JP2004538303A5 - - Google Patents
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- Publication number
- JP2004538303A5 JP2004538303A5 JP2003516507A JP2003516507A JP2004538303A5 JP 2004538303 A5 JP2004538303 A5 JP 2004538303A5 JP 2003516507 A JP2003516507 A JP 2003516507A JP 2003516507 A JP2003516507 A JP 2003516507A JP 2004538303 A5 JP2004538303 A5 JP 2004538303A5
- Authority
- JP
- Japan
- Prior art keywords
- subject
- stem cells
- bis
- progenitor
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000130 stem cell Anatomy 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 238000002617 apheresis Methods 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30919601P | 2001-07-31 | 2001-07-31 | |
| US60/309,196 | 2001-07-31 | ||
| US38215502P | 2002-05-20 | 2002-05-20 | |
| US60/382,155 | 2002-05-20 | ||
| PCT/US2002/024212 WO2003011277A2 (en) | 2001-07-31 | 2002-07-30 | Methods to mobilize progenitor/stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008104148A Division JP2008195730A (ja) | 2001-07-31 | 2008-04-11 | 前駆／幹細胞を動員する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004538303A JP2004538303A (ja) | 2004-12-24 |
| JP2004538303A5 true JP2004538303A5 (https=) | 2008-10-16 |
| JP5137288B2 JP5137288B2 (ja) | 2013-02-06 |
Family
ID=26976666
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003516507A Expired - Lifetime JP5137288B2 (ja) | 2001-07-31 | 2002-07-30 | 前駆／幹細胞を動員する方法 |
| JP2008104148A Withdrawn JP2008195730A (ja) | 2001-07-31 | 2008-04-11 | 前駆／幹細胞を動員する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008104148A Withdrawn JP2008195730A (ja) | 2001-07-31 | 2008-04-11 | 前駆／幹細胞を動員する方法 |
Country Status (28)
| Country | Link |
|---|---|
| US (9) | US6987102B2 (https=) |
| EP (3) | EP3632425A1 (https=) |
| JP (2) | JP5137288B2 (https=) |
| KR (2) | KR100996378B1 (https=) |
| CN (2) | CN102302493B (https=) |
| AT (1) | ATE538785T1 (https=) |
| AU (1) | AU2002318927B2 (https=) |
| BE (1) | BE2019C544I2 (https=) |
| BR (1) | BRPI0211570B8 (https=) |
| CA (1) | CA2455559C (https=) |
| CY (4) | CY1112633T1 (https=) |
| DK (2) | DK2371361T3 (https=) |
| ES (2) | ES2380009T3 (https=) |
| FR (2) | FR12C0042I1 (https=) |
| HU (1) | HUP0402360A2 (https=) |
| IL (2) | IL159312A0 (https=) |
| LT (2) | LT2371361T (https=) |
| LU (2) | LU92033I2 (https=) |
| MX (1) | MXPA04000982A (https=) |
| NL (2) | NL300537I2 (https=) |
| NO (4) | NO336989B1 (https=) |
| NZ (1) | NZ530169A (https=) |
| PL (1) | PL364673A1 (https=) |
| PT (2) | PT1411918E (https=) |
| RU (1) | RU2309741C2 (https=) |
| SI (2) | SI2371361T1 (https=) |
| WO (1) | WO2003011277A2 (https=) |
| ZA (1) | ZA200400658B (https=) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2380009T3 (es) * | 2001-07-31 | 2012-05-07 | Genzyme Global S.A.R.L. | Métodos para movilizar las células madre/progenitoras |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| US7354932B2 (en) | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| CA2467718C (en) | 2001-12-21 | 2011-04-26 | Anormed Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| US20050153941A1 (en) * | 2003-06-27 | 2005-07-14 | Tomoyuki Miyabayashi | Cell differntiation inhibiting agent, cell culture method using the same, culture medium, and cultured cell line |
| WO2005002522A2 (en) * | 2003-06-30 | 2005-01-13 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Compositions and methods for treating tissue ischemia |
| JP2007535479A (ja) | 2003-08-13 | 2007-12-06 | チルドレンズ ホスピタル メディカル センター | ＧＴＰａｓｅを調節するためのキメラペプチド |
| WO2005017160A2 (en) * | 2003-08-13 | 2005-02-24 | Children's Hospital Medical Center | Mobilization of hematopoietic cells |
| IL158868A0 (en) * | 2003-11-13 | 2004-05-12 | Yeda Res & Dev | Methods of generating and using stem cells enriched with immature primitive progenitor |
| WO2005103721A1 (en) * | 2004-04-20 | 2005-11-03 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with cxc chemokine receptor 4 (cxcr4) |
| JP2008509928A (ja) * | 2004-08-13 | 2008-04-03 | アノーメド インコーポレイテッド | 前駆／幹細胞を動員するためのケモカインの組み合わせ |
| US7785582B2 (en) * | 2004-09-07 | 2010-08-31 | Johnson Lanny L | Use of synovium and omentum for tissue engineering |
| US8182806B2 (en) * | 2004-09-07 | 2012-05-22 | Johnson Lanny L | Synovial villi for use with tissue engineering |
| US9789171B2 (en) | 2004-11-05 | 2017-10-17 | The General Hospital Corporation | Anti-fugetactic agents for the treatment of ovarian cancer |
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| CA2619828A1 (en) * | 2005-08-19 | 2007-02-22 | Genzyme Corporation | Methods to enhance chemotherapy |
| EP2267030A1 (en) * | 2005-08-25 | 2010-12-29 | Repair Technologies, Inc. | Devices, compositions and methods for the protection and repair of cells and tissues |
| US8518349B2 (en) | 2005-09-12 | 2013-08-27 | Lanny Johnson | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
| US7927630B2 (en) * | 2005-09-12 | 2011-04-19 | Johnson Lanny L | Use of autologous sediment from fluid aspirates as vehicles for drug delivery |
| US20070116680A1 (en) * | 2005-11-18 | 2007-05-24 | Rensselaer Polytechnic Institute | Stem cells within gel microenvironments |
| MX2008010895A (es) * | 2006-02-24 | 2008-09-03 | Genzyme Corp | Metodos para aumentar el flujo sanguineo y/o promover la regeneracion de tejidos. |
| WO2007108689A2 (en) * | 2006-03-21 | 2007-09-27 | Stichting Skeletal Tissue Engineering | Method for induction of differentiation of stem and progenitor cells |
| JP2010507567A (ja) * | 2006-08-07 | 2010-03-11 | ジェンザイム・コーポレーション | 併用療法 |
| US7883698B2 (en) * | 2007-01-17 | 2011-02-08 | Maria Michejda | Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use |
| WO2010025416A1 (en) * | 2008-08-29 | 2010-03-04 | Genzyme Corporation | Cxcr4 antagonists for kidney injury |
| US20130039882A1 (en) * | 2009-10-28 | 2013-02-14 | Henry Ford Health System | Method to mitigate injury from radiation exposure |
| CN101716167B (zh) * | 2009-12-08 | 2011-12-28 | 中国人民解放军军事医学科学院野战输血研究所 | 一类饱和胺类化合物在制备外周血造血干细胞动员药物中的应用 |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| RU2638802C2 (ru) | 2011-05-16 | 2017-12-15 | Джензим Корпорейшн | Применение антагонистов cxcr4 |
| EP2968563A4 (en) * | 2013-03-15 | 2016-11-30 | Leonard B Miller | COMBINED TREATMENT TO IMPROVE MOU TISSUE HEALING, HEALING ADIPOSE TISSUE GRAFT, ENDOCHREST BONE SEWAGE AND OSTEOINTEGRATION |
| US9988973B2 (en) | 2015-01-06 | 2018-06-05 | Hamilton Sundstrand Corporation | Water injector for aviation cooling system |
| US11890348B2 (en) | 2015-09-18 | 2024-02-06 | The General Hospital Corporation | Localized delivery of anti-fugetactic agent for treatment of cancer |
| CN109069426B (zh) | 2015-12-14 | 2021-10-29 | X4 制药有限公司 | 治疗癌症的方法 |
| WO2017106332A1 (en) | 2015-12-14 | 2017-06-22 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
| PL3393468T3 (pl) | 2015-12-22 | 2023-01-23 | X4 Pharmaceuticals, Inc. | Metody leczenia niedoboru odporności |
| US11337969B2 (en) | 2016-04-08 | 2022-05-24 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3471716A1 (en) * | 2016-06-16 | 2019-04-24 | Centre National De La Recherche Scientifique | Cxcr4 receptor-binding compounds useful for increasing interferon level |
| WO2017223243A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| ES2870920T3 (es) | 2016-06-21 | 2021-10-28 | X4 Pharmaceuticals Inc | Inhibidores de CXCR4 y usos de los mismos |
| WO2018049118A1 (en) | 2016-09-09 | 2018-03-15 | The General Hospital Corporation | Hsp fusion protein with anti-chemorepellant agent for treatment of cancer |
| US11364264B2 (en) | 2016-09-09 | 2022-06-21 | The General Hospital Corporation | Ex vivo antigen-presenting cells or activated CD-positive T cells for treatment of cancer |
| US11453706B2 (en) | 2016-09-09 | 2022-09-27 | The General Hospital Corporation | HSP fusion protein with anti-chemorepellant agent for treatment of infectious disease |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| US11260079B2 (en) | 2017-12-06 | 2022-03-01 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem and progenitor cells |
| CN111712262A (zh) * | 2017-12-06 | 2020-09-25 | 美真达治疗公司 | 用于动员造血干细胞和祖细胞的给药方案 |
| US10058573B1 (en) | 2017-12-06 | 2018-08-28 | Magenta Therapeutics, Inc. | Dosing regimens for the mobilization of hematopoietic stem cells |
| CN111741752A (zh) * | 2017-12-19 | 2020-10-02 | Gpcr治疗公司 | Gpcr异聚体抑制剂及其用途 |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| US12059437B2 (en) | 2019-10-08 | 2024-08-13 | The Regents Of The University Of California | Methods and compositions for hematopoietic stem cell mobilization |
| CA3171250A1 (en) | 2020-03-10 | 2021-09-16 | E. Lynne KELLEY | Methods for treating neutropenia |
| EP4146797A1 (en) | 2020-05-06 | 2023-03-15 | Orchard Therapeutics (Europe) Limited | Treatment for neurodegenerative diseases |
| WO2023056444A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Pharmaceutica N.V. | Methods of increasing progenitor cell production |
| WO2025224720A1 (en) | 2024-04-24 | 2025-10-30 | Biolinerx Ltd. | Methods of selecting treatment regimen against solid tumors |
| CN118987175A (zh) * | 2024-08-13 | 2024-11-22 | 广东壹加再生医学研究院有限公司 | 普乐沙褔联合粒细胞集落刺激因子在制备治疗脑梗死的药物中的应用 |
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-
2002
- 2002-07-30 ES ES02750370T patent/ES2380009T3/es not_active Expired - Lifetime
- 2002-07-30 NZ NZ530169A patent/NZ530169A/en not_active IP Right Cessation
- 2002-07-30 LT LTEP10184509.7T patent/LT2371361T/lt unknown
- 2002-07-30 PT PT02750370T patent/PT1411918E/pt unknown
- 2002-07-30 IL IL15931202A patent/IL159312A0/xx unknown
- 2002-07-30 DK DK10184509.7T patent/DK2371361T3/da active
- 2002-07-30 CN CN201010282230.3A patent/CN102302493B/zh not_active Expired - Lifetime
- 2002-07-30 WO PCT/US2002/024212 patent/WO2003011277A2/en not_active Ceased
- 2002-07-30 SI SI200231096T patent/SI2371361T1/sl unknown
- 2002-07-30 CA CA2455559A patent/CA2455559C/en not_active Expired - Lifetime
- 2002-07-30 RU RU2004105961/15A patent/RU2309741C2/ru active Protection Beyond IP Right Term
- 2002-07-30 AU AU2002318927A patent/AU2002318927B2/en not_active Expired
- 2002-07-30 AT AT02750370T patent/ATE538785T1/de active
- 2002-07-30 CN CN028149955A patent/CN1561208B/zh not_active Expired - Lifetime
- 2002-07-30 MX MXPA04000982A patent/MXPA04000982A/es active IP Right Grant
- 2002-07-30 EP EP19179517.8A patent/EP3632425A1/en not_active Withdrawn
- 2002-07-30 BR BR0211570-0 patent/BRPI0211570B8/pt not_active IP Right Cessation
- 2002-07-30 DK DK02750370.5T patent/DK1411918T3/da active
- 2002-07-30 PT PT10184509T patent/PT2371361T/pt unknown
- 2002-07-30 SI SI200230976T patent/SI1411918T1/sl unknown
- 2002-07-30 PL PL02364673A patent/PL364673A1/xx unknown
- 2002-07-30 ES ES10184509T patent/ES2742730T3/es not_active Expired - Lifetime
- 2002-07-30 KR KR1020097024731A patent/KR100996378B1/ko not_active Expired - Lifetime
- 2002-07-30 KR KR10-2004-7001333A patent/KR20040020075A/ko not_active Ceased
- 2002-07-30 HU HU0402360A patent/HUP0402360A2/hu unknown
- 2002-07-30 JP JP2003516507A patent/JP5137288B2/ja not_active Expired - Lifetime
- 2002-07-30 EP EP02750370A patent/EP1411918B1/en not_active Revoked
- 2002-07-30 US US10/209,001 patent/US6987102B2/en not_active Expired - Lifetime
- 2002-07-30 EP EP10184509.7A patent/EP2371361B1/en not_active Revoked
-
2003
- 2003-12-11 IL IL159312A patent/IL159312A/en active IP Right Grant
-
2004
- 2004-01-27 ZA ZA2004/00658A patent/ZA200400658B/en unknown
- 2004-01-29 NO NO20040407A patent/NO336989B1/no active Protection Beyond IP Right Term
-
2005
- 2005-11-08 US US11/269,773 patent/US7935692B2/en not_active Expired - Lifetime
-
2006
- 2006-06-02 US US11/446,390 patent/US20060223180A1/en not_active Abandoned
-
2007
- 2007-08-20 US US11/841,837 patent/US7897590B2/en not_active Expired - Lifetime
-
2008
- 2008-04-11 JP JP2008104148A patent/JP2008195730A/ja not_active Withdrawn
-
2011
- 2011-02-08 US US13/023,381 patent/US20110129448A1/en not_active Abandoned
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2012
- 2012-03-07 CY CY20121100223T patent/CY1112633T1/el unknown
- 2012-06-27 CY CY2012017C patent/CY2012017I1/el unknown
- 2012-06-27 LU LU92033C patent/LU92033I2/fr unknown
- 2012-06-28 FR FR12C0042C patent/FR12C0042I1/fr active Active
- 2012-06-28 NL NL300537C patent/NL300537I2/nl unknown
-
2013
- 2013-03-14 US US13/826,913 patent/US20130273009A1/en not_active Abandoned
-
2014
- 2014-10-03 US US14/506,297 patent/US20150246019A1/en not_active Abandoned
-
2015
- 2015-05-27 NO NO20150674A patent/NO344632B1/no not_active IP Right Cessation
-
2016
- 2016-03-18 US US15/074,836 patent/US20170049747A1/en not_active Abandoned
- 2016-06-10 NO NO2016011C patent/NO2016011I1/no unknown
-
2018
- 2018-08-21 US US16/107,761 patent/US20190216773A1/en not_active Abandoned
-
2019
- 2019-08-20 CY CY20191100889T patent/CY1122199T1/el unknown
- 2019-10-10 FR FR19C1058C patent/FR19C1058I2/fr active Active
- 2019-10-14 CY CY2019038C patent/CY2019038I1/el unknown
- 2019-10-23 BE BE2019C544C patent/BE2019C544I2/fr unknown
- 2019-11-19 LT LTPA2019018C patent/LTC2371361I2/lt unknown
- 2019-11-26 LU LU00139C patent/LUC00139I2/fr unknown
-
2020
- 2020-01-22 NL NL301031C patent/NL301031I2/nl unknown
- 2020-03-05 NO NO2020003C patent/NO2020003I1/no unknown
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