JP2006524511A5 - - Google Patents
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- JP2006524511A5 JP2006524511A5 JP2006513300A JP2006513300A JP2006524511A5 JP 2006524511 A5 JP2006524511 A5 JP 2006524511A5 JP 2006513300 A JP2006513300 A JP 2006513300A JP 2006513300 A JP2006513300 A JP 2006513300A JP 2006524511 A5 JP2006524511 A5 JP 2006524511A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- virus
- recombinant
- parainfluenza virus
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 claims 35
- 208000002606 Paramyxoviridae Infections Diseases 0.000 claims 17
- 239000012634 fragment Substances 0.000 claims 15
- 241000351643 Metapneumovirus Species 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000002773 nucleotide Substances 0.000 claims 8
- 125000003729 nucleotide group Chemical group 0.000 claims 8
- 238000012258 culturing Methods 0.000 claims 7
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 210000002966 serum Anatomy 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 2
- 108091006027 G proteins Proteins 0.000 claims 2
- 102000030782 GTP binding Human genes 0.000 claims 2
- 108091000058 GTP-Binding Proteins 0.000 claims 2
- 241000712003 Human respirovirus 3 Species 0.000 claims 2
- 241000711955 Turkey rhinotracheitis virus Species 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 1
- 241000712005 Bovine respirovirus 3 Species 0.000 claims 1
- 101001065501 Escherichia phage MS2 Lysis protein Proteins 0.000 claims 1
- 241000342334 Human metapneumovirus Species 0.000 claims 1
- 101150039699 M2-1 gene Proteins 0.000 claims 1
- 101150103632 M2-2 gene Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 101710141454 Nucleoprotein Proteins 0.000 claims 1
- 102100034574 P protein Human genes 0.000 claims 1
- 101710181008 P protein Proteins 0.000 claims 1
- 241000711504 Paramyxoviridae Species 0.000 claims 1
- 101710177166 Phosphoprotein Proteins 0.000 claims 1
- 241000711904 Pneumoviridae Species 0.000 claims 1
- 108020004511 Recombinant DNA Proteins 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 101001039853 Sonchus yellow net virus Matrix protein Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 241001493065 dsRNA viruses Species 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- LWGJTAZLEJHCPA-UHFFFAOYSA-N n-(2-chloroethyl)-n-nitrosomorpholine-4-carboxamide Chemical compound ClCCN(N=O)C(=O)N1CCOCC1 LWGJTAZLEJHCPA-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46618103P | 2003-04-25 | 2003-04-25 | |
| US49927403P | 2003-08-28 | 2003-08-28 | |
| US55093104P | 2004-03-05 | 2004-03-05 | |
| PCT/US2004/012723 WO2005027825A2 (en) | 2003-04-25 | 2004-04-23 | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084567A Division JP2011167197A (ja) | 2003-04-25 | 2011-04-06 | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006524511A JP2006524511A (ja) | 2006-11-02 |
| JP2006524511A5 true JP2006524511A5 (https=) | 2007-06-14 |
Family
ID=34381928
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006513300A Pending JP2006524511A (ja) | 2003-04-25 | 2004-04-23 | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
| JP2011084567A Ceased JP2011167197A (ja) | 2003-04-25 | 2011-04-06 | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011084567A Ceased JP2011167197A (ja) | 2003-04-25 | 2011-04-06 | メタニューモウイルス由来の異種抗原を含む組換えパラインフルエンザウイルス発現系およびワクチン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20050142148A1 (https=) |
| EP (1) | EP1622574A4 (https=) |
| JP (2) | JP2006524511A (https=) |
| KR (2) | KR101187955B1 (https=) |
| CN (1) | CN1813061B (https=) |
| AU (1) | AU2004273776B2 (https=) |
| CA (1) | CA2523657A1 (https=) |
| MX (1) | MXPA05011268A (https=) |
| WO (1) | WO2005027825A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040002853A (ko) | 2001-01-19 | 2004-01-07 | 비로노바티브 비.브이. | 감응성 포유류에서 호흡계 질환을 유발하는 바이러스 |
| US20040096451A1 (en) * | 2002-07-25 | 2004-05-20 | Young James F. | Methods of treating and preventing RSV, hMPV, and PIV using anti-RSV, anti-hMPV, and anti-PIV antibodies |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| EP1485468A4 (en) | 2002-02-21 | 2007-01-03 | Medimmune Vaccines Inc | RECOMBINANT PARAIN FLUENZAVIRUS EXPRESSION SYSTEMS AND VACCINES WITH ANTIGENS FROM METAPNEUMOVIRUS STEM-RELATED HETEROLOGISTS |
| CN101410519B (zh) * | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| CA2600484A1 (en) * | 2005-03-10 | 2006-09-21 | Medimmune Vaccines, Inc. | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus |
| US7759104B2 (en) * | 2005-07-14 | 2010-07-20 | Mayo Foundation For Medical Education And Research | Paramyxoviridae virus preparations |
| US20090017517A1 (en) * | 2007-07-13 | 2009-01-15 | Medimmune, Llc | Preparation of Negative-Stranded RNA Viruses by Electroporation |
| US20090186050A1 (en) * | 2007-11-16 | 2009-07-23 | Fouchier Ron A M | Live attenuated metapneumovirus strains and their use in vaccine formulations and chimeric metapneumovirus strains |
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| PL2370099T3 (pl) | 2008-12-09 | 2016-10-31 | Zmodyfikowane białka F RSV i sposoby ich zastosowania | |
| EP2445527A2 (en) * | 2009-06-24 | 2012-05-02 | ID Biomedical Corporation of Quebec | Vaccine |
| KR101073991B1 (ko) * | 2009-10-27 | 2011-10-21 | 대한민국 | 국내사육 닭에서 유행하는 신규한 ｂ형 조류메타뉴모바이러스 ｓｃ1509주 및 이의 용도 |
| RU2014117068A (ru) * | 2011-09-30 | 2015-11-10 | Новавакс, Инк. | Вакцина на основе рекомбинантных наночастиц f из rsv против респираторно-синцитиального вируса |
| JP6132420B2 (ja) * | 2011-10-25 | 2017-05-24 | 国立大学法人岐阜大学 | 変異狂犬病ウイルス合成・増殖方法、並びに狂犬病ワクチン製剤 |
| GB201119032D0 (en) * | 2011-11-03 | 2011-12-14 | Isis Innovation | Multisomes: encapsulated droplet networks |
| US9695444B2 (en) | 2012-12-26 | 2017-07-04 | BioComo Inc. | Vaccine prepared utilizing human parainfluenza virus type 2 vector |
| EP2970398B1 (en) | 2013-03-13 | 2024-05-08 | The United States of America, as Represented by The Secretary, Department of Health and Human Services | Prefusion rsv f proteins and their use |
| CN105229021A (zh) * | 2013-03-15 | 2016-01-06 | 加利福尼亚大学董事会 | 在哺乳动物中起抗病毒免疫作用的rna干扰 |
| CL2013002829A1 (es) * | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
| JP6589159B2 (ja) * | 2014-04-01 | 2019-10-16 | 共立製薬株式会社 | 新規ネコモルビリウイルス株、不活化ワクチン製剤、並びにネコモルビリウイルス感染症予防方法 |
| DK3247388T3 (da) | 2015-01-20 | 2025-12-22 | Us Health | Rekombinant human/bovin parainfluenzavirus 3 (b/hpiv3), der udtrykker et kimærisk rsv/bpiv3 f-protein, og anvendelser deraf |
| CA2996007A1 (en) | 2015-09-03 | 2017-03-09 | Novavax, Inc. | Vaccine compositions having improved stability and immunogenicity |
| EP4011451A1 (en) | 2015-10-22 | 2022-06-15 | ModernaTX, Inc. | Metapneumovirus mrna vaccines |
| WO2017172890A1 (en) | 2016-03-29 | 2017-10-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Substitutions-modified prefusion rsv f proteins and their use |
| WO2018107088A2 (en) * | 2016-12-08 | 2018-06-14 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| US11084850B2 (en) | 2016-12-16 | 2021-08-10 | The Pirbright Institute | Recombinant prefusion RSV F proteins and uses thereof |
| US11273214B2 (en) | 2017-05-29 | 2022-03-15 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant chimeric bovine/human parainfluenza virus 3 expressing RSV G and its use |
| JP7317796B2 (ja) | 2017-07-24 | 2023-07-31 | ノババックス，インコーポレイテッド | 呼吸器疾患を治療するための方法および組成物 |
| CN120227451A (zh) | 2018-03-19 | 2025-07-01 | 诺瓦瓦克斯股份有限公司 | 多价流感纳米颗粒疫苗 |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| TWI708877B (zh) | 2019-10-18 | 2020-11-01 | 福懋興業股份有限公司 | 導電布及其製備方法與應用 |
| CN111961652A (zh) * | 2020-07-09 | 2020-11-20 | 温氏食品集团股份有限公司 | 一种禽偏肺病毒的无血清全悬浮培养方法及其在疫苗中的应用 |
| CN117729935A (zh) | 2021-04-27 | 2024-03-19 | 美国政府(由卫生和人类服务部的部长所代表) | 表达sars-cov-2刺突蛋白的重组嵌合牛/人副流感病毒3及其用途 |
| CN113593639B (zh) * | 2021-08-05 | 2023-08-25 | 湖南大学 | 一种用于病毒基因组变异分析、监测方法和系统 |
| MX2024006506A (es) | 2021-11-30 | 2024-08-14 | Sanofi Pasteur Inc | Vacunas basadas en vectores virales de metapneumovirus humano. |
| KR20250006975A (ko) * | 2022-05-02 | 2025-01-13 | 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 | 부위 특이적 게놈 변형을 위한 다성분 시스템 |
| WO2026003578A1 (en) * | 2024-06-26 | 2026-01-02 | Popvax Private Limited | Multisubunit rsv, hmpv and hpiv vaccines and therapeutics |
| WO2026003579A1 (en) * | 2024-06-27 | 2026-01-02 | Popvax Private Limited | Multisubunit papillomavirus vaccines and therapeutics |
| WO2026080706A1 (en) | 2024-10-10 | 2026-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Recombinant chimeric bovine/human parainfluenza virus 3 expressing avian influenza virus proteins and use thereof |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166057A (en) * | 1989-08-28 | 1992-11-24 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand rna virus expression-systems |
| US5854037A (en) * | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US5824307A (en) * | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| US5869036A (en) * | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
| US6180398B1 (en) * | 1996-07-12 | 2001-01-30 | Virogeneitics Corporation | Two-step immunization procedure against the pyramyxoviridae family of viruses using recombinant virus and subunit protein preparation |
| US7192593B2 (en) * | 1997-05-23 | 2007-03-20 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Use of recombinant parainfluenza viruses (PIVs) as vectors to protect against infection and disease caused by PIV and other human pathogens |
| US6656719B1 (en) | 1997-10-27 | 2003-12-02 | Merck & Co., Inc. | Serum-free, low-protein media for rotavirus vaccine production |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| ES2288473T3 (es) * | 1999-05-18 | 2008-01-16 | Dnavec Research Inc. | Vector de virus deficiente en el gen de la envoltura de paramyxoviridae. |
| CA2378661A1 (en) * | 1999-07-09 | 2001-01-18 | Alexander C. Schmidt | Attenuated human-bovine chimeric parainfluenza virus (piv) vaccines |
| EP1103610A1 (en) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
| US20030232061A1 (en) * | 2001-10-18 | 2003-12-18 | Fouchier Ronaldus Adrianus Maria | Recombinant parainfluenza virus expression systems and vaccines comprising heterologous antigens derived from metapneumovirus |
| KR20040002853A (ko) * | 2001-01-19 | 2004-01-07 | 비로노바티브 비.브이. | 감응성 포유류에서 호흡계 질환을 유발하는 바이러스 |
| US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| AU2002364121C1 (en) * | 2001-11-21 | 2010-02-18 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Recovery of recombinant human parainfluenza virus type 1 (HPIVI) from cDNA |
| EP1485468A4 (en) * | 2002-02-21 | 2007-01-03 | Medimmune Vaccines Inc | RECOMBINANT PARAIN FLUENZAVIRUS EXPRESSION SYSTEMS AND VACCINES WITH ANTIGENS FROM METAPNEUMOVIRUS STEM-RELATED HETEROLOGISTS |
| US7704491B2 (en) * | 2003-02-28 | 2010-04-27 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant human metapneumovirus and its use |
| CN101410519B (zh) * | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| US20040229219A1 (en) * | 2003-04-30 | 2004-11-18 | Gallaher William R. | Method of inhibiting human metapneumovirus and human coronavirus in the prevention and treatment of severe acute respiratory syndrome (SARS) |
-
2004
- 2004-04-23 EP EP04809338A patent/EP1622574A4/en not_active Withdrawn
- 2004-04-23 MX MXPA05011268A patent/MXPA05011268A/es active IP Right Grant
- 2004-04-23 AU AU2004273776A patent/AU2004273776B2/en not_active Ceased
- 2004-04-23 US US10/831,781 patent/US20050142148A1/en not_active Abandoned
- 2004-04-23 KR KR1020057020308A patent/KR101187955B1/ko not_active Expired - Fee Related
- 2004-04-23 CA CA002523657A patent/CA2523657A1/en not_active Abandoned
- 2004-04-23 KR KR1020117016892A patent/KR20110097971A/ko not_active Abandoned
- 2004-04-23 WO PCT/US2004/012723 patent/WO2005027825A2/en not_active Ceased
- 2004-04-23 CN CN2004800178032A patent/CN1813061B/zh not_active Expired - Fee Related
- 2004-04-23 JP JP2006513300A patent/JP2006524511A/ja active Pending
-
2010
- 2010-10-20 US US12/908,351 patent/US20120045471A1/en not_active Abandoned
-
2011
- 2011-04-06 JP JP2011084567A patent/JP2011167197A/ja not_active Ceased
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