JP2004531501A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004531501A5 JP2004531501A5 JP2002576253A JP2002576253A JP2004531501A5 JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5 JP 2002576253 A JP2002576253 A JP 2002576253A JP 2002576253 A JP2002576253 A JP 2002576253A JP 2004531501 A5 JP2004531501 A5 JP 2004531501A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 125000003545 alkoxy group Chemical group 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000002252 acyl group Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- -1 hydroxy-phenylene Chemical group 0.000 claims 5
- 150000003839 salts Chemical group 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- WTYGESWNSUGPKO-HSZRJFAPSA-N (2r)-2-amino-2-ethyl-4-[3-methoxy-4-(4-phenylbutoxy)phenyl]butan-1-ol Chemical compound COC1=CC(CC[C@@](N)(CO)CC)=CC=C1OCCCCC1=CC=CC=C1 WTYGESWNSUGPKO-HSZRJFAPSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- CETMIEJVKCOWKS-HXUWFJFHSA-N (2r)-2-amino-2-methyl-4-[4-(3-phenylpropoxy)phenyl]butan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1=CC=CC=C1 CETMIEJVKCOWKS-HXUWFJFHSA-N 0.000 claims 1
- TTWYWDKXOGKVDD-HXUWFJFHSA-N (2r)-2-amino-4-[4-(3-cyclohexylpropoxy)phenyl]-2-methylbutan-1-ol Chemical compound C1=CC(CC[C@@](N)(CO)C)=CC=C1OCCCC1CCCCC1 TTWYWDKXOGKVDD-HXUWFJFHSA-N 0.000 claims 1
- UIFQPECWUIOGLQ-UHFFFAOYSA-N 1-[4-[3-amino-4-hydroxy-3-(hydroxymethyl)butyl]phenyl]-5-cyclohexylpentan-1-one Chemical compound C1=CC(CCC(CO)(CO)N)=CC=C1C(=O)CCCCC1CCCCC1 UIFQPECWUIOGLQ-UHFFFAOYSA-N 0.000 claims 1
- FROOZUIUGSQXIX-JOCHJYFZSA-N [(2r)-2-amino-2-methyl-4-[4-(5-phenylpentoxy)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CC[C@](N)(C)COP(O)(O)=O)=CC=C1OCCCCCC1=CC=CC=C1 FROOZUIUGSQXIX-JOCHJYFZSA-N 0.000 claims 1
- XGJCXFMLNLXLFE-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(5-phenylpentanoyl)phenyl]butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1=CC=CC=C1 XGJCXFMLNLXLFE-UHFFFAOYSA-N 0.000 claims 1
- HZRGEJWFLNYLGP-UHFFFAOYSA-N [2-amino-2-(hydroxymethyl)-4-[4-(7-phenylheptanoyl)phenyl]butyl] dihydrogen phosphate Chemical class C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCCCC1=CC=CC=C1 HZRGEJWFLNYLGP-UHFFFAOYSA-N 0.000 claims 1
- HNYWOJFTDKYXMR-UHFFFAOYSA-N [2-amino-4-[4-(5-cyclohexylpentanoyl)phenyl]-2-(hydroxymethyl)butyl] dihydrogen phosphate Chemical compound C1=CC(CCC(CO)(N)COP(O)(O)=O)=CC=C1C(=O)CCCCC1CCCCC1 HNYWOJFTDKYXMR-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 125000004115 pentoxy group Chemical group [*]OC([H])([H])C([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0107506A GB0107506D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0107507A GB0107507D0 (en) | 2001-03-26 | 2001-03-26 | Organic compounds |
| GB0108346A GB0108346D0 (en) | 2001-04-03 | 2001-04-03 | Organic compounds |
| PCT/EP2002/003389 WO2002076995A2 (en) | 2001-03-26 | 2002-03-26 | 2-amino-propanol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531501A JP2004531501A (ja) | 2004-10-14 |
| JP2004531501A5 true JP2004531501A5 (enExample) | 2005-06-02 |
| JP4012823B2 JP4012823B2 (ja) | 2007-11-21 |
Family
ID=27256123
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002576253A Expired - Fee Related JP4012823B2 (ja) | 2001-03-26 | 2002-03-26 | ２−アミノ−誘導体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7326801B2 (enExample) |
| EP (1) | EP1377593B1 (enExample) |
| JP (1) | JP4012823B2 (enExample) |
| KR (1) | KR20030093279A (enExample) |
| CN (1) | CN1620461A (enExample) |
| AT (1) | ATE314383T1 (enExample) |
| BR (1) | BR0208365A (enExample) |
| CA (1) | CA2442178A1 (enExample) |
| CZ (1) | CZ20032560A3 (enExample) |
| DE (1) | DE60208355T2 (enExample) |
| DK (1) | DK1377593T3 (enExample) |
| ES (1) | ES2254675T3 (enExample) |
| IL (1) | IL157773A0 (enExample) |
| MX (1) | MXPA03008755A (enExample) |
| NO (1) | NO20034291L (enExample) |
| PL (1) | PL367348A1 (enExample) |
| SK (1) | SK11942003A3 (enExample) |
| WO (1) | WO2002076995A2 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA04006709A (es) | 2002-01-11 | 2004-10-04 | Sankyo Co | Derivados de aminoalcohol o derivados de acido fosfonico y composiciones farmaceuticas que los contienen. |
| RU2358717C2 (ru) * | 2002-05-16 | 2009-06-20 | Новартис Аг | Применение средств, связывающих edg-рецептор, в лечении ракового заболевания |
| JP5227492B2 (ja) | 2002-05-16 | 2013-07-03 | ノバルティス アーゲー | 癌におけるｅｄｇレセプター結合剤の使用 |
| GB0217152D0 (en) | 2002-07-24 | 2002-09-04 | Novartis Ag | Organic compounds |
| AU2003259296A1 (en) | 2002-07-30 | 2004-02-16 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
| CN100516024C (zh) * | 2002-09-13 | 2009-07-22 | 诺瓦提斯公司 | 氨基-丙醇衍生物 |
| JP4571497B2 (ja) | 2002-09-19 | 2010-10-27 | 杏林製薬株式会社 | アミノアルコール誘導体とその付加塩及び免疫抑制剤 |
| MXPA05003254A (es) * | 2002-09-24 | 2005-06-08 | Novartis Ag | Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion. |
| MXPA05008531A (es) * | 2003-02-11 | 2005-11-17 | Irm Llc | Compuestos biciclicos novedosos y composiciones. |
| DK1602660T3 (da) * | 2003-02-18 | 2011-05-23 | Kyorin Seiyaku Kk | Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer |
| CA2707750A1 (en) | 2003-04-08 | 2004-10-21 | Novartis Ag | Solid pharmaceutical compositions comprising a s1p receptor agonist and a sugar alcohol |
| AU2004234067B2 (en) * | 2003-04-30 | 2008-02-28 | Novartis Ag | Aminopropanol derivatives as sphingosine-1-phosphate receptor modulators |
| AU2004234066B2 (en) * | 2003-04-30 | 2008-02-21 | Novartis Ag | Amino-propanol derivatives as sphingosine-1-phosphate receptor modulator |
| GB0313612D0 (en) * | 2003-06-12 | 2003-07-16 | Novartis Ag | Organic compounds |
| EP1660449B1 (en) * | 2003-08-28 | 2009-11-18 | Novartis AG | Aminopropanol derivatives |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
| WO2005044780A1 (ja) * | 2003-11-10 | 2005-05-19 | Kyorin Pharmaceutical Co., Ltd. | アミノカルボン酸誘導体とその付加塩及びｓ１ｐ受容体調節剤 |
| GB0329498D0 (en) * | 2003-12-19 | 2004-01-28 | Novartis Ag | Organic compounds |
| GB0500020D0 (en) | 2005-01-04 | 2005-02-09 | Novartis Ag | Organic compounds |
| KR20110136901A (ko) | 2004-02-24 | 2011-12-21 | 상꾜 가부시키가이샤 | 아미노 알코올 화합물 |
| GB0405289D0 (en) * | 2004-03-09 | 2004-04-21 | Novartis Ag | Organic compounds |
| WO2005105146A1 (en) * | 2004-05-03 | 2005-11-10 | Novartis Ag | Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor |
| GB0411929D0 (en) | 2004-05-27 | 2004-06-30 | Novartis Ag | Organic compounds |
| CN101905023B (zh) * | 2004-07-16 | 2012-07-11 | 杏林制药株式会社 | 有效的医药使用方法及与副作用发生的防御相关的方法 |
| PL1773307T3 (pl) | 2004-07-30 | 2015-03-31 | Novartis Ag | Preparaty 2-amino-1,3-propanodioli i ich analogów |
| BRPI0514316A (pt) | 2004-08-13 | 2008-06-10 | Praecis Pharm Inc | métodos e composições para modulação de atividade de receptor de esfingosina-1-fosfato (s1p) |
| PL1806338T3 (pl) * | 2004-10-12 | 2016-07-29 | Kyorin Seiyaku Kk | Sposób wytwarzania chlorowodorku 2-amino-2-[2-[4-(3-benzyloksyfenylotio)-2-chlorofenyio]etylo]-1,3-propanodioiu i jego hydratów oraz produkty pośrednie w ich wytwarzaniu |
| EP2384749A1 (en) | 2004-11-29 | 2011-11-09 | Novartis AG | Dosage regimen of an S1P receptor agonist |
| CA2596990A1 (en) | 2005-02-14 | 2006-08-24 | University Of Virginia Patent Foundation | Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups |
| GB0504544D0 (en) * | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| EP1933860A2 (en) | 2005-09-01 | 2008-06-25 | Ares Trading S.A. | Treatment of optic neuritis |
| SI1932522T1 (sl) * | 2005-10-07 | 2012-08-31 | Kyorin Seiyaku Kk | Terapevtsko sredstvo za jetrno bolezen, ki vsebuje 2-amino-1,3- propandiolni derivat kot aktivno sestavino |
| RU2433117C2 (ru) * | 2005-12-15 | 2011-11-10 | Мицубиси Танабе Фарма Корпорейшн | Аминное соединение и его применение в медицинских целях |
| KR20080086546A (ko) | 2006-01-27 | 2008-09-25 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 신경병증성 통증의 치료 방법 |
| TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
| WO2007092638A1 (en) | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
| EP2518079A3 (en) | 2006-04-11 | 2012-12-12 | Novartis AG | HCV/HIV inhibitors and their uses |
| CA2659599C (en) | 2006-08-08 | 2014-06-17 | Kyorin Pharmaceutical Co., Ltd. | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
| RU2430925C2 (ru) | 2006-08-08 | 2011-10-10 | Киорин Фармасьютикал Ко., Лтд. | Производное аминофосфата и модулятор рецептора s1p, содержащий его в качестве активного ингредиента |
| AU2007323618A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
| JP2010510251A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸受容体活性を有するベンゾシクロヘプチルアナログ |
| JP2010510250A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン＝１−燐酸受容体アゴニスト活性を有するヒドリンダンアナログ |
| BRPI0813683A2 (pt) | 2007-06-14 | 2019-09-24 | Mitsubishi Tanabe Pharma Corp | composto amina e uso farmacêutico do mesmo |
| JP5452237B2 (ja) * | 2008-02-07 | 2014-03-26 | 杏林製薬株式会社 | アミノアルコール誘導体を有効成分とする炎症性腸疾患の治療剤又は予防剤 |
| US20110182850A1 (en) | 2009-04-10 | 2011-07-28 | Trixi Brandl | Organic compounds and their uses |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| CN103179966B (zh) | 2010-10-08 | 2017-03-15 | 诺瓦提斯公司 | 磺酰胺ns3抑制剂的维生素e制剂 |
| GB201715786D0 (en) | 2017-09-29 | 2017-11-15 | Univ College Cardiff Consultants Ltd | Compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR0155015B1 (ko) * | 1992-10-21 | 1998-12-01 | 고우야 마사시 | 2-아미노-1,3-프로판디올 화합물 및 면역 억제제 |
| ES2065855B1 (es) * | 1993-05-31 | 1995-09-01 | Menarini Lab | Procedimiento para la preparacion de nuevos derivados desoxiazafosfolipidicos con accion inhibidora de la fosfolipasa a2, nuevos derivados desoxiazafosfolipidicos obtenidos y utilizacion de los mismos. |
| DE69524962T4 (de) | 1994-08-22 | 2003-08-28 | Mitsubishi Pharma Corp., Osaka | Benzolderivate und deren medizinische verwendung |
| ES2240868T3 (es) | 1997-04-04 | 2005-10-16 | Mitsubishi Pharma Corporation | Compuesto de 2-aminopropano -1,3-diol, su uso farmaceutico e intermedios en su sintesis. |
| CZ200350A3 (cs) * | 2000-07-13 | 2003-05-14 | Sankyo Company Limited | Aminoalkoholové deriváty |
| WO2002018395A1 (en) | 2000-08-31 | 2002-03-07 | Merck & Co., Inc. | Phosphate derivatives as immunoregulatory agents |
-
2002
- 2002-03-26 MX MXPA03008755A patent/MXPA03008755A/es unknown
- 2002-03-26 AT AT02727484T patent/ATE314383T1/de active
- 2002-03-26 KR KR10-2003-7012474A patent/KR20030093279A/ko not_active Ceased
- 2002-03-26 IL IL15777302A patent/IL157773A0/xx unknown
- 2002-03-26 CA CA002442178A patent/CA2442178A1/en not_active Abandoned
- 2002-03-26 WO PCT/EP2002/003389 patent/WO2002076995A2/en not_active Ceased
- 2002-03-26 BR BR0208365-5A patent/BR0208365A/pt not_active Application Discontinuation
- 2002-03-26 CZ CZ20032560A patent/CZ20032560A3/cs unknown
- 2002-03-26 CN CNA028068378A patent/CN1620461A/zh active Pending
- 2002-03-26 US US10/472,127 patent/US7326801B2/en not_active Expired - Fee Related
- 2002-03-26 DK DK02727484T patent/DK1377593T3/da active
- 2002-03-26 PL PL02367348A patent/PL367348A1/xx not_active Application Discontinuation
- 2002-03-26 ES ES02727484T patent/ES2254675T3/es not_active Expired - Lifetime
- 2002-03-26 DE DE60208355T patent/DE60208355T2/de not_active Expired - Lifetime
- 2002-03-26 SK SK1194-2003A patent/SK11942003A3/sk unknown
- 2002-03-26 JP JP2002576253A patent/JP4012823B2/ja not_active Expired - Fee Related
- 2002-03-26 EP EP02727484A patent/EP1377593B1/en not_active Expired - Lifetime
-
2003
- 2003-09-25 NO NO20034291A patent/NO20034291L/no not_active Application Discontinuation
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022551185A5 (enExample) | ||
| CN1085213C (zh) | 用于治疗的三唑衍生物 | |
| JP2002540208A5 (enExample) | ||
| RU2379295C2 (ru) | Производные пиридазинона в качестве агонистов рецептора тиреоидного гормона | |
| JP2010530881A5 (enExample) | ||
| EP2292590A3 (en) | Prodrugs of 9-aminomethyl tetracycline compounds | |
| JP2007511546A5 (enExample) | ||
| JP2008505157A5 (enExample) | ||
| JP2004516314A5 (enExample) | ||
| AU624526B2 (en) | Benzopyran compounds, processes for their production and pharmaceutical compositions | |
| JP2002539181A5 (enExample) | ||
| JP2002539156A5 (enExample) | ||
| JP2006524660A5 (enExample) | ||
| EP2308828A3 (en) | CaSR antagonist | |
| JP2002527414A5 (enExample) | ||
| JP2004524299A5 (enExample) | ||
| JP2004525178A5 (enExample) | ||
| KR20010070962A (ko) | 유기 인 화합물 및 이의 용도 | |
| JP2005502636A5 (enExample) | ||
| JP2006523626A5 (enExample) | ||
| JP2002539089A5 (enExample) | ||
| EP2266971A3 (en) | Hiv protease inhibiting compounds | |
| JP2003509494A5 (enExample) | ||
| JP2007536240A5 (enExample) | ||
| JP2004518639A5 (enExample) |