JP2006526608A5 - - Google Patents
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- JP2006526608A5 JP2006526608A5 JP2006508422A JP2006508422A JP2006526608A5 JP 2006526608 A5 JP2006526608 A5 JP 2006526608A5 JP 2006508422 A JP2006508422 A JP 2006508422A JP 2006508422 A JP2006508422 A JP 2006508422A JP 2006526608 A5 JP2006526608 A5 JP 2006526608A5
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- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- formula
- methoxy
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 2
- 125000006582 (C5-C6) heterocycloalkyl group Chemical group 0.000 claims description 2
- BVCRERJDOOBZOH-UHFFFAOYSA-N bicyclo[2.2.1]heptanyl Chemical group C1C[C+]2CC[C-]1C2 BVCRERJDOOBZOH-UHFFFAOYSA-N 0.000 claims description 2
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims description 2
- 125000005508 decahydronaphthalenyl group Chemical group 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000003566 oxetanyl group Chemical group 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 description 5
- 238000010189 synthetic method Methods 0.000 description 2
- 0 COc(cc12)ccc1[o]c(C(Nc1nnn[n]1)=O)c2O* Chemical compound COc(cc12)ccc1[o]c(C(Nc1nnn[n]1)=O)c2O* 0.000 description 1
- RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47625103P | 2003-06-05 | 2003-06-05 | |
| PCT/IB2004/001788 WO2004108709A1 (en) | 2003-06-05 | 2004-05-24 | Tetrazol benzofurancarboxamides with p13k aktivity as therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006526608A JP2006526608A (ja) | 2006-11-24 |
| JP2006526608A5 true JP2006526608A5 (https=) | 2007-09-06 |
Family
ID=33511768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006508422A Abandoned JP2006526608A (ja) | 2003-06-05 | 2004-05-24 | Ｐｉ３ｋ活性を有する治療薬としてのテトラゾールベンゾフランカルボキシアミド |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20050020631A1 (https=) |
| EP (1) | EP1644364A1 (https=) |
| JP (1) | JP2006526608A (https=) |
| BR (1) | BRPI0411098A (https=) |
| CA (1) | CA2527934A1 (https=) |
| MX (1) | MXPA05012894A (https=) |
| WO (1) | WO2004108709A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| US8906894B1 (en) * | 2000-07-27 | 2014-12-09 | Thomas N. Thomas | Methods for preventing and treating thrombotic disorders |
| US20050054614A1 (en) * | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
| WO2005016348A1 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| FR2862646B1 (fr) * | 2003-11-20 | 2006-02-24 | Merck Sante Sas | Nouveaux composes antidiabetiques contenant des derives benzofuranes, benzothiophenes |
| CA2561516A1 (en) * | 2004-03-30 | 2005-10-13 | Pfizer Products Inc. | Combinations of signal transduction inhibitors |
| SI2612862T1 (sl) | 2004-05-13 | 2017-04-26 | Icos Corporation | Kinazolini kot inhibitorji humane fosfatidilinozitol 3-kinaze delta |
| JP2008500338A (ja) * | 2004-05-25 | 2008-01-10 | イコス・コーポレイション | 造血細胞の異常増殖を治療及び／又は予防する方法 |
| WO2006089106A2 (en) * | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| CN102271683B (zh) | 2008-11-13 | 2014-07-09 | 吉里德卡利斯托加公司 | 恶性血液病的治疗 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| CA2756347A1 (en) | 2009-03-24 | 2010-09-30 | Gilead Calistoga Llc | Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| CN102458410A (zh) | 2009-04-20 | 2012-05-16 | 吉联亚·卡利斯托加有限责任公司 | 治疗实体瘤的方法 |
| EA201270184A1 (ru) | 2009-07-21 | 2012-08-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Лечение расстройств печени ингибиторами pi3k |
| WO2011048936A1 (ja) | 2009-10-19 | 2011-04-28 | 大正製薬株式会社 | アミノチアゾール誘導体 |
| PL223225B1 (pl) * | 2012-02-21 | 2016-10-31 | Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk | Halogenopochodne benzo[b]furanów, ewentualnie w postaci farmaceutycznie dopuszczalnej soli oraz zastosowanie halogenopochodnych benzo[b]furanów |
| SI2834241T1 (sl) | 2012-03-05 | 2021-06-30 | Gilead Calistoga Llc | Polimorfne oblike (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilkinazolin-4(3H)-ONA |
| US9708327B2 (en) | 2013-12-20 | 2017-07-18 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (S)-2-(1-(9H-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one |
| WO2015095601A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Process methods for phosphatidylinositol 3-kinase inhibitors |
| EP3154960A1 (en) | 2014-06-13 | 2017-04-19 | Gilead Sciences, Inc. | Phosphatidylinositol 3-kinase inhibitors |
| US11351156B2 (en) | 2017-10-13 | 2022-06-07 | Inserm | Combination treatment of pancreatic cancer |
| EP3713963A1 (en) | 2017-11-23 | 2020-09-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A new marker for predicting the sensitivity to pi3k inhibitors |
| CN117813293A (zh) * | 2021-06-14 | 2024-04-02 | 蝎子疗法股份有限公司 | 可用于治疗癌症的脲衍生物 |
| WO2022265993A1 (en) | 2021-06-14 | 2022-12-22 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
| WO2025087879A2 (en) | 2023-10-23 | 2025-05-01 | Institut National de la Santé et de la Recherche Médicale | Suppressing the pi3kgamma/akt signalling pathway for the treatment of acute myeloid leukemia |
| TW202600543A (zh) * | 2024-03-11 | 2026-01-01 | 大陸商長春金賽藥業有限責任公司 | ＰＩ３Ｋα抑制劑化合物、藥物組合物及其用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3954748A (en) * | 1968-07-29 | 1976-05-04 | Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France | 3-Alkoxy-thianapthene-2-carboxamides |
| IE58555B1 (en) * | 1984-12-10 | 1993-10-06 | Warner Almbert Company | Novel benzothiophenes and benzofurans having antiallergy activity |
| US4703053A (en) * | 1985-10-28 | 1987-10-27 | Warner-Lambert Company | Benzothiophenes and benzofurans and antiallergic use thereof |
| US4800211A (en) * | 1986-08-18 | 1989-01-24 | Merck & Co., Inc. | 5-methylthio-3-hydroxybenzo [b]thiophene-2-carboxamide derivatives as cyclooxygenase and lipoxygenase inhibitors |
| US4767776A (en) * | 1987-02-20 | 1988-08-30 | Warner-Lambert Company | N-1H-tetrazol-5-yl-2-naphthalene carboxamides and their use as antiallergy and antiinflammatory agents |
| US4764525A (en) * | 1987-02-25 | 1988-08-16 | Warner-Lambert Company | N-1H-tetrazol-5-ylbenzamides having use as antiallergy and antiinflammatory agents |
| US4931459A (en) * | 1987-07-14 | 1990-06-05 | Warner-Lambert Company | Method for treating acute respirator distress syndrome |
| US4910317A (en) * | 1987-07-14 | 1990-03-20 | Warner-Lambert Company | Benzofurans and benzothiophenes having antiallergic activity and method of use thereof |
| WO1992004321A1 (en) * | 1990-09-10 | 1992-03-19 | Rhone-Poulenc Rorer International (Holdings) Inc. | Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity |
| US5208253A (en) * | 1992-02-24 | 1993-05-04 | Warner-Lambert Company | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion |
| US5426113A (en) * | 1994-04-08 | 1995-06-20 | Warner-Lambert Company | Method of preventing ulcer formation caused by nonsteroidal antiinflammatory drugs employing tetrazol-benzothiophene carboxamide compounds |
| HRP950288A2 (en) * | 1994-05-31 | 1997-08-31 | Bayer Ag | Oxalylamino-benzofuran- and benzothienyl-derivatives |
| US5731317A (en) * | 1995-03-10 | 1998-03-24 | Merck & Co., Inc. | Bridged piperidines promote release of growth hormone |
| ES2132855T3 (es) * | 1995-09-07 | 1999-08-16 | Oreal | Extracto de iridaceas y composiciones que lo contienen. |
| US6444613B1 (en) * | 1999-03-12 | 2002-09-03 | Hoechst Schering Agrevo Gmbh | Defoliant |
| DE19911165B4 (de) * | 1999-03-12 | 2008-03-13 | Bayer Cropscience Ag | Entlaubungsmittel |
| EP1857443B1 (en) * | 2000-01-24 | 2012-03-28 | AstraZeneca AB | Therapeutic morpholino-substituted compounds |
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2004
- 2004-05-24 MX MXPA05012894A patent/MXPA05012894A/es not_active Application Discontinuation
- 2004-05-24 WO PCT/IB2004/001788 patent/WO2004108709A1/en not_active Ceased
- 2004-05-24 EP EP04734569A patent/EP1644364A1/en not_active Withdrawn
- 2004-05-24 JP JP2006508422A patent/JP2006526608A/ja not_active Abandoned
- 2004-05-24 BR BRPI0411098-6A patent/BRPI0411098A/pt not_active IP Right Cessation
- 2004-05-24 CA CA002527934A patent/CA2527934A1/en not_active Abandoned
- 2004-06-03 US US10/860,527 patent/US20050020631A1/en not_active Abandoned