JP2008511573A5 - - Google Patents
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- Publication number
- JP2008511573A5 JP2008511573A5 JP2007528770A JP2007528770A JP2008511573A5 JP 2008511573 A5 JP2008511573 A5 JP 2008511573A5 JP 2007528770 A JP2007528770 A JP 2007528770A JP 2007528770 A JP2007528770 A JP 2007528770A JP 2008511573 A5 JP2008511573 A5 JP 2008511573A5
- Authority
- JP
- Japan
- Prior art keywords
- filtered
- tetrahydrofuran
- compound
- cooled
- hours
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 8
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000006114 decarboxylation reaction Methods 0.000 description 2
- 238000007257 deesterification reaction Methods 0.000 description 2
- 239000000706 filtrate Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- HOBJEFOCIRXQKH-BYPYZUCNSA-N (5s)-5-(hydroxymethyl)pyrrolidin-2-one Chemical compound OC[C@@H]1CCC(=O)N1 HOBJEFOCIRXQKH-BYPYZUCNSA-N 0.000 description 1
- HQGPKMSGXAUKHT-UHFFFAOYSA-N L-pyroglutamic acid methyl ester Natural products COC(=O)C1CCC(=O)N1 HQGPKMSGXAUKHT-UHFFFAOYSA-N 0.000 description 1
- 239000012448 Lithium borohydride Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000001743 benzylic group Chemical group 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- HQGPKMSGXAUKHT-BYPYZUCNSA-N methyl (2s)-5-oxopyrrolidine-2-carboxylate Chemical compound COC(=O)[C@@H]1CCC(=O)N1 HQGPKMSGXAUKHT-BYPYZUCNSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0419361.1A GB0419361D0 (en) | 2004-08-31 | 2004-08-31 | Organic compounds |
| PCT/EP2005/009347 WO2006024501A1 (en) | 2004-08-31 | 2005-08-30 | Alternative synthesis of renin inhibitors and intermediates thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008511573A JP2008511573A (ja) | 2008-04-17 |
| JP2008511573A5 true JP2008511573A5 (enExample) | 2008-10-09 |
Family
ID=33155811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007528770A Pending JP2008511573A (ja) | 2004-08-31 | 2005-08-30 | レニン阻害剤およびその中間体の代替的製造法 |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7910774B2 (enExample) |
| EP (2) | EP1978012A1 (enExample) |
| JP (1) | JP2008511573A (enExample) |
| KR (1) | KR20070045300A (enExample) |
| CN (2) | CN102417464A (enExample) |
| AT (1) | ATE485257T1 (enExample) |
| AU (1) | AU2005279351B2 (enExample) |
| BR (1) | BRPI0514742A (enExample) |
| CA (1) | CA2576749C (enExample) |
| DE (1) | DE602005024282D1 (enExample) |
| ES (1) | ES2354986T3 (enExample) |
| GB (1) | GB0419361D0 (enExample) |
| MX (1) | MX2007002419A (enExample) |
| PL (1) | PL1789377T3 (enExample) |
| PT (1) | PT1789377E (enExample) |
| RU (1) | RU2411230C2 (enExample) |
| WO (1) | WO2006024501A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| GB0519764D0 (en) | 2005-09-28 | 2005-11-09 | Novartis Ag | Organic compounds |
| GB0521083D0 (en) | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
| GB2431646A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431649A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431653A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431648A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB2431651A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Synthesis of aryl-octanoyl amide compounds |
| GB2431642A (en) * | 2005-10-25 | 2007-05-02 | Novartis Ag | Alternative synthesis of aryl-octanoyl amide compounds |
| GB0522789D0 (en) | 2005-11-08 | 2005-12-14 | Novartis Ag | Organic compounds |
| MY148758A (en) | 2006-11-07 | 2013-05-31 | Novartis Ag | Crystalline forms of aliskiren hemifumarate |
| DE102007049039A1 (de) | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| EP2062874B1 (en) | 2007-11-20 | 2014-12-17 | KRKA, tovarna zdravil, d.d., Novo mesto | Process and intermediates for the preparation of aliskiren |
| EP2189442B1 (en) | 2008-11-20 | 2014-10-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of aliskiren |
| RU2550691C2 (ru) * | 2009-08-11 | 2015-05-10 | Новартис Аг | Раскрытие циклов лактонов и лактамов |
| WO2011051853A1 (en) | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| CN101774986B (zh) * | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN102329244A (zh) * | 2010-07-13 | 2012-01-25 | 凯瑞斯德生化(苏州)有限公司 | 一种rs-托特罗定的制备方法及中间体化合物 |
| CN102372653A (zh) * | 2010-08-10 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 二苯甲醇类衍生物、其制备方法及其在医药上的应用 |
| EP2551260A1 (en) | 2011-07-28 | 2013-01-30 | Chemo Ibérica, S.A. | Chemical process for opening ring compounds |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| ITMI20120354A1 (it) * | 2012-03-07 | 2013-09-08 | Friulchem Spa | Processo per la produzione di aliskirene |
| CN103044273B (zh) * | 2012-11-29 | 2014-12-24 | 珠海保税区丽珠合成制药有限公司 | 一种酒石酸托特罗定的合成方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL88619A0 (en) * | 1987-12-15 | 1989-07-31 | Pfizer | Non-peptidic renin inhibitors |
| DE3837197A1 (de) | 1988-11-02 | 1990-05-03 | Continental Ag | Vorrichtung zum aufbereiten von unvulkanisiertem kautschuk |
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| GB9523493D0 (en) * | 1995-11-16 | 1996-01-17 | British Biotech Pharm | Preparation of allyl succinate derivatives and starting materials therefore |
| CN100482636C (zh) | 2000-07-05 | 2009-04-29 | 斯皮德尔药品公司 | 取代的辛酰胺的制备方法 |
| EP1303478B1 (en) * | 2000-07-25 | 2004-05-26 | Speedel Pharma AG | Process for the preparation of substituted octanoyl amides |
| PT1215201E (pt) * | 2000-12-14 | 2007-02-28 | Speedel Pharma Ag | Processo para a preparação de ariloctanoil amidas |
| WO2003103653A1 (en) * | 2002-06-11 | 2003-12-18 | Elan Pharmaceuticals, Inc. | Methods of treating alzheimer's disease using aryl alkanoic acid amides |
-
2004
- 2004-08-31 GB GBGB0419361.1A patent/GB0419361D0/en not_active Ceased
-
2005
- 2005-08-30 CN CN2011103045513A patent/CN102417464A/zh active Pending
- 2005-08-30 EP EP08158568A patent/EP1978012A1/en not_active Withdrawn
- 2005-08-30 CN CN2005800292634A patent/CN101010281B/zh not_active Expired - Fee Related
- 2005-08-30 WO PCT/EP2005/009347 patent/WO2006024501A1/en not_active Ceased
- 2005-08-30 PL PL05775930T patent/PL1789377T3/pl unknown
- 2005-08-30 RU RU2007111752/04A patent/RU2411230C2/ru not_active IP Right Cessation
- 2005-08-30 EP EP05775930A patent/EP1789377B1/en not_active Expired - Lifetime
- 2005-08-30 US US11/573,790 patent/US7910774B2/en not_active Expired - Fee Related
- 2005-08-30 AU AU2005279351A patent/AU2005279351B2/en not_active Ceased
- 2005-08-30 BR BRPI0514742-5A patent/BRPI0514742A/pt not_active IP Right Cessation
- 2005-08-30 DE DE602005024282T patent/DE602005024282D1/de not_active Expired - Lifetime
- 2005-08-30 KR KR1020077004734A patent/KR20070045300A/ko not_active Abandoned
- 2005-08-30 AT AT05775930T patent/ATE485257T1/de active
- 2005-08-30 JP JP2007528770A patent/JP2008511573A/ja active Pending
- 2005-08-30 PT PT05775930T patent/PT1789377E/pt unknown
- 2005-08-30 MX MX2007002419A patent/MX2007002419A/es active IP Right Grant
- 2005-08-30 CA CA2576749A patent/CA2576749C/en not_active Expired - Fee Related
- 2005-08-30 ES ES05775930T patent/ES2354986T3/es not_active Expired - Lifetime
-
2011
- 2011-02-07 US US13/022,243 patent/US8143416B2/en not_active Expired - Fee Related
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