JP2004529067A5 - - Google Patents
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- Publication number
- JP2004529067A5 JP2004529067A5 JP2002533901A JP2002533901A JP2004529067A5 JP 2004529067 A5 JP2004529067 A5 JP 2004529067A5 JP 2002533901 A JP2002533901 A JP 2002533901A JP 2002533901 A JP2002533901 A JP 2002533901A JP 2004529067 A5 JP2004529067 A5 JP 2004529067A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- ile
- leu
- val
- ala
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical class 0.000 description 6
- 125000000539 amino acid group Chemical group 0.000 description 3
- 241000287828 Gallus gallus Species 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 241000252212 Danio rerio Species 0.000 description 1
- 101000616562 Danio rerio Sonic hedgehog protein A Proteins 0.000 description 1
- 241000289669 Erinaceus europaeus Species 0.000 description 1
- 108700024394 Exon Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24056400P | 2000-10-13 | 2000-10-13 | |
| US60/240,564 | 2000-10-13 | ||
| PCT/US2001/032100 WO2002030462A2 (en) | 2000-10-13 | 2001-10-15 | Hedgehog antagonists, methods and uses related thereto |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008101692A Division JP2008214356A (ja) | 2000-10-13 | 2008-04-09 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
| JP2009113082A Division JP2009179630A (ja) | 2000-10-13 | 2009-05-07 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004529067A JP2004529067A (ja) | 2004-09-24 |
| JP2004529067A5 true JP2004529067A5 (enExample) | 2009-07-02 |
| JP5196700B2 JP5196700B2 (ja) | 2013-05-15 |
Family
ID=22907059
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002533901A Expired - Fee Related JP5196700B2 (ja) | 2000-10-13 | 2001-10-15 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
| JP2008101692A Abandoned JP2008214356A (ja) | 2000-10-13 | 2008-04-09 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
| JP2009113082A Pending JP2009179630A (ja) | 2000-10-13 | 2009-05-07 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008101692A Abandoned JP2008214356A (ja) | 2000-10-13 | 2008-04-09 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
| JP2009113082A Pending JP2009179630A (ja) | 2000-10-13 | 2009-05-07 | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040060568A1 (enExample) |
| EP (1) | EP1387674B1 (enExample) |
| JP (3) | JP5196700B2 (enExample) |
| AU (3) | AU9684401A (enExample) |
| CA (1) | CA2425356C (enExample) |
| DK (1) | DK1387674T3 (enExample) |
| ES (1) | ES2623711T3 (enExample) |
| WO (1) | WO2002030462A2 (enExample) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2280736C (en) * | 1997-02-10 | 2012-05-29 | The President And Fellows Of Harvard College | Methods for modulating hematopoiesis and vascular growth |
| US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
| US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
| JP2002524528A (ja) | 1998-09-11 | 2002-08-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法 |
| DE69942063D1 (de) | 1998-09-11 | 2010-04-08 | Curis Inc | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
| DE60028411T2 (de) | 1999-10-13 | 2007-01-04 | Johns Hopkins University School Of Medicine | Verbindungen zur regulierung des hedgehog-signalwegs, zusammensetzungen und verwendungen davon |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| US7230000B1 (en) | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US7671200B2 (en) | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| US7498304B2 (en) | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| ES2623711T3 (es) * | 2000-10-13 | 2017-07-12 | Curis, Inc. | Antagonistas de hedgehog, procedimientos y usos relacionados con los mismos |
| US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
| CA2452152A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| US7166595B2 (en) * | 2002-05-09 | 2007-01-23 | Cytokinetics, Inc. | Compounds, methods and compositions |
| AU2003270015A1 (en) | 2002-05-09 | 2003-12-02 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2003103575A2 (en) | 2002-05-23 | 2003-12-18 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2004009036A2 (en) | 2002-07-23 | 2004-01-29 | Cytokinetics, Inc. | Compounds compositions and methods |
| GB0221539D0 (en) * | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
| WO2004034972A2 (en) | 2002-09-30 | 2004-04-29 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| FR2850022B1 (fr) * | 2003-01-22 | 2006-09-08 | Centre Nat Rech Scient | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
| US20080118493A1 (en) * | 2003-07-15 | 2008-05-22 | Beachy Philip A | Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem Tumors Having Elevated Hedgehog Pathway Activity |
| US20070231828A1 (en) * | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
| US20080095761A1 (en) * | 2003-10-01 | 2008-04-24 | The Johns Hopkins University | Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis |
| US20080057071A1 (en) * | 2003-10-20 | 2008-03-06 | Watkins David N | Use Of Hedgehog Pathway Inhibitors In Small-Cell Lung Cancer |
| WO2005097207A2 (en) * | 2004-03-26 | 2005-10-20 | Curis, Inc. | Rna interference modulators of hedgehog signaling and uses thereof |
| CN101044139B (zh) * | 2004-08-27 | 2011-06-08 | 无限药品股份有限公司 | 环杷明类似物及其使用方法 |
| ES2578728T3 (es) | 2004-08-27 | 2016-07-29 | Infinity Pharmaceuticals, Inc. | Proceso para la preparación de compuestos análogos de ciclopamina |
| US7517870B2 (en) * | 2004-12-03 | 2009-04-14 | Fondazione Telethon | Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization |
| AU2006283040B2 (en) * | 2005-08-22 | 2011-08-25 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
| US7625759B2 (en) | 2005-12-19 | 2009-12-01 | Genentech, Inc. | Method for using BOC/CDO to modulate hedgehog signaling |
| US7622496B2 (en) | 2005-12-23 | 2009-11-24 | Zealand Pharma A/S | Modified lysine-mimetic compounds |
| WO2008121102A2 (en) * | 2006-02-21 | 2008-10-09 | The Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
| CA2647277A1 (en) * | 2006-04-05 | 2007-11-08 | Genentech, Inc. | Method for using boc/cdo to modulate hedgehog signaling |
| CA2650338C (en) * | 2006-04-27 | 2013-04-16 | Illinois Tool Works Inc. | Pan chiller system with single state coolant |
| WO2007136250A2 (en) * | 2006-05-24 | 2007-11-29 | Stichting Voor De Technische Wetenschappen | A pharmaceutical composition suitable for the treatment of cancer and method of preparing said pharmaceutical composition |
| ES2558856T3 (es) | 2006-12-21 | 2016-02-09 | Zealand Pharma A/S | Síntesis de compuestos de pirrolidina |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
| CN101687877B (zh) | 2007-03-07 | 2014-07-23 | 无限发现股份有限公司 | 杂环环杷明类似物及其使用方法 |
| EP2134719B1 (en) | 2007-03-07 | 2013-07-17 | Infinity Discovery, Inc. | Cyclopamine lactam analogs and methods of use thereof |
| WO2009058945A1 (en) | 2007-10-30 | 2009-05-07 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
| US8669243B2 (en) | 2007-10-30 | 2014-03-11 | The Wistar Institute | Steroid-derived cyclopamine analogs and methods for using the same in the prevention or treatment of cancer |
| WO2009086451A1 (en) | 2007-12-27 | 2009-07-09 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
| EP2235063B1 (en) | 2007-12-28 | 2015-09-02 | Genentech, Inc. | Anti-hedgehog antibodies |
| FR2948367A1 (fr) | 2009-07-24 | 2011-01-28 | Centre Nat Rech Scient | Derives d'acyl-guanidines modulateurs de la voie de signalisation des proteines hedgehog |
| CA2769795C (en) | 2009-08-05 | 2020-01-07 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| JP5326962B2 (ja) * | 2009-09-17 | 2013-10-30 | 住友大阪セメント株式会社 | 防汚加工製品及びその製造方法 |
| RU2490267C2 (ru) * | 2010-05-28 | 2013-08-20 | Учреждение Российской Академии Наук Институт Нефтехимии И Катализа Ран | Способ получения конъюгата (6-гидрокси-2,5,7,8-тетраметилхроман-2-ил)ацетальдегида с 20-гидроксиэкдизоном и его применение в качестве антиоксидантного средства, ингибирующего процесс перекисного окисления липидов |
| US9376447B2 (en) | 2010-09-14 | 2016-06-28 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| FR2967498B1 (fr) | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
| US9708299B2 (en) | 2011-01-03 | 2017-07-18 | Genentech, Inc. | Hedgehog antagonists having zinc binding moieties |
| EP2715366B1 (en) * | 2011-06-02 | 2017-07-19 | Novartis AG | Biomarkers for hedgehog inhibitor therapy |
| CN106822153B (zh) * | 2011-06-06 | 2019-12-17 | 爱荷华大学研究基金会 | 用于抑制肌萎缩的方法 |
| FR2980477B1 (fr) | 2011-09-23 | 2013-10-18 | Centre Nat Rech Scient | Nouveaux composes modulateurs de la voie de signalisation des proteines hedgehog, leurs formes marquees, et applications |
| JP6233932B2 (ja) | 2012-08-30 | 2017-11-22 | 国立大学法人広島大学 | BBF2H7(BBF2 human homologue on chromosome7)部分アミノ酸配列を有するペプチドまたはそれに結合する抗体を含む細胞増殖調節用組成物 |
| AU2014278178B2 (en) | 2013-06-11 | 2021-01-21 | President And Fellows Of Harvard College | SC-beta cells and compositions and methods for generating the same |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| US10548908B2 (en) * | 2016-09-15 | 2020-02-04 | Nostopharma, LLC | Compositions and methods for preventing and treating heterotopic ossification and pathologic calcification |
| ES2870106T3 (es) | 2017-05-05 | 2021-10-26 | Zealand Pharma As | Moduladores de la comunicación intercelular de uniones comunicantes y su uso para el tratamiento de la enfermedad del ojo diabético |
| WO2019099725A1 (en) | 2017-11-15 | 2019-05-23 | Semma Therapeutics, Inc. | Islet cell manufacturing compositions and methods of use |
| WO2019169351A1 (en) | 2018-03-02 | 2019-09-06 | Semma Therapeutics, Inc. | Methods of enhancing stem cell differentiation into beta cells |
| EP3833365A4 (en) | 2018-08-10 | 2022-05-11 | Vertex Pharmaceuticals Incorporated | Stem cell derived islet differentiation |
| JP7705448B2 (ja) | 2020-07-31 | 2025-07-09 | バーテックス ファーマシューティカルズ インコーポレイテッド | 膵内分泌細胞の分化 |
| JP2024542041A (ja) | 2021-11-01 | 2024-11-13 | バーテックス ファーマシューティカルズ インコーポレイテッド | 幹細胞由来の膵臓島分化 |
| WO2025231369A1 (en) * | 2024-05-03 | 2025-11-06 | Emory University | Veragranine analogs, pharmaceutical compositions, and uses in managing pain or inflammatory conditions |
| WO2026069163A1 (en) | 2024-09-25 | 2026-04-02 | Crispr Therapeutics Ag | Differentiation method for producing immature beta cells |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789543A (en) * | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
| US6610656B1 (en) * | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
| US6165747A (en) * | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
| US6261786B1 (en) * | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
| US6384192B1 (en) * | 1993-12-30 | 2002-05-07 | President & Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins |
| US7060450B1 (en) * | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
| NZ278765A (en) | 1993-12-30 | 1998-05-27 | Harvard College | Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use |
| US6884775B1 (en) * | 1993-12-30 | 2005-04-26 | President And Fellows Of Harvard College | Methods and compositions for regulating skeletogenic formation |
| US20030186357A1 (en) * | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
| CA2184092A1 (en) | 1994-02-25 | 1995-08-31 | Thomas M. Jessell | Dna encoding the vertebrate homolog of hedgehog, vhh-1, expressed by the notochord, and uses thereof |
| EP1616942A3 (en) * | 1994-10-07 | 2006-11-22 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and their use |
| US6027882A (en) * | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
| US6429354B1 (en) * | 1994-10-07 | 2002-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and uses related thereto |
| US6946257B1 (en) * | 1994-10-07 | 2005-09-20 | Regents Of The University Of California | Patched genes and uses related thereto |
| US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
| US5759811A (en) | 1996-11-13 | 1998-06-02 | The Regents Of The University Of California | Mutant human hedgehog gene |
| JPH10215867A (ja) * | 1997-02-04 | 1998-08-18 | Asahi Glass Co Ltd | タンパク質誘導体、該タンパク質をコードする遺伝子および該タンパク質の製造法 |
| CA2280736C (en) * | 1997-02-10 | 2012-05-29 | The President And Fellows Of Harvard College | Methods for modulating hematopoiesis and vascular growth |
| CA2302780A1 (en) | 1997-08-29 | 1999-03-04 | Ontogeny, Inc. | Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto |
| US6639051B2 (en) | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
| US6867216B1 (en) * | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
| JP5067986B2 (ja) * | 1998-04-09 | 2012-11-07 | ジョンズ ホプキンズ ユニヴァーシティー スクール オブ メディシン | ヘッジホッグシグナリング経路の阻害剤としてのステロイドアルカロイド誘導体の使用 |
| DE69942063D1 (de) * | 1998-09-11 | 2010-04-08 | Curis Inc | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
| JP2002524528A (ja) * | 1998-09-11 | 2002-08-06 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | ヘッジホッグ様ポリペプチドによる肺組織の調節、およびそれに関する製剤および使用方法 |
| DE69939327D1 (de) * | 1998-11-02 | 2008-09-25 | Curis Inc | Funktionelle antagonisten von hedgehog-aktivität |
| US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
| GB0013674D0 (en) | 1999-06-08 | 2000-07-26 | Lorantis Ltd | Therapeutic use |
| US20050080138A1 (en) * | 1999-09-16 | 2005-04-14 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| DE60017157T2 (de) | 1999-09-16 | 2005-12-22 | Curis, Inc., Cambridge | Vermittler von igel signalwegen, deren zusammenstellungen und verwendungen |
| DE60028411T2 (de) * | 1999-10-13 | 2007-01-04 | Johns Hopkins University School Of Medicine | Verbindungen zur regulierung des hedgehog-signalwegs, zusammensetzungen und verwendungen davon |
| IL148972A0 (en) | 1999-10-14 | 2002-11-10 | Curis Inc | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| US6552016B1 (en) * | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
| WO2001074344A2 (en) | 2000-03-30 | 2001-10-11 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
| US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| CA2412215A1 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
| ES2623711T3 (es) * | 2000-10-13 | 2017-07-12 | Curis, Inc. | Antagonistas de hedgehog, procedimientos y usos relacionados con los mismos |
| US7708998B2 (en) * | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
| AU2002247847A1 (en) | 2001-04-09 | 2002-10-21 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
| EA007339B1 (ru) | 2001-07-27 | 2006-08-25 | Кьюэрис, Инк. | Медиаторы путей передачи сигналов генами hedgehog, содержащие их композиции и способы применения указанных веществ |
| FR2834403B1 (fr) * | 2001-12-27 | 2004-02-06 | France Telecom | Systeme cryptographique de signature de groupe |
-
2001
- 2001-10-15 ES ES01977751.5T patent/ES2623711T3/es not_active Expired - Lifetime
- 2001-10-15 EP EP01977751.5A patent/EP1387674B1/en not_active Expired - Lifetime
- 2001-10-15 US US09/977,864 patent/US20040060568A1/en not_active Abandoned
- 2001-10-15 AU AU9684401A patent/AU9684401A/xx active Pending
- 2001-10-15 AU AU2001296844A patent/AU2001296844B2/en not_active Ceased
- 2001-10-15 CA CA2425356A patent/CA2425356C/en not_active Expired - Lifetime
- 2001-10-15 DK DK01977751.5T patent/DK1387674T3/en active
- 2001-10-15 WO PCT/US2001/032100 patent/WO2002030462A2/en not_active Ceased
- 2001-10-15 JP JP2002533901A patent/JP5196700B2/ja not_active Expired - Fee Related
-
2006
- 2006-10-20 AU AU2006230725A patent/AU2006230725B2/en not_active Ceased
-
2008
- 2008-04-09 JP JP2008101692A patent/JP2008214356A/ja not_active Abandoned
-
2009
- 2009-05-07 JP JP2009113082A patent/JP2009179630A/ja active Pending
-
2010
- 2010-06-01 US US12/791,785 patent/US8486400B2/en not_active Expired - Fee Related
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