JPS61260006A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic having high safety to the skin, stability with time, smooth feeling in use, etc. free from pH dependence, obtained by blending a cosmetic base of one or more of extracted components of a fruit body and a mold of Auricularia auricula. CONSTITUTION:A cosmetic obtained by blending a cosmetic base with 0.001-20.0wt% one or more extracted components obtained by extracting a fruit body or a mold of Auricularia auricula, e.g., Tremellaceae such as Tremella fuciformis Berk, Tremella foliacea Fr., Dacryomycetaceae such as Dacryomyces aurantinus (Schw.) Farlow, Calocera viscosa Fr., etc. with water or a water-soluble solvent such as methanol, ethanol, propylene glycol, etc. or a mixed solvent of them. EFFECT:Having both a refreshing feeling after application and high skin dressing effect, showing water retention on the skin, improving skin luter, preventing and improving fine wrinkles, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a cosmetic composition containing one or more components extracted from fruiting bodies or fungal cells of wood fungi.

Traditionally, water-soluble polymers used in cosmetics include:
Gum arabic, gum tragacanth, xanthan gum, pectin, sodium alginate, carboxyvinyl polymer (commercial name: Carbobol, Goodrich), etc. are commonly used. The purpose is to adjust the viscosity of the product, obtain a smooth feeling of use, and create a favorable protective film for the skin.
etc. However, gum arabic, gum tragacanth, xanthan gum, pectin, etc. have the disadvantage that they feel sticky when used, and in the case of sodium alginate, when incorporated into cosmetics, the viscosity decreases over time, which impairs the quality of the product. It had the disadvantage of being dropped.

In the case of carboxyvinyl polymer, there is a problem in that the viscosity changes depending on the pH, and it can usually only be used within the pH range of 5.5 to 8.0.

As a result of extensive research into this problem, we have found that it is highly safe for the skin, stable over time even when added to cosmetics, and
To obtain a desirable water-soluble polymer that has no pH dependence and has excellent effects not seen in conventional water-soluble polymers, that is, a smooth feeling of use, a light lingering feeling, and a high skin conditioning effect. reached.

In other words, the present inventors found that when the extract from the fruiting bodies or fungal cells of wood ear mushrooms is applied to the skin, it spreads very smoothly without irritating the skin, and after drying, it is extremely light and does not become sticky or bulky. It has been found that a firm coating can be obtained. Furthermore, it has been found that excellent skin conditioning effects such as improved skin moisture retention, improved skin color and luster, and prevention and improvement of small wrinkles can be obtained.

Furthermore, regarding the components of the hot water extract of the fruiting bodies or fungi of fungi of the present invention, a report by Hirai et al. (Pharmaceutical Journal, 37.3
74-380 (1985)), the inhibitory effect on histamine release on mast cells collected from the intraperitoneal cavity of rats was measured. No histamine-releasing effect was observed in any of them; on the contrary, huncanavalin A (aonA) or aom
-pound48/80 (pound 4B/80, a
The effect of suppressing histamine release (histamine release inhibitory effect) by om p 48/80) was observed,
It was also found that it is an excellent anti-inflammatory agent (Table 1).

Table 1 Effect of suppressing histamine release (Release inhibition rate %) The present invention was made based on the above findings, and it is found that when extracts of the fruiting bodies or fungal cells of wood ear mushrooms are blended as cosmetic ingredients, Excellent as a sticky agent and also has moisture retention properties.

The present invention provides a cosmetic that has excellent skin conditioning effects such as increasing skin color and luster, preventing and improving fine wrinkles, and leaves a protective film with a very light feel upon use. Furthermore, cosmetics with no pH dependence and excellent stability over time can be obtained.

The active ingredients of the fruiting bodies or bacterial cell extracts of wood fungi of the present invention are mainly polysaccharides. For example, in wood ear, an acidic polysaccharide consisting of xylose, mannose, glucuronic acid, and a small amount of glucose (Ukai et al., ch.
em.

Pharm, Bull...! 10,635-645(1
982)), and in the white fungus, acidic polysaccharides consisting of xylose, mannose, glucuronic acid, and structures with acetyl groups in these molecules
hem, Pharm.

B u z 1. ．． 22, 1102-1107 (197
4)) It has been reported that Regarding other wood ear fungi, the main component of the viscous extract is polysaccharide. According to the present invention, these extracted components may be purified by conventional methods such as protein removal, but there is no problem in using them as they are in cosmetics without purification.

The fungi used in the present invention include Basidiomycetes (Ba
aidiomyaetea), Heterobasidiomycota (H@'t
11 R OB A8161 & ＠) S Kirage eyes (Auri -Quljlri & 108), the jellyfish (auriaula -RIACEAE).
Auriculariaauricula-judae
(Pr,) qu41. ) S Arage fungus (A, po
lytriaha (Mont,)Sacc,).

Mesenteriaa (Di
aka, ) Pera, ), etc.
mella-1es), Tremelidae (Tremel
Tremella laceae)
fuciformis Bark, ), Hydaki jellyfish (l
xidia grandu-1osa Fr,),
Tremsllafoliaae
a Fr, ), Nikawa Haritake (Trems-11o
don gelatlnosum (Saop,)
Fr, ), etc., and Dacryomidae
ycstalea), Dacryo
Dacryo mycetaaeae
myces aurantius (Schw,) F
arrow), Gue-pinia
apathularia Fr,), Nikawahokitake (Oaloaera viscoaa Fr)
, ), etc. are exemplified. The classification of the fungi mentioned above is based on Rokuya Imazeki and Tsuguo Hongo, "Illustrated Encyclopedia of Japanese Fungi," pages 1 and 2, pages 130-132, 1957, published by Yokyusha and "
"Zoku Primary Color Illustrated Encyclopedia of Japanese Fungi" pp. 170-172, 1965.
Published by Nursery Company.

The fruiting bodies and fungi of the fungi used in the present invention can be either natural or artificially cultured, and either raw or dried can be used as raw materials in the present invention.

In the case of the fruiting bodies of White Wood Fungus, Wood Fungus, and Wood Fungus, dried products of these are available on the market, so there is no problem in using them as they are as raw materials for the cosmetic composition of the present invention.

In addition, when using fungal bodies instead of fruiting bodies, the fungal culture medium is
It can be either solid or liquid, but liquid media are more convenient to produce and handle.

Any normal medium may be used as the medium, such as glucose,
A medium containing a carbon source such as sucrose or glycerin, a nitrogen source such as yeast extract, peptone, or malt extract, and an inorganic salt such as sulfate or phosphate can be used. Furthermore, a growth promoter or the like may be added to the above medium. As the culture conditions, it is appropriate to carry out shaking culture or aeration culture at a temperature of 20 to 62° C. and a pH of 3 to 7 for 5 to 20 days.

The extract component of the fruiting bodies or fungal cells of wood fungi used in the present invention is the fruiting body or fungal cells of wood fungi, for example, in water,
It is extracted with a water-soluble solvent such as methanol, ethanol, propylene glycol, or a mixture thereof, and can be used as a raw material for cosmetics after being concentrated or diluted as necessary. In addition, the extract can be freeze-dried or spray-dried and used as a dry powder as a raw material for cosmetics. Considering the stability of the extract over time, it is better to handle the extract in the powder state.

The extraction efficiency will be increased if the fruiting bodies of the wood ear mushrooms used as raw materials are thoroughly crushed before extraction. Alternatively, it is also desirable to immerse the raw wood ear fungus in advance in a water-soluble solvent to swell it, and then crush it with a homogenizer, mixer, etc. for extraction. The extraction operation is usually carried out with hot water, preferably under pressurized conditions.
For example, at a temperature of 120-200℃, about 30-120℃
It is best to extract with hot water for about a minute. Also, low temperature (5 to 40
℃), neutral salts such as table salt and potassium chloride,
Extraction with an aqueous solution containing alkalis such as sodium hydroxide and potassium hydroxide can also be used.

In addition, in the present invention, there is no particular restriction on the amount of the water-soluble solvent used for extracting the fruiting bodies or fungal cells of wood fungi, but usually about 1
Extraction can be carried out using up to 100 times (by weight) the amount used. Furthermore, extraction can be performed by re-spelling.

According to the present invention, extracted components of the fruiting bodies or fungal cells of wood ear fungi can be used as base cosmetics for various cosmetics, as well as basic cosmetics such as lotions, milky lotions, and creams, makeup cosmetics such as ftendesi, and hair cosmetics. It can be used in the form of hair cosmetics such as liquid and hair cream. Moreover, these cosmetics can be manufactured by conventional methods.

The extracted component of the fruiting bodies or fungal cells of wood ear mushrooms used in the present invention is 0.001 to 20.0% by weight based on the cosmetic base material.
It is appropriate to use. The amount of the above-mentioned extract of wood ear fungi relative to the cosmetic base material is the amount when a freeze-dried product of the extract ingredient of wood ear fungus is used. Note that this does not apply if a diluted product is used instead of the freeze-dried product, and the above usage amount or more can be used. If the blending amount is less than 0.001% by weight, sufficient effects cannot be obtained. Moreover, if the amount exceeds 20.0% by weight, the effect will not be enhanced and it will be uneconomical.

Next, the active properties of the cosmetic composition of the present invention will be explained while showing examples. Note that the content of the present invention is not limited to these. The amounts shown in Examples and Comparative Examples refer to parts by weight.

The extracted components of the fruiting bodies of wood ear mushrooms in the Examples are those extracted by the following method.

The case of white fungus is shown as an example. White jellyfish fruiting body (
After finely pulverizing commercially available dry product) 50f, it is extracted with water 21 at 95°C for 3 hours. After disposing of the remains, E.
The liquid is concentrated and then freeze-dried to obtain about 10-15 f of a pale white to pale yellowish white powder. By repeating the above extraction 2 to 3 times, approximately 50 to 6
0% by weight of the hot water extract component of the fruiting body of the white fungus is obtained.

Example 1 Lotion formulation Amount A) 0.6 parts of hot water extract of white fungus fruiting body 1.3-butylene glycol 8.0 glycerin
2.0 xanthan gum 0.2
Purified water 44.6B) Ethanol 5.0, -methyl hydroxybenzoate 0.1 Polyoxyethylene (40
) Hydrogenated castor oil 0.1 fragrance
Appropriate amount of purified water 10.0 Manufacturing method: Uniformly dissolve component A and component B, then mix to form a product.

Comparative Example 1 A lotion was prepared using the same formulation as Example 1 except that the hot water extract component of the fruiting body of the white fungus was removed.

Example 2 Skin cream formulation A) Stearic acid 4.0 parts Cetyl alcohol 3.0 Stearyl alcohol 1.0 Liquid paraffin
6.5 Petrolatum 10.0 Sorbitan monostearate 1.5 Polyoxyethylene (25) monostearate 3.0 B) 1.3-Butylene glycol 5.0 Potassium hydroxide 0.1 Hot water extraction of wood ear fruiting body Ingredients 1. Op-methyl hydroxybenzoate 0
．． 2 Purified water 64.70) Fragrance
Proper amount production method: After heating and dissolving oil phase component A and water phase component B at 70 to 75°C, add component B to component A and emulsify it.
Add, mix, and cool to 50°C to prepare a product.

Example 3 Emulsion formulation A) Stearic acid 5.0 parts Cetyl alcohol 5.0 Liquid paraffin
2.0 glycerin monostearate
1.3 Sorbitan Monooleate 1.5 Polyoxyethylene (10) Sorbitan Monooleate
0.8B) Glycerin
6.0 Hot water extract component of fruiting body of Arage fungus 0.8 Methyl p-hydroxybenzoate 0.2 Purified water
714a) Flavorings
Proper amount manufacturing method: A product is prepared in the same manner as in Example 2.

Example 4 Pack (wash-off type) Prescription glycerin 15゜01.3-butylene glycol 10.0 Methyl p-hydroxybenzoate 0.2 Polyoxyethylene (40) hydrogenated castor oil 0.5 Hot water extracted ingredients of white fungus fruiting body
2.0 citric acid 0.1
Sodium citrate 0.3 flavor
Appropriate amount of purified water
71.9 Manufacturing method: Dissolve each component uniformly to make a product.

Example 5 Puncture (film type) Formulation A) Ethanol 10.0 Pluronic surfactant 2.0 Glycerin
7.0 polyvinyl alcohol
12. Methyl Op-hydroxybenzoate 0.1 B) Hot water extract component of white fungus fruiting body 1.0 Purified water 67.90) Fragrance
Proper amount manufacturing method: After mixing component A uniformly, component B is added and stirred at 70° C. for 30 minutes. Add component 0 during cooling and cool to 40°C to obtain a product.

In order to clarify the safety of the components extracted from the fruiting bodies or fungi of fungi of the present invention, a primary irritation test on the human body was conducted using an occlusive patch test. That is, using Fin Chamber (Taisho Pharmaceutical Co., Ltd.), an occlusive patch was applied to the flexor side of the forearm on 30 healthy subjects for 24 hours, and after removal of the patch test bandage, 1 hour, 24 hours, and 4 hours later.
Judgment was made using the average direct judgment after 8 hours. No erythema was observed in any of the extracts of fruiting bodies or fungal cells of wood fungi, and it was confirmed that there was no primary irritation. The test was conducted using a 10% by weight aqueous solution of each sample.

Table 2 Human body occlusion patch test results The acute toxicity test results for oral administration using mice are shown below, and no acute toxicity was observed, confirming that it is a highly safe cosmetic raw material.

Hot water extract component of wood ear fungus fruit body L Dso > 2.5 f / kf Hot water extract component of wood ear fungus body L Dso > 2.5 f / kg Hot water extract component of wood ear fungus body L Dso > 2.5 f / kg 25-5 to further clarify the effects of the cosmetics of the present invention
A usage test was conducted on 30 general women under the age of 0, and a questionnaire survey was conducted using a double-blind method, focusing on the skin conditioning effect. A lotion using a hot water extracted component of the fruiting body of White jellyfish (the lotion of Example 1) and a conventional lotion that does not contain the hot water extracted component of the fruiting body of White jellyfish (from the formulation of Example 1, a lotion extracted from hot water of the fruiting body of White jellyfish) (with ingredients removed)
Table 3 summarizes the results of using the product for one month. In addition,
No skin problems occurred during the test period.

Table 3 Questionnaire Results for Skin Conditioning Effects As is clear from Table 3, excellent skin conditioning effects were obtained by adding the hot water extracted component of the fruiting body of the white fungus. Similar tests were conducted on hot water extracts of fruiting bodies or fungal cells of other wood ear fungi, and excellent skin conditioning effects were obtained in all cases. In addition, the products have good stability over time; for example, in the products of Examples 1 to 5,
It remained stable even after 6 months in a constant temperature bath of 5 to 40°C.

Claims (4)

[Claims] (1) A cosmetic product characterized by containing one or more components extracted from the fruiting bodies or fungal bodies of wood ear mushrooms. (2) The cosmetic composition according to claim (1), wherein the wood fungus is one or more types selected from the family Asteraceae, such as wood ear fungus and wood fungus. (3) The cosmetic according to claim (1), wherein the wood fungus is one or more species selected from the family Funamicaceae, such as the fungus and the fungus. (4) The cosmetic composition according to claim (1), wherein the fungi is one or more species selected from the family Acanthaceae, such as Acanthus vulgare and Acanthus nigra.