyl methyl taurine Na 5.0
Cocamidopropyl betaine 5.0
Lauryl glucoside 2.0
PEG-9 laurate glyceryl 2.0
Planool-LG2 (Nippon Seika) 0.2
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
1,2-pentanediol 10.0
Glycerin 14.0
Part B Glyceryl caprylate 1.0
Hexanediol 1.0
Polyquaternium-51 1.0
Tremoist-SL (Nippon Seika) 1.0
Inulin 0.3
Microcrystalline cellulose 0.3
Polyquaternium-7 0.8
Purified water Amount to be 100 in total ---------------------------------------------------------------------------------
(Preparation method)
Part A was dissolved by heating to about 80 ° C. Part B was heated to about 80 ° C. Part B was gradually added to Part A while stirring, and the mixture was cooled to 40 ° C after mixing.

Example 40 Body Shampoo

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Cocoyl methyl taurine Na 10.0
Lauroyl hydrolyzed silk Na 6.0
Lauroylmethylalanine Na 10.0
Coco Amphoacetic Acid Na (30%) 4.0
Cocamidopropyl betaine (30%) 10.0
Olefin (C14-16) sodium sulfonate 5.0
Polyquaternium-10 1.3
Hydroxypropyl methylcellulose 0.3
Acetyl hyaluronate Na 0.02
Cocamide DEA 3.0
1,2-pentanediol 5.0
Glycerin 5.0
Methyl paraben 0.2
Purified water Amount to be 100 in total ---------------------------------------------------------------------------------
(Preparation method)
All components were heated at about 80 ° C. and uniformly stirred and mixed.

Example 41 Non-silicone shampoo

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Planool-LG2 (Nippon Seika) 0.03
Diethylhexyl succinate (Nippon Seika) 0.01
Neosolue-AquaS (Nippon Seika) 0.1
Tremoist-SL (Nippon Seika) 0.5
Sodium laureth-4 carboxylate (28%) 10.0
Laureth-6 carboxylic acid 4.0
Cocamidopropyl betaine (30%) 10.0
Lauroylmethylalanine Na (30%) 5.0
Cocamide methyl MEA 3.0
Coconut oil fatty acid PEG-7 glyceryl 5.0
Na hydroxide 1% solution 0.5
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
1,2-pentanediol 5.0
Phenoxyethanol 0.4
Na benzoate 0.2
Purified water Amount to be 100 in total ---------------------------------------------------------------------------------
(Preparation method)
All components were heated at about 80 ° C. and uniformly stirred and mixed.

Example 42 Hair Treatment Without Rinse

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Polyquaternium-37 2.0
Squalane 2.0
PPG-3 caprylyl ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Sunflower seed wax 0.1
Polyethylene wax 0.1
Mokuro 0.2
Ceresin 0.1
Dicapric acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Neosolue-DP (Nippon Seika) 0.2
Tocopherol acetate 0.02
Elcalacton MCT (Nippon Seika) 2.0
Dipentaerythrityl tripolyhydroxystearate 1.5
PPG-5 phytosteryl 0.5
1,2-pentanediol 5.0
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Hydrolyzed hyaluronic acid 0.1
Panthenol 0.1
Hydroxypropyltrimonium hyaluronate 0.01
Polyquaternium-11 0.2
Glycosyl trehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
Part C Purified water Amount that totals 100 Hydroxypropyl starch phosphate 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part C was uniformly dispersed and heated to about 80 ° C. Next, part A was heated to about 80 ° C. to dissolve it. Part A was added while stirring Part C, and after uniform mixing, the mixture was cooled to about 40 ° C. Next, Part B was added and mixed uniformly.

Example 43 Non-silicone hair treatment

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Planpool-LG2 (Nippon Seika) 0.5
Propanediol 3.0
Behenamidopropyldimethylamine 1.5
Cetanol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba seed oil 1.0
Isododecane 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamide methyl MEA 0.8
Caesarpinia spinosa hydroxypropyltrimonium chloride 0.1
Rice bran wax 0.5
Elcalacton DES (Nippon Seika) 2.0
Glycerin 1.0
Part B Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
1,2-pentanediol 3.0
Purified water 20.0
Part C Phenoxyethanol 0.4
Tremoist-SL (Nippon Seika) 1.0
Lactic acid 0.4
Purified water Amount to be 100 in total --------------------------------------------------------------
(Preparation method)
Parts A and C were each uniformly mixed at about 80 ° C. Part B was uniformly dispersed at about 70 ° C. Part C was gradually added to Part A while stirring, mixed uniformly, and then cooled to about 50 ° C. Part B was added and mixed uniformly.

Example 44 Dandruff shampoo

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
PPG-3 caprylyl ether 0.2
Lauroylmethylalanine Na (30%) 13.0
Cocamidopropyl betaine (30%) 20.0
Cocoyl glutamate TEA (30%) 5.0
Cocamide DEA 1.0
1,2-pentanediol 3.0
Glycerin 1.0
Glyceryl caprylate 0.4
Glyceryl undecylenate 0.1
Neosolue-AquaS (Nippon Seika) 1.0
Sorbitol 1.6
Miconazole nitrate 0.75
Glycol distearate 1.5
Polyquaternium-7 0.3
Part B Na benzoate 0.4
Na chloride 0.2
Purified water Total amount to be 100 Part C Assembly extract 3.0
Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Polyquaternium-47 0.1
Pirocton olamine 0.1
Purified water 9.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part B was heated to about 80 ° C. and uniformly dissolved. Part A was placed in another container, heated and dissolved. Part B was gradually added to Part A, mixed uniformly, and Part C was added at about 60 ° C.

Example 45 Shampoo

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Diisostearyl malate (Nippon Seika) 0.3
Cocoyl sarcosine Na 10.0
Sodium cocoyl glutamate (30%) 10.0
Lauryl hydroxysultaine (30%) 10.0
Glycol distearate 0.5
Stearoxypropyldimethylamine 0.5
Neosolue-AquaS (Nippon Seika) 0.5
Isostearic acid 0.3
Glyceryl undecylenate 0.5
BG 0.1
Cocamide methyl MEA 3.0
Phenoxyethanol 0.6
Part B Citric acid 0.1
Methyl paraben 0.2
EDTA-2Na 0.1
Purified water Amount to be 100 in total Part C Polyquaternium-10 0.2
Guar hydroxypropyltrimonium chloride 0.1
Tremoist-SL (Nippon Seika) 3.0
Purified water 6.7
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A was uniformly mixed at about 80 ° C. Part B, which was set aside, was heated to about 60 ° C. and made uniform. Part B was gradually added to Part A while stirring, mixed uniformly, and then cooled to about 50 ° C. Part C was further added and mixed uniformly.

Example 46 Leave-on hair treatment

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Neosolue-Aqulio (Nippon Seika) 2.0
Cetrimonium chloride (25%) 3.8
Isostearic acid 0.02
Elcalacton DES (Nippon Seika) 1.0
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
1,2-hexanediol 2.0
Phenoxyethanol 0.5
Part B Ethanol 5.0
Part C Hydrolyzed keratin 0.2
Hydrolyzed silk 0.1
Hydrolyzed conchiolin 0.1
Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
Purified water Amount to be 100 in total ---------------------------------------------------
(Preparation method)
Part C was heated to about 80 ° C. and dissolved. Next, part A was heated to about 80 ° C. to dissolve it. Part A was added with stirring to part A, mixed uniformly, and cooled to about 40 ° C. Next, Part B was added and mixed uniformly.

Example 47 Sunscreen cosmetic

Component Content (% by weight)
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
Part A Phosphatidylinositol (Soybrain PI50) 0.05
Hydrogenated lecithin (PC content 97%) 0.1
Phytocompo-PP (Nippon Seika) 1.0
1,2-pentanediol 9.0
BG 10.0
Glycerin 9.0
B part octocrylene 4.0
Octyl salicylate 4.0
Hexyl diethylaminohydroxybenzoyl benzoate 2.25
t-butylmethoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Nippon Seika) 2.0
Diisobutyl adipate (Nippon Seika) 2.0
Behenyl alcohol 2.0
Cetearyl alcohol 2.0
Planool-MAS (Nippon Seika) 1.0
Planool-LG1 (Nippon Seika) 0.5
Planool-LG4 (Nippon Seika) 0.5
Planool-S (Nippon Seika) 0.5
Tocopherol 0.05
Part C Neosolue-AquaS (Nippon Seika) 1.0
Methylparaben qs Water q D to be 100 in total D carbomer (2%) 5.0
Tremoist-SL (Nippon Seika) 10.0
Water-dispersed titanium oxide 5.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
(Preparation method)
Part A is uniformly dispersed. Part B and Part C are each heated and melted at about 70 ° C. Part B is gradually added to part A, then part C is gradually added and emulsified. Cool while stirring, add Part D at 45 ° C. and stir.

In the above formulation, details of the components described by the product name are as follows.
@ Plandol-H: dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
@ Plandol-S: dimer dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl)
@ Plandiol-G: dimer dilinoleyl bis dimer dilinoleate (behenyl / isostearyl / phytosteryl)
〇Plandiol-DP: bisdiglyceryl polyacyl adipate-2
{Plandol-ISS: phytosteryl isostearate} Planool-SUN: sunflower seed oil fatty acid phytosteryl〇 Planool-MAS: macadamia nut oil fatty acid phytosteryl〇 Plandiol-LG1: lauroylglutamate di (phytosteryl / octyldodecyl / octyldodecyl)
@ Plandiol-LG2: dilauroylglutamate (phytosteryl / octyldodecyl)
@ Plandiol-LG3: di (phytosteryl / octyldodecyl / behenyl) lauroylglutamate
@ Plandol-LG4: di (phytosteryl / octyldodecyl / behenyl) lauroylglutamate
〇LUSPLAN DD-IS: dimer dilinoleyl diisostearate〇LUSPLAN PI-DA: di (distearyl / phytosteryl) dimer dilinoleate
〇LUSPLAN DD-DHR: Dimer linoleyl hydrogenated rosin condensate 〇LUSPLAN DD-DA5: Dimer linoleic acid dimer linoleil 〇LUSPLAN DD-DA7: Dimer linoleic acid dimer linoleyl 〇LUSPLAN SR-DM4: Die Dimer dilinoleyl dimerinoleate, glyceryl tri (caprylic / capric acid) @LUSPLAN SR-DP4: dimer dilinoleyl dimer dilinoleate, pentaerythrityl tetraisostearate @ Neosolue-Aqulio: bisethoxydiglycol cyclohexanedicarboxylate {Neosolue-Aqua: (eicosanediacid / tetradecandioic acid) polyglyceryl-10, glycerin} Neosolue-AquaS: (eicosanediacid / (Tradecandioic acid) polyglyceryl-10, glycerin {Neosolue-MP: methylpentanediol dineopentanoate} Neosolue-DE: diethylpentanediol dineopentanoate} Neosolue-MCT: glyceryl tri (caprylic acid / capric acid) phytocompo-PP: hydrogenated Lecithin, phytosterols @ Phytocompo-C: hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
〇Phytopresome Asta: hydrogenated lecithin, phytosterols, astaxanthin〇Phytopresome Lipo-Q: hydrogenated lecithin, phytosterols, lipoic acid, coenzyme Q10
〇Phytopresome Cera23: hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3
〇 Phytopresome MEL: glycolipid, hydrogenated lecithin, BG, purified water カ ラ Elcalactone MCT: γ-docosalactone, tri (caprylic / capric acid) glyceryl 〇 Elcalactone DES: γ-docosalactone, diethyl sebacate 〇 Tremoist- TP: White jellyfish polysaccharide @ Tremoist-SL: White jellyfish polysaccharide aqueous solution (1%)
〇LP70H: hydrogenated lysolecithin

Claims (10)

A cosmetic or a skin external preparation containing the following components (A) to (C).
(A) Phospholipid composition comprising the following components (A1) and (A2) (A1) phosphatidylinositol (A2) lecithin (B) polyhydric alcohol (C) water The cosmetic or external preparation for skin according to claim 1, wherein the weight ratio of the components (A1) and (A2) is 5:95 to 50:50. The content of the component (A) is 0.001 to 5% by weight, and the weight ratio of the components (A) and (B) is 1: 5 to 1: 200. 3. The cosmetic or external preparation for skin according to item 1. The cosmetic or external preparation for skin according to any one of claims 1 to 3, wherein the lecithin of the component (A2) is lecithin having a phosphatidylcholine (PC) content of 50 to 99% by weight. The cosmetic or skin external preparation according to any one of claims 1 to 4, wherein the lecithin of the component (A2) is a mixture of hydrogenated lecithin and unhydrogenated lecithin. The polyhydric alcohol of the component (B) essentially contains at least one selected from 1,2-pentanediol, 1,2-hexanediol and hexylene glycol. The cosmetic or external preparation for skin according to any one of the above. The cosmetic or external preparation for skin according to any one of claims 1 to 6, further comprising a sterol or a triterpene as the component (D). The cosmetic or external preparation for skin according to any one of claims 1 to 7, further comprising an antioxidant as the component (E). The cosmetic or skin external preparation according to any one of claims 1 to 8, wherein the cosmetic or skin external preparation is substantially free of a surfactant other than the component (A). The cosmetic or the external preparation for skin according to any one of claims 1 to 9, which has transparency in appearance.