JP2004532830A5 - - Google Patents
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- Publication number
- JP2004532830A5 JP2004532830A5 JP2002573043A JP2002573043A JP2004532830A5 JP 2004532830 A5 JP2004532830 A5 JP 2004532830A5 JP 2002573043 A JP2002573043 A JP 2002573043A JP 2002573043 A JP2002573043 A JP 2002573043A JP 2004532830 A5 JP2004532830 A5 JP 2004532830A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- use according
- influenza
- virus
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229960005486 vaccine Drugs 0.000 claims 10
- 206010022000 influenza Diseases 0.000 claims 7
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 239000000463 material Substances 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 229960003971 influenza vaccine Drugs 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical class C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 2
- 229920000053 polysorbate 80 Polymers 0.000 claims 2
- 230000001681 protective effect Effects 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- HSINOMROUCMIEA-FGVHQWLLSA-N (2s,4r)-4-[(3r,5s,6r,7r,8s,9s,10s,13r,14s,17r)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-17-yl]-2-methylpentanoic acid Chemical compound C([C@@]12C)C[C@@H](O)C[C@H]1[C@@H](CC)[C@@H](O)[C@@H]1[C@@H]2CC[C@]2(C)[C@@H]([C@H](C)C[C@H](C)C(O)=O)CC[C@H]21 HSINOMROUCMIEA-FGVHQWLLSA-N 0.000 claims 1
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 claims 1
- 239000004380 Cholic acid Substances 0.000 claims 1
- 101710154606 Hemagglutinin Proteins 0.000 claims 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 1
- 101710176177 Protein A56 Proteins 0.000 claims 1
- 229920004890 Triton X-100 Polymers 0.000 claims 1
- 239000013504 Triton X-100 Substances 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000003613 bile acid Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 claims 1
- 235000019416 cholic acid Nutrition 0.000 claims 1
- 229960002471 cholic acid Drugs 0.000 claims 1
- 238000005352 clarification Methods 0.000 claims 1
- 238000000432 density-gradient centrifugation Methods 0.000 claims 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000000185 hemagglutinin Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- -1 nonylphenoxy Chemical group 0.000 claims 1
- 229920002114 octoxynol-9 Polymers 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920000056 polyoxyethylene ether Polymers 0.000 claims 1
- 229940051841 polyoxyethylene ether Drugs 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 239000001397 quillaja saponaria molina bark Chemical class 0.000 claims 1
- 229930182490 saponin Chemical class 0.000 claims 1
- 150000007949 saponins Chemical class 0.000 claims 1
- 241000712461 unidentified influenza virus Species 0.000 claims 1
- 210000000605 viral structure Anatomy 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0104538.4 | 2001-02-23 | ||
| GB0104538A GB0104538D0 (en) | 2001-02-23 | 2001-02-23 | Novel Vaccine |
| GB0107511.8 | 2001-03-26 | ||
| GB0107511A GB0107511D0 (en) | 2001-03-26 | 2001-03-26 | Novel vaccine |
| GB0108365A GB0108365D0 (en) | 2001-04-03 | 2001-04-03 | Novel compounds |
| GB0108365.8 | 2001-04-03 | ||
| PCT/EP2002/001844 WO2002074336A2 (en) | 2001-02-23 | 2002-02-21 | Influenza vaccine formulations for intradermal delivery |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009063830A Division JP5960380B2 (ja) | 2001-02-23 | 2009-03-17 | 新規なワクチン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004532830A JP2004532830A (ja) | 2004-10-28 |
| JP2004532830A5 true JP2004532830A5 (enExample) | 2005-12-22 |
| JP5208347B2 JP5208347B2 (ja) | 2013-06-12 |
Family
ID=27256080
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002573043A Expired - Fee Related JP5208347B2 (ja) | 2001-02-23 | 2002-02-21 | 新規なワクチン |
| JP2009063830A Expired - Fee Related JP5960380B2 (ja) | 2001-02-23 | 2009-03-17 | 新規なワクチン |
| JP2011201447A Expired - Fee Related JP6076592B2 (ja) | 2001-02-23 | 2011-09-15 | 新規なワクチン |
| JP2015084294A Expired - Fee Related JP6211555B2 (ja) | 2001-02-23 | 2015-04-16 | 新規なワクチン |
| JP2017134258A Pending JP2017186367A (ja) | 2001-02-23 | 2017-07-10 | 新規なワクチン |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009063830A Expired - Fee Related JP5960380B2 (ja) | 2001-02-23 | 2009-03-17 | 新規なワクチン |
| JP2011201447A Expired - Fee Related JP6076592B2 (ja) | 2001-02-23 | 2011-09-15 | 新規なワクチン |
| JP2015084294A Expired - Fee Related JP6211555B2 (ja) | 2001-02-23 | 2015-04-16 | 新規なワクチン |
| JP2017134258A Pending JP2017186367A (ja) | 2001-02-23 | 2017-07-10 | 新規なワクチン |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20040071734A1 (enExample) |
| EP (3) | EP2269639B1 (enExample) |
| JP (5) | JP5208347B2 (enExample) |
| AT (1) | ATE503493T1 (enExample) |
| AU (1) | AU2002254901A1 (enExample) |
| CA (1) | CA2438942A1 (enExample) |
| CY (1) | CY1111553T1 (enExample) |
| DE (3) | DE60239594D1 (enExample) |
| DK (1) | DK1361890T3 (enExample) |
| PT (1) | PT1361890E (enExample) |
| WO (1) | WO2002074336A2 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20021044A3 (cs) * | 1999-09-24 | 2002-08-14 | Smithkline Beecham Biologicals S. A. | Pouľití antigenu chřipkového viru pro výrobu vakciny |
| DK1361890T3 (da) * | 2001-02-23 | 2011-06-27 | Glaxosmithkline Biolog Sa | Influenzavaccineformuleringer til intradermal indgift |
| AR032575A1 (es) * | 2001-02-23 | 2003-11-12 | Smithkline Beecham Biolog | Uso de una preparacion antigenica de gripe para la fabricacion de una vacuna intradermica de la gripe y estuche farmaceutico que comprende dicha vacuna |
| CA2445120A1 (en) * | 2001-04-27 | 2002-11-07 | Glaxosmithkline Biologicals Sa | Devices for the intradermal administration of influenza vaccines |
| CA2451816A1 (en) * | 2001-06-29 | 2003-01-09 | Becton, Dickinson And Company | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
| US20060110406A1 (en) | 2003-02-25 | 2006-05-25 | Medimmune Vaccines, Inc. | Refrigerator-temperature stable influenza vaccine compositions |
| AU2004263813B8 (en) | 2003-02-25 | 2008-09-11 | Medimmune, Llc | Methods of producing influenza vaccine compositions |
| US20050123550A1 (en) * | 2003-05-12 | 2005-06-09 | Laurent Philippe E. | Molecules enhancing dermal delivery of influenza vaccines |
| US7588774B2 (en) | 2003-05-12 | 2009-09-15 | Becton, Dickinson And Company | Molecules enhancing dermal delivery of influenza vaccines |
| CA2816222A1 (en) * | 2003-06-16 | 2005-03-03 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
| KR101230187B1 (ko) * | 2004-10-06 | 2013-02-07 | 메디뮨 엘엘씨 | 냉장 온도 안정성 인플루엔자 백신 조성물 |
| CN101076355A (zh) * | 2004-11-03 | 2007-11-21 | 希龙公司 | 流感疫苗 |
| EP2471552B1 (en) | 2005-03-08 | 2015-05-06 | MedImmune, LLC | Reassortant influenza viruses |
| KR20070116652A (ko) * | 2005-03-23 | 2007-12-10 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Ｃｄ4 ｔ－세포 및/또는 개선된 ｂ－메모리 세포 반응을유도하는 인플루엔자 바이러스 및 수중유 에멀젼애주번트의 용도 |
| JP4828189B2 (ja) * | 2005-09-14 | 2011-11-30 | 雅美 森山 | 分泌型ＩｇＡ及びＩｇＧ抗体誘導剤 |
| SI1951296T2 (sl) | 2005-11-01 | 2014-09-30 | Novartis Vaccines And Diagnostics Gmbh | Iz celic izpeljana virusna cepiva z nizko stopnjo preostale celiäśne dna z obdelavo z betapropiolaktonom |
| ES2377884T3 (es) | 2005-11-04 | 2012-04-02 | Novartis Vaccines And Diagnostics S.R.L. | Vacunas contra la gripe que incluyen combinaciones de adyuvantes particulados e inmunopotenciadores |
| EP1951301A2 (en) | 2005-11-04 | 2008-08-06 | Novartis Vaccines and Diagnostics S.r.l. | Emulsions with free aqueous-phase surfactant for adjuvanting split influenza vaccines |
| CA2628206A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics S.R.L. | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| AU2006310337B9 (en) | 2005-11-04 | 2013-11-28 | Novartis Ag | Adjuvanted influenza vaccines including cytokine-inducing agents |
| US10842867B2 (en) | 2005-11-04 | 2020-11-24 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| HUE049580T2 (hu) | 2006-01-27 | 2020-09-28 | Seqirus Uk Ltd | Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok |
| WO2007110776A1 (en) * | 2006-03-24 | 2007-10-04 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Storage of influenza vaccines without refrigeration |
| EP2043682B1 (en) | 2006-07-17 | 2014-04-02 | GlaxoSmithKline Biologicals S.A. | Influenza vaccine |
| GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
| ES3031467T3 (en) | 2006-09-11 | 2025-07-09 | Seqirus Uk Ltd | Making influenza virus vaccines without using eggs |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
| PE20090146A1 (es) | 2007-04-20 | 2009-03-23 | Glaxosmithkline Biolog Sa | Composicion inmunogenica contra el virus influenza |
| CA2684699C (en) * | 2007-06-14 | 2017-03-21 | Berna Biotech Ag | Intradermal influenza vaccine |
| AU2008269439B2 (en) | 2007-06-27 | 2013-12-19 | Novartis Ag | Low-additive influenza vaccines |
| GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| EP2235532B1 (en) | 2007-12-24 | 2013-04-24 | Novartis AG | Assays for adsorbed influenza vaccines |
| US8506966B2 (en) | 2008-02-22 | 2013-08-13 | Novartis Ag | Adjuvanted influenza vaccines for pediatric use |
| CN101998990B (zh) | 2008-03-18 | 2013-11-27 | 诺华股份有限公司 | 流感病毒疫苗抗原制备方法的改进 |
| RU2523587C2 (ru) * | 2008-07-11 | 2014-07-20 | МЕДИММЬЮН, ЭлЭлСи | Варианты гемагглютинина и нейрамидазы вируса гриппа |
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| JP5778039B2 (ja) | 2009-02-10 | 2015-09-16 | ノバルティス アーゲー | 流行関連株のためのインフルエンザワクチンレジメン |
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| CA2763816A1 (en) | 2009-04-27 | 2010-11-04 | Novartis Ag | Adjuvanted vaccines for protecting against influenza |
| NZ596432A (en) | 2009-05-21 | 2013-05-31 | Novartis Ag | Reverse genetics using non-endogenous pol i promoters |
| JP2013500712A (ja) | 2009-07-31 | 2013-01-10 | ノバルティス アーゲー | 逆遺伝学系 |
| CA2773637A1 (en) | 2009-09-10 | 2011-03-17 | Novartis Ag | Combination vaccines against respiratory tract diseases |
| PL2491117T3 (pl) | 2009-10-20 | 2014-05-30 | Novartis Ag | Udoskonalone sposoby odzyskiwania wirusa wykorzystujące odwrotną genetykę |
| GB0918830D0 (en) * | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
| CN102946727B (zh) | 2010-05-06 | 2015-08-19 | 诺华有限公司 | 微生物灭活的有机过氧化物化合物 |
| WO2011145081A1 (en) | 2010-05-21 | 2011-11-24 | Novartis Ag | Influenza virus reassortment method |
| PL2575872T3 (pl) | 2010-06-01 | 2021-02-22 | Seqirus UK Limited | Zatężanie antygenów szczepionkowych grypy bez liofilizacji |
| CN102939104A (zh) | 2010-06-01 | 2013-02-20 | 诺华有限公司 | 用冻干浓缩疫苗抗原 |
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| AU2011290471B2 (en) | 2010-08-20 | 2015-08-20 | Novartis Ag | Soluble needle arrays for delivery of influenza vaccines |
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| JP6054883B2 (ja) | 2012-03-02 | 2016-12-27 | ノバルティス アーゲー | インフルエンザウイルスの再集合 |
| WO2013131898A1 (en) | 2012-03-06 | 2013-09-12 | Crucell Holland B.V. | Improved vaccination against influenza |
| US20150161359A1 (en) | 2012-06-04 | 2015-06-11 | Novartis Ag | Methods for safety testing |
| GB201218195D0 (en) | 2012-10-10 | 2012-11-21 | Istituto Zooprofilattico Sperimentale Delle Venezie | Composition |
| MX2015006927A (es) | 2012-12-03 | 2016-02-05 | Novartis Ag | Redistribucion de virus de la influenza. |
| UY34506A (es) * | 2012-12-10 | 2014-06-30 | Fernando Amaury Ferreira Chiesa | Adyuvante de vacunación, preparación y vacunas que lo contienen |
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| BR112015030582A2 (pt) | 2013-06-06 | 2017-08-29 | Novartis Ag | Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressão |
| JP6373376B2 (ja) | 2013-11-15 | 2018-08-15 | ノバルティス アーゲー | 残留細胞培養不純物の除去 |
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| US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
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| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
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| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US12258540B2 (en) | 2017-10-30 | 2025-03-25 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| WO2020174288A1 (en) | 2019-02-25 | 2020-09-03 | Seqirus UK Limited | Adjuvanted multivalent influenza vaccines |
| US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
| CN114929270A (zh) | 2019-11-07 | 2022-08-19 | 塞其里斯英国有限公司 | 用于生产具有减小的颗粒大小的病毒疫苗的组合物和方法 |
| WO2021099419A1 (en) | 2019-11-18 | 2021-05-27 | Seqirus UK Limited | Method for producing reassortant influenza viruses |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
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-
2002
- 2002-02-21 DK DK02724176.9T patent/DK1361890T3/da active
- 2002-02-21 CA CA002438942A patent/CA2438942A1/en not_active Abandoned
- 2002-02-21 EP EP10178402.3A patent/EP2269639B1/en not_active Expired - Lifetime
- 2002-02-21 AU AU2002254901A patent/AU2002254901A1/en not_active Abandoned
- 2002-02-21 PT PT02724176T patent/PT1361890E/pt unknown
- 2002-02-21 EP EP20100178427 patent/EP2281573A3/en not_active Withdrawn
- 2002-02-21 JP JP2002573043A patent/JP5208347B2/ja not_active Expired - Fee Related
- 2002-02-21 AT AT02724176T patent/ATE503493T1/de active
- 2002-02-21 DE DE60239594T patent/DE60239594D1/de not_active Expired - Lifetime
- 2002-02-21 US US10/469,191 patent/US20040071734A1/en not_active Abandoned
- 2002-02-21 EP EP02724176A patent/EP1361890B1/en not_active Revoked
- 2002-02-21 WO PCT/EP2002/001844 patent/WO2002074336A2/en not_active Ceased
-
2007
- 2007-06-13 US US11/762,488 patent/US8557251B2/en not_active Expired - Fee Related
-
2009
- 2009-03-17 JP JP2009063830A patent/JP5960380B2/ja not_active Expired - Fee Related
-
2011
- 2011-06-08 CY CY20111100550T patent/CY1111553T1/el unknown
- 2011-09-15 JP JP2011201447A patent/JP6076592B2/ja not_active Expired - Fee Related
- 2011-09-29 DE DE201112100053 patent/DE122011100053I1/de active Pending
- 2011-09-29 DE DE201112100054 patent/DE122011100054I1/de active Pending
- 2011-10-12 US US13/271,839 patent/US9138471B2/en not_active Expired - Fee Related
- 2011-10-12 US US13/271,810 patent/US20120029437A1/en not_active Abandoned
-
2015
- 2015-04-16 JP JP2015084294A patent/JP6211555B2/ja not_active Expired - Fee Related
-
2017
- 2017-07-10 JP JP2017134258A patent/JP2017186367A/ja active Pending
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