ES2272703T3 - Derivados de piperidina acilados como agonistas de receptor de melanocortina-4. - Google Patents
Derivados de piperidina acilados como agonistas de receptor de melanocortina-4. Download PDFInfo
- Publication number
- ES2272703T3 ES2272703T3 ES02725001T ES02725001T ES2272703T3 ES 2272703 T3 ES2272703 T3 ES 2272703T3 ES 02725001 T ES02725001 T ES 02725001T ES 02725001 T ES02725001 T ES 02725001T ES 2272703 T3 ES2272703 T3 ES 2272703T3
- Authority
- ES
- Spain
- Prior art keywords
- baselineskip
- alkyl
- independently selected
- phenyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 0 CC(C)(CO1)N(CC(CC2)(CCN2C(C(CCN(*)C2)C2c(cc2)ccc2Cl)=O)C2CCCCC2)C1=O Chemical compound CC(C)(CO1)N(CC(CC2)(CCN2C(C(CCN(*)C2)C2c(cc2)ccc2Cl)=O)C2CCCCC2)C1=O 0.000 description 2
- PYRFXZVTSQRNCQ-UHFFFAOYSA-N CC(C)(C)N(CC1C(N(CC2)CCC2(CCC(C)(C)O)C2CCCCC2)=O)CC1c(c(F)c1)ccc1F Chemical compound CC(C)(C)N(CC1C(N(CC2)CCC2(CCC(C)(C)O)C2CCCCC2)=O)CC1c(c(F)c1)ccc1F PYRFXZVTSQRNCQ-UHFFFAOYSA-N 0.000 description 1
- HVHCKXFXUVOMAW-UHFFFAOYSA-N CC(C)(C)N(CCC1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1Cl Chemical compound CC(C)(C)N(CCC1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1Cl HVHCKXFXUVOMAW-UHFFFAOYSA-N 0.000 description 1
- CADLMVQVXUHHOM-QXPUDEPPSA-N CC(C)(C)N(CC[C@H]1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1F Chemical compound CC(C)(C)N(CC[C@H]1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1F CADLMVQVXUHHOM-QXPUDEPPSA-N 0.000 description 1
- SRRUIQWRRSQQAD-SSYAZFEXSA-N CC(C)(C)N(C[C@H]1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1F Chemical compound CC(C)(C)N(C[C@H]1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1F SRRUIQWRRSQQAD-SSYAZFEXSA-N 0.000 description 1
- GDFAUWUHCZAGTD-UHFFFAOYSA-N CC(C)(C)NC(C(CC1)(CCN1C(C(CN(C1)C(C)(C)C)C1c(cc1)ccc1F)=O)C1CCCCC1)=O Chemical compound CC(C)(C)NC(C(CC1)(CCN1C(C(CN(C1)C(C)(C)C)C1c(cc1)ccc1F)=O)C1CCCCC1)=O GDFAUWUHCZAGTD-UHFFFAOYSA-N 0.000 description 1
- SCLCTRAMHCQANN-SSYAZFEXSA-N CC(C)(C)NC(C(CC1)(CCN1[IH]([C@H](CCN(C1)C(C)(C)C)C1c(cc1)ccc1F)=O)C1CCCCC1)=O Chemical compound CC(C)(C)NC(C(CC1)(CCN1[IH]([C@H](CCN(C1)C(C)(C)C)C1c(cc1)ccc1F)=O)C1CCCCC1)=O SCLCTRAMHCQANN-SSYAZFEXSA-N 0.000 description 1
- GAGPEAGIULECIM-UHFFFAOYSA-N CC(C)(CO1)N(CC(CC2)(CCN2C(C(CCN(C2)C(N)=N)C2c(cc2)ccc2Cl)=O)C2CCCCC2)C1=O Chemical compound CC(C)(CO1)N(CC(CC2)(CCN2C(C(CCN(C2)C(N)=N)C2c(cc2)ccc2Cl)=O)C2CCCCC2)C1=O GAGPEAGIULECIM-UHFFFAOYSA-N 0.000 description 1
- HEZQNOYYPJCVMB-UHFFFAOYSA-N CC(C)N(CCC1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1Cl Chemical compound CC(C)N(CCC1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1Cl HEZQNOYYPJCVMB-UHFFFAOYSA-N 0.000 description 1
- NUWJLIBEONEXGZ-UHFFFAOYSA-N CCN(CCC1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1Cl Chemical compound CCN(CCC1C(N(CC2)CCC2(CN(C(C)(C)CO2)C2=O)C2CCCCC2)=O)CC1c(cc1)ccc1Cl NUWJLIBEONEXGZ-UHFFFAOYSA-N 0.000 description 1
- WKBSERNAICYENV-XMMISQBUSA-N CCOC(C(CC1)(CCN1C([C@H](CN(C1)C(C)(C)C)C1c(ccc(F)c1)c1F)=O)C1CCCCC1)=O Chemical compound CCOC(C(CC1)(CCN1C([C@H](CN(C1)C(C)(C)C)C1c(ccc(F)c1)c1F)=O)C1CCCCC1)=O WKBSERNAICYENV-XMMISQBUSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27225801P | 2001-02-28 | 2001-02-28 | |
| US272258P | 2001-02-28 | ||
| US30057201P | 2001-06-22 | 2001-06-22 | |
| US300572P | 2001-06-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2272703T3 true ES2272703T3 (es) | 2007-05-01 |
Family
ID=26955403
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02725001T Expired - Lifetime ES2272703T3 (es) | 2001-02-28 | 2002-02-25 | Derivados de piperidina acilados como agonistas de receptor de melanocortina-4. |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7015235B2 (https=) |
| EP (1) | EP1372653B1 (https=) |
| JP (1) | JP4323169B2 (https=) |
| AT (1) | ATE341327T1 (https=) |
| AU (1) | AU2002255597B8 (https=) |
| CA (1) | CA2439149C (https=) |
| DE (1) | DE60215132T2 (https=) |
| ES (1) | ES2272703T3 (https=) |
| WO (1) | WO2002068387A2 (https=) |
Families Citing this family (90)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE430565T1 (de) | 2001-02-28 | 2009-05-15 | Merck & Co Inc | Acylierte piperidinderivate als melanocortin-4- rezeptoragonisten |
| IL157253A0 (en) * | 2001-02-28 | 2004-02-19 | Merck & Co Inc | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| US6911447B2 (en) | 2001-04-25 | 2005-06-28 | The Procter & Gamble Company | Melanocortin receptor ligands |
| JP4336196B2 (ja) | 2001-07-18 | 2009-09-30 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン受容体作動薬としての架橋ピペリジン誘導体 |
| US7115607B2 (en) | 2001-07-25 | 2006-10-03 | Amgen Inc. | Substituted piperazinyl amides and methods of use |
| US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| CA2462200A1 (en) | 2001-08-10 | 2003-02-20 | Palatin Technologies, Inc. | Peptidomimetics of biologically active metallopeptides |
| US7354923B2 (en) | 2001-08-10 | 2008-04-08 | Palatin Technologies, Inc. | Piperazine melanocortin-specific compounds |
| US7026335B2 (en) | 2002-04-30 | 2006-04-11 | The Procter & Gamble Co. | Melanocortin receptor ligands |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| AU2003268493A1 (en) | 2002-09-11 | 2004-04-30 | Merck & Co., Inc. | Piperazine urea derivatives as melanocortin-4 receptor agonists |
| TW200504033A (en) | 2002-10-23 | 2005-02-01 | Procter & Gamble | Melanocortin receptor ligands |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2004078717A1 (en) * | 2003-03-03 | 2004-09-16 | Merck & Co., Inc. | Acylated piperazine derivatives as melanocortin-4 receptor agonists |
| US6998488B2 (en) | 2003-03-10 | 2006-02-14 | Merck & Co., Inc. | Process and intermediates for the preparation of 4-aryl piperidines |
| CA2519939A1 (en) * | 2003-03-26 | 2004-10-14 | Merck & Co., Inc. | Bicyclic piperidine derivatives as melanocortin-4 receptor agonists |
| JP3856815B2 (ja) | 2003-04-04 | 2006-12-13 | メルク エンド カムパニー インコーポレーテッド | メラノコルチン−４受容体アゴニストとしてのアシル化スピロピペリジン誘導体 |
| AR044510A1 (es) * | 2003-04-14 | 2005-09-14 | Merck & Co Inc | Procedimiento e intermedios para preparar acidos carboxilicos de pirrolidina |
| US7049323B2 (en) | 2003-04-25 | 2006-05-23 | Bristol-Myers Squibb Company | Amidoheterocycles as modulators of the melanocortin-4 receptor |
| EP1648457A2 (en) | 2003-07-22 | 2006-04-26 | Merck & Co., Inc. | Piperidine derivatives as melanocortin-4 receptor agonists |
| AU2004274309B2 (en) | 2003-09-22 | 2010-04-08 | Msd K.K. | Novel piperidine derivative |
| GB0402492D0 (en) * | 2004-02-04 | 2004-03-10 | Pfizer Ltd | Pharmaceutically active compounds |
| US7649002B2 (en) | 2004-02-04 | 2010-01-19 | Pfizer Inc | (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists |
| US7351776B2 (en) * | 2004-03-02 | 2008-04-01 | Bridgestone Corporation | Bulk polymerization process |
| US20080125403A1 (en) | 2004-04-02 | 2008-05-29 | Merck & Co., Inc. | Method of Treating Men with Metabolic and Anthropometric Disorders |
| EP1773338B1 (en) * | 2004-07-19 | 2010-01-06 | Merck & Co., Inc. | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| EP2286840A3 (en) | 2004-11-01 | 2013-09-04 | Amylin Pharmaceuticals, LLC | Treatment of obesity and related diseases |
| GB0428514D0 (en) * | 2004-12-31 | 2005-02-09 | Prosidion Ltd | Compounds |
| CA2609388C (en) | 2005-05-30 | 2013-08-06 | Banyu Pharmaceutical Co., Ltd. | Novel piperidine derivative |
| US20070021433A1 (en) | 2005-06-03 | 2007-01-25 | Jian-Qiang Fan | Pharmacological chaperones for treating obesity |
| AU2006275702A1 (en) | 2005-07-29 | 2007-02-08 | Concert Pharmaceuticals Inc. | Novel pharmaceutical compounds |
| WO2007015162A1 (en) * | 2005-08-04 | 2007-02-08 | Pfizer Limited | Piperidinoyl-pyrrolidine and piperidinoyl-piperidine compounds |
| JPWO2007018248A1 (ja) | 2005-08-10 | 2009-02-19 | 萬有製薬株式会社 | ピリドン化合物 |
| EP2330124B1 (en) | 2005-08-11 | 2015-02-25 | Amylin Pharmaceuticals, LLC | Hybrid polypeptides with selectable properties |
| BRPI0614649A2 (pt) | 2005-08-11 | 2011-04-12 | Amylin Pharmaceuticals Inc | polipeptìdeos hìbridos com propriedades selecionáveis |
| EP1921065B1 (en) | 2005-08-24 | 2010-10-20 | Banyu Pharmaceutical Co., Ltd. | Phenylpyridone derivative |
| WO2007029847A1 (ja) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | 二環性芳香族置換ピリドン誘導体 |
| BRPI0616463A2 (pt) | 2005-09-29 | 2011-06-21 | Merck & Co Inc | composto, composição farmacêutica, e, uso de um composto |
| EP1940401B1 (en) | 2005-10-18 | 2012-07-11 | Merck Sharp & Dohme Corp. | Acylated spiropiperidine derivatives as melanocortin-4 receptor modulators |
| WO2007048027A2 (en) | 2005-10-21 | 2007-04-26 | Novartis Ag | Combination of a renin-inhibitor and an anti-dyslipidemic agent and/or an antiobesity agent |
| AU2006307046A1 (en) | 2005-10-27 | 2007-05-03 | Msd K.K. | Novel benzoxathiin derivative |
| US8158791B2 (en) | 2005-11-10 | 2012-04-17 | Msd K.K. | Aza-substituted spiro derivatives |
| ES2402581T3 (es) | 2006-02-23 | 2013-05-06 | Pfizer Limited | Piperidinoilpirrolidinas como agonistas del receptor de melanocortina tipo 4 |
| CN101426782B (zh) * | 2006-02-23 | 2012-10-31 | 辉瑞股份有限公司 | 黑皮质素4型受体激动剂哌啶羰基吡咯烷 |
| JP5489333B2 (ja) | 2006-09-22 | 2014-05-14 | メルク・シャープ・アンド・ドーム・コーポレーション | 脂肪酸合成阻害剤を用いた治療の方法 |
| AU2007301126A1 (en) | 2006-09-28 | 2008-04-03 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| CA2682727C (en) | 2007-04-02 | 2016-03-22 | Banyu Pharmaceutical Co., Ltd. | Indoledione derivative |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| ES2428326T3 (es) * | 2007-10-04 | 2013-11-07 | Merck Sharp & Dohme Corp. | Derivados de aril sulfona sustituida como bloqueadores de canales de calcio |
| US20110015181A1 (en) | 2008-03-06 | 2011-01-20 | Makoto Ando | Alkylaminopyridine derivative |
| EP2272841A1 (en) | 2008-03-28 | 2011-01-12 | Banyu Pharmaceutical Co., Ltd. | Diarylmethylamide derivative having antagonistic activity on melanin-concentrating hormone receptor |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009261248A1 (en) | 2008-06-19 | 2009-12-23 | Banyu Pharmaceutical Co., Ltd. | Spirodiamine-diarylketoxime derivative |
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| WO1994022460A1 (en) * | 1993-04-05 | 1994-10-13 | University Patents, Inc. | Diagnosis and treatment of erectile dysfunction |
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| AU4929601A (en) * | 2000-03-23 | 2001-10-03 | Merck & Co Inc | Substituted piperidines as melanocortin receptor agonists |
| EP1289526A4 (en) * | 2000-05-30 | 2005-03-16 | Merck & Co Inc | MELANOCORTIN RECEPTOR AGONISTS |
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| IL157253A0 (en) * | 2001-02-28 | 2004-02-19 | Merck & Co Inc | Acylated piperidine derivatives as melanocortin-4 receptor agonists |
| ATE430565T1 (de) | 2001-02-28 | 2009-05-15 | Merck & Co Inc | Acylierte piperidinderivate als melanocortin-4- rezeptoragonisten |
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2002
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- 2002-02-25 WO PCT/US2002/005623 patent/WO2002068387A2/en not_active Ceased
- 2002-02-25 EP EP02725001A patent/EP1372653B1/en not_active Expired - Lifetime
- 2002-02-25 ES ES02725001T patent/ES2272703T3/es not_active Expired - Lifetime
- 2002-02-25 AT AT02725001T patent/ATE341327T1/de not_active IP Right Cessation
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- 2002-02-25 JP JP2002567901A patent/JP4323169B2/ja not_active Expired - Fee Related
- 2002-02-25 AU AU2002255597A patent/AU2002255597B8/en not_active Ceased
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2005
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| DE60215132D1 (de) | 2006-11-16 |
| WO2002068387A8 (en) | 2003-09-04 |
| WO2002068387A3 (en) | 2003-02-20 |
| US20060035935A1 (en) | 2006-02-16 |
| EP1372653B1 (en) | 2006-10-04 |
| ATE341327T1 (de) | 2006-10-15 |
| DE60215132T2 (de) | 2007-08-23 |
| JP2004527498A (ja) | 2004-09-09 |
| CA2439149C (en) | 2012-04-24 |
| AU2002255597B2 (en) | 2006-03-02 |
| AU2002255597B8 (en) | 2006-10-26 |
| WO2002068387A2 (en) | 2002-09-06 |
| US7015235B2 (en) | 2006-03-21 |
| US20040097546A1 (en) | 2004-05-20 |
| CA2439149A1 (en) | 2002-09-06 |
| JP4323169B2 (ja) | 2009-09-02 |
| EP1372653A2 (en) | 2004-01-02 |
| EP1372653A4 (en) | 2005-10-05 |
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