JP2008534558A5 - - Google Patents
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- Publication number
- JP2008534558A5 JP2008534558A5 JP2008503525A JP2008503525A JP2008534558A5 JP 2008534558 A5 JP2008534558 A5 JP 2008534558A5 JP 2008503525 A JP2008503525 A JP 2008503525A JP 2008503525 A JP2008503525 A JP 2008503525A JP 2008534558 A5 JP2008534558 A5 JP 2008534558A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- optionally
- heterocyclyl
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000623 heterocyclic group Chemical group 0.000 claims 17
- 229910052757 nitrogen Inorganic materials 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 9
- -1 carbamoyloxy Chemical class 0.000 claims 9
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 239000001301 oxygen Substances 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052736 halogen Inorganic materials 0.000 claims 5
- 150000002367 halogens Chemical class 0.000 claims 5
- 229920006395 saturated elastomer Polymers 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 4
- 239000005977 Ethylene Substances 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 4
- 125000005059 halophenyl group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000004043 oxo group Chemical class O=* 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- 125000000876 trifluoromethoxy group Chemical class FC(F)(F)O* 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical class FC(F)(F)* 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 125000006625 (C3-C8) cycloalkyloxy group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004434 sulfur atom Chemical group 0.000 claims 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 2
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000001647 Renal Insufficiency Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- 125000001769 aryl amino group Chemical group 0.000 claims 2
- 125000003917 carbamoyl group Chemical class [H]N([H])C(*)=O 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 claims 2
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 2
- 201000006370 kidney failure Diseases 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 208000010125 myocardial infarction Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 125000003831 tetrazolyl group Chemical group 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 241000790917 Dioxys <bee> Species 0.000 claims 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000005530 alkylenedioxy group Chemical group 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- 0 CC[C@]1(*)[C@](**N)C(*2)NC2(*)C1* Chemical compound CC[C@]1(*)[C@](**N)C(*2)NC2(*)C1* 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66655605P | 2005-03-31 | 2005-03-31 | |
| US75085305P | 2005-12-16 | 2005-12-16 | |
| PCT/EP2006/061197 WO2006103277A2 (en) | 2005-03-31 | 2006-03-30 | 2 , 4 , 5-substituted piperidines as renin inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008069369A Division JP2008201787A (ja) | 2005-03-31 | 2008-03-18 | ピペリジン置換体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008534558A JP2008534558A (ja) | 2008-08-28 |
| JP2008534558A5 true JP2008534558A5 (https=) | 2009-05-14 |
Family
ID=36586065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008503525A Pending JP2008534558A (ja) | 2005-03-31 | 2006-03-30 | ピペリジン置換体 |
| JP2008069369A Pending JP2008201787A (ja) | 2005-03-31 | 2008-03-18 | ピペリジン置換体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008069369A Pending JP2008201787A (ja) | 2005-03-31 | 2008-03-18 | ピペリジン置換体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20100029628A1 (https=) |
| EP (1) | EP1863803B1 (https=) |
| JP (2) | JP2008534558A (https=) |
| AR (2) | AR055756A1 (https=) |
| AT (1) | ATE479681T1 (https=) |
| BR (2) | BRPI0608758A2 (https=) |
| CA (1) | CA2601702A1 (https=) |
| DE (1) | DE602006016573D1 (https=) |
| IL (2) | IL186130A0 (https=) |
| PL (1) | PL1863803T3 (https=) |
| PT (1) | PT1863803E (https=) |
| TW (2) | TW200716622A (https=) |
| WO (1) | WO2006103277A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE462703T1 (de) | 2004-08-25 | 2010-04-15 | Actelion Pharmaceuticals Ltd | Bicyclononen-derivate als renin-inhibitoren |
| TW200716622A (en) * | 2005-03-31 | 2007-05-01 | Speedel Experimenta Ag | Substituted piperidines |
| GEP20115206B (en) | 2005-05-27 | 2011-04-26 | Actelion Pharmaceuticals Ltd | Novel piperidine carboxylic acid amide derivatives |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| PL2018380T3 (pl) | 2006-05-19 | 2012-05-31 | Abbvie Bahamas Ltd | Skondensowane azabicykliczne pochodne alkanowe podstawione bicykloheterocyklem o aktywności wobec OUN |
| TW200815425A (en) * | 2006-06-08 | 2008-04-01 | Speedel Experimenta Ag | 2,5-disubstituted piperidines |
| TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
| EP1958634A3 (en) * | 2007-02-14 | 2008-09-24 | Speedel Experimenta AG | Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease |
| TW200922596A (en) * | 2007-10-25 | 2009-06-01 | Speedel Experimenta Ag | 4,4-disubstituted piperidines |
| EA201000720A1 (ru) * | 2007-11-02 | 2010-10-29 | Новартис Аг | 4,4-дизамещённые пиперидины как ингибиторы ренина |
| JP5484069B2 (ja) | 2007-12-19 | 2014-05-07 | 大日本住友製薬株式会社 | 二環性へテロ環誘導体 |
| CA2714347A1 (en) * | 2008-02-08 | 2009-08-13 | Novartis Ag | Substituted piperidines as renin inhibitors |
| KR20100131427A (ko) * | 2008-02-08 | 2010-12-15 | 노파르티스 아게 | 레닌 억제제로서의 치환된 피페리딘 |
| KR101403311B1 (ko) | 2008-05-05 | 2014-06-05 | 액테리온 파마슈티칼 리미티드 | 레닌 억제제로서의 3,4-치환된 피페리딘 유도체 |
| EP2163245A1 (en) | 2008-09-10 | 2010-03-17 | Novartis Ag | Renin inhibitors for the treatment of psoriasis |
| WO2010132873A2 (en) | 2009-05-15 | 2010-11-18 | Northwestern University | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase |
| KR20120109292A (ko) | 2009-06-24 | 2012-10-08 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Ｎ-치환-시클릭 아미노 유도체 |
| HK1246743A1 (zh) * | 2015-01-09 | 2018-09-14 | J.W. Speaker Corporation | 用於车辆的跟踪和照明系统及方法 |
| DE102015013191A1 (de) * | 2015-10-10 | 2017-04-13 | Daimler Ag | Verfahren zum Betrieb einer Leuchteinheit und Leuchteinheit |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199800409T1 (xx) * | 1995-09-07 | 1998-05-21 | F.Hoffmann-La Roche Ag | Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler |
| US6376672B1 (en) * | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| US6197959B1 (en) * | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US20040204455A1 (en) * | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
| TW200716622A (en) * | 2005-03-31 | 2007-05-01 | Speedel Experimenta Ag | Substituted piperidines |
-
2006
- 2006-03-29 TW TW095110894A patent/TW200716622A/zh unknown
- 2006-03-29 TW TW097113173A patent/TW200833687A/zh unknown
- 2006-03-29 AR ARP060101217A patent/AR055756A1/es unknown
- 2006-03-30 BR BRPI0608758-2A patent/BRPI0608758A2/pt not_active IP Right Cessation
- 2006-03-30 BR BRPI0621969-1A patent/BRPI0621969A2/pt not_active IP Right Cessation
- 2006-03-30 JP JP2008503525A patent/JP2008534558A/ja active Pending
- 2006-03-30 PL PL06725445T patent/PL1863803T3/pl unknown
- 2006-03-30 DE DE602006016573T patent/DE602006016573D1/de not_active Expired - Lifetime
- 2006-03-30 WO PCT/EP2006/061197 patent/WO2006103277A2/en not_active Ceased
- 2006-03-30 PT PT06725445T patent/PT1863803E/pt unknown
- 2006-03-30 AT AT06725445T patent/ATE479681T1/de active
- 2006-03-30 US US11/887,227 patent/US20100029628A1/en not_active Abandoned
- 2006-03-30 CA CA002601702A patent/CA2601702A1/en not_active Abandoned
- 2006-03-30 EP EP06725445A patent/EP1863803B1/en not_active Expired - Lifetime
-
2007
- 2007-09-20 IL IL186130A patent/IL186130A0/en unknown
-
2008
- 2008-02-05 AR ARP080100485A patent/AR065188A2/es not_active Application Discontinuation
- 2008-02-11 IL IL189429A patent/IL189429A0/en unknown
- 2008-03-14 US US12/076,221 patent/US7687495B2/en not_active Expired - Fee Related
- 2008-03-18 JP JP2008069369A patent/JP2008201787A/ja active Pending
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