JP2004521124A5 - - Google Patents
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- Publication number
- JP2004521124A5 JP2004521124A5 JP2002563891A JP2002563891A JP2004521124A5 JP 2004521124 A5 JP2004521124 A5 JP 2004521124A5 JP 2002563891 A JP2002563891 A JP 2002563891A JP 2002563891 A JP2002563891 A JP 2002563891A JP 2004521124 A5 JP2004521124 A5 JP 2004521124A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- ring
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26780901P | 2001-02-09 | 2001-02-09 | |
| PCT/US2002/004680 WO2002064094A2 (en) | 2001-02-09 | 2002-02-05 | 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521124A JP2004521124A (ja) | 2004-07-15 |
| JP2004521124A5 true JP2004521124A5 (https=) | 2009-01-15 |
Family
ID=23020208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002563891A Pending JP2004521124A (ja) | 2001-02-09 | 2002-02-05 | 糖尿病および脂質障害用の２−アリールオキシ−２−アリールアルカン酸類 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7091230B2 (https=) |
| EP (1) | EP1366012A4 (https=) |
| JP (1) | JP2004521124A (https=) |
| AU (1) | AU2002251978B2 (https=) |
| CA (1) | CA2437118A1 (https=) |
| WO (1) | WO2002064094A2 (https=) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| PE20020323A1 (es) * | 2000-08-22 | 2002-06-13 | Novartis Ag | COMPOSICION FARMACEUTICA QUE COMPRENDE UN POTENCIADOR DE LA SECRESION DE INSULINA E INHIBIDORES DE HMG-Co-A-REDUCTASA O INHIBIDORES DE LA ENZIMA CONVERTIDORA DE ANGIOTENSINA (ACE) |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| DK1355644T3 (da) | 2001-01-26 | 2006-10-23 | Schering Corp | Anvendelse af substituerede azetidinonforbindelser til behandling af sitosterolæmi |
| IL156585A0 (en) * | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| AU2002241956A1 (en) * | 2001-01-26 | 2002-08-06 | Schering Corporation | Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| HU230253B1 (hu) | 2001-01-26 | 2015-11-30 | Merck Sharp & Dohme Corp | Peroxiszóma proliferátor-aktivált receptor (PPAR) aktivátor(ok) és szterin-abszorpció inhibitor(ok) kombinációi és alkalmazásuk vaszkuláris indikációk kezelésére |
| US20020183305A1 (en) * | 2001-01-26 | 2002-12-05 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
| PL364178A1 (en) * | 2001-01-26 | 2004-12-13 | Schering Corporation | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
| JP2005504091A (ja) | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| AU2003225027A1 (en) * | 2002-04-16 | 2003-11-03 | Merck And Co., Inc. | Combination therapy using a ppar alpha/gamma agonist |
| EP1511736A4 (en) * | 2002-06-07 | 2006-06-07 | Cortical Pty Ltd | THERAPEUTIC MOLECULES AND METHOD 1 |
| FR2845601B1 (fr) * | 2002-10-11 | 2005-07-08 | Servier Lab | Nouvelle association entre un compose heterocyclique et un agent antioxydant et les compositions pharmaceutiques qui les contiennent |
| FR2845602B1 (fr) * | 2002-10-11 | 2005-07-08 | Servier Lab | Association entre un ligand des recepteurs actives par les proliferateurs de peroxisomes et un agent antioxydant et les compositions pharmaceutiques qui les contiennent |
| WO2004043457A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorptions inhibitors for the treatment of autoimmune disorders |
| ATE404191T1 (de) * | 2002-12-10 | 2008-08-15 | Novartis Pharma Ag | Kombinationen von einem dpp-iv inhibitor und einem ppar- alpha agonist |
| MXPA05007485A (es) | 2003-01-14 | 2006-01-30 | Arena Pharm Inc | Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia. |
| CA2517571C (en) | 2003-03-07 | 2011-07-05 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| JP2006519869A (ja) | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
| JP4589919B2 (ja) | 2003-03-07 | 2010-12-01 | シェーリング コーポレイション | 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用 |
| EA200501607A1 (ru) * | 2003-04-14 | 2006-06-30 | ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи | Замещённые фенилалкановые кислоты |
| BRPI0409914A (pt) | 2003-04-30 | 2006-04-25 | Inst For Pharm Discovery Inc | ácidos carboxìlicos substituìdos |
| US7718377B2 (en) | 2003-05-29 | 2010-05-18 | Kyoto Pharmaceutical Industries, Ltd. | Insulin resistance curative and method of screening the same |
| RS20060018A (sr) | 2003-07-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | Derivati spojenih arila i heteroarila kao modulatori metabolizma u profilaksi i lečenju sa njima povezanih stanja |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| KR100706600B1 (ko) * | 2004-11-25 | 2007-04-12 | 주식회사 엘지생명과학 | ＰＰＡＲ ｇａｍｍａ와 ＰＰＡＲ ａｌｐｈａ의 활성을항진시키는 신규 화합물, 그것의 제조방법, 및 그것을함유한 약제 조성물 |
| WO2006057503A1 (en) * | 2004-11-25 | 2006-06-01 | Lg Life Sciences, Ltd. | NOVEL COMPOUNDS AS AGONIST FOR PPARϜ AND PPARα, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME |
| WO2006096564A1 (en) | 2005-03-04 | 2006-09-14 | Merck & Co., Inc. | Fused aromatic compounds having anti-diabetic activity |
| EP1865954A4 (en) * | 2005-03-21 | 2010-12-15 | Metabolex Inc | METHOD FOR AVOIDING OEDEM IN THE TREATMENT OR PREVENTION OF DISEASES AFFECTING PPAR GAMMA INCLUDING CANCER |
| US20070161006A1 (en) * | 2006-01-10 | 2007-07-12 | Vita Genomics, Inc. | Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma |
| WO2008030604A2 (en) | 2006-09-08 | 2008-03-13 | Rhode Island Hospital | Treatment, prevention, and reversal of alcohol-induced brain disease |
| AU2008248186B2 (en) | 2007-05-07 | 2014-02-06 | Merck Sharp & Dohme Corp. | Method of treatment using fused aromatic compounds having anti-diabetic activity |
| WO2009148046A1 (ja) * | 2008-06-03 | 2009-12-10 | 株式会社カネカ | 光学活性アミノ酸誘導体の製造方法 |
| JP5374085B2 (ja) * | 2008-07-22 | 2013-12-25 | 株式会社 資生堂 | ４−アルキルレゾルシノールおよび４−アルケニルレゾルシノールの製造方法 |
| CN101811968B (zh) * | 2010-02-09 | 2014-07-30 | 深圳市有为化学技术有限公司 | 多官能团化苯甲酰甲酸羟基酮酯类化合物及含有该类化合物的光引发剂 |
| EP3323818A1 (en) | 2010-09-22 | 2018-05-23 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| WO2013071077A1 (en) | 2011-11-09 | 2013-05-16 | Cornell University | The use of pan-ppar agonists for prevention and treatment of huntington's disease and tauopathies |
| EP2975031A4 (en) | 2013-03-14 | 2017-04-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| PL3242666T3 (pl) | 2015-01-06 | 2025-02-17 | Arena Pharmaceuticals, Inc. | Związek do zastosowania w leczeniu dolegliwości związanych z receptorem s1p1 |
| BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
| MX2019009841A (es) | 2017-02-16 | 2020-01-30 | Arena Pharm Inc | Compuestos y metodos para el tratamiento de la colangitis biliar primaria. |
| CA3102136A1 (en) | 2018-06-06 | 2019-12-12 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3378582A (en) | 1964-03-20 | 1968-04-16 | Merck & Co Inc | (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids |
| US3517050A (en) | 1966-10-03 | 1970-06-23 | Merck & Co Inc | Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid |
| US3787423A (en) | 1972-03-08 | 1974-01-22 | Merck & Co Inc | Beta-picolyloxy ester of(3-trifluoromethylphenoxy)(4-chlorophenyl)acetic acid and derivatives |
| US3953465A (en) | 1972-04-11 | 1976-04-27 | Merck & Co., Inc. | 2-[α-(3-Trifluoromethylphenoxyl)-4-chlorobenzyl]oxazole and methods for preparing the same |
| US3816446A (en) | 1972-04-11 | 1974-06-11 | Merck & Co Inc | (alpha-(3-trifluoromethylphenoxy)-4-chlorobenzyl)heterocycles |
| ZA765075B (en) | 1975-09-25 | 1977-08-31 | American Cyanamid Co | Hypolipemic compounds and method of treatment |
| US4168385A (en) | 1975-09-25 | 1979-09-18 | American Cyanamid Company | Hypolipemic phenylacetic acid derivatives |
| US4125732A (en) | 1977-05-06 | 1978-11-14 | American Cyanamid Company | 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters |
| US4820715A (en) | 1984-06-28 | 1989-04-11 | Bristol-Myers Company | Anti-emetic quinuclidinyl benzamides |
| US4748272A (en) | 1986-08-01 | 1988-05-31 | Rorer Pharmaceutical Corp. | Phenoxyphenylacetates for use as potential modulators of arichidonic acid pathways |
| US4920132A (en) | 1987-11-03 | 1990-04-24 | Rorer Pharmaceutical Corp. | Quinoline derivatives and use thereof as antagonists of leukotriene D4 |
| US5449682A (en) | 1990-02-13 | 1995-09-12 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted benzyl element |
| US5240938A (en) | 1991-02-13 | 1993-08-31 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring |
| US5264439A (en) | 1990-02-13 | 1993-11-23 | Merck & Co., Inc. | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element |
| US5183810A (en) | 1990-02-13 | 1993-02-02 | Merck & Co., Inc. | Imidazole angiotensin II antagonists incorporating a substituted benzyl element |
| US5177095A (en) | 1990-02-13 | 1993-01-05 | Merck & Co., Inc. | Triazole angiotensin II antagonists incorporating a substituted benzyl element |
| DE4123341A1 (de) | 1991-07-15 | 1993-01-21 | Thomae Gmbh Dr K | Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US5420133A (en) | 1993-03-19 | 1995-05-30 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
| US5374638A (en) | 1993-03-19 | 1994-12-20 | Merck & Co., Inc. | Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma |
| PT617001E (pt) * | 1993-03-19 | 2000-06-30 | Merck & Co Inc | Derivados do acido fenoxifenilacetico |
| US5401745A (en) | 1993-03-19 | 1995-03-28 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
| US5767310A (en) | 1993-03-19 | 1998-06-16 | Merck & Co., Inc. | Phenoxyphenylacetic acid derivatives |
| US5565485A (en) * | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| US5334598A (en) | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| US5391566A (en) | 1993-07-20 | 1995-02-21 | Merck & Co., Inc. | Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives |
| US5538991A (en) | 1994-09-14 | 1996-07-23 | Merck & Co., Inc. | Endothelin antagonists bearing 5-membered heterocyclic amides |
| US5559135A (en) | 1994-09-14 | 1996-09-24 | Merck & Co., Inc. | Endothelin antagonists bearing pyridyl amides |
| WO1996009818A1 (en) | 1994-09-27 | 1996-04-04 | Merck & Co., Inc. | Endothelin receptor antagonists for the treatment of emesis |
| US5596124A (en) | 1994-12-09 | 1997-01-21 | American Cyanamid Company | Method for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted)benzene compounds |
| DE19530032A1 (de) | 1995-08-16 | 1997-02-20 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
| WO1997021693A1 (en) | 1995-12-12 | 1997-06-19 | Merck & Co., Inc. | Stereoselective process |
| US5708186A (en) | 1995-12-12 | 1998-01-13 | Merck & Co Inc | Stereoselective process |
| US5688974A (en) | 1995-12-12 | 1997-11-18 | Merck & Co., Inc. | Process for the preparation of an endothelin antagonist |
| WO1997021700A1 (en) | 1995-12-12 | 1997-06-19 | Merck & Co., Inc. | Process for the preparation of an endothelin antagonist |
| AU721452B2 (en) * | 1996-02-02 | 2000-07-06 | Merck & Co., Inc. | Antidiabetic agents |
| WO1997028137A1 (en) * | 1996-02-02 | 1997-08-07 | Merck & Co., Inc. | Heterocyclic derivatives as antidiabetic and antiobesity agents |
| DE19614204A1 (de) | 1996-04-10 | 1997-10-16 | Thomae Gmbh Dr K | Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| EP0988289A2 (en) | 1997-06-05 | 2000-03-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds, their production and use |
| EP1077970A1 (en) | 1998-05-12 | 2001-02-28 | American Home Products Corporation | 11-aryl-benzo(b)naphtho(2,3-d)furans and 11-aryl-benzo(b)naphtho(2,3-d)thiophenes useful in the treatment of insulin resistance and hyperglycemia |
| JP2002514636A (ja) | 1998-05-12 | 2002-05-21 | アメリカン・ホーム・プロダクツ・コーポレイション | インスリン抵抗性または高血糖症の治療に有用なフェニルオキソ−酢酸類 |
| US6110963A (en) | 1998-05-12 | 2000-08-29 | American Home Products Corporation | Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia |
| US6262118B1 (en) | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
| US6624194B1 (en) | 1999-06-04 | 2003-09-23 | Metabolex, Inc. | Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| JP2003523336A (ja) * | 2000-02-18 | 2003-08-05 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質障害のためのアリールオキシ酢酸 |
-
2002
- 2002-02-05 CA CA002437118A patent/CA2437118A1/en not_active Abandoned
- 2002-02-05 EP EP02721022A patent/EP1366012A4/en not_active Withdrawn
- 2002-02-05 JP JP2002563891A patent/JP2004521124A/ja active Pending
- 2002-02-05 US US10/470,954 patent/US7091230B2/en not_active Expired - Fee Related
- 2002-02-05 AU AU2002251978A patent/AU2002251978B2/en not_active Ceased
- 2002-02-05 WO PCT/US2002/004680 patent/WO2002064094A2/en not_active Ceased
-
2006
- 2006-01-18 US US11/334,152 patent/US7495020B2/en not_active Expired - Fee Related
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