JP2004531220A5 - - Google Patents
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- JP2004531220A5 JP2004531220A5 JP2002557978A JP2002557978A JP2004531220A5 JP 2004531220 A5 JP2004531220 A5 JP 2004531220A5 JP 2002557978 A JP2002557978 A JP 2002557978A JP 2002557978 A JP2002557978 A JP 2002557978A JP 2004531220 A5 JP2004531220 A5 JP 2004531220A5
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- Japan
- Prior art keywords
- protein
- amino acid
- acid sequence
- identity
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 145
- 241000700605 Viruses Species 0.000 claims 60
- 102000004169 proteins and genes Human genes 0.000 claims 58
- 108090000623 proteins and genes Proteins 0.000 claims 58
- 241000351643 Metapneumovirus Species 0.000 claims 45
- 150000007523 nucleic acids Chemical group 0.000 claims 39
- 108020004707 nucleic acids Proteins 0.000 claims 36
- 102000039446 nucleic acids Human genes 0.000 claims 36
- 238000000034 method Methods 0.000 claims 31
- 210000004027 cell Anatomy 0.000 claims 15
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 14
- 108091006027 G proteins Proteins 0.000 claims 14
- 102000030782 GTP binding Human genes 0.000 claims 14
- 108091000058 GTP-Binding Proteins 0.000 claims 14
- 101150039699 M2-1 gene Proteins 0.000 claims 14
- 101150103632 M2-2 gene Proteins 0.000 claims 14
- 101710085938 Matrix protein Proteins 0.000 claims 14
- 101710127721 Membrane protein Proteins 0.000 claims 14
- 101710141454 Nucleoprotein Proteins 0.000 claims 14
- 102100034574 P protein Human genes 0.000 claims 14
- 101710181008 P protein Proteins 0.000 claims 14
- 101710177166 Phosphoprotein Proteins 0.000 claims 14
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 13
- 241000711504 Paramyxoviridae Species 0.000 claims 13
- 241000711902 Pneumovirus Species 0.000 claims 11
- 230000000120 cytopathologic effect Effects 0.000 claims 11
- 241001493065 dsRNA viruses Species 0.000 claims 11
- 238000012360 testing method Methods 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 208000015181 infectious disease Diseases 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 6
- 125000003729 nucleotide group Chemical group 0.000 claims 6
- 241000342334 Human metapneumovirus Species 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 241000271566 Aves Species 0.000 claims 4
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 108700026244 Open Reading Frames Proteins 0.000 claims 4
- 241000711955 Turkey rhinotracheitis virus Species 0.000 claims 4
- 230000002238 attenuated effect Effects 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 238000002856 computational phylogenetic analysis Methods 0.000 claims 3
- 230000002458 infectious effect Effects 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- 241000711404 Avian avulavirus 1 Species 0.000 claims 2
- 229920001917 Ficoll Polymers 0.000 claims 2
- 241000893570 Hendra henipavirus Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000713196 Influenza B virus Species 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 241000712079 Measles morbillivirus Species 0.000 claims 2
- 241000711386 Mumps virus Species 0.000 claims 2
- 241000711408 Murine respirovirus Species 0.000 claims 2
- 241000526636 Nipah henipavirus Species 0.000 claims 2
- 241000711904 Pneumoviridae Species 0.000 claims 2
- 241001068295 Replication defective viruses Species 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000003556 assay Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 231100000676 disease causative agent Toxicity 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 1
- 241000972773 Aulopiformes Species 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 238000009007 Diagnostic Kit Methods 0.000 claims 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
- 206010066226 Metapneumovirus infection Diseases 0.000 claims 1
- 206010051497 Rhinotracheitis Diseases 0.000 claims 1
- 241000439025 Tupavirus Species 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000005260 human cell Anatomy 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 108700010900 influenza virus proteins Proteins 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 239000002356 single layer Substances 0.000 claims 1
- 230000017960 syncytium formation Effects 0.000 claims 1
- 210000003501 vero cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200213 | 2001-01-19 | ||
| EP01200213.5 | 2001-01-19 | ||
| EP01203985 | 2001-10-18 | ||
| EP01203985.5 | 2001-10-18 | ||
| PCT/NL2002/000040 WO2002057302A2 (en) | 2001-01-19 | 2002-01-18 | A virus causing respiratory tract illness in susceptible mammals |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011050982A Division JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004531220A JP2004531220A (ja) | 2004-10-14 |
| JP2004531220A5 true JP2004531220A5 (https=) | 2005-12-22 |
| JP5503096B2 JP5503096B2 (ja) | 2014-05-28 |
Family
ID=26076820
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002557978A Expired - Lifetime JP5503096B2 (ja) | 2001-01-19 | 2002-01-18 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2011050982A Pending JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2013142224A Expired - Lifetime JP5813060B2 (ja) | 2001-01-19 | 2013-07-08 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011050982A Pending JP2011177173A (ja) | 2001-01-19 | 2011-03-09 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
| JP2013142224A Expired - Lifetime JP5813060B2 (ja) | 2001-01-19 | 2013-07-08 | 感受性哺乳動物において気道疾患を引き起こすウイルス |
Country Status (21)
| Country | Link |
|---|---|
| US (10) | US8927206B2 (https=) |
| EP (1) | EP1351981B1 (https=) |
| JP (3) | JP5503096B2 (https=) |
| KR (4) | KR20040002853A (https=) |
| CN (2) | CN101921732A (https=) |
| AU (1) | AU2002228471B2 (https=) |
| BR (1) | BR0206591A (https=) |
| CA (1) | CA2435180C (https=) |
| DK (1) | DK1351981T3 (https=) |
| EA (1) | EA006879B1 (https=) |
| ES (1) | ES2393468T3 (https=) |
| HU (1) | HUP0500244A3 (https=) |
| IL (1) | IL157003A0 (https=) |
| MX (1) | MXPA03006430A (https=) |
| NO (1) | NO335551B1 (https=) |
| NZ (2) | NZ555567A (https=) |
| PL (1) | PL213926B1 (https=) |
| SG (1) | SG149684A1 (https=) |
| UA (1) | UA93981C2 (https=) |
| WO (1) | WO2002057302A2 (https=) |
| ZA (1) | ZA200305655B (https=) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060094105A1 (en) | 1998-04-24 | 2006-05-04 | University Hospitals Of Cleveland | Mixed cell diagnostic systems for detection of respiratory, herpes and enteric viruses |
| US20040096451A1 (en) * | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| KR20040002853A (ko) | 2001-01-19 | 2004-01-07 | 비로노바티브 비.브이. | 감응성 포유류에서 호흡계 질환을 유발하는 바이러스 |
| EP1485468A4 (en) * | 2002-02-21 | 2007-01-03 | Medimmune Vaccines Inc | RECOMBINANT PARAIN FLUENZAVIRUS EXPRESSION SYSTEMS AND VACCINES WITH ANTIGENS FROM METAPNEUMOVIRUS STEM-RELATED HETEROLOGISTS |
| DE10221836A1 (de) * | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| AU2003297602A1 (en) * | 2002-12-02 | 2004-06-23 | University Of Maryland, College Park | Avian pneumovirus genes, recombinant avian pneumoviruses and methods of making |
| AU2003294533A1 (en) * | 2002-12-19 | 2004-07-14 | Universite Laval | Molecular methods and compositions for detecting and quantifying respiratory viruses |
| US7704491B2 (en) | 2003-02-28 | 2010-04-27 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant human metapneumovirus and its use |
| WO2004085650A1 (en) | 2003-03-24 | 2004-10-07 | The University Of Hong Kong | A high-troughput diagnostic assay for the human virus causing severe acute respiratory syndrome (sars) |
| EP1613345B1 (en) * | 2003-03-28 | 2010-05-26 | MedImmune, LLC | Compositions and methods involving respiratory syncytial virus subgroup b strain 9320 |
| AU2004229501B2 (en) | 2003-04-11 | 2011-08-18 | Medimmune, Llc | Recombinant IL-9 antibodies and uses thereof |
| CN101410519B (zh) * | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| EP1622574A4 (en) * | 2003-04-25 | 2006-10-18 | Medimmune Vaccines Inc | EXPRESSION SYSTEMS OF RECOMBINANT PARAINFLUENZA VIRUSES AND VACCINES COMPRISING HETEROLOGOUS ANTIGENS DERIVED FROM METAPNEUMOVIRUS |
| EP1473037A1 (en) * | 2003-05-02 | 2004-11-03 | Vironovative B.V. | Treatment of hPMV infections with Ribavirin |
| WO2005028673A1 (en) * | 2003-09-22 | 2005-03-31 | Institut Pasteur | A method for detecting nipah virus and method for providing immunoprotection against henipaviruses |
| AU2005249360B2 (en) | 2004-04-12 | 2011-07-21 | Medimmune, Llc | Anti-IL-9 antibody formulations and uses thereof |
| JP4546212B2 (ja) * | 2004-10-21 | 2010-09-15 | 三菱化学メディエンス株式会社 | 抗原蛋白質を発現した細胞を利用する抗体測定方法 |
| CA2600484A1 (en) * | 2005-03-10 | 2006-09-21 | Medimmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| US20080175836A1 (en) * | 2005-12-09 | 2008-07-24 | Karp Nelson M | Immunogenic composition based on conditionally live virion and method for producing the same |
| US8492097B2 (en) | 2006-04-24 | 2013-07-23 | Diagnostic Hybrids, Inc. | Compositions and methods for human metapneumovirus monoclonal antibodies |
| US20090017517A1 (en) * | 2007-07-13 | 2009-01-15 | Medimmune, Llc | Preparation of Negative-Stranded RNA Viruses by Electroporation |
| US20090186050A1 (en) * | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| WO2009062532A1 (en) * | 2007-11-16 | 2009-05-22 | Vironovative Bv | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| EP3351628B1 (en) | 2008-10-24 | 2023-07-26 | The Government of The United States of America as represented by The Secretary, Department of Health and Human Services | Human ebola virus species and compositions and methods thereof |
| KR101073991B1 (ko) * | 2009-10-27 | 2011-10-21 | 대한민국 | 국내사육 닭에서 유행하는 신규한 ｂ형 조류메타뉴모바이러스 ｓｃ1509주 및 이의 용도 |
| CN101880732B (zh) * | 2010-06-29 | 2012-10-10 | 中国药品生物制品检定所 | 猴副流感病毒5型的rt-pcr检测方法及试剂盒 |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DE19216461T1 (de) | 2011-10-03 | 2021-10-07 | Modernatx, Inc. | Modifizierte nukleoside, nukleotide und nukleinsäuren und verwendungen davon |
| CA3018046A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| CN104350069B (zh) | 2012-03-20 | 2017-12-01 | 胡默波斯生物医学公司 | 中和rsv、mpv和pvm的抗体和其应用 |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
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| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| EA039682B1 (ru) * | 2012-06-04 | 2022-02-28 | Хумабс Биомед Са | Антитела, нейтрализующие rsv, mpv и pvm, и их применения |
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| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| MX2015009819A (es) | 2013-01-28 | 2015-10-29 | Evec Inc | Anticuerpo humano especifico a metapneumovirus humano, o fragmento de union al antigeno del mismo. |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
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| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| CL2013002829A1 (es) | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| US10774114B2 (en) * | 2014-03-10 | 2020-09-15 | Fondation The Ark | Respiratory syncytial virus (RSV) replication inhibitors |
| EP4011451A1 (en) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Metapneumovirus mrna vaccines |
| DE102016215118A1 (de) | 2016-08-12 | 2018-02-15 | Anicon Labor Gmbh | Infektiöse Bronchitis (IB)-Virus Varianten und diesbezügliche Zusammensetzungen, Verwendungen und Verfahren |
| KR102102065B1 (ko) * | 2016-10-31 | 2020-04-20 | 우한 산리 바이오테크놀로지 캄파니 리미티드 | 호흡기 세포융합 바이러스 백신 |
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| EP3595676A4 (en) | 2017-03-17 | 2021-05-05 | Modernatx, Inc. | RNA VACCINES AGAINST ZOONOSES |
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| WO2022258755A1 (en) | 2021-06-09 | 2022-12-15 | Universität Duisburg-Essen | Method for immortalising vesicle-secreting cells |
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