MXPA05011042A - Compuestos para el tratamieno de trastornos metabolicos. - Google Patents

Compuestos para el tratamieno de trastornos metabolicos.

Info

Publication number
MXPA05011042A
MXPA05011042A MXPA05011042A MXPA05011042A MXPA05011042A MX PA05011042 A MXPA05011042 A MX PA05011042A MX PA05011042 A MXPA05011042 A MX PA05011042A MX PA05011042 A MXPA05011042 A MX PA05011042A MX PA05011042 A MXPA05011042 A MX PA05011042A
Authority
MX
Mexico
Prior art keywords
carbon atoms
ring
alkyl
hydrogen
treatment
Prior art date
Application number
MXPA05011042A
Other languages
English (en)
Inventor
Borstel Reid W Von
Original Assignee
Wellstat Therapeutics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellstat Therapeutics Corp filed Critical Wellstat Therapeutics Corp
Publication of MXPA05011042A publication Critical patent/MXPA05011042A/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Se dan a conocer agentes utiles para el tratamiento de diferentes trastornos metabolicos, tales como sindrome de resistencia a la insulina, diabetes, hiperlipidemia, enfermedad de higado graso, caquexia, obesidad, ateroesclerosis, y arterioesclerosis. (ver formula I) En donde n es 1 o 2; m es 0, 1, 2, 3, o 4; q es 0 o 1; t es 0 o 1; R2 es alquilo que tiene de 1 a 3 atomos de carbono; R3 es hidrogeno, halogeno, alquilo que tiene de 1 a 3 atomos de carbono, o alcoxilo que tiene de 1 a 3 atomos de carbono; A es fenilo, insustituido o sustituido por 1 o 2 grupos seleccionados a partir de: halogeno, alquilo que tiene 1 o 2 atomos de carbono, y perfluorometilo; alcoxilo que tiene 1 o 2 atomos de carbono, y perfluorometoxilo; o cicloalquilo que tiene de 3 a 6 atomos de carbono del anillo, en donde el cicloalquilo esta insustituido, o uno o dos atomos de carbono del anillo estan independientemente mono-sustituidos por metilo o etilo; o un anillo heteroaromatico de 5 o 6 miembros que tiene 1 o 2 hetero-atomos del anillo seleccionados a partir de N, S, y O, y el anillo heteroaromatico se enlaza de una manera covalente con el resto del compuesto de la formula I mediante un atomo de carbono del anillo; y R1 es hidrogeno o alquilo que tiene 1 o 2 atomos de carbono, en el entendido de que, cuando m es 0 o 1, R1 no es hidrogeno. De una manera alternativa, cuando R1 es hidrogeno, el agente biologicamente activo puede ser una sal farmaceuticamente aceptable del compuesto de la Formula I.
MXPA05011042A 2003-04-15 2004-04-08 Compuestos para el tratamieno de trastornos metabolicos. MXPA05011042A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US46296003P 2003-04-15 2003-04-15
PCT/US2004/010799 WO2004091486A2 (en) 2003-04-15 2004-04-08 Compounds for the treatment of metabolic disorders

Publications (1)

Publication Number Publication Date
MXPA05011042A true MXPA05011042A (es) 2005-12-15

Family

ID=33300020

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05011042A MXPA05011042A (es) 2003-04-15 2004-04-08 Compuestos para el tratamieno de trastornos metabolicos.

Country Status (25)

Country Link
US (2) US7514555B2 (es)
EP (1) EP1633340B1 (es)
JP (2) JP4766693B2 (es)
KR (1) KR101127390B1 (es)
CN (2) CN101912380A (es)
AT (1) ATE487474T1 (es)
AU (1) AU2004229418B2 (es)
BR (1) BRPI0409469B1 (es)
CA (1) CA2521621C (es)
CY (1) CY1111310T1 (es)
DE (1) DE602004030004D1 (es)
DK (1) DK1633340T3 (es)
ES (1) ES2353601T3 (es)
HK (1) HK1084026A1 (es)
IL (1) IL171269A (es)
MX (1) MXPA05011042A (es)
NO (1) NO20054791L (es)
NZ (1) NZ542739A (es)
PL (1) PL1633340T3 (es)
PT (1) PT1633340E (es)
RU (1) RU2358722C2 (es)
SI (1) SI1633340T1 (es)
UA (1) UA80195C2 (es)
WO (1) WO2004091486A2 (es)
ZA (1) ZA200507704B (es)

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EP1556085A4 (en) * 2002-11-01 2012-08-22 Wellstat Therapeutics Corp COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
US7615575B2 (en) 2003-02-13 2009-11-10 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN101912380A (zh) * 2003-04-15 2010-12-15 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
JP4697973B2 (ja) 2003-04-22 2011-06-08 ウェルスタット セラピューティクス コーポレイション 代謝障害の処置のための化合物
KR101192272B1 (ko) * 2003-04-30 2012-10-17 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
RU2349584C2 (ru) * 2003-08-20 2009-03-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических нарушений
WO2006127133A2 (en) * 2005-04-01 2006-11-30 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
UA95613C2 (ru) * 2005-11-09 2011-08-25 Уеллстат Терепьютикс Корпорейшн Соединения для лечения расстройсв метаболизма
CA2637373A1 (en) * 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CA2637375A1 (en) 2006-01-25 2007-08-02 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
US7947735B2 (en) 2006-01-25 2011-05-24 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders
CN101378740A (zh) * 2006-02-02 2009-03-04 维尔斯达医疗公司 用于治疗代谢紊乱的化合物
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KR101192272B1 (ko) 2003-04-30 2012-10-17 웰스태트 테러퓨틱스 코포레이션 대사 질환의 치료용 화합물
RU2349584C2 (ru) 2003-08-20 2009-03-20 Веллстат Терапьютикс Корпорейшн Соединения для лечения метаболических нарушений
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US7947735B2 (en) 2006-01-25 2011-05-24 Wellstat Therapeutics Corporation Compounds for the treatment of metabolic disorders

Also Published As

Publication number Publication date
US20060014784A1 (en) 2006-01-19
CY1111310T1 (el) 2015-08-05
CN1774244A (zh) 2006-05-17
ZA200507704B (en) 2007-02-28
NO20054791D0 (no) 2005-10-18
AU2004229418B2 (en) 2008-07-31
KR101127390B1 (ko) 2012-03-23
ES2353601T3 (es) 2011-03-03
PL1633340T3 (pl) 2011-04-29
CA2521621C (en) 2011-11-01
ATE487474T1 (de) 2010-11-15
NO20054791L (no) 2005-12-20
EP1633340B1 (en) 2010-11-10
JP2006523696A (ja) 2006-10-19
CA2521621A1 (en) 2004-10-28
DK1633340T3 (da) 2011-02-07
KR20050121262A (ko) 2005-12-26
RU2005135441A (ru) 2006-03-20
BRPI0409469B1 (pt) 2016-04-26
SI1633340T1 (sl) 2011-02-28
WO2004091486A3 (en) 2005-01-20
JP4766693B2 (ja) 2011-09-07
RU2358722C2 (ru) 2009-06-20
EP1633340A2 (en) 2006-03-15
BRPI0409469A (pt) 2006-04-18
US20090156681A1 (en) 2009-06-18
JP5371062B2 (ja) 2013-12-18
US7973052B2 (en) 2011-07-05
JP2011178808A (ja) 2011-09-15
UA80195C2 (en) 2007-08-27
DE602004030004D1 (de) 2010-12-23
IL171269A (en) 2011-09-27
EP1633340A4 (en) 2009-05-27
US7514555B2 (en) 2009-04-07
AU2004229418A1 (en) 2004-10-28
NZ542739A (en) 2007-02-23
CN101912380A (zh) 2010-12-15
PT1633340E (pt) 2011-02-22
WO2004091486A2 (en) 2004-10-28
HK1084026A1 (en) 2006-07-21

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