JP2004530637A5 - - Google Patents
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- Publication number
- JP2004530637A5 JP2004530637A5 JP2002539305A JP2002539305A JP2004530637A5 JP 2004530637 A5 JP2004530637 A5 JP 2004530637A5 JP 2002539305 A JP2002539305 A JP 2002539305A JP 2002539305 A JP2002539305 A JP 2002539305A JP 2004530637 A5 JP2004530637 A5 JP 2004530637A5
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- guareshi
- carrying
- manufacturing
- ammonium hydroxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- MLIREBYILWEBDM-UHFFFAOYSA-N cyanoacetic acid Chemical compound OC(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-N 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 4
- 239000000908 ammonium hydroxide Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 150000002148 esters Chemical class 0.000 claims description 3
- -1 pentamethylene glutarimide Chemical compound 0.000 claims description 3
- ANGDWNBGPBMQHW-UHFFFAOYSA-N methyl cyanoacetate Chemical compound COC(=O)CC#N ANGDWNBGPBMQHW-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 5
- 150000003949 imides Chemical class 0.000 claims 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- ZIUSEGSNTOUIPT-UHFFFAOYSA-N ethyl 2-cyanoacetate Chemical compound CCOC(=O)CC#N ZIUSEGSNTOUIPT-UHFFFAOYSA-N 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012065 filter cake Substances 0.000 description 1
- 229960002870 gabapentin Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000020477 pH reduction Effects 0.000 description 1
- 239000002798 polar solvent Substances 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24489100P | 2000-11-02 | 2000-11-02 | |
| PCT/US2001/042783 WO2002036545A1 (en) | 2000-11-02 | 2001-10-26 | Improved process for production of gabapentin intermediate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004530637A JP2004530637A (ja) | 2004-10-07 |
| JP2004530637A5 true JP2004530637A5 (enExample) | 2005-04-14 |
Family
ID=22924517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002539305A Withdrawn JP2004530637A (ja) | 2000-11-02 | 2001-10-26 | ガバペンチン中間体の製造のための改善方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6613904B2 (enExample) |
| EP (1) | EP1337506A4 (enExample) |
| JP (1) | JP2004530637A (enExample) |
| KR (1) | KR20030048105A (enExample) |
| CN (1) | CN1471507A (enExample) |
| AU (1) | AU2002213506A1 (enExample) |
| CA (1) | CA2427237A1 (enExample) |
| CZ (1) | CZ20031432A3 (enExample) |
| DE (1) | DE01981893T1 (enExample) |
| ES (1) | ES2209674T1 (enExample) |
| HR (1) | HRP20030443A2 (enExample) |
| HU (1) | HUP0303352A3 (enExample) |
| IL (1) | IL155733A0 (enExample) |
| IS (1) | IS6799A (enExample) |
| MX (1) | MXPA03003899A (enExample) |
| NO (1) | NO20031927L (enExample) |
| PL (1) | PL365569A1 (enExample) |
| SK (1) | SK6372003A3 (enExample) |
| WO (1) | WO2002036545A1 (enExample) |
| YU (1) | YU33303A (enExample) |
| ZA (1) | ZA200303349B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050004219A1 (en) * | 2003-07-01 | 2005-01-06 | Medtronic, Inc. | Pump systems including injectable gabapentin compositions |
| US20050090548A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of epilepsy |
| US20050090549A1 (en) * | 2003-10-23 | 2005-04-28 | Medtronic, Inc. | Intrathecal gabapentin for treatment of pain |
| US20050187295A1 (en) * | 2004-02-19 | 2005-08-25 | Surendra Kalyan | Processes for the preparation of gabapentin |
| ITMI20040501A1 (it) * | 2004-03-17 | 2004-06-17 | Caffaro Spa Ind Chim | Procedimento per la preparazione della monoaamide dell'acrido ciclosendiacetico |
| ITMI20041271A1 (it) * | 2004-06-24 | 2004-09-24 | Zambon Spa | Processo di preparazione di gabapentina |
| CN100341856C (zh) | 2005-08-19 | 2007-10-10 | 江苏恩华药业集团有限公司 | 盐酸加巴喷丁制备方法 |
| US8495974B2 (en) | 2009-05-18 | 2013-07-30 | Vito Agosta | Fuel system and method for burning liquid ammonia in engines and boilers |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1142168B (de) * | 1959-07-01 | 1963-01-10 | Warner Lambert Pharmaceutical | Verfahren zur Herstellung von ª‰,ª‰-Penta-methylenbutyrolacton bzw. Salzen der 3, 3-Pentamethylen-4-hydroxybuttersaeure |
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| DE3928182A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von gabapentin |
| PL185991B1 (pl) | 1996-03-14 | 2003-09-30 | Warner Lambert Co | Nowe podstawione cykliczne aminokwasy i kompozycja farmaceutyczna |
-
2001
- 2001-10-26 CA CA002427237A patent/CA2427237A1/en not_active Abandoned
- 2001-10-26 PL PL01365569A patent/PL365569A1/xx not_active Application Discontinuation
- 2001-10-26 SK SK637-2003A patent/SK6372003A3/sk unknown
- 2001-10-26 JP JP2002539305A patent/JP2004530637A/ja not_active Withdrawn
- 2001-10-26 US US09/984,058 patent/US6613904B2/en not_active Expired - Fee Related
- 2001-10-26 MX MXPA03003899A patent/MXPA03003899A/es active IP Right Grant
- 2001-10-26 AU AU2002213506A patent/AU2002213506A1/en not_active Abandoned
- 2001-10-26 HR HR20030443A patent/HRP20030443A2/hr not_active Application Discontinuation
- 2001-10-26 IL IL15573301A patent/IL155733A0/xx unknown
- 2001-10-26 WO PCT/US2001/042783 patent/WO2002036545A1/en not_active Ceased
- 2001-10-26 CZ CZ20031432A patent/CZ20031432A3/cs unknown
- 2001-10-26 DE DE0001337506T patent/DE01981893T1/de active Pending
- 2001-10-26 KR KR10-2003-7006056A patent/KR20030048105A/ko not_active Ceased
- 2001-10-26 ES ES01981893T patent/ES2209674T1/es active Pending
- 2001-10-26 CN CNA018181899A patent/CN1471507A/zh active Pending
- 2001-10-26 HU HU0303352A patent/HUP0303352A3/hu unknown
- 2001-10-26 YU YU33303A patent/YU33303A/sh unknown
- 2001-10-26 EP EP01981893A patent/EP1337506A4/en not_active Withdrawn
-
2003
- 2003-04-29 NO NO20031927A patent/NO20031927L/no not_active Application Discontinuation
- 2003-04-30 IS IS6799A patent/IS6799A/is unknown
- 2003-04-30 ZA ZA200303349A patent/ZA200303349B/en unknown
- 2003-06-06 US US10/455,314 patent/US6881843B2/en not_active Expired - Fee Related
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