BRPI0409469A - compostos para o tratamento de distúrbios metabólicos - Google Patents

compostos para o tratamento de distúrbios metabólicos

Info

Publication number
BRPI0409469A
BRPI0409469A BRPI0409469-7A BRPI0409469A BRPI0409469A BR PI0409469 A BRPI0409469 A BR PI0409469A BR PI0409469 A BRPI0409469 A BR PI0409469A BR PI0409469 A BRPI0409469 A BR PI0409469A
Authority
BR
Brazil
Prior art keywords
carbon atoms
ring
alkyl
hydrogen
treatment
Prior art date
Application number
BRPI0409469-7A
Other languages
English (en)
Inventor
Kirvin L Hodge
Shalini Sharma
Reid W Von Borstel
Stephen D Wolpe
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of BRPI0409469A publication Critical patent/BRPI0409469A/pt
Publication of BRPI0409469B1 publication Critical patent/BRPI0409469B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/12Ophthalmic agents for cataracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Abstract

"COMPOSTOS PARA O TRATAMENTO DE DISTúRBIOS METABóLICOS". Agentes usados para o tratamento de vários distúrbios metabólicos, tais como síndrome de resistência à insulina, diabetes, hiperlipidemia, doença do fígado gorduroso, caquexia, obesidade, aterosclerose e arteriosclerose são divulgados: em que n é 1 ou 2; m é 0, 1, 2, 3 ou 4; q é 0 ou 1; t é 0 ou 1; R¬ 2¬ é alquila tendo de 1 a 3 átomos de carbono; R¬ 3¬ é hidrogênio, halo, alquila tendo de 1 a 3 átomos de carbono ou alcóxi tendo de 1 a 3 átomos de carbono; A é fenila não substituída ou substituída por 1 ou 2 grupos selecionados de: halo, alquila tendo 1 ou 2 átomos de carbono, perfluorometila, alcóxi tendo 1 ou 2 átomos de carbono e perfluorometóxi; ou cicloalquila tendo de 3 a 6 átomos de carbono no anel, em que a cicloalquila é não substituída ou um ou dois carbonos no anel são independentemente monosubstituídos por metila ou etila; ou um anel heteroaromático de 5 ou 6 elementos tendo 1 ou 2 heteroátomos no anel selecionados de N, S e 0 e o anel heteroaromático é covalentemente preso ao restante do composto da fórmula I através de um carbono no anel; e R¬ 1¬ é hidrogênio ou alquila tendo 1 ou 2 átomos de carbono, contanto que quando m é O ou 1, R¬ 1¬ não é hidrogênio. Alternativamente, quando R¬ 1¬ é hidrogênio, o agente biologicamente ativo pode ser um sal farmaceuticamente aceitável do composto da Fórmula I.
BRPI0409469A 2003-04-15 2004-04-08 compostos para o tratamento de distúrbios metabólicos, seu uso e composição farmacêutica compreendendo os mesmos BRPI0409469B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46296003P 2003-04-15 2003-04-15
PCT/US2004/010799 WO2004091486A2 (en) 2003-04-15 2004-04-08 Compounds for the treatment of metabolic disorders

Publications (2)

Publication Number Publication Date
BRPI0409469A true BRPI0409469A (pt) 2006-04-18
BRPI0409469B1 BRPI0409469B1 (pt) 2016-04-26

Family

ID=33300020

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409469A BRPI0409469B1 (pt) 2003-04-15 2004-04-08 compostos para o tratamento de distúrbios metabólicos, seu uso e composição farmacêutica compreendendo os mesmos

Country Status (25)

Country Link
US (2) US7514555B2 (pt)
EP (1) EP1633340B1 (pt)
JP (2) JP4766693B2 (pt)
KR (1) KR101127390B1 (pt)
CN (2) CN101912380A (pt)
AT (1) ATE487474T1 (pt)
AU (1) AU2004229418B2 (pt)
BR (1) BRPI0409469B1 (pt)
CA (1) CA2521621C (pt)
CY (1) CY1111310T1 (pt)
DE (1) DE602004030004D1 (pt)
DK (1) DK1633340T3 (pt)
ES (1) ES2353601T3 (pt)
HK (1) HK1084026A1 (pt)
IL (1) IL171269A (pt)
MX (1) MXPA05011042A (pt)
NO (1) NO20054791L (pt)
NZ (1) NZ542739A (pt)
PL (1) PL1633340T3 (pt)
PT (1) PT1633340E (pt)
RU (1) RU2358722C2 (pt)
SI (1) SI1633340T1 (pt)
UA (1) UA80195C2 (pt)
WO (1) WO2004091486A2 (pt)
ZA (1) ZA200507704B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100344616C (zh) * 2001-06-12 2007-10-24 维尔斯达医疗公司 用于治疗代谢失调的化合物
EP1556085A4 (en) * 2002-11-01 2012-08-22 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
US7615575B2 (en) 2003-02-13 2009-11-10 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN101912380A (zh) * 2003-04-15 2010-12-15 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
JP4697973B2 (ja) 2003-04-22 2011-06-08 ウェルスタット セラピューティクス コーポレイション 代謝障害の処置のための化合物
KR101192272B1 (ko) * 2003-04-30 2012-10-17 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
RU2349584C2 (ru) * 2003-08-20 2009-03-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических нарушений
WO2006127133A2 (en) * 2005-04-01 2006-11-30 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
UA95613C2 (ru) * 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
CA2637373A1 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637375A1 (en) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7947735B2 (en) 2006-01-25 2011-05-24 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN101378740A (zh) * 2006-02-02 2009-03-04 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
US8044243B2 (en) * 2006-02-13 2011-10-25 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
JP2009528375A (ja) * 2006-02-28 2009-08-06 ウェルスタット セラピューティクス コーポレイション 代謝障害を処置するための化合物
AU2007235145B2 (en) * 2006-03-31 2011-09-22 Wellstat Therapeutics Corporation Combination treatment of metabolic disorders
EP2019673A4 (en) 2006-05-18 2010-06-16 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLISM DISORDER
CN101466266A (zh) * 2006-06-09 2009-06-24 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
AU2007285827A1 (en) * 2006-08-17 2008-02-21 Wellstat Therapeutics Corporation Combination treatment for metabolic disorders
JP5496913B2 (ja) * 2008-01-15 2014-05-21 ウェルスタット セラピューティクス コーポレイション 代謝異常の治療のための化合物
CA2716860C (en) 2008-03-13 2017-08-29 Wellstat Therapeutics Corporation Compounds and method for reducing uric acid
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US8703991B2 (en) 2008-11-04 2014-04-22 Wellstat Therapeutics Corporation Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids
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CN101912380A (zh) * 2003-04-15 2010-12-15 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
JP4697973B2 (ja) 2003-04-22 2011-06-08 ウェルスタット セラピューティクス コーポレイション 代謝障害の処置のための化合物
KR101192272B1 (ko) 2003-04-30 2012-10-17 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
RU2349584C2 (ru) 2003-08-20 2009-03-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических нарушений
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WO2006127133A2 (en) 2005-04-01 2006-11-30 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637375A1 (en) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7947735B2 (en) 2006-01-25 2011-05-24 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders

Also Published As

Publication number Publication date
US20060014784A1 (en) 2006-01-19
CY1111310T1 (el) 2015-08-05
CN1774244A (zh) 2006-05-17
ZA200507704B (en) 2007-02-28
NO20054791D0 (no) 2005-10-18
AU2004229418B2 (en) 2008-07-31
KR101127390B1 (ko) 2012-03-23
ES2353601T3 (es) 2011-03-03
PL1633340T3 (pl) 2011-04-29
CA2521621C (en) 2011-11-01
ATE487474T1 (de) 2010-11-15
NO20054791L (no) 2005-12-20
EP1633340B1 (en) 2010-11-10
JP2006523696A (ja) 2006-10-19
CA2521621A1 (en) 2004-10-28
DK1633340T3 (da) 2011-02-07
KR20050121262A (ko) 2005-12-26
RU2005135441A (ru) 2006-03-20
BRPI0409469B1 (pt) 2016-04-26
SI1633340T1 (sl) 2011-02-28
WO2004091486A3 (en) 2005-01-20
JP4766693B2 (ja) 2011-09-07
RU2358722C2 (ru) 2009-06-20
EP1633340A2 (en) 2006-03-15
MXPA05011042A (es) 2005-12-15
US20090156681A1 (en) 2009-06-18
JP5371062B2 (ja) 2013-12-18
US7973052B2 (en) 2011-07-05
JP2011178808A (ja) 2011-09-15
UA80195C2 (en) 2007-08-27
DE602004030004D1 (de) 2010-12-23
IL171269A (en) 2011-09-27
EP1633340A4 (en) 2009-05-27
US7514555B2 (en) 2009-04-07
AU2004229418A1 (en) 2004-10-28
NZ542739A (en) 2007-02-23
CN101912380A (zh) 2010-12-15
PT1633340E (pt) 2011-02-22
WO2004091486A2 (en) 2004-10-28
HK1084026A1 (en) 2006-07-21

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B15K Others concerning applications: alteration of classification

Free format text: AS CLASSIFICACOES ANTERIORES ERAM: A61K 31/19 , A61K 31/34 , A61K 31/36

Ipc: A61K 31/19 (2006.01), A61K 31/34 (2006.01), A61K 3

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 26/04/2016, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)