|
US7012084B2
(en)
|
2001-02-28 |
2006-03-14 |
Merck & Co., Inc. |
Acylated piperidine derivatives as melanocortin-4 receptor agonists
|
|
CA2439152C
(en)
*
|
2001-02-28 |
2008-06-17 |
Merck & Co., Inc. |
Acylated piperidine derivatives as melanocortin-4 receptor agonists
|
|
US6911447B2
(en)
|
2001-04-25 |
2005-06-28 |
The Procter & Gamble Company |
Melanocortin receptor ligands
|
|
US7115628B2
(en)
|
2001-07-18 |
2006-10-03 |
Merck & Co., Inc. |
Bridged piperidine derivatives as melanocortin receptor agonists
|
|
US6977264B2
(en)
|
2001-07-25 |
2005-12-20 |
Amgen Inc. |
Substituted piperidines and methods of use
|
|
US7115607B2
(en)
|
2001-07-25 |
2006-10-03 |
Amgen Inc. |
Substituted piperazinyl amides and methods of use
|
|
AU2002331064B2
(en)
|
2001-08-10 |
2007-08-23 |
Palatin Technologies, Inc. |
Peptidomimetics of biologically active metallopeptides
|
|
US7354923B2
(en)
|
2001-08-10 |
2008-04-08 |
Palatin Technologies, Inc. |
Piperazine melanocortin-specific compounds
|
|
US7456184B2
(en)
|
2003-05-01 |
2008-11-25 |
Palatin Technologies Inc. |
Melanocortin receptor-specific compounds
|
|
US7026335B2
(en)
|
2002-04-30 |
2006-04-11 |
The Procter & Gamble Co. |
Melanocortin receptor ligands
|
|
US7105526B2
(en)
|
2002-06-28 |
2006-09-12 |
Banyu Pharmaceuticals Co., Ltd. |
Benzimidazole derivatives
|
|
WO2004024720A1
(en)
|
2002-09-11 |
2004-03-25 |
Merck & Co., Inc. |
Piperazine urea derivatives as melanocortin-4 receptor agonists
|
|
TW200504033A
(en)
|
2002-10-23 |
2005-02-01 |
Procter & Gamble |
Melanocortin receptor ligands
|
|
US7772188B2
(en)
|
2003-01-28 |
2010-08-10 |
Ironwood Pharmaceuticals, Inc. |
Methods and compositions for the treatment of gastrointestinal disorders
|
|
WO2004078717A1
(en)
*
|
2003-03-03 |
2004-09-16 |
Merck & Co., Inc. |
Acylated piperazine derivatives as melanocortin-4 receptor agonists
|
|
US6998488B2
(en)
|
2003-03-10 |
2006-02-14 |
Merck & Co., Inc. |
Process and intermediates for the preparation of 4-aryl piperidines
|
|
CN1764458A
(zh)
|
2003-03-26 |
2006-04-26 |
麦克公司 |
作为黑皮质素－4受体激动剂的双环哌啶衍生物
|
|
CN1768041A
(zh)
|
2003-04-04 |
2006-05-03 |
麦克公司 |
作为黑皮质素－4受体激动剂的酰化螺哌啶衍生物
|
|
AR044510A1
(es)
*
|
2003-04-14 |
2005-09-14 |
Merck & Co Inc |
Procedimiento e intermedios para preparar acidos carboxilicos de pirrolidina
|
|
US7049323B2
(en)
|
2003-04-25 |
2006-05-23 |
Bristol-Myers Squibb Company |
Amidoheterocycles as modulators of the melanocortin-4 receptor
|
|
WO2005009950A2
(en)
|
2003-07-22 |
2005-02-03 |
Merck & Co., Inc. |
Piperidine derivatives as melanocortin-4 receptor agonists
|
|
ATE547404T1
(de)
|
2003-09-22 |
2012-03-15 |
Msd Kk |
Piperidinderivate
|
|
GB0402492D0
(en)
*
|
2004-02-04 |
2004-03-10 |
Pfizer Ltd |
Pharmaceutically active compounds
|
|
US7649002B2
(en)
|
2004-02-04 |
2010-01-19 |
Pfizer Inc |
(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
|
|
JP5111101B2
(ja)
*
|
2004-03-02 |
2012-12-26 |
株式会社ブリヂストン |
バルク重合プロセス
|
|
EP1734963A4
(en)
|
2004-04-02 |
2008-06-18 |
Merck & Co Inc |
METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
|
|
JP2008506779A
(ja)
|
2004-07-19 |
2008-03-06 |
メルク エンド カムパニー インコーポレーテッド |
メラノコルチン−４受容体作用薬としてのアシル化ピペリジン誘導体
|
|
CN101094689B
(zh)
|
2004-11-01 |
2013-06-12 |
安米林药品有限责任公司 |
治疗肥胖以及肥胖相关疾病和病症的方法
|
|
GB0428514D0
(en)
*
|
2004-12-31 |
2005-02-09 |
Prosidion Ltd |
Compounds
|
|
WO2007022123A2
(en)
|
2005-08-11 |
2007-02-22 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
BRPI0610580B8
(pt)
|
2005-05-30 |
2021-05-25 |
Banyu Pharma Co Ltd |
composto derivado de piperidina
|
|
US20070021433A1
(en)
|
2005-06-03 |
2007-01-25 |
Jian-Qiang Fan |
Pharmacological chaperones for treating obesity
|
|
AU2006275702A1
(en)
|
2005-07-29 |
2007-02-08 |
Concert Pharmaceuticals Inc. |
Novel pharmaceutical compounds
|
|
CA2617654A1
(en)
*
|
2005-08-04 |
2007-02-08 |
Pfizer Limited |
Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds
|
|
JPWO2007018248A1
(ja)
|
2005-08-10 |
2009-02-19 |
萬有製薬株式会社 |
ピリドン化合物
|
|
EP2330125A3
(en)
|
2005-08-11 |
2012-12-12 |
Amylin Pharmaceuticals, Inc. |
Hybrid polypeptides with selectable properties
|
|
WO2007024004A1
(ja)
|
2005-08-24 |
2007-03-01 |
Banyu Pharmaceutical Co., Ltd. |
フェニルピリドン誘導体
|
|
WO2007029847A1
(ja)
|
2005-09-07 |
2007-03-15 |
Banyu Pharmaceutical Co., Ltd. |
二環性芳香族置換ピリドン誘導体
|
|
EP1940842B1
(en)
*
|
2005-09-29 |
2012-05-30 |
Merck Sharp & Dohme Corp. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
AU2006304305B2
(en)
|
2005-10-18 |
2010-04-01 |
Merck Sharp & Dohme Corp. |
Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators
|
|
JP2009512715A
(ja)
|
2005-10-21 |
2009-03-26 |
ノバルティス アクチエンゲゼルシャフト |
レニン阻害剤と抗異脂肪血症剤および／または抗肥満症剤の組み合わせ
|
|
EP1944301A4
(en)
|
2005-10-27 |
2012-01-04 |
Msd Kk |
NEW BENZOXATHIIN DERIVATIVES
|
|
ES2381205T3
(es)
|
2005-11-10 |
2012-05-24 |
Msd K.K. |
Derivado espiro aza-sustituido
|
|
WO2007096763A2
(en)
|
2006-02-23 |
2007-08-30 |
Pfizer Limited |
Melanocortin type 4 receptor agonist piperidinoylpyrrolidines
|
|
CN101426782B
(zh)
*
|
2006-02-23 |
2012-10-31 |
辉瑞股份有限公司 |
黑皮质素4型受体激动剂哌啶羰基吡咯烷
|
|
US8173629B2
(en)
|
2006-09-22 |
2012-05-08 |
Merck Sharp & Dohme Corp. |
Method of treatment using fatty acid synthesis inhibitors
|
|
US20090247560A1
(en)
|
2006-09-28 |
2009-10-01 |
Banyu Pharmaceutical Co., Ltd. |
Diaryl ketimine derivative
|
|
JP5319518B2
(ja)
|
2007-04-02 |
2013-10-16 |
Ｍｓｄ株式会社 |
インドールジオン誘導体
|
|
MX354786B
(es)
|
2007-06-04 |
2018-03-21 |
Synergy Pharmaceuticals Inc |
Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
|
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
|
JP2010540629A
(ja)
*
|
2007-10-04 |
2010-12-24 |
メルク・シャープ・エンド・ドーム・コーポレイション |
カルシウムチャネル遮断薬としての置換アリールスルホン誘導体
|
|
EP2264026A4
(en)
|
2008-03-06 |
2012-03-28 |
Msd Kk |
ALKYLAMINOPYRIDINDERIVATE
|
|
WO2009119726A1
(ja)
|
2008-03-28 |
2009-10-01 |
萬有製薬株式会社 |
メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
|
|
ES2522968T3
(es)
|
2008-06-04 |
2014-11-19 |
Synergy Pharmaceuticals Inc. |
Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
|
|
JPWO2009154132A1
(ja)
|
2008-06-19 |
2011-12-01 |
Ｍｓｄ株式会社 |
スピロジアミン−ジアリールケトオキシム誘導体
|
|
AU2009270833B2
(en)
|
2008-07-16 |
2015-02-19 |
Bausch Health Ireland Limited |
Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
|
|
EP2319841A1
(en)
|
2008-07-30 |
2011-05-11 |
Msd K.K. |
(5-membered)-(5-membered) or (5-membered)-(6-membered) fused ring cycloalkylamine derivative
|
|
KR101280786B1
(ko)
|
2008-08-06 |
2013-07-05 |
화이자 리미티드 |
멜라노코르틴 4 작용제로서 다이아제핀 및 다이아조칸 화합물
|
|
EP2348857B1
(en)
|
2008-10-22 |
2016-02-24 |
Merck Sharp & Dohme Corp. |
Novel cyclic benzimidazole derivatives useful anti-diabetic agents
|
|
US8329914B2
(en)
|
2008-10-31 |
2012-12-11 |
Merck Sharp & Dohme Corp |
Cyclic benzimidazole derivatives useful as anti-diabetic agents
|
|
UA99555C2
(en)
|
2008-11-12 |
2012-08-27 |
Элджи Лайф Саенсез Лтд. |
Melanocortin receptor agonists
|
|
EP2358200A4
(en)
|
2008-11-17 |
2012-05-16 |
Merck Sharp & Dohme |
SUBSTITUTED BICYCLIC AMINES FOR THE TREATMENT OF DIABETES
|
|
CN102245570A
(zh)
*
|
2008-12-16 |
2011-11-16 |
弗·哈夫曼-拉罗切有限公司 |
制备吡咯烷-3-甲酸类的方法
|
|
US8324250B2
(en)
*
|
2009-03-19 |
2012-12-04 |
Hoffmann-La Roche Inc. |
Piperidine derivatives as NK3 receptor antagonists
|
|
WO2011011506A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Spirocyclic oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
CA2768577A1
(en)
|
2009-07-23 |
2011-01-27 |
Schering Corporation |
Benzo-fused oxazepine compounds as stearoyl-coenzyme a delta-9 desaturase inhibitors
|
|
US8476227B2
(en)
|
2010-01-22 |
2013-07-02 |
Ethicon Endo-Surgery, Inc. |
Methods of activating a melanocortin-4 receptor pathway in obese subjects
|
|
US9044606B2
(en)
|
2010-01-22 |
2015-06-02 |
Ethicon Endo-Surgery, Inc. |
Methods and devices for activating brown adipose tissue using electrical energy
|
|
JP2013520502A
(ja)
|
2010-02-25 |
2013-06-06 |
メルク・シャープ・エンド・ドーム・コーポレイション |
有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体
|
|
WO2011137024A1
(en)
|
2010-04-26 |
2011-11-03 |
Merck Sharp & Dohme Corp. |
Novel spiropiperidine prolylcarboxypeptidase inhibitors
|
|
EP2563127A4
(en)
|
2010-04-27 |
2013-11-06 |
Merck Sharp & Dohme |
PROLYLCARBOXYPEPTIDASE INHIBITORS
|
|
EP2568812B1
(en)
|
2010-05-11 |
2016-10-26 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
WO2011156246A1
(en)
|
2010-06-11 |
2011-12-15 |
Merck Sharp & Dohme Corp. |
Novel prolylcarboxypeptidase inhibitors
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
WO2012100342A1
(en)
|
2011-01-27 |
2012-08-02 |
Université de Montréal |
Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators
|
|
SG192941A1
(en)
|
2011-02-25 |
2013-09-30 |
Merck Sharp & Dohme |
Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents
|
|
RU2015106909A
(ru)
|
2012-08-02 |
2016-09-27 |
Мерк Шарп И Доум Корп. |
Антидиабетические трициклические соединения
|
|
KR20150118158A
(ko)
|
2013-02-22 |
2015-10-21 |
머크 샤프 앤드 돔 코포레이션 |
항당뇨병 비시클릭 화합물
|
|
WO2014139388A1
(en)
|
2013-03-14 |
2014-09-18 |
Merck Sharp & Dohme Corp. |
Novel indole derivatives useful as anti-diabetic agents
|
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
|
AU2014235215A1
(en)
|
2013-03-15 |
2015-10-01 |
Synergy Pharmaceuticals Inc. |
Agonists of guanylate cyclase and their uses
|
|
BR112015030326A2
(pt)
|
2013-06-05 |
2017-08-29 |
Synergy Pharmaceuticals Inc |
Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos
|
|
WO2015051496A1
(en)
|
2013-10-08 |
2015-04-16 |
Merck Sharp & Dohme Corp. |
Antidiabetic tricyclic compounds
|
|
KR102431436B1
(ko)
|
2014-08-29 |
2022-08-10 |
테스 파마 에스.알.엘. |
α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제
|
|
US10080884B2
(en)
|
2014-12-29 |
2018-09-25 |
Ethicon Llc |
Methods and devices for activating brown adipose tissue using electrical energy
|
|
US10092738B2
(en)
|
2014-12-29 |
2018-10-09 |
Ethicon Llc |
Methods and devices for inhibiting nerves when activating brown adipose tissue
|
|
WO2018069532A1
(en)
|
2016-10-14 |
2018-04-19 |
Tes Pharma S.R.L. |
Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
|
|
US11072602B2
(en)
|
2016-12-06 |
2021-07-27 |
Merck Sharp & Dohme Corp. |
Antidiabetic heterocyclic compounds
|
|
EP3558298B1
(en)
|
2016-12-20 |
2026-03-11 |
Merck Sharp & Dohme LLC |
Antidiabetic spirochroman compounds
|
|
AR117122A1
(es)
|
2018-11-20 |
2021-07-14 |
Tes Pharma S R L |
INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA
|