CA2746787A1 - Method of increasing testosterone and related steroid concentrations in women - Google Patents
Method of increasing testosterone and related steroid concentrations in women Download PDFInfo
- Publication number
- CA2746787A1 CA2746787A1 CA2746787A CA2746787A CA2746787A1 CA 2746787 A1 CA2746787 A1 CA 2746787A1 CA 2746787 A CA2746787 A CA 2746787A CA 2746787 A CA2746787 A CA 2746787A CA 2746787 A1 CA2746787 A1 CA 2746787A1
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- Prior art keywords
- testosterone
- penetration enhancer
- composition
- pharmaceutical composition
- enhancer comprises
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/651,777 | 2000-08-30 | ||
| US09/651,777 US6503894B1 (en) | 2000-08-30 | 2000-08-30 | Pharmaceutical composition and method for treating hypogonadism |
| US70375300A | 2000-11-01 | 2000-11-01 | |
| US09/703,753 | 2000-11-01 | ||
| US29239801P | 2001-05-21 | 2001-05-21 | |
| US60/292,398 | 2001-05-21 | ||
| CA002497686A CA2497686A1 (en) | 2000-08-30 | 2001-08-29 | Method of increasing testosterone and related steroid concentrations in women |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002497686A Division CA2497686A1 (en) | 2000-08-30 | 2001-08-29 | Method of increasing testosterone and related steroid concentrations in women |
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|---|---|
| CA2746787A1 true CA2746787A1 (en) | 2002-03-07 |
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| CA2746787A Abandoned CA2746787A1 (en) | 2000-08-30 | 2001-08-29 | Method of increasing testosterone and related steroid concentrations in women |
| CA002420895A Expired - Lifetime CA2420895C (en) | 2000-08-30 | 2001-08-29 | Method for treating erectile dysfunction and increasing libido in men |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002420895A Expired - Lifetime CA2420895C (en) | 2000-08-30 | 2001-08-29 | Method for treating erectile dysfunction and increasing libido in men |
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| EP (2) | EP1315502B1 (enExample) |
| JP (1) | JP2004524267A (enExample) |
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| SI (1) | SI1315502T1 (enExample) |
| TR (1) | TR200300776T2 (enExample) |
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| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
| US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
| US20040092494A9 (en) * | 2000-08-30 | 2004-05-13 | Dudley Robert E. | Method of increasing testosterone and related steroid concentrations in women |
| US20040002482A1 (en) * | 2000-08-30 | 2004-01-01 | Dudley Robert E. | Androgen pharmaceutical composition and method for treating depression |
| US20030139384A1 (en) * | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
| JP5039252B2 (ja) * | 2000-08-31 | 2012-10-03 | ユニメッド ファーマシューティカルズ，リミティド ライアビリティ カンパニー | 性機能低下を治療するための医薬組成物及び方法 |
| MY139721A (en) | 2002-04-19 | 2009-10-30 | Cpex Pharmaceuticals Inc | Pharmaceutical composition |
| CA2489865C (en) | 2002-06-25 | 2012-05-08 | Acrux Dds Pty Ltd | Transdermal delivery rate control using amorphous pharmaceutical compositions |
| AUPS317302A0 (en) * | 2002-06-25 | 2002-07-18 | Drug Delivery Solutions Pty Ltd | Metastable pharmaceutical compositions |
| IL152573A (en) | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| IL152575A (en) | 2002-10-31 | 2008-12-29 | Transpharma Medical Ltd | A skin-to-skin transmission system of water-insoluble drugs |
| US8883769B2 (en) | 2003-06-18 | 2014-11-11 | White Mountain Pharma, Inc. | Methods for the treatment of fibromyalgia and chronic fatigue syndrome |
| US20040259852A1 (en) | 2003-06-18 | 2004-12-23 | White Hillary D. | Trandsdermal compositions and methods for treatment of fibromyalgia and chronic fatigue syndrome |
| MX347237B (es) | 2004-05-11 | 2017-04-20 | Eb Ip Lybrido B V | Formulaciones farmaceuticas y usos de las mismas en el tratamiento de la disfuncion sexual femenina. |
| EP1634583A1 (en) * | 2004-09-09 | 2006-03-15 | Laboratoires Besins International | Testosterone gels comprising propylene glycol as penetration enhancer |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| EP1896038B1 (en) * | 2005-06-03 | 2016-11-09 | Acrux DDS Pty Ltd | Method and composition for testosterone transdermal delivery |
| CN101212975A (zh) | 2005-06-03 | 2008-07-02 | 艾克若克斯Dds有限公司 | 用于透皮给药的方法和组合物 |
| US20070065494A1 (en) * | 2005-08-03 | 2007-03-22 | Watson Laboratories, Inc. | Formulations and Methods for Enhancing the Transdermal Penetration of a Drug |
| JP5584415B2 (ja) | 2005-10-12 | 2014-09-03 | ユニメッド・ファーマシューティカルズ・エルエルシー | 改良したテストステロンゲル製剤及び使用の方法 |
| EP1790343A1 (en) | 2005-11-11 | 2007-05-30 | Emotional Brain B.V. | Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction |
| US8613360B2 (en) | 2006-09-29 | 2013-12-24 | M-I L.L.C. | Shaker and degasser combination |
| EP1925307A1 (en) | 2006-11-03 | 2008-05-28 | Emotional Brain B.V. | Use of 3-alpha-androstanediol in the treatment of sexual dysfunction |
| GB2461725B (en) | 2008-07-10 | 2012-06-13 | United Wire Ltd | Improved sifting screen |
| US20100022494A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100022991A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | System and device for maintaining physiological levels of steroid hormone in a subject |
| US20100022497A1 (en) * | 2008-07-24 | 2010-01-28 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing a cardiovascular disease or condition utilizing estrogen receptor modulators based on APOE allelic profile of a mammalian subject |
| US20110190201A1 (en) * | 2008-07-24 | 2011-08-04 | Searete Llc | Method, device, and kit for maintaining physiological levels of steroid hormone in a subject |
| US20100061976A1 (en) * | 2008-07-24 | 2010-03-11 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject |
| AU2011252700B2 (en) | 2010-05-12 | 2015-07-09 | Pomerleau Mechanica Inc. | Systems and methods for drying drill cuttings |
| RU2474424C2 (ru) * | 2010-09-24 | 2013-02-10 | Государственное образовательное учреждение высшего профессионального образования "Ивановская государственная медицинская академия Федерального агентства по здравоохранению и социальному развитию" | Способ коррекции гиперэстрадиолемии и нормогонадотропного гипогонадизма у мужчин |
| EP2640398A4 (en) | 2010-11-18 | 2014-05-14 | White Mountain Pharma Inc | METHOD FOR TREATING CHRONIC OR BZW. NON-RELIABLE PAIN AND / OR INCREASE OF PATIENT PAIN THRESHOLD AND PHARMACEUTICAL COMPOSITION FOR USE THEREOF |
| US9795639B1 (en) | 2013-03-16 | 2017-10-24 | BioDlogics, LLC | Methods for the treatment of erectile dysfunction by human birth tissue material compostion |
| US8785426B1 (en) | 2013-12-13 | 2014-07-22 | Upsher-Smith Laboratories, Inc. | Testosterone gel compositions and related methods |
| PL3710012T3 (pl) * | 2018-02-02 | 2025-11-17 | Acerus Biopharma Inc. | Sposoby terapii testosteronem |
| AU2020379828A1 (en) | 2019-11-06 | 2022-04-28 | Smartech Topical, Inc. | Topical formulations of cyclooxygenase inhibitors and their use |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4496556A (en) * | 1982-08-16 | 1985-01-29 | Norman Orentreich | Topical applications for preventing dry skin |
| US4855305A (en) * | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
| US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
| TW224048B (enExample) * | 1992-03-30 | 1994-05-21 | Hoechst Roussel Pharma | |
| WO1993025168A1 (en) * | 1992-06-11 | 1993-12-23 | Theratech, Inc. | The use of glycerin in moderating transdermal drug delivery |
| US5776923A (en) * | 1993-01-19 | 1998-07-07 | Endorecherche, Inc. | Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone |
| US5698589A (en) * | 1993-06-01 | 1997-12-16 | International Medical Innovations, Inc. | Water-based topical cream containing nitroglycerin and method of preparation and use thereof |
| JP4036496B2 (ja) * | 1995-10-24 | 2008-01-23 | リンテック株式会社 | ゲル製剤の製造方法 |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5730987A (en) * | 1996-06-10 | 1998-03-24 | Omar; Lotfy Ismail | Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba |
| DE19701949A1 (de) * | 1997-01-13 | 1998-07-16 | Jenapharm Gmbh | Transdermales therapeutisches System |
| GB9700878D0 (en) * | 1997-01-17 | 1997-03-05 | Scherer Ltd R P | Dosage forms and method for ameliorating male erectile dysfunction |
| BR9807828A (pt) * | 1997-02-07 | 2000-03-08 | Theratech Inc | Composições e método para a suplementação de testosterona em mulheres com sintomas de deficiência de testosterona |
| US6037346A (en) * | 1997-10-28 | 2000-03-14 | Vivus, Inc. | Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
| BR9814014B1 (pt) * | 1997-11-10 | 2014-10-07 | Strakan Int Ltd | Composição para aplicação tópica tendo propriedades de melhora da penetração |
| WO1999066870A1 (en) * | 1998-06-25 | 1999-12-29 | Lavipharm Laboratories, Inc. | A device and method for the treatment of erectile dysfunction |
| JP2000225116A (ja) * | 1998-12-04 | 2000-08-15 | Eisai Co Ltd | 陰茎径の測定法 |
| JP2000212080A (ja) * | 1999-01-26 | 2000-08-02 | Hiroshi Azuma | 勃起機能不全改善剤 |
| DE19903087A1 (de) * | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| RO121628B1 (ro) * | 1999-02-05 | 2008-01-30 | Cipla Limited | Compoziţie medicinală, topică, pulverizabilă,dozator care o conţine, procedeu de realizare a dozatorului şi utilizarea compoziţiei menţionate |
| US6087362A (en) * | 1999-03-16 | 2000-07-11 | Pentech Pharmaceuticals, Inc. | Apomorphine and sildenafil composition |
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2001
- 2001-08-29 NZ NZ524601A patent/NZ524601A/en not_active IP Right Cessation
- 2001-08-29 TR TR2003/00776T patent/TR200300776T2/xx unknown
- 2001-08-29 AU AU2001286995A patent/AU2001286995B2/en not_active Expired
- 2001-08-29 AT AT01966486T patent/ATE460939T1/de active
- 2001-08-29 EP EP01966486A patent/EP1315502B1/en not_active Expired - Lifetime
- 2001-08-29 CA CA2746787A patent/CA2746787A1/en not_active Abandoned
- 2001-08-29 JP JP2002522900A patent/JP2004524267A/ja active Pending
- 2001-08-29 DK DK01966486.1T patent/DK1315502T3/da active
- 2001-08-29 ES ES01966486T patent/ES2341090T3/es not_active Expired - Lifetime
- 2001-08-29 WO PCT/US2001/027205 patent/WO2002017927A1/en not_active Ceased
- 2001-08-29 MX MXPA03001858A patent/MXPA03001858A/es active IP Right Grant
- 2001-08-29 IL IL15469201A patent/IL154692A0/xx active IP Right Grant
- 2001-08-29 KR KR1020037003148A patent/KR100861603B1/ko not_active Expired - Lifetime
- 2001-08-29 AU AU8699501A patent/AU8699501A/xx active Pending
- 2001-08-29 CN CNA018172660A patent/CN1473047A/zh active Pending
- 2001-08-29 EP EP10184108A patent/EP2283865A1/en not_active Withdrawn
- 2001-08-29 BR BR0113651-8A patent/BR0113651A/pt not_active Application Discontinuation
- 2001-08-29 PT PT01966486T patent/PT1315502E/pt unknown
- 2001-08-29 DE DE60141587T patent/DE60141587D1/de not_active Expired - Lifetime
- 2001-08-29 CA CA002420895A patent/CA2420895C/en not_active Expired - Lifetime
- 2001-08-29 PL PL366037A patent/PL205279B1/pl unknown
- 2001-08-29 SI SI200130964T patent/SI1315502T1/sl unknown
-
2003
- 2003-02-28 NO NO20030955A patent/NO332649B1/no not_active IP Right Cessation
-
2004
- 2004-02-25 US US10/787,071 patent/US20050054623A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| SI1315502T1 (sl) | 2010-07-30 |
| JP2004524267A (ja) | 2004-08-12 |
| NO20030955L (no) | 2003-04-28 |
| CY1110085T1 (el) | 2015-01-14 |
| MXPA03001858A (es) | 2004-05-21 |
| EP1315502B1 (en) | 2010-03-17 |
| IL154692A0 (en) | 2003-09-17 |
| EP2283865A1 (en) | 2011-02-16 |
| PT1315502E (pt) | 2010-05-06 |
| AU2001286995B2 (en) | 2006-11-30 |
| BR0113651A (pt) | 2004-11-09 |
| KR100861603B1 (ko) | 2008-10-07 |
| CA2420895A1 (en) | 2002-03-07 |
| TR200300776T2 (tr) | 2005-10-21 |
| DE60141587D1 (de) | 2010-04-29 |
| DK1315502T3 (da) | 2010-07-19 |
| CA2420895C (en) | 2007-03-13 |
| NZ524601A (en) | 2006-04-28 |
| WO2002017927A1 (en) | 2002-03-07 |
| NO20030955D0 (no) | 2003-02-28 |
| EP1315502A1 (en) | 2003-06-04 |
| ATE460939T1 (de) | 2010-04-15 |
| CN1473047A (zh) | 2004-02-04 |
| US20050054623A1 (en) | 2005-03-10 |
| AU8699501A (en) | 2002-03-13 |
| ES2341090T3 (es) | 2010-06-15 |
| PL366037A1 (en) | 2005-01-24 |
| KR20030043949A (ko) | 2003-06-02 |
| PL205279B1 (pl) | 2010-03-31 |
| NO332649B1 (no) | 2012-11-26 |
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| FZDE | Discontinued |
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