AR055756A1 - Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos - Google Patents
Piperidinas sustituidas; procesos de preparacion y su uso como medicamentosInfo
- Publication number
- AR055756A1 AR055756A1 ARP060101217A ARP060101217A AR055756A1 AR 055756 A1 AR055756 A1 AR 055756A1 AR P060101217 A ARP060101217 A AR P060101217A AR P060101217 A ARP060101217 A AR P060101217A AR 055756 A1 AR055756 A1 AR 055756A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- optionally
- hydrogen
- group
- Prior art date
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 28
- 125000003545 alkoxy group Chemical group 0.000 abstract 18
- 229910052757 nitrogen Inorganic materials 0.000 abstract 9
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 229910052799 carbon Inorganic materials 0.000 abstract 7
- 125000004432 carbon atom Chemical group C* 0.000 abstract 7
- 125000004414 alkyl thio group Chemical group 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 229910052760 oxygen Inorganic materials 0.000 abstract 4
- 239000001301 oxygen Substances 0.000 abstract 4
- 229920006395 saturated elastomer Polymers 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 3
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 abstract 3
- 125000004450 alkenylene group Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- -1 carbamoyloxy Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 2
- 239000005977 Ethylene Substances 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003302 alkenyloxy group Chemical group 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000011593 sulfur Chemical group 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000000876 trifluoromethoxy group Chemical class FC(F)(F)O* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical class FC(F)(F)* 0.000 abstract 2
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000005078 alkoxycarbonylalkyl group Chemical group 0.000 abstract 1
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000002431 aminoalkoxy group Chemical group 0.000 abstract 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001769 aryl amino group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 1
- 150000001925 cycloalkenes Chemical class 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000005331 diazinyl group Chemical group N1=NC(=CC=C1)* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000006517 heterocyclyl carbonyl group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000004043 oxo group Chemical class O=* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
- 230000002285 radioactive effect Effects 0.000 abstract 1
- 239000002461 renin inhibitor Substances 0.000 abstract 1
- 229940086526 renin-inhibitors Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66655605P | 2005-03-31 | 2005-03-31 | |
| US75085305P | 2005-12-16 | 2005-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR055756A1 true AR055756A1 (es) | 2007-09-05 |
Family
ID=36586065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP060101217A AR055756A1 (es) | 2005-03-31 | 2006-03-29 | Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos |
| ARP080100485A AR065188A2 (es) | 2005-03-31 | 2008-02-05 | Piperidinas sustituidas, preparacion farmaceutica y uso de dichas piperidinas para preparar medicamentos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100485A AR065188A2 (es) | 2005-03-31 | 2008-02-05 | Piperidinas sustituidas, preparacion farmaceutica y uso de dichas piperidinas para preparar medicamentos |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20100029628A1 (https=) |
| EP (1) | EP1863803B1 (https=) |
| JP (2) | JP2008534558A (https=) |
| AR (2) | AR055756A1 (https=) |
| AT (1) | ATE479681T1 (https=) |
| BR (2) | BRPI0621969A2 (https=) |
| CA (1) | CA2601702A1 (https=) |
| DE (1) | DE602006016573D1 (https=) |
| IL (2) | IL186130A0 (https=) |
| PL (1) | PL1863803T3 (https=) |
| PT (1) | PT1863803E (https=) |
| TW (2) | TW200833687A (https=) |
| WO (1) | WO2006103277A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1786814B1 (en) | 2004-08-25 | 2010-03-31 | Actelion Pharmaceuticals Ltd. | Bicyclononene derivatives as renin inhibitors |
| AR055756A1 (es) * | 2005-03-31 | 2007-09-05 | Speedel Experimenta Ag | Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos |
| EP1893578A2 (en) | 2005-05-27 | 2008-03-05 | Actelion Pharmaceuticals Ltd. | Novel piperidine carboxylic acid amide derivatives |
| GB0514203D0 (en) | 2005-07-11 | 2005-08-17 | Novartis Ag | Organic compounds |
| UA92083C2 (ru) | 2006-05-19 | 2010-09-27 | Эбботт Леборетриз | Азабициклические алкановые производные, замещенные конденсированным бициклогетероциклом |
| JP2009539806A (ja) * | 2006-06-08 | 2009-11-19 | シュペーデル・エクスペリメンタ・アーゲー | ２，５−二置換ピペリジン |
| TW200821303A (en) * | 2006-08-08 | 2008-05-16 | Speedel Experimenta Ag | Organic compounds |
| EP1958634A3 (en) * | 2007-02-14 | 2008-09-24 | Speedel Experimenta AG | Substituted piperidines as inhibitors of beta-secretase, cathepsin D, plasmepsin II and/or HIV protease |
| TW200922596A (en) * | 2007-10-25 | 2009-06-01 | Speedel Experimenta Ag | 4,4-disubstituted piperidines |
| JP2011503022A (ja) * | 2007-11-02 | 2011-01-27 | ノバルティス アーゲー | レニン阻害剤としての４，４−二置換ピペリジン |
| RU2010129690A (ru) | 2007-12-19 | 2012-01-27 | Дайниппон Сумитомо Фарма Ко., Лтд. (Jp) | Бициклические гетероциклические производные |
| WO2009098275A1 (en) * | 2008-02-08 | 2009-08-13 | Novartis Ag | Substituted piperidines as renin inhibitors |
| CN101939318A (zh) * | 2008-02-08 | 2011-01-05 | 诺瓦提斯公司 | 作为肾素抑制剂的取代的哌啶化合物 |
| CN102015682B (zh) | 2008-05-05 | 2014-07-16 | 埃科特莱茵药品有限公司 | 作为肾素抑制剂的3,4-取代的哌啶衍生物 |
| EP2163245A1 (en) | 2008-09-10 | 2010-03-17 | Novartis Ag | Renin inhibitors for the treatment of psoriasis |
| US8389731B2 (en) * | 2009-05-15 | 2013-03-05 | Northwestern University | Chiral pyrrolidine core compounds en route to inhibitors of nitric oxide synthase |
| KR20120109292A (ko) | 2009-06-24 | 2012-10-08 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | Ｎ-치환-시클릭 아미노 유도체 |
| CA2975379A1 (en) * | 2015-01-09 | 2016-07-14 | J.W. Speaker Corporation | Tracking and lighting systems and methods for a vehicle |
| DE102015013191A1 (de) * | 2015-10-10 | 2017-04-13 | Daimler Ag | Verfahren zum Betrieb einer Leuchteinheit und Leuchteinheit |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2167865C2 (ru) * | 1995-09-07 | 2001-05-27 | Ф. Хоффманн-Ля Рош Аг | Производные пиперидина, способ их получения, фармацевтическая композиция на их основе и промежуточные вещества |
| US6376672B1 (en) * | 1999-04-27 | 2002-04-23 | Hoffmann-La Roche Inc. | Naphthalenylmethoxypiperidines as renin inhibitors |
| US6197959B1 (en) * | 1999-04-27 | 2001-03-06 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| US20040204455A1 (en) * | 2003-04-10 | 2004-10-14 | Cody Wayne Livingston | Piperidine derivative rennin inhibitors |
| AR055756A1 (es) * | 2005-03-31 | 2007-09-05 | Speedel Experimenta Ag | Piperidinas sustituidas; procesos de preparacion y su uso como medicamentos |
-
2006
- 2006-03-29 AR ARP060101217A patent/AR055756A1/es unknown
- 2006-03-29 TW TW097113173A patent/TW200833687A/zh unknown
- 2006-03-29 TW TW095110894A patent/TW200716622A/zh unknown
- 2006-03-30 PT PT06725445T patent/PT1863803E/pt unknown
- 2006-03-30 CA CA002601702A patent/CA2601702A1/en not_active Abandoned
- 2006-03-30 US US11/887,227 patent/US20100029628A1/en not_active Abandoned
- 2006-03-30 AT AT06725445T patent/ATE479681T1/de active
- 2006-03-30 BR BRPI0621969-1A patent/BRPI0621969A2/pt not_active IP Right Cessation
- 2006-03-30 DE DE602006016573T patent/DE602006016573D1/de not_active Expired - Lifetime
- 2006-03-30 BR BRPI0608758-2A patent/BRPI0608758A2/pt not_active IP Right Cessation
- 2006-03-30 PL PL06725445T patent/PL1863803T3/pl unknown
- 2006-03-30 WO PCT/EP2006/061197 patent/WO2006103277A2/en not_active Ceased
- 2006-03-30 JP JP2008503525A patent/JP2008534558A/ja active Pending
- 2006-03-30 EP EP06725445A patent/EP1863803B1/en not_active Expired - Lifetime
-
2007
- 2007-09-20 IL IL186130A patent/IL186130A0/en unknown
-
2008
- 2008-02-05 AR ARP080100485A patent/AR065188A2/es not_active Application Discontinuation
- 2008-02-11 IL IL189429A patent/IL189429A0/en unknown
- 2008-03-14 US US12/076,221 patent/US7687495B2/en not_active Expired - Fee Related
- 2008-03-18 JP JP2008069369A patent/JP2008201787A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| TW200833687A (en) | 2008-08-16 |
| WO2006103277A3 (en) | 2006-12-28 |
| BRPI0621969A2 (pt) | 2011-07-19 |
| WO2006103277A2 (en) | 2006-10-05 |
| EP1863803A2 (en) | 2007-12-12 |
| ATE479681T1 (de) | 2010-09-15 |
| DE602006016573D1 (de) | 2010-10-14 |
| JP2008534558A (ja) | 2008-08-28 |
| AR065188A2 (es) | 2009-05-20 |
| PT1863803E (pt) | 2010-11-18 |
| JP2008201787A (ja) | 2008-09-04 |
| IL186130A0 (en) | 2008-01-20 |
| CA2601702A1 (en) | 2006-10-05 |
| TW200716622A (en) | 2007-05-01 |
| EP1863803B1 (en) | 2010-09-01 |
| IL189429A0 (en) | 2008-06-05 |
| US20100029628A1 (en) | 2010-02-04 |
| US20080171748A1 (en) | 2008-07-17 |
| BRPI0608758A2 (pt) | 2009-07-07 |
| US7687495B2 (en) | 2010-03-30 |
| PL1863803T3 (pl) | 2011-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |