JP2004524267A5 - - Google Patents
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- Publication number
- JP2004524267A5 JP2004524267A5 JP2002522900A JP2002522900A JP2004524267A5 JP 2004524267 A5 JP2004524267 A5 JP 2004524267A5 JP 2002522900 A JP2002522900 A JP 2002522900A JP 2002522900 A JP2002522900 A JP 2002522900A JP 2004524267 A5 JP2004524267 A5 JP 2004524267A5
- Authority
- JP
- Japan
- Prior art keywords
- hydroalcoholic gel
- gel according
- testosterone
- hydroalcoholic
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 18
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 229960003604 testosterone Drugs 0.000 description 9
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003961 penetration enhancing agent Substances 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000037361 pathway Effects 0.000 description 4
- 150000003431 steroids Chemical class 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical group O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 3
- 208000010228 Erectile Dysfunction Diseases 0.000 description 3
- 229940099471 Phosphodiesterase inhibitor Drugs 0.000 description 3
- 229920002125 Sokalan® Polymers 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 239000002571 phosphodiesterase inhibitor Substances 0.000 description 3
- 239000004584 polyacrylic acid Substances 0.000 description 3
- 230000035936 sexual power Effects 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229960002639 sildenafil citrate Drugs 0.000 description 2
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 1
- QADHLRWLCPCEKT-UHFFFAOYSA-N Androstenediol Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)O)C4C3CC=C21 QADHLRWLCPCEKT-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FMGSKLZLMKYGDP-UHFFFAOYSA-N Dehydroepiandrosterone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CC=C21 FMGSKLZLMKYGDP-UHFFFAOYSA-N 0.000 description 1
- 206010052649 Primary hypogonadism Diseases 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 description 1
- QADHLRWLCPCEKT-LOVVWNRFSA-N androst-5-ene-3beta,17beta-diol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC=C21 QADHLRWLCPCEKT-LOVVWNRFSA-N 0.000 description 1
- 229960003473 androstanolone Drugs 0.000 description 1
- 229950009148 androstenediol Drugs 0.000 description 1
- 229960005471 androstenedione Drugs 0.000 description 1
- AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 1
- 229920006318 anionic polymer Polymers 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- FMGSKLZLMKYGDP-USOAJAOKSA-N dehydroepiandrosterone Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC=C21 FMGSKLZLMKYGDP-USOAJAOKSA-N 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 210000002149 gonad Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229960002847 prasterone Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/651,777 US6503894B1 (en) | 2000-08-30 | 2000-08-30 | Pharmaceutical composition and method for treating hypogonadism |
| US70375300A | 2000-11-01 | 2000-11-01 | |
| PCT/US2001/027205 WO2002017927A1 (en) | 2000-08-30 | 2001-08-29 | Method for treating erectile dysfunction and increasing libido in men |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004524267A JP2004524267A (ja) | 2004-08-12 |
| JP2004524267A5 true JP2004524267A5 (enExample) | 2008-09-11 |
Family
ID=27096141
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002522900A Pending JP2004524267A (ja) | 2000-08-30 | 2001-08-29 | 男性の勃起障害の治療方法、及び性衝動の増強方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20050054623A1 (enExample) |
| EP (2) | EP2283865A1 (enExample) |
| JP (1) | JP2004524267A (enExample) |
| KR (1) | KR100861603B1 (enExample) |
| CN (1) | CN1473047A (enExample) |
| AT (1) | ATE460939T1 (enExample) |
| AU (2) | AU8699501A (enExample) |
| BR (1) | BR0113651A (enExample) |
| CA (2) | CA2420895C (enExample) |
| CY (1) | CY1110085T1 (enExample) |
| DE (1) | DE60141587D1 (enExample) |
| DK (1) | DK1315502T3 (enExample) |
| ES (1) | ES2341090T3 (enExample) |
| IL (1) | IL154692A0 (enExample) |
| MX (1) | MXPA03001858A (enExample) |
| NO (1) | NO332649B1 (enExample) |
| NZ (1) | NZ524601A (enExample) |
| PL (1) | PL205279B1 (enExample) |
| PT (1) | PT1315502E (enExample) |
| SI (1) | SI1315502T1 (enExample) |
| TR (1) | TR200300776T2 (enExample) |
| WO (1) | WO2002017927A1 (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| JP5039252B2 (ja) * | 2000-08-31 | 2012-10-03 | ユニメッド ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 性機能低下を治療するための医薬組成物及び方法 |
| MY139721A (en) | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| AUPS317302A0 (en) * | 2002-06-25 | 2002-07-18 | Drug Delivery Solutions Pty Ltd | Metastable pharmaceutical compositions |
| JP5160018B2 (ja) | 2002-06-25 | 2013-03-13 | アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド | 非晶質医薬組成物を用いる経皮送達速度調節 |
| IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| IL152575A (en) | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
| US8883769B2 (en) | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| RS52945B (sr) | 2004-05-11 | 2014-02-28 | Emotional Brain B.V. | Farmaceutske formulacije i njihova primena u lečenju ženske seksualne disfunkcije |
| EP1634583A1 (en) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| CA2610708C (en) * | 2005-06-03 | 2013-10-08 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| US8435944B2 (en) | 2005-06-03 | 2013-05-07 | Acrux Dds Pty Ltd. | Method and composition for transdermal drug delivery |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| CA2624788C (en) | 2005-10-12 | 2011-04-19 | Unimed Pharmaceuticals, Llc | Improved testosterone gel and method of use |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| US8613360B2 (en) | 2006-09-29 | 2013-12-24 | M-I L.L.C. | Shaker and degasser combination |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| GB2461725B (en) | 2008-07-10 | 2012-06-13 | United Wire Ltd | Improved sifting screen |
| US20100022991A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and device for maintaining physiological levels of steroid hormone in a subject |
| US20110190201A1 (en) * | 2008-07-24 | 2011-08-04 | Searete Llc | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
| US20100022494A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100022497A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject |
| BR112012028782A2 (pt) | 2010-05-12 | 2017-06-13 | Guy Pomerleau Daniel | sistemas e métodos para a secagem de cascalhos de perfuração |
| RU2474424C2 (ru) * | 2010-09-24 | 2013-02-10 | Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин |
| US9642863B2 (en) | 2010-11-18 | 2017-05-09 | White Mountain Pharma, Inc. | Methods for treating chronic or unresolvable pain and/or increasing the pain threshold in a subject and pharmaceutical compositions for use therein |
| US9795639B1 (en) * | 2013-03-16 | 2017-10-24 | BioDlogics, LLC | Methods for the treatment of erectile dysfunction by human birth tissue material compostion |
| US8785426B1 (en) | 2013-12-13 | 2014-07-22 | Upsher-Smith Laboratories, Inc. | Testosterone gel compositions and related methods |
| MX2020008147A (es) * | 2018-02-02 | 2020-10-28 | Acerus Biopharma Inc | Metodos de terapia de testosterona. |
| EP4054549A4 (en) | 2019-11-06 | 2023-12-06 | Smartech Topical, Inc. | TOPICAL FORMULATIONS OF CYCLO-OXYGENASE INHIBITORS AND THEIR USE |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496556A (en) * | 1982-08-16 | 1985-01-29 | Norman Orentreich | Topical applications for preventing dry skin |
| US4855305A (en) * | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| TW224048B (enExample) * | 1992-03-30 | 1994-05-21 | Hoechst Roussel Pharma | |
| AU677206B2 (en) * | 1992-06-11 | 1997-04-17 | Theratech, Inc. | The use of glycerin in moderating transdermal drug delivery |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| JP4036496B2 (ja) * | 1995-10-24 | 2008-01-23 | リンテック株式会社 | ゲル製剤の製造方法 |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5730987A (en) * | 1996-06-10 | 1998-03-24 | Omar; Lotfy Ismail | Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| GB9700878D0 (en) * | 1997-01-17 | 1997-03-05 | Scherer Ltd R P | Dosage forms and method for ameliorating male erectile dysfunction |
| JP2001512440A (ja) * | 1997-02-07 | 2001-08-21 | セラテック・インコーポレーテッド | テストステロンの欠乏症状を持つ女性のテストステロン補充のための組生物および方法 |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| KR100648536B1 (ko) * | 1997-11-10 | 2006-11-24 | 셀러지 파마세우티칼스, 인크 | 침투 보강 및 자극 감소를 위한 계 |
| PL345087A1 (en) * | 1998-06-25 | 2001-12-03 | Lavipharm Lab | A device and method for the treatment of erectile dysfunction |
| JP2000225116A (ja) * | 1998-12-04 | 2000-08-15 | Eisai Co Ltd | 陰茎径の測定法 |
| JP2000212080A (ja) * | 1999-01-26 | 2000-08-02 | Hiroshi Azuma | 勃起機能不全改善剤 |
| DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| ATE252380T1 (de) * | 1999-02-05 | 2003-11-15 | Cipla Ltd | Topische sprays enthaltend eine filmbildende zusammensetzung |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
-
2001
- 2001-08-29 JP JP2002522900A patent/JP2004524267A/ja active Pending
- 2001-08-29 NZ NZ524601A patent/NZ524601A/en not_active IP Right Cessation
- 2001-08-29 AT AT01966486T patent/ATE460939T1/de active
- 2001-08-29 MX MXPA03001858A patent/MXPA03001858A/es active IP Right Grant
- 2001-08-29 IL IL15469201A patent/IL154692A0/xx active IP Right Grant
- 2001-08-29 WO PCT/US2001/027205 patent/WO2002017927A1/en not_active Ceased
- 2001-08-29 TR TR2003/00776T patent/TR200300776T2/xx unknown
- 2001-08-29 KR KR1020037003148A patent/KR100861603B1/ko not_active Expired - Lifetime
- 2001-08-29 CA CA002420895A patent/CA2420895C/en not_active Expired - Lifetime
- 2001-08-29 EP EP10184108A patent/EP2283865A1/en not_active Withdrawn
- 2001-08-29 CA CA2746787A patent/CA2746787A1/en not_active Abandoned
- 2001-08-29 BR BR0113651-8A patent/BR0113651A/pt not_active Application Discontinuation
- 2001-08-29 PT PT01966486T patent/PT1315502E/pt unknown
- 2001-08-29 EP EP01966486A patent/EP1315502B1/en not_active Expired - Lifetime
- 2001-08-29 SI SI200130964T patent/SI1315502T1/sl unknown
- 2001-08-29 AU AU8699501A patent/AU8699501A/xx active Pending
- 2001-08-29 AU AU2001286995A patent/AU2001286995B2/en not_active Expired
- 2001-08-29 PL PL366037A patent/PL205279B1/pl unknown
- 2001-08-29 ES ES01966486T patent/ES2341090T3/es not_active Expired - Lifetime
- 2001-08-29 CN CNA018172660A patent/CN1473047A/zh active Pending
- 2001-08-29 DE DE60141587T patent/DE60141587D1/de not_active Expired - Lifetime
- 2001-08-29 DK DK01966486.1T patent/DK1315502T3/da active
-
2003
- 2003-02-28 NO NO20030955A patent/NO332649B1/no not_active IP Right Cessation
-
2004
- 2004-02-25 US US10/787,071 patent/US20050054623A1/en not_active Abandoned
-
2010
- 2010-06-15 CY CY20101100550T patent/CY1110085T1/el unknown
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