JP2012505905A5 - - Google Patents
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- Publication number
- JP2012505905A5 JP2012505905A5 JP2011532217A JP2011532217A JP2012505905A5 JP 2012505905 A5 JP2012505905 A5 JP 2012505905A5 JP 2011532217 A JP2011532217 A JP 2011532217A JP 2011532217 A JP2011532217 A JP 2011532217A JP 2012505905 A5 JP2012505905 A5 JP 2012505905A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- alkoxy
- alkyl
- pattern
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 125000003545 alkoxy group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 16
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000002245 particle Substances 0.000 claims 13
- 125000001475 halogen functional group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 3
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 claims 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 2
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000003302 alkenyloxy group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000005133 alkynyloxy group Chemical group 0.000 claims 2
- 230000036765 blood level Effects 0.000 claims 2
- 235000012000 cholesterol Nutrition 0.000 claims 2
- -1 cyano, hydroxy, acetyl Chemical group 0.000 claims 2
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 2
- 125000005844 heterocyclyloxy group Chemical group 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- 102000006991 Apolipoprotein B-100 Human genes 0.000 claims 1
- 108010008150 Apolipoprotein B-100 Proteins 0.000 claims 1
- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims 1
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 229960005370 atorvastatin Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10648308P | 2008-10-17 | 2008-10-17 | |
| US61/106,483 | 2008-10-17 | ||
| PCT/US2009/060679 WO2010045361A1 (en) | 2008-10-17 | 2009-10-14 | Methods of reducing small, dense ldl particles |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012505905A JP2012505905A (ja) | 2012-03-08 |
| JP2012505905A5 true JP2012505905A5 (enExample) | 2012-11-29 |
| JP5694941B2 JP5694941B2 (ja) | 2015-04-01 |
Family
ID=42106878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532217A Active JP5694941B2 (ja) | 2008-10-17 | 2009-10-14 | 小型高密度ｌｄｌ粒子を減少させる方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20100152295A1 (enExample) |
| EP (1) | EP2346498B1 (enExample) |
| JP (1) | JP5694941B2 (enExample) |
| KR (1) | KR20110091680A (enExample) |
| CN (1) | CN102209532B (enExample) |
| BR (1) | BRPI0920170A2 (enExample) |
| CA (1) | CA2740874C (enExample) |
| ES (1) | ES2712052T3 (enExample) |
| MX (1) | MX2011004077A (enExample) |
| TW (1) | TWI491392B (enExample) |
| WO (1) | WO2010045361A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130273154A1 (en) * | 2011-03-02 | 2013-10-17 | Joseph M. Fayad | Oral formulations Mimetic of Roux-en-Y gastric bypass actions on the ileal brake; Compositions, Methods of Treatment, Diagnostics and Systems for treatment of metabolic syndrome manifestations including insulin resistance, fatty liver disease, hpperlipidemia, and type 2 diabetes |
| KR20200006177A (ko) | 2011-03-02 | 2020-01-17 | 제롬 쉔타그 | 단독으로 또는 c형 간염 바이러스 감염과 결합되는 간 지방증의 치료를 위한 조성물, 방법 및 진단 |
| MX2016006583A (es) * | 2013-11-20 | 2016-09-06 | Cymabay Therapeutics Inc | Tratamiento de hipercolesterolemia familiar homocigotica. |
| UA120756C2 (uk) | 2014-03-20 | 2020-02-10 | Сімабей Терапьютікс, Інк. | Лікування внутрішньопечінкових холестатичних захворювань |
| US10272058B2 (en) | 2014-03-20 | 2019-04-30 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
| WO2015157697A1 (en) | 2014-04-11 | 2015-10-15 | Cymabay Therapeutics, Inc. | Treatment of nafld and nash |
| PT3522880T (pt) * | 2016-10-05 | 2021-02-22 | Mitobridge Inc | Métodos de tratamento de lesão renal aguda |
| US10512622B2 (en) | 2017-07-14 | 2019-12-24 | Cymabay Therapeutics, Inc. | Treatment of intrahepatic cholestatic diseases |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI802783A7 (fi) | 1979-09-05 | 1981-01-01 | Glaxo Group Ltd | Fenolijohdoksia. |
| AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| US7576131B2 (en) | 1999-06-04 | 2009-08-18 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| GB9914977D0 (en) | 1999-06-25 | 1999-08-25 | Glaxo Group Ltd | Chemical compounds |
| JP2001354671A (ja) | 2000-04-14 | 2001-12-25 | Nippon Chemiphar Co Ltd | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| WO2002014291A1 (fr) | 2000-08-11 | 2002-02-21 | Nippon Chemiphar Co.,Ltd. | ACTIVATEURS DE PPAR$G(d) |
| JPWO2002046154A1 (ja) | 2000-12-05 | 2004-04-08 | 日本ケミファ株式会社 | ペルオキシソーム増殖剤応答性受容体δの活性化剤 |
| GB0031109D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| WO2002100351A2 (en) | 2001-06-11 | 2002-12-19 | Merck & Co., Inc. | A method for treating inflammatory diseases by administering a ppar-delta agonist |
| GB0121436D0 (en) * | 2001-09-04 | 2001-10-24 | Pfizer Ltd | Biomodulated multiparticulate formulations |
| WO2004092117A1 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| US20070037882A1 (en) | 2003-04-22 | 2007-02-15 | Astellas Pharma Inc. | Remedy for cerebral neurodegenerative diseases using ppar agonist |
| US7199259B2 (en) | 2003-06-20 | 2007-04-03 | Metabolex, Inc. | Resolution of α-(phenoxy)phenylacetic acid derivatives |
| NZ545943A (en) * | 2003-09-19 | 2009-09-25 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| WO2005115384A2 (en) * | 2004-05-25 | 2005-12-08 | Metabolex, Inc. | Bicyclic, substituted triazoles as modulators of ppar and methods of their preparation |
| US7622491B2 (en) * | 2004-08-13 | 2009-11-24 | Metabolex Inc. | Modulators of PPAR and methods of their preparation |
| MY147518A (en) * | 2004-09-15 | 2012-12-31 | Janssen Pharmaceutica Nv | 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs |
| JO3006B1 (ar) * | 2005-09-14 | 2016-09-05 | Janssen Pharmaceutica Nv | املاح ليسين مبتكرة من مشتقات حامض 4-((فينوكسي الكيل)ثيو) فينوكسي الخليك |
| UA120756C2 (uk) * | 2014-03-20 | 2020-02-10 | Сімабей Терапьютікс, Інк. | Лікування внутрішньопечінкових холестатичних захворювань |
| WO2015157697A1 (en) * | 2014-04-11 | 2015-10-15 | Cymabay Therapeutics, Inc. | Treatment of nafld and nash |
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2009
- 2009-10-14 CN CN200980144827.7A patent/CN102209532B/zh active Active
- 2009-10-14 WO PCT/US2009/060679 patent/WO2010045361A1/en not_active Ceased
- 2009-10-14 ES ES09821200T patent/ES2712052T3/es active Active
- 2009-10-14 KR KR1020117011217A patent/KR20110091680A/ko not_active Ceased
- 2009-10-14 CA CA2740874A patent/CA2740874C/en active Active
- 2009-10-14 EP EP09821200.4A patent/EP2346498B1/en active Active
- 2009-10-14 BR BRPI0920170A patent/BRPI0920170A2/pt not_active Application Discontinuation
- 2009-10-14 JP JP2011532217A patent/JP5694941B2/ja active Active
- 2009-10-14 MX MX2011004077A patent/MX2011004077A/es active IP Right Grant
- 2009-10-15 US US12/579,996 patent/US20100152295A1/en not_active Abandoned
- 2009-10-16 TW TW098135183A patent/TWI491392B/zh active
-
2016
- 2016-01-13 US US14/995,024 patent/US20160324811A1/en not_active Abandoned
-
2018
- 2018-10-31 US US16/176,349 patent/US11007162B2/en active Active