JP2004531501A5 - - Google Patents
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- Publication number
- JP2004531501A5 JP2004531501A5 JP2002576253A JP2002576253A JP2004531501A5 JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5 JP 2002576253 A JP2002576253 A JP 2002576253A JP 2002576253 A JP2002576253 A JP 2002576253A JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- -1 hydroxy-phenylene Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- WTYGESWNSUGPKO-HSZRJFAPSA-N (2r)-2-amino-2-ethyl-4-[3-methoxy-4-(4-phenylbutoxy)phenyl]butan-1-ol Chemical compound COC1=CC(CC[C@@](N)(CO)CC)=CC=C1OCCCCC1=CC=CC=C1 WTYGESWNSUGPKO-HSZRJFAPSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- CETMIEJVKCOWKS-HXUWFJFHSA-N (2r)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1=CC=CC=C1 CETMIEJVKCOWKS-HXUWFJFHSA-N 0.000 claims 1
- TTWYWDKXOGKVDD-HXUWFJFHSA-N (2r)-2-amino-4-[4-(3-cyclohexylpropoxy)phenyl]-2-methylbutan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1CCCCC1 TTWYWDKXOGKVDD-HXUWFJFHSA-N 0.000 claims 1
- UIFQPECWUIOGLQ-UHFFFAOYSA-N 1-[4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl]-5-cyclohexylpentan-1-one Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(=O)CCCCC1CCCCC1 UIFQPECWUIOGLQ-UHFFFAOYSA-N 0.000 claims 1
- FROOZUIUGSQXIX-JOCHJYFZSA-N [(2r)-2-amino-2-methyl-4-[4-(5-phenylpentoxy)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CC[C@](N)(C)COP(O)(O)=O)=CC=C1OCCCCCC1=CC=CC=C1 FROOZUIUGSQXIX-JOCHJYFZSA-N 0.000 claims 1
- XGJCXFMLNLXLFE-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(5-phenylpentanoyl)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1=CC=CC=C1 XGJCXFMLNLXLFE-UHFFFAOYSA-N 0.000 claims 1
- HZRGEJWFLNYLGP-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(7-phenylheptanoyl)phenyl]butyl] dihydrogen phosphate Chemical class C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCCCC1=CC=CC=C1 HZRGEJWFLNYLGP-UHFFFAOYSA-N 0.000 claims 1
- HNYWOJFTDKYXMR-UHFFFAOYSA-N [2-amino-4-[4-(5-cyclohexylpentanoyl)phenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1CCCCC1 HNYWOJFTDKYXMR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107507A GB0107507D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0107506A GB0107506D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0108346A GB0108346D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
| PCT/EP2002/003389 WO2002076995A2 (en) | 2001-03-26 | 2002-03-26 | 2-amino-propanol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531501A JP2004531501A (ja) | 2004-10-14 |
| JP2004531501A5 true JP2004531501A5 (enExample) | 2005-06-02 |
| JP4012823B2 JP4012823B2 (ja) | 2007-11-21 |
Family
ID=27256123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576253A Expired - Fee Related JP4012823B2 (ja) | 2001-03-26 | 2002-03-26 | ２−アミノ−誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7326801B2 (enExample) |
| EP (1) | EP1377593B1 (enExample) |
| JP (1) | JP4012823B2 (enExample) |
| KR (1) | KR20030093279A (enExample) |
| CN (1) | CN1620461A (enExample) |
| AT (1) | ATE314383T1 (enExample) |
| BR (1) | BR0208365A (enExample) |
| CA (1) | CA2442178A1 (enExample) |
| CZ (1) | CZ20032560A3 (enExample) |
| DE (1) | DE60208355T2 (enExample) |
| DK (1) | DK1377593T3 (enExample) |
| ES (1) | ES2254675T3 (enExample) |
| IL (1) | IL157773A0 (enExample) |
| MX (1) | MXPA03008755A (enExample) |
| NO (1) | NO20034291L (enExample) |
| PL (1) | PL367348A1 (enExample) |
| SK (1) | SK11942003A3 (enExample) |
| WO (1) | WO2002076995A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60328161D1 (de) | 2002-01-11 | 2009-08-13 | Daiichi Sankyo Co Ltd | Aminoalkoholderivat oder phosphonsäurederivat und diese enthaltende medizinische zusammensetzung |
| RU2358717C2 (ru) * | 2002-05-16 | 2009-06-20 | Новартис Аг | Применение средств, связывающих edg-рецептор, в лечении ракового заболевания |
| NZ560662A (en) | 2002-05-16 | 2009-09-25 | Novartis Ag | Use of EDG receptor binding agents in cancer |
| GB0217152D0 (en) * | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| EP1546110A4 (en) | 2002-07-30 | 2008-03-26 | Univ Virginia | COMPOUNDS WITH EFFECT ON SIGNAL TRANSMISSION BY SPHINGOSINE-1-PHOSPHATE |
| WO2004024673A1 (en) * | 2002-09-13 | 2004-03-25 | Novartis Ag | Amino-propanol derivatives |
| WO2004026817A1 (ja) * | 2002-09-19 | 2004-04-01 | Kyorin Pharmaceutical Co., Ltd. | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| BR0314760A (pt) | 2002-09-24 | 2005-07-26 | Novartis Ag | Compostos orgânicos |
| EP1594508B1 (en) * | 2003-02-11 | 2012-08-08 | Irm Llc | Novel bicyclic compounds and compositions |
| EP2172472B1 (en) | 2003-02-18 | 2012-12-26 | Kyorin Pharmaceutical Co., Ltd. | Aminophosphonic acid derivative, salt thereof and modulator of S1P receptor |
| BRPI0409250B8 (pt) | 2003-04-08 | 2022-01-18 | Mitsubishi Pharma Corp | Composições farmacêuticas sólidas compreendendo um agonista receptor de s1p e um álcool do açúcar |
| ES2383298T3 (es) | 2003-04-30 | 2012-06-20 | Novartis Ag | Derivados del amino-propanol como moduladores del receptor esfingosina-1-fosfato |
| WO2004096757A1 (en) * | 2003-04-30 | 2004-11-11 | Novartis Ag | Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| PL1660449T3 (pl) * | 2003-08-28 | 2010-05-31 | Novartis Ag | Pochodne aminopropanolu |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| JPWO2005044780A1 (ja) * | 2003-11-10 | 2007-05-17 | 杏林製薬株式会社 | アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤 |
| GB0329498D0 (en) * | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| WO2005079788A1 (ja) | 2004-02-24 | 2005-09-01 | Sankyo Company, Limited | アミノアルコール化合物 |
| GB0405289D0 (en) * | 2004-03-09 | 2004-04-21 | Novartis Ag | Organic compounds |
| KR20070006889A (ko) | 2004-05-03 | 2007-01-11 | 노파르티스 아게 | Ｓ1ｐ 수용체 작용제 및 ｊａｋ3 키나제 억제제를 포함하는조합물 |
| GB0411929D0 (en) | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| US7781617B2 (en) | 2004-07-16 | 2010-08-24 | Kyorin Pharmaceutical Co., Ltd | Effective use method of medicaments and method of preventing expression of side effect |
| US20080096972A1 (en) | 2004-07-30 | 2008-04-24 | Thitiwan Buranachokpaisan | Compound formulations of 2-amino-1, 3-propanediol compounds |
| RU2007109207A (ru) | 2004-08-13 | 2008-09-20 | Прикис Фамэсьютикэлс, Инк. (US) | Соединения-модуляторы активности рецептора сфингозин-1-фосфата (варианты), фармацевтическая композиция, содержащая указанные соединения, и способ лечения нарушения, ассоциированного со сфингозин-1-фосфатом |
| EP2511262B1 (en) * | 2004-10-12 | 2017-02-01 | Kyorin Pharmaceutical Co., Ltd. | Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride |
| CA2589265A1 (en) | 2004-11-29 | 2006-06-01 | Novartis Ag | Dosage regimen of an s1p receptor agonist |
| JP2008530135A (ja) | 2005-02-14 | 2008-08-07 | ユニバーシティ オブ バージニア パテント ファンデーション | アミノ基およびフェニル基で置換されたシクロアルカンならびに５員の複素環を含むスフィンゴシン＝１−リン酸アゴニスト |
| GB0504544D0 (en) * | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| WO2007025991A2 (en) | 2005-09-01 | 2007-03-08 | Ares Trading S.A. | Treatment of optic neuritis |
| PT1932522E (pt) * | 2005-10-07 | 2012-06-26 | Kyorin Seiyaku Kk | Agente terapêutico para doenças do fígado contendo, como princípio activo, um derivado de 2- amino-1,3-propanodiol |
| KR101346527B1 (ko) * | 2005-12-15 | 2013-12-31 | 미쓰비시 타나베 파마 코퍼레이션 | 아민 화합물 및 그 의약 용도 |
| MX2008009579A (es) | 2006-01-27 | 2008-09-25 | Univ Virginia | Metodo para el tratamiento de dolor neuropatico. |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| WO2007092638A1 (en) | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| UA100666C2 (uk) | 2006-04-11 | 2013-01-25 | Новартіс Аг | Інгібітори нсv/віл та їх застосування |
| MY146775A (en) * | 2006-08-08 | 2012-09-28 | Kyorin Seiyaku Kk | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
| SG174028A1 (en) | 2006-08-08 | 2011-09-29 | Kyorin Seiyaku Kk | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
| JP2010510250A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸受容体アゴニスト活性を有するヒドリンダンアナログ |
| JP2010510249A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸アゴニスト活性を有するテトラリンアナログ |
| WO2008064337A2 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
| ES2581879T3 (es) | 2007-06-14 | 2016-09-08 | Mitsubishi Tanabe Pharma Corporation | Compuesto de amina y su uso farmacéutico |
| US8476305B2 (en) * | 2008-02-07 | 2013-07-02 | Kyorin Pharmaceutical Co., Ltd. | Therapeutic agent or prophylactic agent for inflammatory bowel disease comprising amino alcohol derivative as active ingredient |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| AU2011311880B2 (en) | 2010-10-08 | 2014-07-24 | Novartis Ag | Vitamin E formulations of sulfamide NS3 inhibitors |
| GB201715786D0 (en) | 2017-09-29 | 2017-11-15 | Univ College Cardiff Consultants Ltd | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994008943A1 (fr) | 1992-10-21 | 1994-04-28 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose 2-amino-1,3-propanediol et immunosuppresseur |
| ES2065855B1 (es) | 1993-05-31 | 1995-09-01 | Menarini Lab | Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos. |
| ATE211726T1 (de) | 1994-08-22 | 2002-01-15 | Welfide Corp | Benzolderivate und deren medizinische verwendung |
| USRE39072E1 (en) | 1997-04-04 | 2006-04-18 | Mitsubishi Pharma Corporation | 2-aminopropane-1,3-diol compounds, medicinal use thereof, and intermediates in synthesizing the same |
| EP1300405B1 (en) | 2000-07-13 | 2007-04-18 | Sankyo Company, Limited | Amino alcohol derivatives |
| EP1315735A4 (en) * | 2000-08-31 | 2005-04-06 | Merck & Co Inc | Phosphate derivatives as immunoregulatory compounds |
-
2002
- 2002-03-26 MX MXPA03008755A patent/MXPA03008755A/es unknown
- 2002-03-26 PL PL02367348A patent/PL367348A1/xx not_active Application Discontinuation
- 2002-03-26 CN CNA028068378A patent/CN1620461A/zh active Pending
- 2002-03-26 CA CA002442178A patent/CA2442178A1/en not_active Abandoned
- 2002-03-26 BR BR0208365-5A patent/BR0208365A/pt not_active Application Discontinuation
- 2002-03-26 IL IL15777302A patent/IL157773A0/xx unknown
- 2002-03-26 KR KR10-2003-7012474A patent/KR20030093279A/ko not_active Ceased
- 2002-03-26 US US10/472,127 patent/US7326801B2/en not_active Expired - Fee Related
- 2002-03-26 CZ CZ20032560A patent/CZ20032560A3/cs unknown
- 2002-03-26 ES ES02727484T patent/ES2254675T3/es not_active Expired - Lifetime
- 2002-03-26 DK DK02727484T patent/DK1377593T3/da active
- 2002-03-26 EP EP02727484A patent/EP1377593B1/en not_active Expired - Lifetime
- 2002-03-26 DE DE60208355T patent/DE60208355T2/de not_active Expired - Lifetime
- 2002-03-26 JP JP2002576253A patent/JP4012823B2/ja not_active Expired - Fee Related
- 2002-03-26 WO PCT/EP2002/003389 patent/WO2002076995A2/en not_active Ceased
- 2002-03-26 SK SK1194-2003A patent/SK11942003A3/sk unknown
- 2002-03-26 AT AT02727484T patent/ATE314383T1/de active
-
2003
- 2003-09-25 NO NO20034291A patent/NO20034291L/no not_active Application Discontinuation
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