JPS61263905A - Cosmetic - Google Patents

Abstract

PURPOSE:A cosmetic, containing an extract component obtained by extracting a component from the root of Astragalus hoantchy Franch. as a natural product active constituent and further a water-soluble high polymer, and having improved skin beautifying, whitening and beautifying an humectant effect. CONSTITUTION:A cosmetic obtained by incorporating an extract prepared by extraction from mainly the dried root of Astragalus hoantchy Franch., e.g. Astragalus membranaceus Bunge, Atragalus mongholicus Bunge or Hedysarum polybotrys, known as a crude drug, e.g. tonic, diuretic, antinephritis, hypotensive, vasodilator or cardiotonic action, with an organic solvent and/or water in an amount of 0.01-10wt%, preferably 0.1-5wt% based on the total weight of the cosmetic, and further a water-soluble high polymer, e.g. polypeptide, water- soluble collagen or gelatin, in an amount of 0.001-1wt% based on the total weight with other components. EFFECT:Favorable effect, e.g. tension, gloss, smoothness of freshness, is produced.

Description

Detailed Description of the Invention "Object of the Invention" The present invention (beauty I'll effect, whitening effect, moisturizing effect, characterized by containing as an active ingredient an extracted ingredient obtained by extracting from the root of Astragalus) It relates to cosmetics with excellent effects.

BACKGROUND ART Since ancient times, many basic cosmetics have been proposed for the purpose of conditioning, beautifying, and whitening the skin, and each has achieved certain effects.

From the viewpoint of wound healing and cell activating effects, the present inventor has conducted extensive research into natural active ingredients, and as a result has discovered that the extract obtained from the root of Astragalus has beneficial effects on the skin, including skin beautification, whitening, and moisturizing. The present invention was completed after discovering the following effects and hair nourishing effects.

In other words, the present invention relates to a cosmetic composition that contains as an active ingredient an extracted component obtained by extracting the root of the husk.

"Structure of the Invention" It is a homologous plant (LeguminO3ae), specifically Astragalus membr.
ana-ceus), Naimougi (A, mong)
holicus B-unge), tled
ysarLIIIl po+ybotrys). The present invention uses an extract (hereinafter abbreviated as Astragalus extract) extracted mainly from the dried roots of the above plants using an organic solvent and/or water.

The above-mentioned Astragalus extract can be produced by any known method. For example, first, the dried roots of Astragalus astragalus are cut into 2cm thick pieces using a cutting machine.
Cut into small pieces less than m or coarsely ground into powder, and immerse in an extraction solvent obtained by combining organic solvents such as ethyl acetate, acetone, butanol, propanol, ethanol, methanol, and water, each alone or by mixing two or more of them. After extraction, the extraction solvent can be distilled off from the extracted liquid to separate and collect the active ingredients. The extracted extract thus obtained is generally a yellowish brown to brownish viscous liquid (if extracted with hot water, a powdered extract is obtained).

) There is almost no odor.

Further, the above-mentioned extracted extract may be subjected to column chromatography, droplet countercurrent distribution chromatography, etc. as required. Note that the above-mentioned pixels have already been used in other applications. In other words, as a herbal medicine, it is tonic, diuretic, anti-nephritis, anti-hypertensive,
It is taken for the purpose of vasodilation and cardiotonic effect.

In addition, cosmetics containing a water-soluble polymer substance in addition to the Kurayoshi extract have a more favorable skin-conditioning effect. This is probably because the water-soluble polymeric substance becomes a vehicle on the skin, effectively transferring the active ingredient Astragalus extract to the stratum corneum and increasing transdermal absorption.

Such water-soluble polymer substances have a molecular weight of 2,000 or more, and include, for example, polypeptides, water-soluble "lagen," mucopolysaccharides, hyaluronic acid, cicada, casein,
In addition to textrin, gelatin, and pendant, the cosmetics provided by the present invention include creams, milky lotions, lotions, lip balms, lip colors, under make-up, hair care products, and many other cosmetics, which are formulated with Astragalus extract. The amount is arbitrarily selected depending on the properties of the cosmetic, but
Usually, it is about 0.01 to 10% by weight, preferably 0.1 to 5% by weight, based on the total weight. Further, the amount of the water-soluble polymer substance blended is approximately 0.001 to 1% by weight based on the total weight.

Next, as for the method of blending, the Astragalus extract can be blended as it is or by dissolving it in water, alcohol, polyhydric alcohol, etc., and blended into cosmetics in the same manner as conventional medicinal ingredients are blended.

In addition to the above-mentioned Astragalus extract and water-soluble polymeric substances, the cosmetics according to the present invention also contain additives commonly used in cosmetics, such as oils and fats, surfactants, antioxidants, fragrances, pigments, alcohols, and polypropylene. Alcohol, preservative, sunscreen agent, water, humectant, etc. can be added.

"Manufacturing Example" Manufacturing Example-1 I guess, cut 500 CI of dried roots of Astragalus nigra into small pieces of 2 CI or less using a cutting machine, and add 2.0 ml of methanol to this.
Add, stir and extract at room temperature for 1 hour, and filter.

This operation was repeated twice, and the filtrate was collected and concentrated to dryness under reduced pressure.
65q of viscous liquid Astrax extract was obtained. (yield 1
3%) Production Example-2 After cutting the dried root 2'OOC1 of Naimououuki with a cutter, it is crushed with a crusher to form a powder.

Add 1.11 liters of 50% aqueous methanol to this and let it stand at room temperature.
Mix, stir, extract and filter for an hour. This operation is repeated twice, and the filtrate is collected and concentrated under reduced pressure to a concentration of about 0.31. Add 0.3 g of water and stir to make a uniform dispersion. Extract the mixture three times using 300 ml of n-butanol each time. The extracts are collected and concentrated under reduced pressure to dryness to form a viscous liquid. Astragalus extract 140 was obtained. (Yield: 7.0%) Mix and stir for 30 minutes to extract, and filter. This operation 2
The filtrate was collected and freeze-dried several times to obtain 50 g of powdered Astrax extract. (Yield: 10%) "Effects of the Invention" Next, in order to confirm the skin conditioning effect of the Astragalus extract used in the present invention, a wound healing test was conducted using rats, and the results are shown in Table 2.

The test method is as follows.

= 6 - <Sample> As an oil-in-water cream, one that does not contain Aquila extract (Comparative Example-1), one that contains 1.0% (Example-1)
, 3.0% (Example 2), and the above three samples were prepared as shown in Table 1 below.

Wound Healing Test As experimental animals, 40 5-week-old SD rats, which had been preliminarily bred for 7 days after purchase, were used in groups 1 to 4, with 10 rats each (l'). The backs of the rats in each group were hair removed using electric clippers, and then treated with absorbent cotton impregnated with a water-ethanol 3-nior disinfectant solution. Next, group 1 was made into an untreated group, group (■) was applied with the cream of Comparative Example-1 after the observation was completed once a day, and groups (■ and IV) were similarly treated with the cream of Example-1 and Example-2, respectively. Cream was applied.

All specimens were applied once a day at 0.1 CI per injury site. In addition, the wound area was measured and visually observed once a day. In addition, the wound area Cmrd> of each group is 10
This is the average value of the animals (rounded to the second decimal place), and the cure rate was calculated using the above formula.

Wound area x] 00 (%) (blank below) Table 1 As shown above, cosmetics containing Astragalus extract have an excellent wound healing effect, and the wound recovers quickly. The condition of the skin after complete recovery (day 1, 20) was also beautiful compared to the untreated group and the Comparative Example-1 group.

Next, the cosmetics applied to the present invention were subjected to sensory evaluation after continuous use for 20 days in a clinical test, and the results are shown in Table 3. At this time, the emollient cream of late Example 3 was used as the product of the present invention, and the emollient cream of Example 3 minus Astragalus extract was used as a control amount.

The test method is as follows.

1 Clinical test: A panel of 10 women applied a control amount of the present invention to the outside of their left upper arm and a control amount of the invention to the outside of their right upper arm twice a day in the same manner as in normal use, and continued this for 20 days. After that, the four sensory evaluation items of skin firmness, gloss, smoothness, and freshness were evaluated using the following criteria.
The average value of 0 participants (rounded to the second decimal place) was used as the evaluation score.

Non-proportionate and small-proportion emergency cases
If you always agree
As mentioned above, the cosmetics applied to the present invention exert favorable effects on the firmness, luster, smoothness, freshness, etc. of the skin by continuous application to the skin.

Furthermore, the hair growth effect of Example 5 was confirmed in clinical trials, although the number of cases was small.

"Example" Next, an example of the present invention will be shown. Examples 1 and 2 are as shown in Clothing-1 above. Hereinafter, the blending amounts are in parts by weight.

-13=L! Example-1 Astragalus extract 0.5C@
Mix and heat an appropriate amount of the above Formulation A to 80°C. To this is added Formulation B, which has been mixed and heated to 80° C. in the same manner, and homogeneously emulsified with a homomixer, and the above C is added and cooled to obtain a product.

Mix and heat Formulation B above to 70'C. To this is added the above-mentioned formulation A mixed and heated to 70° C., uniformly emulsified with a homomixer, and cooled to obtain a product.

The above formulation A was stirred and dissolved, and the above formulation B was added and mixed to obtain a transparent liquid hair nourishing agent.

L! fee
Appropriate amounts of the above formulations A and B are dissolved by heating, and A is added to B to solubilize to obtain a product.

Patent applicant: POLA CHEMICAL INDUSTRIES, INC. = 17 -

Claims (1)

[Scope of Claims] 1) A cosmetic containing as an active ingredient an extracted ingredient obtained by extracting from the root of Astragalus. 2) The cosmetic according to claim 1, which contains a water-soluble polymer substance.