JP2004531501A5 - - Google Patents
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- Publication number
- JP2004531501A5 JP2004531501A5 JP2002576253A JP2002576253A JP2004531501A5 JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5 JP 2002576253 A JP2002576253 A JP 2002576253A JP 2002576253 A JP2002576253 A JP 2002576253A JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- -1 hydroxy-phenylene Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- WTYGESWNSUGPKO-HSZRJFAPSA-N (2r)-2-amino-2-ethyl-4-[3-methoxy-4-(4-phenylbutoxy)phenyl]butan-1-ol Chemical compound COC1=CC(CC[C@@](N)(CO)CC)=CC=C1OCCCCC1=CC=CC=C1 WTYGESWNSUGPKO-HSZRJFAPSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- CETMIEJVKCOWKS-HXUWFJFHSA-N (2r)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1=CC=CC=C1 CETMIEJVKCOWKS-HXUWFJFHSA-N 0.000 claims 1
- TTWYWDKXOGKVDD-HXUWFJFHSA-N (2r)-2-amino-4-[4-(3-cyclohexylpropoxy)phenyl]-2-methylbutan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1CCCCC1 TTWYWDKXOGKVDD-HXUWFJFHSA-N 0.000 claims 1
- UIFQPECWUIOGLQ-UHFFFAOYSA-N 1-[4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl]-5-cyclohexylpentan-1-one Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(=O)CCCCC1CCCCC1 UIFQPECWUIOGLQ-UHFFFAOYSA-N 0.000 claims 1
- FROOZUIUGSQXIX-JOCHJYFZSA-N [(2r)-2-amino-2-methyl-4-[4-(5-phenylpentoxy)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CC[C@](N)(C)COP(O)(O)=O)=CC=C1OCCCCCC1=CC=CC=C1 FROOZUIUGSQXIX-JOCHJYFZSA-N 0.000 claims 1
- XGJCXFMLNLXLFE-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(5-phenylpentanoyl)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1=CC=CC=C1 XGJCXFMLNLXLFE-UHFFFAOYSA-N 0.000 claims 1
- HZRGEJWFLNYLGP-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(7-phenylheptanoyl)phenyl]butyl] dihydrogen phosphate Chemical class C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCCCC1=CC=CC=C1 HZRGEJWFLNYLGP-UHFFFAOYSA-N 0.000 claims 1
- HNYWOJFTDKYXMR-UHFFFAOYSA-N [2-amino-4-[4-(5-cyclohexylpentanoyl)phenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1CCCCC1 HNYWOJFTDKYXMR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107506A GB0107506D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0107507A GB0107507D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0108346A GB0108346D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
| PCT/EP2002/003389 WO2002076995A2 (en) | 2001-03-26 | 2002-03-26 | 2-amino-propanol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531501A JP2004531501A (ja) | 2004-10-14 |
| JP2004531501A5 true JP2004531501A5 (enExample) | 2005-06-02 |
| JP4012823B2 JP4012823B2 (ja) | 2007-11-21 |
Family
ID=27256123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576253A Expired - Fee Related JP4012823B2 (ja) | 2001-03-26 | 2002-03-26 | ２−アミノ−誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7326801B2 (enExample) |
| EP (1) | EP1377593B1 (enExample) |
| JP (1) | JP4012823B2 (enExample) |
| KR (1) | KR20030093279A (enExample) |
| CN (1) | CN1620461A (enExample) |
| AT (1) | ATE314383T1 (enExample) |
| BR (1) | BR0208365A (enExample) |
| CA (1) | CA2442178A1 (enExample) |
| CZ (1) | CZ20032560A3 (enExample) |
| DE (1) | DE60208355T2 (enExample) |
| DK (1) | DK1377593T3 (enExample) |
| ES (1) | ES2254675T3 (enExample) |
| IL (1) | IL157773A0 (enExample) |
| MX (1) | MXPA03008755A (enExample) |
| NO (1) | NO20034291L (enExample) |
| PL (1) | PL367348A1 (enExample) |
| SK (1) | SK11942003A3 (enExample) |
| WO (1) | WO2002076995A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE435202T1 (de) | 2002-01-11 | 2009-07-15 | Daiichi Sankyo Co Ltd | Aminoalkoholderivat oder phosphonsäurederivat und diese enthaltende medizinische zusammensetzung |
| ATE412408T1 (de) | 2002-05-16 | 2008-11-15 | Novartis Pharma Gmbh | Verwendung von edg rezeptor bindenden wirkstoffen für die krebstherapie |
| RU2358717C2 (ru) * | 2002-05-16 | 2009-06-20 | Новартис Аг | Применение средств, связывающих edg-рецептор, в лечении ракового заболевания |
| GB0217152D0 (en) * | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| WO2004010949A2 (en) | 2002-07-30 | 2004-02-05 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
| AU2003273865A1 (en) | 2002-09-13 | 2004-04-30 | Novartis Ag | Amino-propanol derivatives |
| CA2498944C (en) | 2002-09-19 | 2011-05-17 | Yasushi Kohno | Amino alcohol derivatives, salts thereof and immunosuppressive agents |
| KR20080103117A (ko) * | 2002-09-24 | 2008-11-26 | 노파르티스 아게 | 탈수초성 장애의 치료에 있어서의 스핑고신-1-포스페이트 수용체 아고니스트 |
| EP1594508B1 (en) * | 2003-02-11 | 2012-08-08 | Irm Llc | Novel bicyclic compounds and compositions |
| SI1602660T1 (sl) * | 2003-02-18 | 2011-06-30 | Kyorin Seiyaku Kk | Derivati aminofosfonske kisline, njihove adicijske soli in modulatorji receptorja za S1P |
| DE102004016947A1 (de) | 2003-04-08 | 2004-10-21 | Novartis Ag | Feste pharmazeutische Zusammensetzung |
| ES2392167T3 (es) | 2003-04-30 | 2012-12-05 | Novartis Ag | Derivados aminopropanol como moduladores del receptor esfingosina-1-fosfato |
| ATE547395T1 (de) | 2003-04-30 | 2012-03-15 | Novartis Pharma Gmbh | Aminopropanol-derivate als modulatoren des sphingosin-1-phosphat-rezeptors |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| US7528120B2 (en) * | 2003-08-28 | 2009-05-05 | Novartis Ag | Aminopropanol derivatives |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| JPWO2005044780A1 (ja) * | 2003-11-10 | 2007-05-17 | 杏林製薬株式会社 | アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤 |
| GB0329498D0 (en) * | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| RU2332212C2 (ru) | 2004-02-24 | 2008-08-27 | Санкио Компани, Лимитед | Аминоспирт |
| GB0405289D0 (en) * | 2004-03-09 | 2004-04-21 | Novartis Ag | Organic compounds |
| JP2007536310A (ja) | 2004-05-03 | 2007-12-13 | ノバルティス アクチエンゲゼルシャフト | Ｓ１ｐ受容体アゴニストおよびｊａｋ３キナーゼ阻害剤を含む、組合せ剤 |
| GB0411929D0 (en) * | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| CN101014329B (zh) * | 2004-07-16 | 2010-09-08 | 杏林制药株式会社 | 用于对器官或组织的移植的排异反应或骨髓移植的移植物抗宿主反应预防或治疗的药物组合物 |
| US20080096972A1 (en) | 2004-07-30 | 2008-04-24 | Thitiwan Buranachokpaisan | Compound formulations of 2-amino-1, 3-propanediol compounds |
| US7241812B2 (en) | 2004-08-13 | 2007-07-10 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
| AU2005292984B2 (en) * | 2004-10-12 | 2011-01-20 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl]-1,3-propanediol hydrochloride or hydrate thereof and intermediate for the same |
| KR20140095109A (ko) | 2004-11-29 | 2014-07-31 | 노파르티스 아게 | Ｓ１ｐ 수용체 효능제의 투여 용법 |
| EP1863463A1 (en) | 2005-02-14 | 2007-12-12 | University Of Virginia Patent Foundation | Sphingosine 1-phosphate agonists comprising cycloalkanes and 5-membered heterocycles substitued by amino and phenyl groups |
| GB0504544D0 (en) | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| BRPI0616118A2 (pt) | 2005-09-01 | 2011-06-07 | Ares Trading Sa | tratamento de neurite ótica |
| US8048928B2 (en) * | 2005-10-07 | 2011-11-01 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent for treating liver disease containing 2-amino-1,3-propanediol derivative as active ingredient, and method for treating liver disease |
| CN101346346B (zh) | 2005-12-15 | 2012-08-22 | 田边三菱制药株式会社 | 胺化合物及其医药用途 |
| BRPI0707281A2 (pt) | 2006-01-27 | 2011-04-26 | Univ Virginia | método para prevenção ou tratamento de dor neuropática em um mamìfero |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| JP2009526073A (ja) | 2006-02-09 | 2009-07-16 | ユニバーシティ オブ バージニア パテント ファンデーション | 二環式スフィンゴシン−１−リン酸受容体アナログ |
| EP2007789B1 (en) | 2006-04-11 | 2015-05-20 | Novartis AG | Spirocyclic HCV/HIV inhibitors and their uses |
| SG174029A1 (en) | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminoalcohol derivative and immunosuppressant containing the same as active ingredient |
| MY152176A (en) * | 2006-08-08 | 2014-08-15 | Kyorin Seiyaku Kk | Amino phosphate derivative and s1p receptor modulator having same as an active ingredient |
| WO2008064315A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| AU2007323540A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
| EP2097371A2 (en) | 2006-11-21 | 2009-09-09 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| MX2009013730A (es) | 2007-06-14 | 2010-01-26 | Mitsubishi Tanabe Pharma Corp | Compuesto amina y uso farmaceutico del mismo. |
| WO2009099174A1 (ja) * | 2008-02-07 | 2009-08-13 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| CN103179966B (zh) | 2010-10-08 | 2017-03-15 | 诺瓦提斯公司 | 磺酰胺ns3抑制剂的维生素e制剂 |
| GB201715786D0 (en) | 2017-09-29 | 2017-11-15 | Univ College Cardiff Consultants Ltd | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0627406T3 (da) | 1992-10-21 | 1999-07-12 | Taito Co | 2-Amino-1,3-propandiolforbindelser og immunundertrykkende midler |
| ES2065855B1 (es) | 1993-05-31 | 1995-09-01 | Menarini Lab | Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos. |
| KR100358922B1 (ko) * | 1994-08-22 | 2003-01-24 | 미쯔비시 웰 파마 가부시키가이샤 | 벤젠화합물및그의의약으로서의용도 |
| CN1290819C (zh) * | 1997-04-04 | 2006-12-20 | 三菱制药株式会社 | 2－氨基丙烷－1，3－二醇化合物、其作为医药的用途及其合成中间体 |
| BR0112484A (pt) | 2000-07-13 | 2003-09-23 | Sankyo Co | Composto ou um seu sal, éster ou outro derivado farmacologicamente aceitável, composição farmacêutica, uso de um composto ou de um seu sal, éster ou outro derivado farmacologicamente aceitável, e, processo para a preparação do mesmo |
| AU8533101A (en) * | 2000-08-31 | 2002-03-13 | Merck & Co Inc | Phosphate derivatives as immunoregulatory agents |
-
2002
- 2002-03-26 JP JP2002576253A patent/JP4012823B2/ja not_active Expired - Fee Related
- 2002-03-26 AT AT02727484T patent/ATE314383T1/de active
- 2002-03-26 US US10/472,127 patent/US7326801B2/en not_active Expired - Fee Related
- 2002-03-26 PL PL02367348A patent/PL367348A1/xx not_active Application Discontinuation
- 2002-03-26 ES ES02727484T patent/ES2254675T3/es not_active Expired - Lifetime
- 2002-03-26 DK DK02727484T patent/DK1377593T3/da active
- 2002-03-26 EP EP02727484A patent/EP1377593B1/en not_active Expired - Lifetime
- 2002-03-26 WO PCT/EP2002/003389 patent/WO2002076995A2/en not_active Ceased
- 2002-03-26 BR BR0208365-5A patent/BR0208365A/pt not_active Application Discontinuation
- 2002-03-26 IL IL15777302A patent/IL157773A0/xx unknown
- 2002-03-26 KR KR10-2003-7012474A patent/KR20030093279A/ko not_active Ceased
- 2002-03-26 MX MXPA03008755A patent/MXPA03008755A/es unknown
- 2002-03-26 DE DE60208355T patent/DE60208355T2/de not_active Expired - Lifetime
- 2002-03-26 CN CNA028068378A patent/CN1620461A/zh active Pending
- 2002-03-26 CZ CZ20032560A patent/CZ20032560A3/cs unknown
- 2002-03-26 CA CA002442178A patent/CA2442178A1/en not_active Abandoned
- 2002-03-26 SK SK1194-2003A patent/SK11942003A3/sk unknown
-
2003
- 2003-09-25 NO NO20034291A patent/NO20034291L/no not_active Application Discontinuation
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